{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:55:22Z","timestamp":1760144122345,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dementia Centre for Research Collaboration (DCRC) \u2018Implementing Research Evidence into Practice Grant\u2019 2020"},{"name":"James Cook University (JCU) Philanthropic Chiropractic Research Fund 2021"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MPs"],"abstract":"<jats:p>Introduction: Virtually all adults in aged care facilities are frail, a condition which contributes to falls, cognitive decline, hospitalisation, and mortality. Polypharmacy, malnutrition, sedentariness, and sarcopenia are risk factors amenable to intervention. The Asia\u2013Pacific Frailty Management Guidelines recommend anabolic exercise and the optimisation of medications and nutrition. However, no study has evaluated this best practice intervention triad in aged care. Methods: The Frailty Reduction via the Implementation of Exercise, Nutrition, and Deprescribing (FRIEND) Trial (ANZCTR No.ACTRN12622000926730p) is a staged 6-month translational trial evaluating resident outcomes, staff\/caregiver knowledge, and institutional implementation in a Townsville aged care facility. Residents received high-intensity resistance exercise and balance training and medication and nutrition optimisation co-implemented by investigators (exercise physiologist, geriatrician, pharmacist, and nutritionist) and facility staff. Staff and caregivers completed comprehensive education modules and training. We report the trial protocol and recruitment results. Results: 29 residents (21 female, age: 88.6 \u00b1 6.3 years) were recruited. At baseline, the residents were frail (frailty scale nursing home (FRAIL-NH); 6.3 \u00b1 2.4\/14), cognitively impaired (Montreal Cognitive Assessment; 13.8 \u00b1 6.8\/30), functionally impaired (Short Physical Performance Battery; 4.9 \u00b1 3.1\/12, 6 min walk distance; 222.2 \u00b1 104.4 m), and were prescribed numerous medications (15.5 \u00b1 5.9). Two residents died and one withdrew before the intervention\u2019s commencement. Thirty family members and 19 staff (carers, allied health assistants, nurse managers, registered nurses, lifestyle\u2013leisure officers, kitchen\/hospitality staff, and senior leadership) were recruited to receive frailty education modules. Conclusions: The FRIEND trial is currently being implemented with results expected in mid-2024. This is the first trial to evaluate the implementation of the best practice frailty guidelines including anabolic exercise and medication\/nutritional optimisation in residential aged care.<\/jats:p>","DOI":"10.3390\/mps7020026","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:40:11Z","timestamp":1711370411000},"page":"26","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Frailty Reduction via Implementation of Exercise, Nutrition, and Deprescribing (FRIEND) Trial: Study Protocol and Recruitment Results"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-8582","authenticated-orcid":false,"given":"Michael","family":"Inskip","sequence":"first","affiliation":[{"name":"College of Healthcare Sciences, James Cook University, Townsville, QLD 4814, Australia"},{"name":"School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-563X","authenticated-orcid":false,"given":"Carolina","family":"Almendrales Rangel","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3758-2422","authenticated-orcid":false,"given":"Chidiamara Maria","family":"Njoku","sequence":"additional","affiliation":[{"name":"College of Healthcare Sciences, James Cook University, Townsville, QLD 4814, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Barnett","sequence":"additional","affiliation":[{"name":"College of Healthcare Sciences, James Cook University, Townsville, QLD 4814, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Shih","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"The Good Shepherd Home, Townsville, QLD 4814, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-8707","authenticated-orcid":false,"given":"Maria A.","family":"Fiatarone Singh","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia"},{"name":"The Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trinidad","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia"},{"name":"Exercise and Rehabilitation Sciences Laboratory, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7550196, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jadczak, A.D., on behalf of the FIRST Study Collaborators, Robson, L., Cooper, T., Bell, J.S., and Visvanathan, R. 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