{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:01:43Z","timestamp":1780628503926,"version":"3.54.1"},"reference-count":52,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Institute of General Medical Sciences, National Institutes of Health","award":["U54 GM104944"],"award-info":[{"award-number":["U54 GM104944"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MPs"],"abstract":"<jats:p>Interstitial cystitis\/bladder pain syndrome (IC\/BPS) is a chronic condition characterized by pelvic pain coupled with urinary frequency and urgency. The underlying cause of IC\/BPS is unknown; there is no cure. Dietary components exacerbate symptoms. The Anti-Inflammatory Diet for Interstitial Cystitis (AID-IC) employs a randomized, crossover design to evaluate the effect of a plant-based, low saturated fat diet on the quality of life of women with IC\/BPS. Insights on the implementation of the protocol and reflections on the facilitators and barriers experienced during the pilot study follow. The logistics of the protocol proved time-consuming; however, the barriers were surmountable. Quantitative and qualitative findings suggest that the AID-IC therapeutic diet may have lessened symptoms and improved the quality of life for many of the women in the study.<\/jats:p>","DOI":"10.3390\/mps5030040","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T23:14:26Z","timestamp":1652915666000},"page":"40","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti-Inflammatory Diet for Women with Interstitial Cystitis\/Bladder Pain Syndrome: The AID-IC Pilot Study"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-258X","authenticated-orcid":false,"given":"Barbara","family":"Gordon","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Idaho State University, 1311 E Central Drive, Meridian, ID 83642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-1842","authenticated-orcid":false,"given":"Cynthia","family":"Blanton","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Idaho State University, 921 South 8th Avenue, Pocatello, ID 83209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Idaho State University, 921 South 8th Avenue, Pocatello, ID 83209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Jeffery","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Idaho State University, 1311 E Central Drive, Meridian, ID 83642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Richey","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Idaho State University, 1311 E Central Drive, Meridian, ID 83642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Hulse","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Idaho State University, 921 South 8th Avenue, Pocatello, ID 83209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.juro.2011.03.132","article-title":"Prevalence of symptoms of bladder pain syndrome\/interstitial cystitis among adult females in the United States","volume":"186","author":"Berry","year":"2011","journal-title":"J. Urol."},{"key":"ref_2","first-page":"e101848","article-title":"Bladder pain syndrome and interstitial cystitis beyond horizon: Reports from the Global Interstitial Cystitis\/Bladder Pain Society (GIBS) meeting 2019","volume":"10","author":"Javan","year":"2020","journal-title":"Anesthesiol. Pain Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1464-410X.2000.00855.x","article-title":"Interstitial cystitis in Japan","volume":"86","author":"Ito","year":"2001","journal-title":"Br. J. Urol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/S0022-5347(01)66684-9","article-title":"Interstitial cystitis in The Netherlands: Prevalence, diagnostic criteria and therapeutic preferences","volume":"154","author":"Bade","year":"1995","journal-title":"J. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.juro.2012.08.088","article-title":"The prevalence and overlap of interstitial cystitis\/bladder pain syndrome and chronic prostatitis\/chronic pelvic pain syndrome in men: Results of the RAND Interstitial Cystitis Epidemiology male study","volume":"189","author":"Suskind","year":"2013","journal-title":"J. Urol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.juro.2011.03.064","article-title":"AUA guideline for the diagnosis and treatment of interstitial cystitis\/bladder pain syndrome","volume":"185","author":"Hanno","year":"2011","journal-title":"J. Urol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/nau.23421","article-title":"Psychosocial comorbidities in interstitial cystitis\/bladder pain syndrome (IC\/BPS): A systematic review","volume":"37","author":"McKernan","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00192-015-2652-6","article-title":"Urologic chronic pelvic pain syndrome flares and their impact: Qualitative analysis in the MAPP Network","volume":"26","author":"Sutcliffe","year":"2015","journal-title":"Int. Urogynecol. J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Akiyama, Y. (2021). Biomarkers in interstitial cystitis\/bladder pain syndrome with and without Hunner lesion: A review and future perspectives. Diagnostics, 11.","DOI":"10.3390\/diagnostics11122238"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jiang, Y.H., Peng, C.H., Liu, H.T., and Kuo, H.C. (2013). Increased pro-inflammatory cytokines, C-reactive protein and nerve growth factor expressions in serum of patients with interstitial cystitis\/bladder pain syndrome. