{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:59Z","timestamp":1792789679025,"version":"4.5.0"},"reference-count":20,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["22177138"],"award-info":[{"award-number":["22177138"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"award":["22177138"],"award-info":[{"award-number":["22177138"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>As a continuation of our previous study on erinacenones A\u2013L (Part 1), thirteen previously undescribed isoindolin-1-ones, erinacenones M\u2013Y (1\u201313), were isolated from the fermentation broth of Hericium erinaceus. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS), and the absolute configurations of 1\u201313 were determined by comparing their specific rotations with those of related phthalimidines (14\u201323). Compound 11 showed the highest \u03b1-glucosidase inhibitory activity among the tested compounds, with 31.5% inhibition at 50 \u03bcM. These findings significantly enrich the chemical diversity of isoindolinone metabolites from H. erinaceus and provide a foundation for future structure\u2013activity relationship studies.<\/jats:p>","DOI":"10.3390\/molecules31183333","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:12:09Z","timestamp":1789999929000},"page":"3333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Erinacenones M\u2013Y, Part 2: Thirteen New Isoindolinone Alkaloids with \u03b1-Glucosidase Inhibitory Activity from Liquid Cultures of the Edible and Medicinal Mushroom Hericium erinaceus"],"prefix":"10.3390","volume":"31","author":[{"given":"Lin-Lin","family":"Yuan","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Tarim University, Alar 843300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6279-7893","authenticated-orcid":false,"given":"Ji-Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Bioactive Natural Products, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00394-015-0974-2","article-title":"Food protein-derived bioactive peptides in management of type 2 diabetes","volume":"54","author":"Patil","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00216-013-7496-7","article-title":"Analysis of cyathane-type diterpenoids from Cyathus striatus and Hericium erinaceus by high-resolution MALDI MS imaging","volume":"406","author":"Bhandari","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1016\/0040-4039(91)80039-9","article-title":"Hericenone C, D and E, stimulators of nerve growth factor (NGF) synthesis, from the mushroom Hericium erinaceum","volume":"32","author":"Kawagishi","year":"1991","journal-title":"Tetrahedron Lett."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0031-9422(92)80127-Z","article-title":"Chromans, hericenone F, G and H from the mushroom Hericium erinaceum","volume":"32","author":"Kawagishi","year":"1993","journal-title":"Phytochemistry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0040-4039(00)76760-8","article-title":"Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum","volume":"35","author":"Kawagishi","year":"1994","journal-title":"Tetrahedron Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7399","DOI":"10.1016\/0040-4039(96)01687-5","article-title":"Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum","volume":"37","author":"Kawagishi","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ja.2012.65","article-title":"Isohericenone, a new cytotoxic isoindolinone alkaloid from Hericium erinaceum","volume":"65","author":"Kim","year":"2012","journal-title":"J. Antibiot."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.foodchem.2014.08.078","article-title":"Isolation and identification of aromatic compounds in Lion\u2019s Mane Mushroom and their anticancer activities","volume":"170","author":"Li","year":"2015","journal-title":"Food. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.fitote.2016.04.010","article-title":"New isoindolinones from the fruiting bodies of Hericium erinaceum","volume":"111","author":"Wang","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.phymed.2010.05.004","article-title":"Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation","volume":"17","author":"Mori","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yuan, L.L., and Liu, J.K. (2024). Erinacenones A-L: Twelve New Isoindolinone Alkaloids from the Edible and Medicinal Mushroom Hericium erinaceus. Molecules, 29.","DOI":"10.3390\/molecules29204901"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"113197","DOI":"10.1016\/j.jep.2020.113197","article-title":"Characterization of \u03b1-glucosidase inhibitory constituents of the fruiting body of lion\u2019s mane mushroom (Hericium erinaceus)","volume":"262","author":"Lee","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1016\/j.tet.2012.03.046","article-title":"Two new aromatic compounds and a new D-arabinitol ester from the mushroom Hericium erinaceum","volume":"68","author":"Miyazawa","year":"2012","journal-title":"Tetrahedron"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.fitote.2017.08.017","article-title":"Isoindolinone-containing meroterpenoids with \u03b1-glucosidase inhibitory activity from mushroom Hericium caput-medusae","volume":"122","author":"Chen","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1039\/c0np00006j","article-title":"N-Containing compounds of macromycetes","volume":"28","author":"Jiang","year":"2011","journal-title":"Nat. Prod. 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Rehder","volume":"204","author":"Yuan","year":"2022","journal-title":"Phytochemistry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1021\/np070367i","article-title":"Structure and Absolute Configuration of Clerodane Diterpene Glycosides and a Rearranged Cadinane Sesquiterpene Glycoside from the Stems of Tinospora sinensis","volume":"70","author":"Li","year":"2007","journal-title":"J. Nat. 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