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In this study, endophytic fungi isolated from Ocotea diospyrifolia leaves were investigated as potential producers of anti-inflammatory natural products using an integrated workflow combining biological screening, comparative metabolomics, and high-resolution mass spectrometry-based dereplication. Crude extracts from five endophytic fungi (designated as OD1, OD5, OD6, OD7, and OD8) were screened for their ability to inhibit prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) release. Lentinus sp. OD5 extract displayed promising dual inhibitory activity, and its UHPLC-QTOF-HRMS-based metabolomic profiling enabled the annotation of two compounds. Mass spectrometry data analysis, combined with SIRIUS annotation, putatively identified rhodojaponin, a grayanane diterpene with reported anti-inflammatory activity, and tinocordiside, an immunomodulatory diterpenoid glycoside. These findings expand the chemical diversity currently associated with endophytic fungi and provide a strong foundation for the future isolation, structural confirmation, and pharmacological evaluation of anti-inflammatory metabolites with potential therapeutic applications.<\/jats:p>","DOI":"10.3390\/molecules31193499","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:19:08Z","timestamp":1790842748000},"page":"3499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dereplication of Natural Products from an Endophytic Fungus from Ocotea diospyrifolia with Anti-Inflammatory Potential Through Dual Modulation of PGE2 and LTB4 Release"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3782-8431","authenticated-orcid":false,"given":"Giovanni S.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Institute of Chemistry, Federal University of Bahia, Salvador 40170-115, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5594-2954","authenticated-orcid":false,"given":"Marcus V. 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(2024). Inflammation: The Cause of All Diseases. Cells, 13.","DOI":"10.3390\/cells13221906"},{"key":"ref_2","first-page":"5","article-title":"Benign Prostate Hyperplasia and Nutrition","volume":"33","author":"Das","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejps.2018.06.003","article-title":"Safer Anti-Inflammatory Therapy through Dual COX-2\/5-LOX Inhibitors: A Structure-Based Approach","volume":"121","author":"P","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1039\/D1MD00280E","article-title":"Non-Steroidal Anti-Inflammatory Drugs: Recent Advances in the Use of Synthetic COX-2 Inhibitors","volume":"13","author":"Ahmadi","year":"2022","journal-title":"RSC Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: New Adventures of an Old Flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Yang, K., Ma, W., Liang, H., Ouyang, Q., Tang, C., and Lai, L. (2007). Dynamic Simulations on the Arachidonic Acid Metabolic Network. PLoS Comput. Biol., 3.","DOI":"10.1371\/journal.pcbi.0030055"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.drudis.2006.11.008","article-title":"Multi-Target Therapeutics: When the Whole is Greater than the Sum of the Parts","volume":"12","author":"Zimmermann","year":"2007","journal-title":"Drug Discov. Today"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12282-016-0723-2","article-title":"Dual COX\/LOX-2\/5 Inhibition: A Promising Target for Cancer Chemoprevention","volume":"24","author":"Gautam","year":"2017","journal-title":"Breast Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.fct.2015.05.022","article-title":"The Beneficial Role of Curcumin on Inflammation, Diabetes and Neurodegenerative Disease: A Recent Update","volume":"83","author":"Ghosh","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.jalz.2013.05.619","article-title":"P1\u2013392: Licofelone: A Dual COX\/5-LOX Inhibitor Attenuates Intracerebroventricular Streptozotocin-induced Cognitive Deficit, Oxidative Stress and Neuro-inflammatory Cytokines in Rats","volume":"9","author":"Deshmukh","year":"2013","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural Products as Sources of New Drugs over the 30 Years from 1981 to 2010","volume":"75","author":"Newman","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e05885","DOI":"10.1002\/slct.202405885","article-title":"Review on Anti-Inflammatory Activity of Natural Products","volume":"10","author":"Saha","year":"2025","journal-title":"ChemistrySelect"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1572-5995(03)80016-9","article-title":"Generating and Screening a Natural Product Library for Cyclooxygenase and Lipoxygenase Dual Inhibitors","volume":"29","author":"Jia","year":"2003","journal-title":"Stud. Nat. Prod. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jep.2015.02.005","article-title":"Ethnobotanical Study of Plants Used for Therapeutic Purposes in the Atlantic Forest Region, Southern Brazil","volume":"164","author":"Tribess","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"155060","DOI":"10.1016\/j.phymed.2023.155060","article-title":"Bioprospecting-Based Untargeted Metabolomics Identifies Alkaloids as Potential Anti-Inflammatory Bioactive Markers of Ocotea Species (Lauraceae)","volume":"120","author":"Cruz","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"113378","DOI":"10.1016\/j.jep.2020.113378","article-title":"Confirmation of Ethnopharmacological Anti-Inflammatory Properties of Ocotea odorifera and Determination of Its Main Active Compounds","volume":"264","author":"Casoti","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.phytol.2021.02.002","article-title":"Chemistry of Leaves, Bark, and Essential Oils from Ocotea diospyrifolia and Anti-Inflammatory Activity\u2014Dual Inhibition of Edema and Neutrophil Recruitment","volume":"42","author":"Silva","year":"2021","journal-title":"Phytochem. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/mpp.12483","article-title":"Exploitation of Endophytes for Sustainable Agricultural Intensification","volume":"18","author":"Gurr","year":"2017","journal-title":"Mol. Plant Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12934-026-03036-4","article-title":"Untapped Microbial Factories for Next-Generation Therapeutics: Endophytic Fungi of Medicinal Plants","volume":"25","author":"Nagib","year":"2026","journal-title":"Microb. Cell Fact."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/12298093.2022.2126166","article-title":"Isolation and Cytotoxic Potency of Endophytic Fungi Associated with Dysosma Difformis, a Study for the Novel Resources of Podophyllotoxin","volume":"50","year":"2022","journal-title":"Mycobiology"},{"key":"ref_21","first-page":"1631","article-title":"The Metabolome of the Ocotea spp.: From Biosynthetic Aspects to Bioactive Chemical Scaffolds by Integrating the Genus Chemical Database (Ocotea DB)","volume":"89","author":"Bueno","year":"2026","journal-title":"J. Nat. Prod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s11306-014-0656-8","article-title":"Metabolite Identification: Are You Sure? And How Do Your Peers Gauge your Confidence?","volume":"10","author":"Creek","year":"2014","journal-title":"Metabolomics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1248\/cpb.20.1090","article-title":"Stereostructure of Rhodojapoin V and VII, Toxins of Rhododendron japonicum","volume":"20","author":"Hikino","year":"1972","journal-title":"Chem. Pharm. Bull."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8656","DOI":"10.1038\/s41598-023-35161-0","article-title":"Dual Synergistic Inhibition of COX and LOX by Potential Chemicals from Indian Daily Spices Investigated through Detailed Computational Studies","volume":"13","author":"Rudrapal","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.phytol.2018.11.024","article-title":"Anti-Inflammatory Metabolites from Endophytic Fungus Fusarium sp.","volume":"29","author":"Khayat","year":"2019","journal-title":"Phytochem. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"106238","DOI":"10.1016\/j.fitote.2024.106238","article-title":"Discovery of Metabolite from the Insect-Derived Endophytic Penicillium chrysogenum and Their COX-2 Inhibitory Activity","volume":"179","author":"Zhu","year":"2024","journal-title":"Fitoterapia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"113975","DOI":"10.1016\/j.jep.2021.113975","article-title":"Identification of Bioactive Metabolites and Evaluation of in vitro Anti-Inflammatory and in vivo Antinociceptive and Antiarthritic Activities of Endophyte Fungi Isolated from Elaeocarpus floribundus Blume","volume":"273","author":"Mazumder","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1021\/acs.jnatprod.6b01085","article-title":"Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community","volume":"80","author":"Raja","year":"2017","journal-title":"J. Nat. Prod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"129883","DOI":"10.1016\/j.foodchem.2021.129883","article-title":"Recent Advances in Polysaccharides from Lentinus edodes (Berk.): Isolation, Structures and Bioactivities","volume":"358","author":"Sheng","year":"2021","journal-title":"Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4315\/0362-028X.JFP-16-306","article-title":"A Bioprocessed Polysaccharide from Lentinus edodes Mycelia Cultures with Turmeric Protects Chicks from a Lethal Challenge of Salmonella gallinarum","volume":"80","author":"Han","year":"2017","journal-title":"J. Food Prot."