{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:35:36Z","timestamp":1786487736386,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centre of Excellence for Nursing Scholarship (CECRI), Order of Nurses of Rome, Italy","award":["10041"],"award-info":[{"award-number":["10041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MPs"],"abstract":"<jats:p>Background: Telenursing comprises a set of tools and interventions enabling nurses to provide remote care. This study aims to assess the impact of telenursing interventions on the supportive care needs of patients with melanoma and lung cancer who are receiving targeted therapies. Methods: This six-month monocentric, double-arm, randomised, controlled trial study protocol will assess the effect of telenursing on the supportive care needs (primary outcome) in 40 patients (20 in each group) after one month. The secondary outcomes will be monitored at baseline, one, three and six months: supportive care needs (at three and six months), therapeutic adherence, quality of life, usability and satisfaction, performance status, patient-reported outcomes and main adverse events. The SPIRIT guidelines will be used for the reporting. Results: The results from this trial will assess the impact of a telenursing intervention on cancer care. Conclusions: This trial could be a starting point for more extensive studies on telenursing interventions to promote nurses\u2019 skills, as well as the quality and safety of care in patients with cancer, highlighting the impact of more outstanding nursing contributions on cancer care. Trial and Protocol Registration: The study protocol was approved by the relevant Italian Ethics Committee Lazio Area 5 (RS1851\/23, 2773; 6 September 2023) and was registered on ClinicalTrials.gov (trial registry number NCT06254196).<\/jats:p>","DOI":"10.3390\/mps7050078","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T06:45:52Z","timestamp":1727937952000},"page":"78","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Telenursing on Supportive Care Needs in Patients with Melanoma and Lung Cancer on Targeted Therapies: A Randomised Controlled Trial Study Protocol"],"prefix":"10.3390","volume":"7","author":[{"given":"Aurora","family":"De Leo","sequence":"first","affiliation":[{"name":"Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy"},{"name":"Nursing Research Unit IFO, IRCCS Istituti Fisioterapici Ospitalieri, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Liquori","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Spano","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy"},{"name":"Nursing Research Unit IFO, IRCCS Istituti Fisioterapici Ospitalieri, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-937X","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Panattoni","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7933-8490","authenticated-orcid":false,"given":"Sara","family":"Dionisi","sequence":"additional","affiliation":[{"name":"Nursing, Technical, Rehabilitation Department, DaTeR Azienda Unit\u00e0 Sanitaria Locale di Bologna, 40124 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Iacorossi","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Health Professions Sciences, Link Campus University, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4575-1898","authenticated-orcid":false,"given":"Noemi","family":"Giannetta","sequence":"additional","affiliation":[{"name":"Departmental Faculthy of Medicine, Saint Camillus International University of Health and Medical Sciences (UniCamillus), 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0187-9323","authenticated-orcid":false,"given":"Irene","family":"Terrenato","sequence":"additional","affiliation":[{"name":"CTC and Biostatistics and Bioinformatics\u2014Scientific Direction, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-8163","authenticated-orcid":false,"given":"Emanuele","family":"Di Simone","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2641-4044","authenticated-orcid":false,"given":"Marco","family":"Di Muzio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2080-8226","authenticated-orcid":false,"given":"Fabrizio","family":"Petrone","sequence":"additional","affiliation":[{"name":"Nursing, Technical, Rehabilitation, Assistance and Research Direction, IRCCS Istituti Fisioterapici Ospitalieri, IFO, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1001\/jamainternmed.2022.4342","article-title":"Association of UV Radiation Exposure, Diagnostic Scrutiny, and Melanoma Incidence in US Counties","volume":"182","author":"Adamson","year":"2022","journal-title":"JAMA Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejphar.2018.07.034","article-title":"Molecular targeted therapy: Treating cancer with specificity","volume":"834","author":"Lee","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12955-021-01767-z","article-title":"Research trends and hotspots of health-related quality of life: A bibliometric analysis from 2000 to 2019","volume":"19","author":"Zheng","year":"2021","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s40257-013-0021-0","article-title":"Impact of dermatologic adverse events on quality of life in 283 cancer patients: A questionnaire study in a dermatology referral clinic","volume":"14","author":"Rosen","year":"2013","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1111\/jan.15614","article-title":"Supportive care needs of women with gynaecological cancer: A systematic review and synthesis of qualitative studies","volume":"79","author":"Sun","year":"2023","journal-title":"J. Adv. Nurs."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/pon.4590","article-title":"Thyroid cancer patients receiving an interdisciplinary team-based care approach (ITCA-ThyCa) appear to display better outcomes: Program evaluation results indicating a need for further integrated care and support","volume":"27","author":"Henry","year":"2018","journal-title":"Psychooncology"},{"key":"ref_8","unstructured":"International Council of Nurses (2007). International Competencies for Telenursing, International Council of Nurses."