{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:20:54Z","timestamp":1782498054121,"version":"3.54.5"},"reference-count":18,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MPs"],"abstract":"<jats:p>Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications usually involve the generation of continuous and steady fluid flow over cell monolayers for extended durations, usually a few days. Another technique is to generate a fast high-stress wave over the cells to see the immediate effect of flow-induced stresses. This can be achieved by propagating an air\/liquid interface, in other words, a bubble, over cell monolayers. The approach is relevant to the reopening event of fluid-filled lung bronchioles and alveoli during mechanical ventilation therapy of Acute Respiratory Distress Syndrome. This article explains how we generate a stress wave using a parallel plate flow chamber and presents representative results of this wave on cultured lung epithelial cells.<\/jats:p>","DOI":"10.3390\/mps3040065","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T04:18:57Z","timestamp":1600921137000},"page":"65","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of a Flow-Induced Stress Wave and Investigation of Associated Injuries on Cell Monolayers Using a Parallel Plate Flow Chamber"],"prefix":"10.3390","volume":"3","author":[{"given":"Samar","family":"Shurbaji","sequence":"first","affiliation":[{"name":"Biomedical Research Center, Qatar University, Doha, P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-7818","authenticated-orcid":false,"given":"Mahmoud Khatib A. A.","family":"Al-Ruweidi","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Qatar University, Doha, P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Hassan","family":"Ali","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Qatar University, Doha, P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatiha M.","family":"Benslimane","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Qatar University, Doha, P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin C.","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Qatar University, Doha, P.O. 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