{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:09:41Z","timestamp":1792789781944,"version":"4.5.0"},"reference-count":213,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hubei Provincial Department of Science and Technology","award":["2024DJC070"],"award-info":[{"award-number":["2024DJC070"]}]},{"award":["2024DJC070"],"award-info":[{"award-number":["2024DJC070"]}],"id":[{"id":"https:\/\/ror.org\/00tbh0t11","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Hubei Province","award":["2025AFD336"],"award-info":[{"award-number":["2025AFD336"]}]},{"name":"Hubei Key Laboratory of Germplasm Improvement and Utilization of Dabie Shan Dao-di Herbs","award":["202520004"],"award-info":[{"award-number":["202520004"]}]},{"name":"Jingchu University of Technology","award":["YB2602"],"award-info":[{"award-number":["YB2602"]}],"id":[{"id":"https:\/\/ror.org\/037kvhq82","id-type":"ROR","asserted-by":"crossref"}]},{"award":["YB2602"],"award-info":[{"award-number":["YB2602"]}],"id":[{"id":"https:\/\/ror.org\/037kvhq82","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Lonicera japonica Thunb. (L. japonica), an edible medicinal plant that has been widely consumed in East Asian countries, including China, Japan, and Korea, for centuries, has long been regarded as a superior herb in traditional Chinese medicine and is an economically important crop commonly used in beverages, foods, and herbal medicines. Extensive studies have demonstrated that L. japonica possesses a broad spectrum of health-promoting properties, including antioxidant, antibacterial, antiviral, immunomodulatory, metabolic regulatory, and anti-endotoxin activities. This review comprehensively summarizes the distribution, cultivation, quality evaluation, cultivar identification, bioactive constituents, and health-promoting effects of L. japonica, while also highlighting key scientific questions that warrant further investigation. Furthermore, the molecular mechanisms responsible for the major pharmacological activities of L. japonica flowers\u2014including anti-inflammatory and immunomodulatory effects\u2014are comprehensively discussed. This review provides an up-to-date scientific foundation and valuable insights to facilitate the continued development and diversified applications of L. japonica in the pharmaceutical, nutraceutical, and functional food industries.<\/jats:p>","DOI":"10.3390\/molecules31193540","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:02:27Z","timestamp":1791194547000},"page":"3540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights into the Health-Promoting Properties and Nutraceutical and Food Applications of Lonicera japonica Thunb."],"prefix":"10.3390","volume":"31","author":[{"given":"Shuzhen","family":"Wang","sequence":"first","affiliation":[{"name":"LiShizhen Culture and Industry Research Center of Traditional Chinese Medicine, Li Shizhen College of Traditional Chinese Medicine and College of Biology and Agricultural Resources, Huanggang Normal University, Huanggang 438000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Xiang","sequence":"additional","affiliation":[{"name":"LiShizhen Culture and Industry Research Center of Traditional Chinese Medicine, Li Shizhen College of Traditional Chinese Medicine and College of Biology and Agricultural Resources, Huanggang Normal University, Huanggang 438000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Long","sequence":"additional","affiliation":[{"name":"LiShizhen Culture and Industry Research Center of Traditional Chinese Medicine, Li Shizhen College of Traditional Chinese Medicine and College of Biology and Agricultural Resources, Huanggang Normal University, Huanggang 438000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"LiShizhen Culture and Industry Research Center of Traditional Chinese Medicine, Li Shizhen College of Traditional Chinese Medicine and College of Biology and Agricultural Resources, Huanggang Normal University, Huanggang 438000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanju","family":"Zhang","sequence":"additional","affiliation":[{"name":"LiShizhen Culture and Industry Research Center of Traditional Chinese Medicine, Li Shizhen College of Traditional Chinese Medicine and College of Biology and Agricultural Resources, Huanggang Normal University, Huanggang 438000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"He","sequence":"additional","affiliation":[{"name":"LiShizhen Culture and Industry Research Center of Traditional Chinese Medicine, Li Shizhen College of Traditional Chinese Medicine and College of Biology and Agricultural Resources, Huanggang Normal University, Huanggang 438000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8273-2085","authenticated-orcid":false,"given":"Chi-Tang","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6167-0660","authenticated-orcid":false,"given":"Shiming","family":"Li","sequence":"additional","affiliation":[{"name":"LiShizhen Culture and Industry Research Center of Traditional Chinese Medicine, Li Shizhen College of Traditional Chinese Medicine and College of Biology and Agricultural Resources, Huanggang Normal University, Huanggang 438000, China"},{"name":"Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"ref_1","unstructured":"Tao, H.J. (1986). Mingyi Bielu (Supplement to the Records of Eminent Physicians), People\u2019s Medical Publishing House. (In Chinese)."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2011.08.016","article-title":"Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"138","author":"Shang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e31722","DOI":"10.1016\/j.heliyon.2024.e31722","article-title":"Comparative study on chemical constituents of different medicinal parts of Lonicera japonica Thunb. Based on LC-MS combined with multivariate statistical analysis","volume":"10","author":"Zhang","year":"2024","journal-title":"Heliyon"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhang, X., Huo, H., Hu, L., Yang, F., Deng, Y., Hu, X., Wang, H., and Huo, J. (2026). The biological functions of Lonicera japonica in animal husbandry and its application in green breeding. Front. Vet. Sci., 12.","DOI":"10.3389\/fvets.2025.1622768"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Li, J., Ye, C., and Chang, C. (2020). Comparative transcriptomics analysis revealing flower trichome development during flower development in two Lonicera japonica Thunb. cultivars using RNA-seq. BMC Plant Biol., 20.","DOI":"10.1186\/s12870-020-02546-6"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"148062","DOI":"10.1016\/j.foodchem.2026.148062","article-title":"Machine learning-enabled metabolomics for geographical authentication of Lonicera japonica via UHPLC-Q-TOF-MS\/MS and SHAP interpretation","volume":"505","author":"Xue","year":"2026","journal-title":"Food Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e16143","DOI":"10.1002\/ajb2.16143","article-title":"A phylogenomic analysis of Lonicera and its bearing on the evolution of organ fusion","volume":"110","author":"Srivastav","year":"2023","journal-title":"Am. J. Bot."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hou, C., Huang, L., Li, Z., Sun, N., Yang, S., Li, J., and Liu, Z. (2025). Domestication of medicinal plants (Lonicera japonica Thunb.) in China: Comparison of morphological, resistance and biochemical traits between wild and cultivated populations. Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1501396"},{"key":"ref_9","first-page":"4341","article-title":"Annual dynamic variation of seven active components of Lonicera japonica in leaf growth and pruning periods","volume":"47","author":"Huang","year":"2022","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12696","DOI":"10.1038\/srep12696","article-title":"The role of silicon in physiology of the medicinal plant (Lonicera japonica L.) under salt stress","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"12346","DOI":"10.1021\/acs.jafc.3c02646","article-title":"Cationic Conjugated Polymer Fluorescence Resonance Energy Transfer for DNA Methylation Assessment to Discriminate the Geographical Origins of Lonicerae japonicae flos","volume":"71","author":"Wang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.plaphy.2023.01.013","article-title":"Deciphering salt tolerance in tetraploid honeysuckle (Lonicera japonica Thunb.) from ion homeostasis, water balance and antioxidant defense","volume":"195","author":"Yan","year":"2023","journal-title":"Plant Physiol. Biochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"138411","DOI":"10.1016\/j.chemosphere.2023.138411","article-title":"Cadmium stimulated cooperation between bacterial endophytes and plant intrinsic detoxification mechanism in Lonicera japonica thunb","volume":"325","author":"Xie","year":"2023","journal-title":"Chemosphere"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhang, F., Shi, P., Liu, H., Zhang, Y., Yu, X., Li, J., and Pu, G. (2019). A Simple, Rapid, and Practical Method for Distinguishing Lonicerae japonicae Flos from Lonicerae Flos. Molecules, 24.","DOI":"10.3390\/molecules24193455"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Liu, K., Jin, Y., Gu, L., Li, M., Wang, P., Yin, G., Wang, S., Wang, T., Wang, L., and Wang, B. (2023). Classification and Authentication of Lonicerae japonicae Flos and Lonicerae Flos by Using 1H-NMR Spectroscopy and Chemical Pattern Recognition Analysis. Molecules, 28.","DOI":"10.3390\/molecules28196860"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/pca.2943","article-title":"A comprehensive study of the aerial parts of Lonicera japonica Thunb. based on metabolite profiling coupled with PLS-DA","volume":"31","author":"Cai","year":"2020","journal-title":"Phytochem. Anal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/jssc.202100973","article-title":"Study on phenolic acids of Lonicerae japonicae Flos based on ultrahigh performance liquid chromatography-tandem mass spectrometry combined with multivariate statistical analysis","volume":"45","author":"Xiong","year":"2022","journal-title":"J. Sep. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e70348","DOI":"10.1002\/jssc.70348","article-title":"Machine Learning Combining with Ultra-High Performance Liquid Chromatography-Time-of-Flight Mass Spectrometry and Gas Chromatography-Ion Mobility Chromatography Data Fusion for Geographical Origins Discrimination of Lonicerae japonicae Flos","volume":"49","author":"Miao","year":"2026","journal-title":"J. Sep. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1111\/jipb.13112","article-title":"LjaFGD: Lonicera japonica functional genomics database","volume":"63","author":"Xiao","year":"2021","journal-title":"J. Integr. Plant Biol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zhang, J., Pan, B., Yang, J., Pan, Q., Zhu, P., Yang, J., Zhang, M., and Xiao, Q. (2025). LoniComp: A platform for gene function comparison and analysis between Lonicera japonica and Lonicera macranthoides. BMC Genom., 26.","DOI":"10.1186\/s12864-025-11507-y"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/nph.16552","article-title":"The honeysuckle genome provides insight into the molecular mechanism of carotenoid metabolism underlying dynamic flower coloration","volume":"227","author":"Pu","year":"2020","journal-title":"New Phytol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1080\/23802359.2019.1687353","article-title":"Characterization of the complete chloroplast genome of Lonicera japonica (Caprifoliaceae), a long history herb species plant from China","volume":"4","author":"Luo","year":"2019","journal-title":"Mitochondrial DNA Part B"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1080\/23802359.2018.1502637","article-title":"The complete chloroplast genome sequence of Korean Lonicera japonica and intra-species diversity","volume":"3","author":"Kang","year":"2018","journal-title":"Mitochondrial DNA Part B"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20220984","DOI":"10.1515\/biol-2022-0984","article-title":"Comparative analysis of chloroplast genome of Lonicera japonica cv. Damaohua","volume":"19","author":"Zhang","year":"2024","journal-title":"Open Life Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Xia, H., Zhang, L., Wu, G., Fu, C., Long, Y., Xiang, J., Gan, J., Zhou, Y., Yu, L., and Li, M. (2016). Genome-wide identification and characterization of MicroRNAs and target genes in Lonicera japonica. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164140"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zhang, M., Li, M., Fu, H., Wang, K., Tian, X., Qiu, R., Liu, J., Gao, S., Zhong, Z., and Yang, B. (2022). Transcriptomic analysis unravels the molecular response of Lonicera japonica leaves to chilling stress. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.1092857"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e8690","DOI":"10.7717\/peerj.8690","article-title":"Comparative transcriptomic analyses of chlorogenic acid and luteolosides biosynthesis pathways at different flowering stages of diploid and tetraploid Lonicera japonica","volume":"8","author":"Wang","year":"2020","journal-title":"PeerJ"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Xia, Y., Chen, W., Xiang, W., Wang, D., Xue, B., Liu, X., Xing, L., Wu, D., Wang, S., and Guo, Q. (2021). Integrated metabolic profiling and transcriptome analysis of pigment accumulation in Lonicera japonica flower petals during colour-transition. BMC Plant Biol., 21.","DOI":"10.1186\/s12870-021-02877-y"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1071\/FP23033","article-title":"Combinatorial transcriptomics and metabolomics analysis reveals the effects of the harvesting stages on the accumulation of phenylpropanoid metabolites in Lonicera japonica","volume":"50","author":"Ran","year":"2023","journal-title":"Funct. Plant Biol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhang, J.-B., Jin, H.-L., Feng, X.-Y., Feng, S.-L., Zhu, W.-T., Nan, H.-M., and Yuan, Z.-W. (2022). The combination of Lonicerae japonicae Flos and Forsythiae Fructus herb-pair alleviated inflammation in liver fibrosis. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.984611"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lin, Y., Qi, X., Wan, Y., Chen, Z., Fang, H., and Liang, C. (2023). Genome-wide analysis of the MADS-box gene family in Lonicera japonica and a proposed floral organ identity model. BMC Genom., 24.","DOI":"10.1186\/s12864-023-09509-9"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1111\/pbi.14123","article-title":"Comparative genomics of the medicinal plants Lonicera macranthoides and L. japonica provides insight into genus genome evolution and hederagenin-based saponin biosynthesis","volume":"21","author":"Yin","year":"2023","journal-title":"Plant Biotechnol. J."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wang, T., Yang, B., Guan, Q., Chen, X., Zhong, Z., Huang, W., Zhu, W., and Tian, J. (2019). Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors. BMC Plant Biol., 19.","DOI":"10.1186\/s12870-019-1803-1"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"147739","DOI":"10.1016\/j.gene.2023.147739","article-title":"Integrated metabolic profiling and transcriptome analysis of Lonicera japonica flowers for chlorogenic acid, luteolin and endogenous hormone syntheses","volume":"888","author":"Guan","year":"2023","journal-title":"Gene"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11418-016-1041-x","article-title":"De novo transcriptome assembly and characterization of nine tissues of Lonicera japonica to identify potential candidate genes involved in chlorogenic acid, luteolosides, and secoiridoid biosynthesis pathways","volume":"71","author":"Rai","year":"2017","journal-title":"J. Nat. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9301","DOI":"10.1007\/s11033-020-05990-7","article-title":"Regulation of chlorogenic acid, flavonoid, and iridoid biosynthesis by histone H3K4 and H3K9 methylation in Lonicera japonica","volume":"47","author":"Liu","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e18832","DOI":"10.7717\/peerj.18832","article-title":"Cloning and functional verification of Geraniol-10-Hydroxylase gene in Lonicera japonica","volume":"13","author":"Zhang","year":"2025","journal-title":"PeerJ"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"112654","DOI":"10.1016\/j.plantsci.2025.112654","article-title":"Characterization of the Lonicera japonica R2R3-MYB transcription factor gene LjaMYB305 that promotes the flavonoid biosynthesis","volume":"359","author":"Fang","year":"2025","journal-title":"Plant Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wang, Y., Li, L., Ji, W., Liu, S., Fan, J., Lu, H., and Wang, X. (2023). Metabolomics Analysis of Different Tissues of Lonicera japonica Thunb. Based on Liquid Chromatography with Mass Spectrometry. Metabolites, 13.","DOI":"10.3390\/metabo13020186"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"114906","DOI":"10.1016\/j.jpba.2022.114906","article-title":"The metabolic profile elucidation of Lonicera japonica flos water extract and the metabolic characteristics evaluation of bioactive compounds in human gastrointestinal tract in vitro","volume":"219","author":"Chang","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"136472","DOI":"10.1016\/j.ijbiomac.2024.136472","article-title":"Polysaccharides from Lonicera japonica Thunb.: Extraction, purification, structural features and biological activities\u2014A review","volume":"281","author":"Gao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Tong, K., Dai, L., Rui, W., Zhang, Y., Fu, J., Liao, Y., Wang, W., Deng, M., Mi, Y., and Li, Z. (2025). GC-MS, LC-MS, and network pharmacology analysis to investigate the chemical profiles and potential pharmacological activities in flower buds and flowers of Lonicera japonica Thunb. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0320293"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Li, J., Yu, X., Shan, Q., Shi, Z., Li, J., Zhao, X., Chang, C., and Yu, J. (2022). Integrated volatile metabolomic and transcriptomic analysis provides insights into the regulation of floral scents between two contrasting varieties of Lonicera japonica. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.989036"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"107779","DOI":"10.1016\/j.ultsonch.2026.107779","article-title":"Novel green solvent-in situ ultrasound synergistic extraction of phenolic acids from Lonicera japonica Thunb","volume":"127","author":"Liu","year":"2026","journal-title":"Ultrason. Sonochemistry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1055\/s-0035-1546081","article-title":"Effect of Processing on the Traditional Chinese Herbal Medicine Flos Lonicerae: An NMR-based Chemometric Approach","volume":"81","author":"Zhao","year":"2015","journal-title":"Planta Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Yan, K., Cui, M., Zhao, S., Chen, X., and Tang, X. (2016). Salinity Stress Is Beneficial to the Accumulation of Chlorogenic Acids in Honeysuckle (Lonicera japonica Thunb.). Front. Plant Sci., 7.","DOI":"10.3389\/fpls.2016.01563"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1080\/10286020.2016.1205039","article-title":"A comparative study on bioactive constituents in different parts of Lonicera japonica determined by HPLC-ESI-MS","volume":"18","author":"Wang","year":"2016","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, D., Du, N., Wen, L., Zhu, H., Liu, F., Wang, X., Du, J., and Li, S. (2017). An efficient method for the preparative isolation and purification of flavonoid glycosides and caffeoylquinic acid derivatives from leaves of Lonicera japonica Thunb. using high speed counter-current chromatography (HSCCC) and Prep-HPLC guided by DPPH-HPLC Experiments. Molecules, 22.","DOI":"10.3390\/molecules22020229"},{"key":"ref_49","first-page":"269","article-title":"Aanti-complementary phenolic acids from Lonicera japonica","volume":"40","author":"Ni","year":"2015","journal-title":"China J. Chin. Mater. Medica"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"144009","DOI":"10.1016\/j.foodchem.2025.144009","article-title":"Widely targeted metabolomics bridges the sensory characteristics and bioactive components of three typical Lonicera japonica flower tea","volume":"481","author":"Mei","year":"2025","journal-title":"Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"109824","DOI":"10.1016\/j.plaphy.2025.109824","article-title":"Integrated metabolomic and transcriptomic analyses reveal anthocyanin biosynthesis mechanisms and the regulatory role of LjAN2 in Lonicera japonica","volume":"223","author":"Tan","year":"2025","journal-title":"Plant Physiol. Biochem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Liu, Z., Cheng, Y., Xiang, Y., and Chao, Z. (2024). Unveiling the potential applications of buds of Lonicera japonica Thunb. var. chinensis (Wats.) Bak based on in vitro biological activities, bio-active components, and potential applications coupled to targeted metabolomics. Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1418957"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"103470","DOI":"10.1016\/j.jprot.2019.103470","article-title":"Integrative omics of Lonicera japonica Thunb. Flower development unravels molecular changes regulating secondary metabolites","volume":"208","author":"Yang","year":"2019","journal-title":"J. Proteom."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.plaphy.2022.01.022","article-title":"Comparative transcriptome analysis reveals variations of bioactive constituents in Lonicera japonica flowers under salt stress","volume":"173","author":"Cai","year":"2022","journal-title":"Plant Physiol. Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12298-024-01435-8","article-title":"Exploration of exogenous chlorogenic acid as a potential plant stimulant: Enhancing physiochemical properties in Lonicera japonica","volume":"30","author":"Zhang","year":"2024","journal-title":"Physiol. Mol. Biol. Plants"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"19245","DOI":"10.1038\/srep19245","article-title":"Flavone synthases from Lonicera japonica and L. macranthoides reveal differential flavone accumulation","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.aca.2006.01.068","article-title":"Qualitative and quantitative analysis of iridoid glycosides in the flower buds of Lonicera species by capillary high performance liquid chromatography coupled with mass spectrometric detector","volume":"564","author":"Song","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1002\/rcm.4245","article-title":"Structural characterization and identification of iridoid glycosides, saponins, phenolic acids and flavonoids in Flos Lonicerae japonicae by a fast liquid chromatography method with diode-array detection and time-of-flight mass spectrometry","volume":"23","author":"Qi","year":"2009","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/14786419.2016.1219859","article-title":"A new hetero dimeric terpenoid derivative, japonicaside C, from the flower buds of Lonicera japonica","volume":"31","author":"Li","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0031-9422(00)00279-X","article-title":"Secoiridoid glycosides from the flower buds of Lonicera japonica","volume":"55","author":"Kakuda","year":"2000","journal-title":"Phytochemistry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1248\/cpb.50.1041","article-title":"Studies on the constituents of Lonicera species XVII. New iridoid glycosides of the stems and leaves of Lonicera japonica Thunb","volume":"50","author":"Machida","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Yang, R., Fang, L., Li, J., Zhao, Z., Zhang, H., and Zhang, Y. (2019). Separation of Five Iridoid Glycosides from Lonicerae japonicae Flos Using High-Speed Counter-Current Chromatography and Their Anti-Inflammatory and Antibacterial Activities. Molecules, 24.","DOI":"10.3390\/molecules24010197"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijbiomac.2022.12.289","article-title":"Lonicera japonica polysaccharides improve longevity and fitness of Caenorhabditis elegans by activating DAF-16","volume":"229","author":"Zhu","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10719-022-10088-2","article-title":"A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling","volume":"39","author":"Liao","year":"2022","journal-title":"Glycoconj. J."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Li, Y., Liu, B., Yang, J., Sun, J., Ran, J., Liang, X., and Li, Y. (2023). Characterization of polysaccharide from Lonicera japonica Thunb leaves and its application in nano-emulsion. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1248611"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e11876","DOI":"10.1016\/j.heliyon.2022.e11876","article-title":"Immunomodulatory effect of polysaccharides isolated from Lonicera japonica Thunb. in cyclophosphamide-treated BALB\/c mice","volume":"8","author":"Zhang","year":"2022","journal-title":"Heliyon"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Qi, X., Yu, Y., Wang, X., Xu, J., Wang, X., Feng, Z., Zhou, Y., Xiao, H., and Sun, L. (2022). Structural characterization and anti-oxidation activity evaluation of pectin from Lonicera japonica Thunb. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.998462"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"119674","DOI":"10.1016\/j.carbpol.2022.119674","article-title":"A novel polysaccharide from Lonicerae japonicae Caulis: Characterization and effects on the function of fibroblast-like synoviocytes","volume":"292","author":"Bi","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"140618","DOI":"10.1016\/j.ijbiomac.2025.140618","article-title":"A homogalacturonan-rich pectic polysaccharide isolated from Lonicera japonica Thunb. modulates galectin-4-mediated bioactivity and anti-hepatocellular carcinoma activity","volume":"302","author":"Zhang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"An, F., Ren, G., Wu, J., Cao, K., Li, M., Liu, Y., Liu, Y., Hu, X., Song, M., and Wu, R. (2022). Extraction, purification, structural characterization, and antioxidant activity of a novel polysaccharide from Lonicera japonica Thunb. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1035760"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"811","DOI":"10.21037\/atm.2019.12.64","article-title":"The protective effect of Lonicera japonica polysaccharide on mice with depression by inhibiting NLRP3 inflammasome","volume":"7","author":"Liu","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijbiomac.2017.08.154","article-title":"Characterization of a pectin from Lonicera japonica Thunb. and its inhibition effect on A\u03b242 aggregation and promotion of neuritogenesis","volume":"107","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.ijbiomac.2019.10.147","article-title":"Fractionation and antioxidant activities of the water-soluble polysaccharides from Lonicera japonica Thunb","volume":"151","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.ijbiomac.2018.11.077","article-title":"Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica in model rats","volume":"123","author":"Yang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/fsn3.1186","article-title":"Polyethylene glycol-based ultrasonic-assisted enzymatic extraction, characterization, and antioxidant activity in vitro and in vivo of polysaccharides from Lonicerae japonica leaves","volume":"7","author":"Wu","year":"2019","journal-title":"Food Sci. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ijbiomac.2017.02.096","article-title":"Structural elucidation of a polysaccharide from Lonicera japonica flowers, and its neuroprotective effect on cerebral ischemia-reperfusion injury in rat","volume":"99","author":"Su","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijbiomac.2016.03.025","article-title":"Structural elucidation of a pectin from flowers of Lonicera japonica and its antipancreatic cancer activity","volume":"88","author":"Lin","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1021\/acs.jproteome.5b00910","article-title":"Proteomic Analysis of Lonicera japonica Thunb. Immature Flower Buds Using Combinatorial Peptide Ligand Libraries and Polyethylene Glycol Fractionation","volume":"15","author":"Zhu","year":"2016","journal-title":"J. Proteome Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbapap.2017.01.004","article-title":"Variations of metabolites and proteome in Lonicera japonica Thunb. buds and flowers under UV radiation","volume":"1865","author":"Zhu","year":"2017","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12011-017-1138-4","article-title":"Comparison of the Trace Elements and Active Components of Lonicera japonica flos and Lonicera flos Using ICP-MS and HPLC-PDA","volume":"183","author":"Zhao","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12011-015-0327-2","article-title":"Arsenic Speciation in Honeysuckle (Lonicera japonica Thunb.) from China","volume":"168","author":"Tang","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e9693","DOI":"10.1002\/rcm.9693","article-title":"Discrimination and characterization of volatile organic compounds in Lonicerae japonicae flos and Lonicerae flos using multivariate statistics combined with headspace gas chromatography\u2013ion mobility spectrometry and headspace solid-phase microextraction gas chromatography\u2013mass spectrometry techniques","volume":"38","author":"Wu","year":"2024","journal-title":"Rapid Commun. Mass. Spectrom."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.phymed.2016.01.016","article-title":"Study on anti-inflammatory efficacy and correlative ingredients with pharmacodynamics detected in acute inflammation rat model serum from Caulis Lonicerae japonicae","volume":"23","author":"Tang","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.indcrop.2016.05.010","article-title":"Antioxidant and anti-inflammatory activities of Lonicera japonica Thunb. var. sempervillosa Hayata flower bud extracts prepared by water, ethanol and supercritical fluid extraction techniques","volume":"89","author":"Hsu","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"113502","DOI":"10.1016\/j.jep.2020.113502","article-title":"Anti-inflammatory property and functional substances of Lonicerae japonicae Caulis","volume":"267","author":"Su","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_86","first-page":"422","article-title":"Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae japonicae Flos-Forsythiae Fructus drug pair","volume":"16","author":"Li","year":"2024","journal-title":"Chin. Herb. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/00071668.2015.1022711","article-title":"Effect of Lonicera japonica extract on Mycoplasma gallisepticum in naturally infected broiler flocks","volume":"56","author":"Torun","year":"2015","journal-title":"Br. Poult. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"45723","DOI":"10.1038\/srep45723","article-title":"Antiviral activity of chlorogenic acid against influenza A (H1N1\/H3N2) virus and its inhibition of neuraminidase","volume":"7","author":"Ding","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.apsb.2015.01.012","article-title":"Glucosylated caffeoylquinic acid derivatives from the flower buds of Lonicera japonica","volume":"5","author":"Yu","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Zhou, W., Yin, A., Shan, J., Wang, S., Cai, B., and Di, L. (2017). Study on the Rationality for antiviral activity of flos Lonicerae japonicae-Fructus forsythiae herb Chito-oligosaccharide via integral pharmacokinetics. Molecules, 22.","DOI":"10.3390\/molecules22040654"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Lai, K.-H., Chen, Y.-L., Lin, M.-F., El-Shazly, M., Chang, Y.-C., Chen, P.-J., Su, C.-H., Chiu, Y.-C., Illias, A.M., and Chen, C.-C. (2022). Lonicerae japonicae Flos attenuates neutrophilic inflammation by inhibiting oxidative stress. Antioxidants, 11.","DOI":"10.3390\/antiox11091781"},{"key":"ref_92","first-page":"6133","article-title":"Chemical composition of honeysuckle (Lonicerae japonicae) extracts and their potential in inhibiting the SARS-CoV-2 spike protein and ACE2 binding, suppressing ACE2, and scavenging radicals","volume":"71","author":"Gao","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Ma, Q., Liang, D., Song, S., Yu, Q., Shi, C., Xing, X., and Luo, J.B. (2017). Comparative Study on the Antivirus Activity of Shuang\u2013Huang\u2013Lian Injectable Powder and Its Bioactive Compound Mixture against Human Adenovirus III In Vitro. Viruses, 9.","DOI":"10.3390\/v9040079"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00253-023-12910-9","article-title":"Lonicera japonica protects Pelodiscus sinensis by inhibiting the biofilm formation of Aeromonas hydrophila","volume":"108","author":"Huo","year":"2024","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.4014\/jmb.1807.07042","article-title":"Synergistic Antimicrobial Effect of Lonicera japonica and Magnolia obovata Extracts and Potential as a Plant-Derived Natural Preservative","volume":"28","author":"Lee","year":"2018","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"15379","DOI":"10.1039\/D3RA00802A","article-title":"Lonicera japonica Thunb. as a promising antibacterial agent for Bacillus cereus ATCC14579 based on network pharmacology, metabolomics, and in vitro experiments","volume":"13","author":"Xu","year":"2023","journal-title":"RSC Adv."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1049\/iet-nbt.2015.0027","article-title":"Enhanced antimicrobial activity of silver nanoparticles-Lonicera japonica Thunb combo","volume":"10","author":"Yang","year":"2016","journal-title":"IET Nanobiotechnology"},{"key":"ref_98","first-page":"5802343","article-title":"Traditional Chinese medicine compounds containing Lonicera japonica, Chrysanthemum morifolium, and Siraitia grosvenorii inhibits the growth of Streptococcus mutans. Evid.