{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:15:11Z","timestamp":1760228111184,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Gottfried und Julia Bangerter-Rhyner foundation","award":["SFB 1158","DFG KU 3555\/1-1"],"award-info":[{"award-number":["SFB 1158","DFG KU 3555\/1-1"]}]},{"name":"the Swiss Foundation for Research on Muscle Diseases","award":["SFB 1158","DFG KU 3555\/1-1"],"award-info":[{"award-number":["SFB 1158","DFG KU 3555\/1-1"]}]},{"DOI":"10.13039\/501100001659","name":"the Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1158","DFG KU 3555\/1-1"],"award-info":[{"award-number":["SFB 1158","DFG KU 3555\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"the Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1158","DFG KU 3555\/1-1"],"award-info":[{"award-number":["SFB 1158","DFG KU 3555\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heidelberg University Hospital research funding","award":["SFB 1158","DFG KU 3555\/1-1"],"award-info":[{"award-number":["SFB 1158","DFG KU 3555\/1-1"]}]},{"name":"the International Foundation for Research in Paraplegia","award":["SFB 1158","DFG KU 3555\/1-1"],"award-info":[{"award-number":["SFB 1158","DFG KU 3555\/1-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MPs"],"abstract":"<jats:p>Magnetic resonance neurography (MRN), the MR imaging of peripheral nerves, is clinically used for assessing and monitoring peripheral neuropathies based on qualitative, weighted MR imaging. Recently, quantitative MRN has been increasingly reported with various MR parameters as potential biomarkers. An evidence synthesis mapping the available methodologies and normative values of quantitative MRN of human peripheral nerves, independent of the anatomical location and type of neuropathy, is currently unavailable and would likely benefit this young field of research. Therefore, the proposed scoping review will include peer-reviewed literature describing methodologies and normative values of quantitative MRN of human peripheral nerves. The literature search will include the databases MEDLINE (PubMed), EMBASE (Ovid), Web of Science, and Scopus. At least two independent reviewers will screen the titles and abstracts against the inclusion criteria. Potential studies will then be screened in full against the inclusion criteria by two or more independent reviewers. From all eligible studies, data will be extracted by two or more independent reviewers and presented in a diagrammatic or tabular form, separated by MR parameter and accompanied by a narrative summary. The reporting will follow the guidelines of the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Upon completion, the scoping review will provide a map of the available literature, identify possible gaps, and inform on possible future research. SCOPING REVIEW REGISTRATION: Open Science Framework 9P3ZM.<\/jats:p>","DOI":"10.3390\/mps5030039","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T02:46:39Z","timestamp":1651805199000},"page":"39","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Methodologies and MR Parameters in Quantitative Magnetic Resonance Neurography: A Scoping Review Protocol"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-9870","authenticated-orcid":false,"given":"Fabian","family":"Balsiger","sequence":"first","affiliation":[{"name":"Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"},{"name":"Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Wagner","sequence":"additional","affiliation":[{"name":"Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann M. E.","family":"Jende","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Marty","sequence":"additional","affiliation":[{"name":"NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, 78013 Paris, France"},{"name":"NMR Laboratory, CEA, DRF, IBFJ, MIRCen, 78013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bendszus","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3925-5142","authenticated-orcid":false,"given":"Olivier","family":"Scheidegger","sequence":"additional","affiliation":[{"name":"Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"},{"name":"Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix T.","family":"Kurz","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Heidelberg University Hospital, 69120 Heidelberg, Germany"},{"name":"Division of Radiology, German Cancer Research Center, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/mrm.1910280215","article-title":"Magnetic Resonance Neurography","volume":"28","author":"Howe","year":"1992","journal-title":"Magn. 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Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/B978-0-444-53486-6.00040-5","article-title":"Peripheral nerve imaging","volume":"136","author":"Simon","year":"2016","journal-title":"Handb. Clin. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s00330-017-4976-8","article-title":"Magnetic resonance neurography: Current perspectives and literature review","volume":"28","author":"Chhabra","year":"2018","journal-title":"Eur. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.22603\/ssrr.1.2016-0015","article-title":"Recent advances in magnetic resonance neuroimaging of lumbar nerve to clinical applications: A review of clinical studies utilizing Dffusion Tensor Imaging and Diffusion-weighted magnetic resonance neurography","volume":"1","author":"Eguchi","year":"2017","journal-title":"Spine Surg. Relat. 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Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.jhsa.2019.06.021","article-title":"Imaging of the Peripheral Nerve: Concepts and Future Direction of Magnetic Resonance Neurography and Ultrasound","volume":"44","author":"Holzgrefe","year":"2019","journal-title":"J. Hand Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.12688\/f1000research.19695.1","article-title":"Peripheral nerve magnetic resonance imaging","volume":"8","author":"Chen","year":"2019","journal-title":"F1000Research"},{"key":"ref_13","first-page":"90","article-title":"Update in the evaluation of peripheral nerves by MRI, from morphological to functional neurography","volume":"62","author":"Noguerol","year":"2020","journal-title":"Radiolog\u00eda"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00256-019-03290-1","article-title":"Current status and recommendations for imaging in neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis","volume":"49","author":"Ahlawat","year":"2020","journal-title":"Skelet. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cps.2019.12.003","article-title":"Imaging of Damaged Nerves","volume":"47","author":"Purger","year":"2020","journal-title":"Clin. Plast. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s40336-020-00393-x","article-title":"Diffusion tensor imaging of the roots of the brachial plexus: A systematic review and meta-analysis of normative values","volume":"8","author":"Wade","year":"2020","journal-title":"Clin. Transl. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.clinph.2020.03.026","article-title":"Peripheral nerve imaging in amyotrophic lateral sclerosis","volume":"131","author":"Schreiber","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"ref_18","first-page":"20200103","article-title":"A systematic review on diagnostic test accuracy of magnetic resonance neurography versus clinical neurosensory assessment for post-traumatic trigeminal neuropathy in patients reporting neurosensory disturbance","volume":"50","author":"Peeters","year":"2021","journal-title":"Dento Maxillo Facial Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3389\/fnins.2021.727311","article-title":"Magnetic Resonance Imaging as a Biomarker in Diabetic and HIV-Associated Peripheral Neuropathy: A Systematic Review-Based Narrative","volume":"15","author":"Evans","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. 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Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015: Elaboration and explanation","volume":"349","author":"Shamseer","year":"2015","journal-title":"BMJ"}],"container-title":["Methods and Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2409-9279\/5\/3\/39\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:06:46Z","timestamp":1760137606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2409-9279\/5\/3\/39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["mps5030039"],"URL":"https:\/\/doi.org\/10.3390\/mps5030039","relation":{},"ISSN":["2409-9279"],"issn-type":[{"type":"electronic","value":"2409-9279"}],"subject":[],"published":{"date-parts":[[2022,5,6]]}}}