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"56587","DOI":"10.1021\/acsomega.5c08920","article-title":"Dereplication-Guided Isolation of 3-O-Methylfunicone from Endophytic Fungal Co-Culture and Its Inhibitory Effect on Phytophthora palmivora","volume":"10","author":"Santos","year":"2025","journal-title":"ACS Omega"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9621","DOI":"10.1021\/acs.jafc.3c09531","article-title":"Targeting of Antifungal Metabolites from Grapevine Byproducts by UPLC\u2013HRMS\/MS Approaches Using Bioactivity-Based Molecular Networking","volume":"72","author":"Tardif","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41467-022-35734-z","article-title":"Annotation of Natural Product Compound Families Using Molecular Networking Topology and Structural Similarity Fingerprinting","volume":"14","author":"Morehouse","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41592-019-0344-8","article-title":"SIRIUS 4: A Rapid Tool for Turning Tandem Mass Spectra into Metabolite Structure Information","volume":"16","author":"Fleischauer","year":"2019","journal-title":"Nat. Methods"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1021\/np970169z","article-title":"Tinocordiside, a New Rearranged Cadinane Sesquiterpene Glycoside from Tinospora cordifolia","volume":"60","author":"Ghosal","year":"1997","journal-title":"J. Nat. Prod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1021\/acs.jnatprod.7b00799","article-title":"Anti-Inflammatory Grayanane Diterpenoids from the Leaves of Rhododendron molle","volume":"81","author":"Zhou","year":"2018","journal-title":"J. Nat. Prod."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e22551","DOI":"10.1002\/jbt.22551","article-title":"Rhodojaponin II Inhibits TNF-\u03b1-induced Inflammatory Cytokine Secretion in MH7A Human Rheumatoid Arthritis Fibroblast-like Synoviocytes","volume":"34","author":"Kong","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12223-019-00727-x","article-title":"Natural Trypanocidal Product Produced by Endophytic Fungi through Co-Culturing","volume":"65","author":"Silva","year":"2020","journal-title":"Folia Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5943\/ppq\/5\/2\/6","article-title":"A Rapid and Efficient Method of Fungal Genomic DNA Extraction, Suitable for PCR Based Molecular Methods","volume":"5","author":"Aamir","year":"2015","journal-title":"Plant Pathol. Quar."},{"key":"ref_40","unstructured":"Innis, M.A., Gelfand, D.H., Sninsky, J.J., and White, T.J. (1990). Amplification and Direct Sequencing of Fungal Ribosomal RNA Genes for Phylogenetics. PCR Protocol: A Guide to Methods and Applications, Academic Press."},{"key":"ref_41","first-page":"95","article-title":"BioEdit: A User-Friendly Biological Sequence Alignment Editor and Analysis Program for Windows 95\/98\/NT","volume":"41","author":"Hall","year":"1999","journal-title":"Nucleic Acids Symp. Ser."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic Local Alignment Search Tool","volume":"215","author":"Altschup","year":"1990","journal-title":"J. Mol. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","article-title":"The CLUSTAL_X Windows Interface: Flexible Strategies for Multiple Sequence Alignment Aided by Quality Analysis Tools","volume":"25","author":"Thompson","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: Molecular Evolutionary Genetics Analysis Version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01731581","article-title":"A Simple Method for Estimating Evolutionary Rates of Base Substitutions through Comparative Studies of Nucleotide Sequences","volume":"16","author":"Kimura","year":"1980","journal-title":"J. Mol. Evol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1558-5646.1985.tb00420.x","article-title":"Confidence Limits on Phylogenies: An Approach Using the Bootstrap","volume":"39","author":"Felsenstein","year":"1985","journal-title":"Evolution"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/pca.3031","article-title":"In vivo Anti-inflammatory Activity of Fabaceae Species Extracts Screened by a New ex vivo Assay Using Human Whole Blood","volume":"32","author":"Rosa","year":"2021","journal-title":"Phytochem. Anal."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/19\/3499\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:17:03Z","timestamp":1791001023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/19\/3499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":47,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["molecules31193499"],"URL":"https:\/\/doi.org\/10.3390\/molecules31193499","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}