-Based Complement","volume":"2022","author":"Zhou","year":"2022","journal-title":"Altern. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.freeradbiomed.2018.09.035","article-title":"Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans","volume":"129","author":"Yang","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jep.2016.07.022","article-title":"Dual effect of WIN-34B on osteogenesis and osteoclastogenesis in cytokine-induced mesenchymal stem cells and bone marrow cells","volume":"193","author":"Seo","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"20042","DOI":"10.1038\/srep20042","article-title":"A herbal formula comprising rosae multiflorae Fructus and Lonicerae japonicae flos, attenuates collagen-induced arthritis and inhibits TLR4 signalling in rats","volume":"6","author":"Cheng","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Guo, R.H., Kim, S.-J., Choi, C.-H., Na, C.-S., Kang, B.Y., and Kim, Y.R. (2019). Inhibitory effects of ChondroT and its constituent herbs on RANKL-induced osteoclastogenesis. BMC Complement Altern. Med., 19.","DOI":"10.1186\/s12906-019-2737-8"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2016.12.049","article-title":"Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis","volume":"198","author":"Lee","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"35374","DOI":"10.1039\/C8RA07549B","article-title":"Novel caffeoylquinic acid derivatives from Lonicera japonica Thunb. flower buds exert pronounced anti-HBV activities","volume":"8","author":"Ge","year":"2018","journal-title":"RSC Adv."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Yeh, Y.-C., Doan, L.H., Huang, Z.-Y., Chu, L.-W., Shi, T.-H., Lee, Y.-R., Wu, C.-T., Lin, C.-H., Chiang, S.-T., and Liu, H.-K. (2022). Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) suppress SARS-CoV-2 entry and COVID-19 related cytokine Storm in Vitro. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.765553"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Liang, Y., Liu, M., Wang, Y., Liu, L., and Gao, Y. (2023). Analyzing the material basis of Anti-RSV efficacy of Lonicerae japonicae flos based on the PK-PD model. Molecules, 28.","DOI":"10.3390\/molecules28186437"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Xie, X., Gu, L., Xu, W., Yu, X., Yin, G., Wang, J., Jin, Y., Wang, L., Wang, B., and Wang, T. (2022). Integrating anti-influenza virus activity and chemical pattern recognition to explore the quality evaluation method of Lonicerae japonicae Flos. Molecules, 27.","DOI":"10.3390\/molecules27185789"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Ding, J., Li, J., Zhang, Z., Du, Y., Liu, Y., Wang, P., and Du, H. (2023). Network pharmacology combined with metabolomics to explore the mechanism for Lonicerae japonicae flos against respiratory syncytial virus. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-04286-0"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1080\/14786419.2023.2260070","article-title":"Network pharmacology and molecular docking to scientifically validate the potential mechanism of Lonicerae japonicae flos in the clinical treatment of COVID-19","volume":"38","author":"Huang","year":"2024","journal-title":"Nat. Prod. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"113721","DOI":"10.1016\/j.jpba.2020.113721","article-title":"Dissection of the potential anti-influenza materials and mechanism of Lonicerae japonicae flos based on in vivo substances profiling and network pharmacology","volume":"193","author":"Zhang","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1080\/14786419.2017.1371153","article-title":"Two thymol derivatives from the flower buds of Lonicera japonica and their antibacterial activity","volume":"32","author":"Yang","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.3168\/jds.2025-27672","article-title":"Unveiling the mechanism of Lonicera japonica Thunb. polyphenols against Cronobacter sakazakii from powdered infant formula by untargeted metabolomics and its application as a natural disinfectant","volume":"109","author":"Fei","year":"2026","journal-title":"J. Dairy Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"8878633","DOI":"10.1155\/2021\/8878633","article-title":"Protective role of a New polysaccharide extracted from Lonicera japonica Thunb in mice with ulcerative colitis Induced by dextran sulphate sodium","volume":"2021","author":"Zhou","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"125517","DOI":"10.1016\/j.ijbiomac.2023.125517","article-title":"Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice","volume":"245","author":"Sun","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Liu, Z., Li, N., Zheng, Z., Zhang, C., Liu, Z., Song, C., Yan, J., and Mu, S. (2022). Influence of Lonicera japonica and Radix Puerariae Crude Extracts on the Fecal Microbiome and Nutrient Apparent Digestibility of Finishing Pigs. Animals, 12.","DOI":"10.3390\/ani12162109"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2147\/IJN.S356919","article-title":"Characterization of Silver Nanoparticles Synthesized by Leaves of Lonicera japonica Thunb","volume":"17","author":"Zhang","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Shi, Z., Liu, Z., Liu, C., Wu, M., Su, H., Ma, X., Zang, Y., Wang, J., Zhao, Y., and Xiao, X. (2016). Spectrum-effect relationships between chemical fingerprints and antibacterial effects of Lonicerae japonicae Flos and Lonicerae Flos Base on UPLC and Microcalorimetry. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00012"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"111909","DOI":"10.1016\/j.jep.2019.111909","article-title":"Lonicerin, an anti-algE flavonoid against Pseudomonas aeruginosa virulence screened from Shuanghuanglian formula by molecule docking based strategy","volume":"239","author":"Xu","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1021\/acsmedchemlett.4c00051","article-title":"Virtual Screening of inhibitors of Streptococcus mutans biofilm from Lonicera japonica flos and activity validation","volume":"15","author":"Liu","year":"2024","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1111\/1750-3841.17074","article-title":"Network pharmacology combined with an experimental validation study to reveal the effect and mechanism of Lonicera japonica Thunb. extracts against immunomodulation","volume":"89","author":"Wang","year":"2024","journal-title":"J. Food Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.apjtm.2016.07.008","article-title":"Anti-encystment and amoebicidal activity of Lonicera japonica Thunb. and its major constituent chlorogenic acid in vitro","volume":"9","author":"Mahboob","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Yu, W., Tang, J., Gao, C., Zheng, X., and Zhu, P. (2025). Green Synthesis of Copper nanoparticles from the aqueous extract of Lonicera japonica Thunb and evaluation of its catalytic property and cytotoxicity and antimicrobial Activity. Nanomaterials, 15.","DOI":"10.3390\/nano15020091"},{"key":"ref_123","first-page":"97","article-title":"Protective effect of bioactive compounds from Lonicera japonica Thunb. against H2O2-induced cytotoxicity using neonatal rat cardiomyocytes","volume":"19","author":"Wang","year":"2016","journal-title":"Iran. J. Basic. Med. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"153219","DOI":"10.1016\/j.phymed.2020.153219","article-title":"4,5-di-O-caffeoylquinic acid methyl ester isolated from Lonicera japonica Thunb. targets the Keap1\/Nrf2 pathway to attenuate H2O2-induced liver oxidative damage in HepG2 cells","volume":"70","author":"Xiao","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jep.2015.03.012","article-title":"Protective and immunomodulatory effect of flos Lonicerae japonicae by augmenting IL-10 expression in a murine model of acute lung inflammation","volume":"168","author":"Kao","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"116344","DOI":"10.1016\/j.jep.2023.116344","article-title":"A homogeneous Lonicera japonica polysaccharide alleviates atopic dermatitis by promoting Nrf2 activation and NLRP3 inflammasome degradation via p62","volume":"309","author":"Bai","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/fsn3.3067","article-title":"Optimization of protein removal process of Lonicera japonica polysaccharide and its immunomodulatory mechanism in cyclophosphamide-induced mice by metabolomics and network pharmacology","volume":"11","author":"Ding","year":"2022","journal-title":"Food Sci. