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This study applied the Informational Spectrum Method for Small Molecules (ISM-SM), a computational technique utilizing electron\u2013ion interaction potentials (EIIPs), to identify potential tau modulators. Characteristic interaction frequencies derived from known ligands and conserved mammalian tau sequences were used to screen DrugBank and the COCONUT natural product database. The screening identified approved drugs previously reported to indirectly influence tau pathology or Alzheimer\u2019s disease pathways, alongside natural products including Bryostatin-14, which is known to modulate kinases involved in tau phosphorylation. These findings suggest that ISM-SM can serve as an in silico tool to identify candidate small molecules, including repurposed drugs and natural products, with potential relevance to tau function and pathology, complementing other IDP drug discovery strategies.<\/jats:p>","DOI":"10.3390\/mps8060150","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:32:17Z","timestamp":1765380737000},"page":"150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New Approach for Targeting Small-Molecule Candidates for Intrinsically Disordered Proteins"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7296-3223","authenticated-orcid":false,"given":"Milan","family":"Sen\u0107anski","sequence":"first","affiliation":[{"name":"Laboratory of Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences Vinca, National Institute of the Republic of Serbia, University of Belgrade, 11001 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Uversky, V.N. 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