{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:03:27Z","timestamp":1790053407256,"version":"4.0.1"},"reference-count":19,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Inje University","id":[{"id":"https:\/\/ror.org\/04xqwq985","id-type":"ROR","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/04xqwq985","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We report the first total synthesis of xentrivalpeptide A, a cyclic heptadepsipeptide natural product, through a convergent solution-phase strategy. The linear macrocyclization precursor was assembled from two peptide fragments, and a key DEPBT-mediated macrolactamization efficiently furnished the macrocyclic core despite the sterically demanding Val\u2013Val cyclization junction. Late-stage installation of the side chain onto the common cyclic hexadepsipeptide core provides a potentially general route to other members of the xentrivalpeptide family. Additionally, switching the macrocyclization reagent from DEPBT to PyBOP enabled access to the diastereomeric congener 6\u03b1-epi-xentrivalpeptide A.<\/jats:p>","DOI":"10.3390\/molecules31183340","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:12:09Z","timestamp":1789999929000},"page":"3340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Total Synthesis of Xentrivalpeptide A and Its 6\u03b1-epi Derivative"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6442-5790","authenticated-orcid":false,"given":"Joonseong","family":"Hur","sequence":"first","affiliation":[{"name":"College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae-si 50834, Gyeongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunseong","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae-si 50834, Gyeongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1021\/jacs.8b13178","article-title":"Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges","volume":"141","author":"Vinogradov","year":"2019","journal-title":"J. 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