{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:05:51Z","timestamp":1778605551470,"version":"3.51.4"},"reference-count":47,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"THE BORROW FOUNDATION","award":["18688\/23.10.2023"],"award-info":[{"award-number":["18688\/23.10.2023"]}]},{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, Romania","award":["18688\/23.10.2023"],"award-info":[{"award-number":["18688\/23.10.2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MPs"],"abstract":"<jats:p>Background: Oral diseases represent a constant burden for health care and socio-economic systems as they are correlated to other non-communicable diseases. The aim of the proposed intervention is to test the effect of daily tooth brushing and oral health education on the oral health status of kindergarten children. Methods: The protocol will be conducted based on a previous epidemiological survey and conducted over 24 months; it has been developed on different levels. Dental hygienists will receive specific training to deliver oral health promotion to children and nursery educators. Training will focus on tailoring key messages to the specific age at visit; this will be outlined in the care pathway and offer practical preparation for delivering interventions and a toothpaste\/toothbrush scheme. It will also, involving involve offering free daily tooth brushing to every 4\u20136-year-old child attending nursery. Data will be collected in four kindergartens in the capital or metropolitan areas, two kindergartens each in two large cities, and one kindergarten each in four villages from different geographic areas. Procedures used to assess the outcomes of each activity will be tailored to specific outcomes. Daily tooth-brushing activities will be monitored using qualitative research. A cost analysis including the distribution of necessary materials and correct delivery of products that shows price trends and percentage differences over the time span as well as consumer price index evaluation for the given time span will be conducted. Clinical outcomes will be evaluated using the caries incidence rate; this will be calculated for each tooth as the unit of analysis and evaluated using a multi-step approach. Discussion: Downstream oral health prevention interventions, like clinical prevention and oral health promotion, aim to enhance children\u2019s quality of life. The program\u2019s goal is to progress towards upstream interventions for a more significant impact.<\/jats:p>","DOI":"10.3390\/mps8030049","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:20:53Z","timestamp":1746606053000},"page":"49","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["SmilebrightRO\u2014Study Protocol for a Randomized Clinical Trial to Evaluate Oral Health Interventions in Children"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-2609","authenticated-orcid":false,"given":"Ruxandra","family":"Sava-Rosianu","sequence":"first","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Campus","sequence":"additional","affiliation":[{"name":"Department of Cariology, Institute of Odontology at Sahlgrenska Academin, University of Gothenburg, 40530 Gothenburg, Sweden"},{"name":"Department of Dental Sciences and Maxillo-Facial Surgery, Sapienza University of Rome, 00185 Rome, Italy"},{"name":"Department of Cariology, Saveetha Dental College and Hospitals, SIMATS, Chennai 600077, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-6869","authenticated-orcid":false,"given":"Vlad Tiberiu","family":"Alexa","sequence":"additional","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9946-2517","authenticated-orcid":false,"given":"Octavia","family":"Balean","sequence":"additional","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-7341","authenticated-orcid":false,"given":"Ruxandra","family":"Sfeatcu","sequence":"additional","affiliation":[{"name":"Department of Oral Health and Community Dentistry, Faculty of Dentistry, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 041292 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Murariu","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry, Faculty of Dental Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3960-6910","authenticated-orcid":false,"given":"Alexandrina","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Pedodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400083 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-6497","authenticated-orcid":false,"given":"Daniela","family":"Esian","sequence":"additional","affiliation":[{"name":"Department of Pedodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy, 540139 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Daguci","sequence":"additional","affiliation":[{"name":"Department of Oro-Dental Prevention, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Olaru-Posiar","sequence":"additional","affiliation":[{"name":"Faculty of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1686-0150","authenticated-orcid":false,"given":"Vanessa","family":"Bolchis","sequence":"additional","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6242-6787","authenticated-orcid":false,"given":"Antonia","family":"Ilin","sequence":"additional","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-9607","authenticated-orcid":false,"given":"Ramona","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berivan Laura Rebeca","family":"Buzatu","sequence":"additional","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Postolache","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Medicine and Pharmacy Bucharest, 041292 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoleta","family":"Toderas","sequence":"additional","affiliation":[{"name":"Specialization in Clinical Psychology and Psychotherapy, Department of Psychology, Faculty of Sociology and Psychology, West University of Timi\u0219oara, 300223 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-1976","authenticated-orcid":false,"given":"Roxana","family":"Oancea","sequence":"additional","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2705-5020","authenticated-orcid":false,"given":"Daniela","family":"Jumanca","sequence":"additional","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atena","family":"Galuscan","sequence":"additional","affiliation":[{"name":"Translational and Experimental Research Center in Oral Health, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300040 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0528.2004.00175.x","article-title":"Effective use of fluorides for the prevention of dental caries in the 21st century: The WHO approach","volume":"32","author":"Petersen","year":"2004","journal-title":"Community Dent. 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