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1089\/jmf.2014.3341","article-title":"Lonicera japonica THUNB. extract inhibits lipopolysaccharide-stimulated inflammatory responses by suppressing NF-\u03baB signaling in BV-2 microglial cells","volume":"18","author":"Kwon","year":"2015","journal-title":"J. Med. Food"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"8670","DOI":"10.3390\/nu7105423","article-title":"The ethanol extract from Lonicera japonica Thunb. regresses nonalcoholic steatohepatitis in a methionine- and choline-deficient diet-fed animal model","volume":"7","author":"Tzeng","year":"2015","journal-title":"Nutrients"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Lee, H.L., Kim, J.M., Go, M.J., Kim, T.Y., Joo, S.G., Kim, J.H., Lee, H.S., Kim, H.J., and Heo, H.J. (2023). Protective Effect of Lonicera japonica on PM2.5-Induced Pulmonary Damage in BALB\/c Mice via the TGF-\u03b2 and NF-\u03baB Pathway. Antioxidants, 12.","DOI":"10.3390\/antiox12040968"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.fsi.2020.07.032","article-title":"Effects of three medicinal herbs Bidens pilosa, Lonicera japonica, and Cyathula officinalis on growth and non-specific immune responses of cobia (Rachycentron canadum)","volume":"106","author":"Lee","year":"2020","journal-title":"Fish Shellfish. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijbiomac.2017.12.073","article-title":"Comparative investigation for hypoglycemic effects of polysaccharides from four substitutes of Lonicera japonica in Chinese medicine","volume":"109","author":"Zhao","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijbiomac.2017.04.056","article-title":"Hypoglycemic and hypolipidemic effects of a polysaccharide from flower buds of Lonicera japonica in streptozotocin-induced diabetic rats","volume":"102","author":"Wang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"153084","DOI":"10.1016\/j.phymed.2019.153084","article-title":"MiR-let-7a\/f-CCR7 signaling is involved in the anti-metastatic effects of an herbal formula comprising Sophorae Flos and Lonicerae japonicae Flos in melanoma","volume":"64","author":"Liu","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cbi.2015.05.022","article-title":"Modulation effects of sweroside isolated from the Lonicera japonica on melanin synthesis","volume":"238","author":"Jeong","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"10074","DOI":"10.3168\/jds.2020-18504","article-title":"Effect of Lonicera japonica extract on lactation performance, antioxidant status, and endocrine and immune function in heat-stressed mid-lactation dairy cows","volume":"103","author":"Ma","year":"2020","journal-title":"J. Dairy Sci."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Ma, F., Liu, J., Li, S., and Sun, P. (2024). Effects of Lonicera japonica extract with different contents of chlorogenic acid on Lactation performance, serum parameters, and rumen fermentation in heat-stressed holstein high-yielding dairy cows. Animals, 14.","DOI":"10.3390\/ani14081252"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.5713\/ajas.19.0388","article-title":"Effects of Lonicera japonica extract on performance, blood biomarkers of inflammation and oxidative stress during perinatal period in dairy cows","volume":"33","author":"Zhao","year":"2020","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Hua, R., Ding, Y., Liu, X., Niu, B., Chen, X., Zhang, J., Liu, K., Yang, P., Zhu, X., and Xue, J. (2022). Lonicerae japonicae Flos extract promotes sleep in sleep-deprived and lipopolysaccharide-challenged mice. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.848588"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.21037\/apm-20-357","article-title":"Validation of the protective effects of Lonicera japonica polysaccharide on lipopolysaccharide-induced learning and memory impairments via regulation of autophagy based on network pharmacology","volume":"10","author":"Wang","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Chen, Z., Xu, W., Luo, J., Liu, L., and Peng, X. (2024). Lonicera japonica fermented by Lactobacillus plantarum improve multiple patterns driven osteoporosis. Foods, 13.","DOI":"10.3390\/foods13172649"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12950-023-00372-9","article-title":"Lonicera japonica Thunb extract ameliorates lipopolysaccharide-induced acute lung injury associated with luteolin-mediated suppression of NF-\u03baB signaling pathway","volume":"20","author":"Jia","year":"2023","journal-title":"J. Inflamm."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1089\/jmf.2018.4231","article-title":"BST-104, a Water Extract of Lonicera japonica, Has a Gastroprotective Effect via antioxidant and anti-inflammatory activities","volume":"22","author":"Bang","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1265324","DOI":"10.1080\/16546628.2017.1265324","article-title":"Antioxidant activities of aqueous extracts from 12 Chinese edible flowers in vitro and in vivo","volume":"61","author":"Wang","year":"2016","journal-title":"Food Nutr. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"6677437","DOI":"10.1155\/2021\/6677437","article-title":"Characterization and quantification of luteolin-metal complexes in aqueous extract of Lonicerae japonicae Flos and Huangshan Wild Chrysanthemum","volume":"2021","author":"Cai","year":"2021","journal-title":"Int. J. Anal. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Cao, W., Chen, J., Li, L., Ren, G., Duan, X., Zhou, Q., Zhang, M., Gao, D., Zhang, S., and Liu, X. (2022). Cookies Fortified with Lonicera japonica Thunb. extracts: Impact on phenolic acid content, antioxidant activity and physical properties. Molecules, 27.","DOI":"10.3390\/molecules27155033"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/pca.2599","article-title":"Screening of peroxynitrite scavengers in Flos Lonicerae by using two new methods, an HPLC-DAD-CL technique and a peroxynitrite spiking test followed by HPLC-DAD analysis","volume":"27","author":"Qi","year":"2016","journal-title":"Phytochem. Anal."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.talanta.2015.09.039","article-title":"A strategy for comprehensive identification of sequential constituents using ultra-high-performance liquid chromatography coupled with linear ion trap\u2013Orbitrap mass spectrometer, application study on chlorogenic acids in Flos Lonicerae japonicae","volume":"147","author":"Zhang","year":"2016","journal-title":"Talanta"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zhou, X., Dong, Q., Kan, X., Peng, L., Xu, X., Fang, Y., and Yang, J. (2018). Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204152"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/fsn3.1021","article-title":"Extraction optimization, antioxidant activity, and tyrosinase inhibitory capacity of polyphenols from Lonicera japonica","volume":"7","author":"Fan","year":"2019","journal-title":"Food Sci. Nutr."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Yu, M., Yang, L., Xue, Q., Yin, P., Sun, L., and Liu, Y. (2019). Comparison of free, esterified, and insoluble-bound phenolics and their bioactivities in three organs of Lonicera japonica and L. macranthoides. Molecules, 24.","DOI":"10.3390\/molecules24050970"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e4583","DOI":"10.1002\/bmc.4583","article-title":"Spectrum\u2013effect relationship study between HPLC fingerprints and antioxidant of honeysuckle extract","volume":"33","author":"Liu","year":"2019","journal-title":"Biomed. Chromatogr."