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This integrative review establishes a novel socio-technical and technological architecture, conceptualized as Amazonian Nanobioeconomy 5.0, by critically synthesizing the convergence of the Amazonian lipid pharmacopeia, Natural Deep Eutectic Solvents (NaDESs), and Artificial Intelligence\/Machine Learning (AI\/ML) optimization. We critically evaluate how data-driven green nanomanufacturing can overcome the empirical trial-and-error bottlenecks and severe chemical variability inherent to native biodiversity oils and butters. The integration of predictive algorithms\u2014such as tree-based models and Bayesian optimization\u2014with eco-friendly extraction media enables the rational design of solid lipid nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) while accelerating their translation across the biotechnological \u201cValley of Death\u201d. Under the Safe-and-Sustainable-by-Design (SSbD) framework, this convergence offers a composition-dependent green alternative to harmful petrochemical volatile organic compounds, fosters circular biorefineries, and minimizes the global environmental footprint of advanced nanopharmaceuticals and cosmeceuticals. Finally, we articulate how this digital and green deep-tech infrastructure must be non-negotiably tethered to strict territorial governance, fair benefit-sharing, and epistemic justice to prevent data colonialism and foster a truly just planetary transition.<\/jats:p>","DOI":"10.3390\/molecules31183264","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:57:34Z","timestamp":1789473454000},"page":"3264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amazonian Nanobioeconomy 5.0: A Critical Integrative Review and Conceptual Framework Toward a Just Planetary Transition"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2009-2414","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Schuh","sequence":"first","affiliation":[{"name":"Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"},{"name":"Cooil Cosmetics, Bras\u00edlia 72622-401, DF, Brazil"},{"name":"Laboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of Biological Sciences, University of Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Figueiredo","family":"de Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais","family":"Valim","sequence":"additional","affiliation":[{"name":"Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86001, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6851-9582","authenticated-orcid":false,"given":"Thalita do Esp\u00edrito Santo","family":"Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"},{"name":"Cooil Cosmetics, Bras\u00edlia 72622-401, DF, Brazil"},{"name":"Laboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of Biological Sciences, University of Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1648-4403","authenticated-orcid":false,"given":"Brenda Martins dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Cooil Cosmetics, Bras\u00edlia 72622-401, DF, Brazil"},{"name":"Laboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of Biological Sciences, University of Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0485-4617","authenticated-orcid":false,"given":"Pedro Henrique Almeida de Jesus","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Cooil Cosmetics, Bras\u00edlia 72622-401, DF, Brazil"},{"name":"Laboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of Biological Sciences, University of Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0901-5991","authenticated-orcid":false,"given":"Leonardo Froes de Azevedo","family":"Chang","sequence":"additional","affiliation":[{"name":"Cooil Cosmetics, Bras\u00edlia 72622-401, DF, Brazil"},{"name":"Laboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of 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