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s11764-019-00758-w","article-title":"An ecological momentary assessment of self-management in prostate cancer survivors","volume":"13","author":"Paterson","year":"2019","journal-title":"J. Cancer Surviv."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e12516","DOI":"10.1111\/jjns.12516","article-title":"Effectiveness of telenursing for people with lung cancer at home: A systematic review and meta-analysis","volume":"20","author":"Harada","year":"2023","journal-title":"Jpn. J. Nurs. Sci."},{"key":"ref_11","first-page":"767","article-title":"Telenursing Interventions for Patients With Cancer Receiving Chemotherapy: A Scoping Review","volume":"50","author":"Liquori","year":"2023","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"E168","DOI":"10.1188\/17.ONF.E168-E184","article-title":"Effects of Nurse-Led Telephone-Based Supportive Interventions for Patients With Cancer: A Meta-Analysis","volume":"44","author":"Suh","year":"2017","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1089\/tmj.2020.0144","article-title":"Usefulness of a Telemedicine Tool TELEA in the Management of the COVID-19 Pandemic","volume":"26","author":"Golpe","year":"2020","journal-title":"Telemed. J. E Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"151145","DOI":"10.1016\/j.soncn.2021.151145","article-title":"Electronic Patient-Reported Outcome Measures Evaluating Cancer Symptoms: A Systematic Review","volume":"37","year":"2021","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Dionisi, S., Giannetta, N., Di Simone, E., Ricciardi, F., Liquori, G., De Leo, A., Moretti, L., Napoli, C., Di Muzio, M., and Orsi, G.B. (2021). The Use of mHealth in Orthopedic Surgery: A Scoping Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182312549"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/jpm2020035","article-title":"Molecular therapeutic advances in personalized therapy of melanoma and non-small cell lung cancer","volume":"2","author":"Kelleher","year":"2012","journal-title":"J. Pers. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1007\/s00520-021-06056-5","article-title":"Can tele-nursing affect the supportive care needs of patients with cancer undergoing chemotherapy? A randomized controlled trial follow-up study","volume":"29","author":"Ebrahimabadi","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00520-015-2852-0","article-title":"Translation of Supportive Care Needs Survey Short Form 34 (SCNS-SF34) into Italian and cultural validation study","volume":"24","author":"Zeneli","year":"2016","journal-title":"Support. Care Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0895-4356(98)00094-8","article-title":"The Italian SF-36 Health Survey: Translation, validation and norming","volume":"51","author":"Apolone","year":"1998","journal-title":"J. Clin. Epidemiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10339-009-0268-9","article-title":"On the dimensionality of the System Usability Scale: A test of alternative measurement models","volume":"10","author":"Borsci","year":"2009","journal-title":"Cogn. Process."},{"key":"ref_23","unstructured":"Brooke, J. (1996). SUS: A quick and dirty usability scale. Usability Evaluation in Industry, Taylor and Francis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"SOLE Study Group (2019). Translation and initial validation of the Medication Adherence Report Scale (MARS) in Italian patients with Crohn\u2019s Disease. Dig. Liver Dis., 51, 640\u2013647.","DOI":"10.1016\/j.dld.2018.09.026"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0022-3999(99)00057-4","article-title":"Patients\u2019 beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness","volume":"47","author":"Horne","year":"1999","journal-title":"J. Psychosom. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/0959-8049(95)00664-8","article-title":"Karnofsky and ECOG performance status scoring in lung cancer: A prospective, longitudinal study of 536 patients from a single institution","volume":"32A","author":"Buccheri","year":"1996","journal-title":"Eur. J. Cancer"},{"key":"ref_27","unstructured":"National Cancer Institute (2023, January 20). Common Terminology Criteria for Adverse Events, CTCAE, Available online: https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/ctc.htm#ctc_60."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e7586","DOI":"10.1136\/bmj.e7586","article-title":"SPIRIT 2013 explanation and elaboration: Guidance for protocols of clinical trials","volume":"346","author":"Chan","year":"2013","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"De Leo, A., Di Simone, E., Spano, A., Puliani, G., and Petrone, F. (2021). Nursing Management and Adverse Events in Thyroid Cancer Treatments with Tyrosine Kinase Inhibitors. A Narrative Review. Cancers, 13.","DOI":"10.3390\/cancers13235961"},{"key":"ref_30","unstructured":"(2024, June 24). KG Partners Healthcare Software. Available online: https:\/\/www.kgpartners.it\/it\/prodotti\/software-per-la-sanita\/."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/picr.picr_184_23","article-title":"The revamped Good Clinical Practice E6(R3) guideline: Profound changes in principles and practice!","volume":"14","author":"Bhatt","year":"2023","journal-title":"Perspect. Clin. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kwame, A., and Petrucka, P.M. (2021). A literature-based study of patient-centered care and communication in nurse-patient interactions: Barriers, facilitators, and the way forward. BMC Nurs., 20.","DOI":"10.1186\/s12912-021-00684-2"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.clon.2017.02.009","article-title":"Targeted Therapy in Thyroid Cancer: State of the Art","volume":"29","author":"Valerio","year":"2017","journal-title":"Clin. Oncol. (R. Coll. Radiol)"}],"container-title":["Methods and Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2409-9279\/7\/5\/78\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:09:58Z","timestamp":1760112598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2409-9279\/7\/5\/78"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["mps7050078"],"URL":"https:\/\/doi.org\/10.3390\/mps7050078","relation":{},"ISSN":["2409-9279"],"issn-type":[{"value":"2409-9279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]}}}