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076779"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/nau.20938","article-title":"Elevation of serum c-reactive protein in patients with OAB and IC\/BPS implies chronic inflammation in the urinary bladder","volume":"30","author":"Chung","year":"2011","journal-title":"Neurourol. Urodyn."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"F1391","DOI":"10.1152\/ajprenal.00051.2020","article-title":"Urine cytokines as biomarkers for diagnosing interstitial cystitis\/bladder pain syndrome and mapping its clinical characteristics","volume":"318","author":"Jiang","year":"2020","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0022-5347(17)36120-7","article-title":"The natural history of interstitial cystitis: A survey of 374 patients","volume":"149","author":"Koziol","year":"1993","journal-title":"J. Urol."},{"key":"ref_14","unstructured":"(2014, December 31). Interstitial Cystitis Association. Available online: www.ichelp.org\/icdietsurvey."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.urology.2007.10.062","article-title":"Evidence based criteria for the pain of interstitial cystitis\/painful bladder syndrome in women","volume":"71","author":"Warren","year":"2008","journal-title":"Urology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/SPV.0b013e3182044b5c","article-title":"Dietary consumption triggers in interstitial cystitis\/bladder pain syndrome patients","volume":"17","author":"Bassaly","year":"2011","journal-title":"Female Pelvic Med. Reconstr. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00192-012-1966-x","article-title":"Interstitial cystitis patients\u2019 use and rating of complementary and alternative medicine therapies","volume":"24","author":"Hoffmann","year":"2013","journal-title":"Int. Urogynecol. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.juro.2013.11.055","article-title":"Statistical validation of the Shorter-Moldwin Food Sensitivity Questionnaire for patients with interstitial cystitis\/bladder pain syndrome","volume":"191","author":"Shorter","year":"2014","journal-title":"J. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"ACOG Committee on Practice Bulletins\u2014Gynecology (2004). ACOG Practice Bulletin No. 51. Chronic pelvic pain. Obstet. Gynecol., 103, 589\u2013605.","DOI":"10.1097\/00006250-200403000-00045"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00128360-200501000-00009","article-title":"The vulvodynia guideline","volume":"9","author":"Haefner","year":"2005","journal-title":"J. Low. Genit. Tract Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.juro.2015.01.086","article-title":"Diagnosis and treatment of interstitial cystitis\/bladder pain syndrome: AUA guideline amendment","volume":"193","author":"Hanno","year":"2015","journal-title":"J. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1442-2042.2009.02326.x","article-title":"Japanese Urological Association. Clinical guidelines for interstitial cystitis and hypersensitive bladder syndrome","volume":"16","author":"Homma","year":"2009","journal-title":"Int. J. Urol."},{"key":"ref_23","first-page":"365","article-title":"Recommendations for the diagnosis and management of bladder pain syndrome: Spanish urological association consensus document","volume":"39","author":"Estaban","year":"2013","journal-title":"Actas Urol. Esp."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.urology.2006.03.084","article-title":"The role of the urinary epithelium in the pathogenesis of interstitial cystitis\/prostatitis\/urethritis","volume":"69","author":"Parsons","year":"2007","journal-title":"Urology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4161\/gmic.29232","article-title":"The effects of gut microbiota on CNS function in humans","volume":"5","author":"Tillisch","year":"2014","journal-title":"Gut Microbes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.urology.2006.08.1108","article-title":"Neural upregulation in interstitial cystitis","volume":"69","author":"Nazif","year":"2007","journal-title":"Urology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.juro.2011.07.083","article-title":"Expression and distribution of the sweet taste receptor isoforms T1R2 and T1R3 in human and rat bladders","volume":"186","author":"Elliott","year":"2011","journal-title":"J. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s11882-013-0404-6","article-title":"Role of \u201cWestern diet\u201d in inflammatory autoimmune diseases","volume":"14","author":"Manzel","year":"2014","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1017\/S1368980013002115","article-title":"Designing and developing a literature-derived, population-based dietary inflammatory index","volume":"17","author":"Shivappa","year":"2014","journal-title":"Public Health Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s11255-015-1108-8","article-title":"Influence of polyunsaturated fatty acids on urologic inflammation","volume":"47","author":"Tamma","year":"2015","journal-title":"Int. Urol. Nephrol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"647122","DOI":"10.3389\/fnut.2021.647122","article-title":"Dietary Inflammatory Index and Health Outcomes: An Umbrella Review of Systematic Review and Meta-Analyses of Observational Studies","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/advances\/nmy071","article-title":"Perspective: The Dietary Inflammatory Index (DII)-Lessons Learned, Improvements Made, and Future Directions","volume":"10","author":"Shivappa","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2058739218792976","article-title":"TLR4 overexpression enhances saturated fatty acid-induced inflammatory cytokine gene expression in sheep","volume":"16","author":"Xu","year":"2018","journal-title":"Eur. J. Inflamm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.cmet.2018.03.014","article-title":"Evidence that TLR4 Is not a receptor for saturated fatty acids but mediates lipid-induced inflammation by reprogramming macrophage metabolism","volume":"27","author":"Lancaster","year":"2018","journal-title":"Cell Metab."