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.phymed.2018.12.044","article-title":"Effects of a novel biflavonoid of Lonicera japonica flower buds on modulating apoptosis under different oxidative conditions in hepatoma cells","volume":"57","author":"Wan","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"115038","DOI":"10.1016\/j.biopha.2023.115038","article-title":"Caffeoylquinic acids isolated from Lonicera japonica Thunb. as TAK1 inhibitors protects against LPS plus IFN-\u03b3-stimulated inflammation by interacting with KEAP1-regulated NRF2 activation","volume":"165","author":"Ge","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Li, L., Zhang, S., Yu, B., Liu, S.Q., and Xiong, Y. (2024). Fractionating the Flavonoids in Lonicerae japonicae Flos and Lonicerae flos via Solvent extraction coupled with automated solid-phase extraction. Foods, 13.","DOI":"10.3390\/foods13233861"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.5650\/jos.ess23242","article-title":"The Essential oils obtained from (Lonicerae japonicae Flos) flower buds could affect the deposition of sunflower oil under common high temperature conditions and the traditional frying process in Maye","volume":"73","author":"Qu","year":"2024","journal-title":"J. Oleo Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"124864","DOI":"10.1016\/j.carbpol.2025.124864","article-title":"Structure characterization, antioxidant and \u03b2-cell protective effects of the glutaredoxin 2\/glutathione system and glutathione metabolism-related Lonicerae japonicae Caulis pectin","volume":"377","author":"Qi","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"ref_158","first-page":"1499","article-title":"One New conjugate of a secoiridoid glucoside with a sesquiterpene glucoside from the flower buds of Lonicera japonica","volume":"10","author":"Yang","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/ptr.5688","article-title":"Flavonoids isolated from flowers of Lonicera japonica Thunb. inhibit inflammatory responses in BV2 microglial cells by suppressing TNF-\u03b1 and IL-\u03b2 through PI3K\/Akt\/NF-kb signaling pathways","volume":"30","author":"Han","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.2147\/IJN.S248467","article-title":"Effect of Lonicerae japonicae Flos carbonisata-derived carbon dots on rat models of fever and hypothermia Induced by lipopolysaccharide","volume":"15","author":"Wu","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/bab.70051","article-title":"Network pharmacology and experimental evaluation of Lonicera japonica Flos in rheumatoid arthritis","volume":"73","author":"Yu","year":"2026","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Minami, M., and Makino, T. (2020). Effects of Lonicera japonica flower bud extract on Citrobacter rodentium-induced digestive tract infection. Medicines, 7.","DOI":"10.3390\/medicines7090052"},{"key":"ref_163","first-page":"70","article-title":"Three new secoiridoid glycosides from the flower buds of Lonicera japonica","volume":"18","author":"Yang","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/14786419.2019.1587430","article-title":"A new anti-inflammatory lignan from Lonicerae japonicae flos","volume":"35","author":"Yang","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.7150\/ijms.56198","article-title":"Anti-inflammatory effects of Flos Lonicerae japonicae Water Extract are regulated by the STAT\/NF-\u03baB pathway and HO-1 expression in Virus-infected RAW264.7 cells","volume":"18","author":"Lin","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"120053","DOI":"10.1016\/j.carbpol.2022.120053","article-title":"Water-extracted Lonicera japonica polysaccharide attenuates allergic rhinitis by regulating NLRP3-IL-17 signaling axis","volume":"297","author":"Bai","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.1080\/14786419.2021.1921769","article-title":"Two new chemical constituents from Lonicera japonica","volume":"36","author":"Geng","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1080\/14756366.2022.2121392","article-title":"TiO2 nanotube immobilised 5-lipoxygenase-mediated screening and isolation of anti-inflammatory active compounds from the leaves of Lonicera japonica Thunb. J","volume":"37","author":"Zhu","year":"2022","journal-title":"Enzym. Inhib. Med. Chem."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Jeong, S.H., Park, M.Y., Bhosale, P.B., Abusaliya, A., Won, C.K., Park, K.I., Kim, E., Heo, J.D., Kim, H.W., and Ahn, M. (2023). Potential antioxidant and anti-inflammatory effects of Lonicera japonica and Citri Reticulatae Pericarpium Polyphenolic Extract (LCPE). Antioxidants, 12.","DOI":"10.3390\/antiox12081582"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"106764","DOI":"10.1016\/j.fitote.2025.106764","article-title":"Lonicera japonica Thunb. in acute lung injury: A systematic review of bioactive components and multi-target mechanisms","volume":"185","author":"Cao","year":"2026","journal-title":"Fitoterapia"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1080\/14786419.2024.2431999","article-title":"Enrichment optimisation and identification of total iridoid glycosides from Lonicera japonica Thunb. and its anti-inflammatory activity","volume":"40","author":"Hsieh","year":"2026","journal-title":"Nat. Prod. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.3390\/cimb46070433","article-title":"Lonicera japonica Thunb. ethanol extract exerts a protective effect on normal human gastric epithelial cells by modulating the activity of tumor-necrosis-factor-\u03b1-Induced inflammatory cyclooxygenase 2\/Prostaglandin E2 and Matrix Metalloproteinase 9","volume":"46","author":"Hsieh","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_173","first-page":"805","article-title":"Lonicera japonica caulis ameliorates LPS and TNF-\u03b1-Induced HT-29 cell injury by inhibiting the MAPK\/ERK\/JNK\/p38 pathway","volume":"37","author":"Lu","year":"2024","journal-title":"Biomed. Environ. Sci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"128435","DOI":"10.1016\/j.ijbiomac.2023.128435","article-title":"WLJP-025p, a homogeneous Lonicera japonica polysaccharide, attenuates atopic dermatitis by regulating the MAPK\/NF\u03baB\/AP-1 axis via Act1","volume":"256","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"23972","DOI":"10.1038\/s41598-025-08769-7","article-title":"Effects of brackish water irrigation on biomass allocation and carbon, nitrogen stoichiometry in Lonicera japonica","volume":"15","author":"Liu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"13812","DOI":"10.1007\/s11356-018-3182-9","article-title":"Discovery and mechanism study of a novel chromium-accumulating plant, Lonicera japonica Thunb","volume":"26","author":"Meng","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jep.2015.12.056","article-title":"The effect of Flos Lonicerae japonicae extract on gastro-intestinal motility function","volume":"179","author":"Nam","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e71774","DOI":"10.1002\/fsn3.71774","article-title":"A herbal pair of Taraxacum officinale F.H.Wigg. and Lonicera japonica Thunb. ameliorates obesity and modulates AMPK signaling","volume":"14","author":"Jin","year":"2026","journal-title":"Food Sci. Nutr."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/ptr.5413","article-title":"Effects of Lonicera japonica Thunb. on type 2 diabetes via PPAR-\u03b3 activation in Rats","volume":"29","author":"Han","year":"2015","journal-title":"Phytotherary Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jep.2016.05.039","article-title":"Lonicerae japonicae Flos attenuates diabetic retinopathy by inhibiting retinal angiogenesis","volume":"189","author":"Zhou","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.apsb.2017.04.010","article-title":"Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KKAy mice","volume":"7","author":"Liu","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Guo, C., Zhang, X., Yu, Y., Wu, Y., Xie, L., and Chang, C. (2022). Lonicerae japonicae Flos extract and chlorogenic acid attenuates high-fat-diet-induced prediabetes via CTRPs-AdipoRs-AMPK\/PPAR\u03b1 axes. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1007679"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Li, G., Bao, C., Zhang, H., and Bai, L. (2025). Ultrasound-assisted extraction of polyphenols from Lonicera japonica leaves and their \u03b1-glucosidase inhibition. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1542217"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"e71167","DOI":"10.1111\/jcmm.71167","article-title":"A network pharmacology and experimental validation strategy for hypoglycemic study of Lonicerae japonicae Flos on diabetes","volume":"30","author":"Nan","year":"2026","journal-title":"J. Cell. Mol. Med."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Sun, L., Ding, F., You, G., Liu, H., Wang, M., Ren, X., and Deng, Y. (2017). Development and validation of an UPLC-MS\/MS method for pharmacokinetic comparison of five alkaloids from JinQi Jiangtang tablets and its monarch drug Coptidis Rhizoma. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10010004"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Weng, W., Jiang, S., Sun, C., Pan, X., Xian, L., Lu, X., and Zhang, C. (2022). Cytotoxic secondary metabolites isolated from Penicillium sp. YT2019-3321, an endophytic fungus derived from Lonicera japonica. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1099592"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.biopha.2018.03.099","article-title":"The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-\u03baB\/IL-6\/STAT3 signaling in hepatocellular carcinoma","volume":"102","author":"Lu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.biopha.2017.08.007","article-title":"Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis","volume":"95","author":"Han","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_189","first-page":"2127","article-title":"Isochlorogenic acid C reverses epithelial\u2013mesenchymal transition via down-regulation of EGFR pathway in MDA-MB-231 cells","volume":"38","author":"Yu","year":"2018","journal-title":"Anticancer. Res."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"103198","DOI":"10.1016\/j.bioorg.2019.103198","article-title":"Chemical constituents from Lonicera japonica flower buds and their anti-hepatoma and anti-HBV activities","volume":"92","author":"Ge","year":"2019","journal-title":"Bioorganic Chem."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"116969","DOI":"10.1016\/j.jep.2023.116969","article-title":"Inhibitory effect of Lonicera japonica-derived exosomal miR2911 on human papilloma virus","volume":"318","author":"Chi","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"101559","DOI":"10.1016\/j.mtbio.2025.101559","article-title":"Lymph node-targeted delivery of Lonicera japonica thunb. polysaccharides for enhancing antitumor immunotherapy","volume":"31","author":"Zhang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"119832","DOI":"10.1016\/j.jep.2025.119832","article-title":"Mechanistic study of Lonicerae japonicae Flos (Caprifoliaceae) in non-small cell lung cancer prevention and treatment through integrative pharmacology, multi-machine learning, artificial intelligence, and in vitro experiments","volume":"348","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.plaphy.2021.09.009","article-title":"Use Chou\u2019s 5-steps rule to identify protein post-translational modification and its linkage to secondary metabolism during the floral development of Lonicera japonica Thunb","volume":"167","author":"Wang","year":"2021","journal-title":"Plant Physiol. Biochem."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Xiang, Q., Xiang, Y., Liu, Y., Chen, Y., He, Q., Chen, T., Tang, L., He, B., and Li, J. (2024). Revealing the potential therapeutic mechanism of Lonicerae japonicae Flos in Alzheimer\u2019s disease: A computational biology approach. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1468561"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"110796","DOI":"10.1016\/j.brainresbull.2023.110796","article-title":"Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice","volume":"204","author":"Qin","year":"2023","journal-title":"Brain Res. Bull."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/1028415X.2015.1135572","article-title":"Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in \u03b2-amyloid-infused rats","volume":"20","author":"Park","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"153254","DOI":"10.1016\/j.phymed.2020.153254","article-title":"An herbal formula inhibits STAT3 signaling and attenuates bone erosion in collagen-induced arthritis rats","volume":"76","author":"Chen","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Her, Y., Lee, T.K., Ahn, J.H., Lim, S.S., Kang, B.G., Park, J.S., Kim, B., Sim, H., Lee, J.C., and Kim, H.S. (2020). Chemical composition of a novel distillate from fermented mixture of nine anti-Inflammatory herbs and its UVB-protective efficacy in mouse dorsal skin via attenuating collagen disruption and inflammation. Molecules, 26.","DOI":"10.3390\/molecules26010124"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/1871523016666170720160037","article-title":"Evaluation of in vitro anti-psoriatic activity of a novel polyherbal formulation by multiparametric analysis","volume":"16","author":"Shraibom","year":"2017","journal-title":"Anti-Inflamm. Anti-Allergy Agents Med. Chem."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Sun, C.Y., Zhao, P., Yan, P.Z., Li, J., and Zhao, D.S. (2022). Investigation of Lonicera japonica Flos against nonalcoholic fatty liver disease using network integration and experimental validation. Medicina, 58.","DOI":"10.3390\/medicina58091176"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"106516","DOI":"10.1016\/j.fitote.2025.106516","article-title":"The hepatoprotective effect of Lonicera japonica Flos on rats with high-fat diet-induced non-alcoholic fatty liver disease","volume":"183","author":"Ma","year":"2025","journal-title":"Fitoterapia"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"8643","DOI":"10.1039\/D2FO01719A","article-title":"Inhibition of reinstatement of alcohol-induced conditioned place preference in mice by Lonicera japonica polysaccharide","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Wang, X., Liu, S., Yang, L., Dong, J., Zhang, S., Lv, J., Yang, L., and Jiang, H. (2022). Pharmacokinetic comparison of eight major compounds of Lonicerae japonicae flos after oral administration in normal rats and rats with liver injury. Molecules, 27.","DOI":"10.3390\/molecules27238211"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11418-019-01334-3","article-title":"Sweroside ameliorated carbon tetrachloride (CCl4)-induced liver fibrosis through FXR-miR-29a signaling pathway","volume":"74","author":"Gong","year":"2020","journal-title":"J. Nat. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"118333","DOI":"10.1016\/j.jep.2024.118333","article-title":"The protective effect of Lonicera japonica Thunb. against lipopolysaccharide-induced acute lung injury in mice: Modulation of inflammation, oxidative stress, and ferroptosis","volume":"331","author":"Xiong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"e71417","DOI":"10.1096\/fj.202503711RR","article-title":"Integrative analysis of Q-markers and transcriptomics reveals the material basis and mechanism of Lonicerae japonicae Flos in inhibiting ferroptosis","volume":"40","author":"Xiong","year":"2026","journal-title":"FASEB J."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"121740","DOI":"10.1016\/j.jep.2026.121740","article-title":"Attenuation of acute lung injury by Lonicerae japonicae Flos extracts is associated with the rebalancing of Th1\/Th2\/Th17\/Treg cells in lungs and colons","volume":"367","author":"Wang","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"156326","DOI":"10.1016\/j.phymed.2024.156326","article-title":"Downregulation of cardiac inflammation via the CaMKII \u03b4\/NF-\u03baB pathway in heart failure by Lonicerae japonicae Flos and Angelicae sinensis Radix","volume":"136","author":"Tang","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1111\/jcmm.14351","article-title":"Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-\u03b1-induced injury via inhibiting NF-\u03baB and JNK signals","volume":"23","author":"Tian","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"154146","DOI":"10.1016\/j.phymed.2022.154146","article-title":"Lonicerae japonicae flos ameliorates radiotherapy-induced mesenteric artery endothelial dysfunction through GTPCH1\/BH4\/eNOS pathway","volume":"102","author":"Mu","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Wang, Y., Liu, J., Wang, X., Liu, S., Wang, G., Zhou, J., Yuan, Y., Chen, T., Jiang, C., and Zha, L. (2016). Validation of suitable reference genes for assessing gene expression of microRNAs in Lonicera japonica. Front. Plant Sci., 7.","DOI":"10.3389\/fpls.2016.01101"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Sampath, V., Baek, Y.J., and Kim, I.H. (2026). Scutellaria baicalensis and Lonicera japonica herbal extracts enhanced the performance and physiological responses of pigs subjected to hot and dry season. Front. Vet. Sci., 12.","DOI":"10.3389\/fvets.2025.1740443"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/19\/3540\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:21:27Z","timestamp":1791260487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/19\/3540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":213,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["molecules31193540"],"URL":"https:\/\/doi.org\/10.3390\/molecules31193540","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]}}}