{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:48:10Z","timestamp":1791953290411,"version":"4.3.4"},"reference-count":242,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nicotinamide adenine dinucleotide (+)-dependent class III histone deacetylases, widely known as sirtuins (SIRTs), have been found to play key functions in a wide range of biological processes implicated in ageing processes. The downregulation of some specific SIRTs was reported in ageing and in some neurological diseases such as Alzheimer\u2019s disease. SIRT modulator factors, such as diet, exercise and various natural compounds, have recently emerged as a potential new avenue of therapy to modify the progression of Alzheimer\u2019s disease and delay some ageing effects. This review synthesises recent advances in the understanding of the modulatory effects of SIRTs in the context of healthy ageing with a particular focus on cognitive function and implications for Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3390\/molecules31193528","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:02:27Z","timestamp":1791194547000},"page":"3528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Specific Sirtuin Modulation: Emerging Therapeutic Strategies for Healthy Cognitive Ageing and Potential Implications for Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"31","author":[{"given":"Charlotte","family":"McDermott","sequence":"first","affiliation":[{"name":"School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia"},{"name":"Healthy Brain and Mind Research Centre, Australian Catholic University, Melbourne, VIC 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Cole","sequence":"additional","affiliation":[{"name":"School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia"},{"name":"Healthy Brain and Mind Research Centre, Australian Catholic University, Melbourne, VIC 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-4610","authenticated-orcid":false,"given":"Madison","family":"Pearson","sequence":"additional","affiliation":[{"name":"School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia"},{"name":"Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Brisbane, QLD 4014, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2554-4955","authenticated-orcid":false,"given":"Pia","family":"Winberg","sequence":"additional","affiliation":[{"name":"School of Medical, Indigenous and Health Science, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0926-5473","authenticated-orcid":false,"given":"Francesca","family":"Fernandez","sequence":"additional","affiliation":[{"name":"School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia"},{"name":"Healthy Brain and Mind Research Centre, Australian Catholic University, Melbourne, VIC 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/01.NURSE.0000820024.83629.ee","article-title":"Palliative care for patients with advanced dementia","volume":"52","author":"Navia","year":"2022","journal-title":"Nursing"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Haque, R., Alam, K., Gow, J., and Neville, C. 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