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Oberbach, A., Schlichting, N., Heinrich, M., Till, H., Stolzenburg, J.-U., and Neuhaus, J. (2012). Free fatty acid palmitate impairs vitality and function of cultured human bladder smooth muscle cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0041026"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1093\/aje\/kwq065","article-title":"Dietary macronutrient and energy intake and urinary incontinence in women","volume":"171","author":"Maserejian","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12937-018-0354-x","article-title":"A randomized controlled cross-over trial investigating the effect of anti-inflammatory diet on disease activity and quality of life in rheumatoid arthritis: The Anti-inflammatory Diet In Rheumatoid Arthritis (ADIRA) study protocol","volume":"17","author":"Winkvist","year":"2018","journal-title":"Nutr. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.urology.2009.06.078","article-title":"Validation of a modified National Institutes of Health chronic prostatitis symptom index to assess genitourinary pain in both men and women","volume":"74","author":"Clemens","year":"2009","journal-title":"Urology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J. Sex Marital Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s11136-011-0085-3","article-title":"Validation of a quality-of-life scale for women with bladder pain syndrome\/interstitial cystitis","volume":"21","author":"Bogart","year":"2012","journal-title":"Qual. Life Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Genoni, A., Lo, J., Lyons-Wall, P., and Devine, A. (2016). Compliance, palatability and feasibility of paleolithic and Australian guide to healthy eating diets in healthy women: A 4-week dietary intervention. Nutrients, 8.","DOI":"10.3390\/nu8080481"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1590\/S1677-55382009000400011","article-title":"Multimodal therapy for painful bladder syndrome\/interstitial cystitis: Pilot study combining behavioral, pharmacologic, and endoscopic therapies","volume":"35","author":"Hanley","year":"2009","journal-title":"Int. Braz. J. Urol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e325","DOI":"10.1016\/j.juro.2011.02.626","article-title":"The effects of caffeine on the symptoms of interstitial cystitis\/painful bladder syndrome: A randomized, placebo-controlled double blind study","volume":"185","author":"Herati","year":"2011","journal-title":"J. Urol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.urology.2017.02.053","article-title":"Clinical efficacy of 1-year intensive systematic dietary manipulation as complementary and alternative medicine therapies on female patients with interstitial cystitis\/bladder pain syndrome","volume":"106","year":"2017","journal-title":"Urology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/oxfordjournals.schbul.a006992","article-title":"Approaches to multisite clinical trials: The National Institute of Mental Health perspective","volume":"29","author":"Lebowitz","year":"2003","journal-title":"Schizophr. Bull."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"O37","DOI":"10.1186\/1745-6215-16-S2-O37","article-title":"The importance of rapport and relationship building when recruiting to clinical trials: A qualitative investigation of trial recruitment consultations in a surgical RCT","volume":"16","author":"Constable","year":"2015","journal-title":"Trials"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13063-021-05200-0","article-title":"Australasian Kidney Trials Network. Conducting clinical trials during the COVID-19 pandemic\u2014A collaborative trial network response","volume":"22","author":"Robison","year":"2021","journal-title":"Trials"},{"key":"ref_49","unstructured":"(2021, October 01). Clemson University. Available online: https:\/\/hgic.clemson.edu\/factsheet\/planning-meals-for-a-family."},{"key":"ref_50","unstructured":"Armstrong, S., Arsenault, M., and Betwick, S. (2019). Menu Planning in Long Term Care and Canada\u2019s Food Guide, Dietitians of Canada."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s12393-020-09216-1","article-title":"Impact of Processing Factors on Quality of Frozen Vegetables and Fruits","volume":"12","year":"2020","journal-title":"Food Eng. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1526-4610.2012.02296.x","article-title":"IgG-based elimination diet in migraine plus irritable bowel syndrome","volume":"53","author":"Aydinlar","year":"2013","journal-title":"Headache"}],"container-title":["Methods and Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2409-9279\/5\/3\/40\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:14:01Z","timestamp":1760138041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2409-9279\/5\/3\/40"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,18]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["mps5030040"],"URL":"https:\/\/doi.org\/10.3390\/mps5030040","relation":{},"ISSN":["2409-9279"],"issn-type":[{"value":"2409-9279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,18]]}}}