{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:03:33Z","timestamp":1790003013002,"version":"4.0.1"},"reference-count":72,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2024-547"],"award-info":[{"award-number":["075-15-2024-547"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The amination of 2-chloro-1,10-phenanthroline with various alkylamines and diamines was investigated. The Pd-catalyzed reaction and catalyst-free protocols were shown to lead to different products. Catalyst-free amination of this substrate using aliphatic amines yielded secondary phenanthrolin-2-yl amines in 40\u201380% yields. The Pd-catalyzed reaction afforded tertiary di(phenanthrolin-2-yl)amines even in the presence of excess amine. This allows for the synthesis of unsymmetric N,N-diheteroaryl-substituted diamines in 44\u201350% yields with good selectivity. Using 2-bromo-1,10-phenanthroline leads to an increase in their yields (62\u201391%). We have also demonstrated the possibility to obtain N,N,N\u2032,N\u2032-tetraheteroarylated derivatives of diamines in yields of up to 55%. Thus obtained compounds can serve as promising ligands for various applications.<\/jats:p>","DOI":"10.3390\/molecules31183344","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:12:09Z","timestamp":1789999929000},"page":"3344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual Chemodivergence in the Amination of 2-Chloro-1,10-Phenanthroline with Di- and Polyamines: Comparison of the Pd-Catalyzed and Catalyst-Free Pathways"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1193-0636","authenticated-orcid":false,"given":"Violetta A.","family":"Ionova","sequence":"first","affiliation":[{"name":"Lomonosov Moscow State University, Department of Chemistry, 1-3, Leninskie Gory, Moscow 119991, Russia"},{"name":"A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninskiy Pr. 29, Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-8880","authenticated-orcid":false,"given":"Victoria E.","family":"Gontcharenko","sequence":"additional","affiliation":[{"name":"P.N. 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