{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:08:43Z","timestamp":1792789723913,"version":"4.5.0"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Medical Research Agency","award":["2024\/ABM\/02\/00051-00"],"award-info":[{"award-number":["2024\/ABM\/02\/00051-00"]}],"id":[{"id":"https:\/\/ror.org\/026nedj88","id-type":"ROR","asserted-by":"crossref"}]},{"award":["2024\/ABM\/02\/00051-00"],"award-info":[{"award-number":["2024\/ABM\/02\/00051-00"]}],"id":[{"id":"https:\/\/ror.org\/026nedj88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Methods Protoc.","MPs"],"abstract":"<jats:p>Background: Prolonged hospitalization, postoperative complications, and unplanned readmission remain major problems after major surgery. RESET evaluates a continuous perioperative pathway integrating individualized prehabilitation, coordinated inpatient care, enhanced-recovery principles, discharge planning, and transitional care in adults undergoing oncological surgery and patients aged 70 years or older undergoing non-oncological surgery. Methods: RESET is a prospective, two-center, two-arm randomized controlled study (NCT07727876). Up to 12,800 patients will be screened and approximately 8960 randomized 9:1 to RESET or standard care, including about 5740 oncological and 3220 non-oncological participants. The three primary outcomes are prolonged index hospitalization (\u226514 days), unplanned readmission within 30 days after discharge, and postoperative complications within 30 days after surgery. Each outcome is evaluated separately in both clinical populations, yielding six primary hypothesis tests. Holm\u2019s procedure will control the family-wise error rate at \u03b1 = 0.01 across all six tests, with endpoint- and population-specific confirmatory conclusions. Secondary outcomes include length of stay, multidomain health status, satisfaction, adherence, organizational effectiveness, and direct healthcare costs. Conclusions: RESET will evaluate the clinical and implementation effects of an integrated perioperative pathway across two surgical populations.<\/jats:p>","DOI":"10.3390\/mps9050134","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:01:38Z","timestamp":1789981298000},"page":"134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ready for Safe Cancer Treatment (RESET): Protocol for a Large-Scale Randomized Controlled Trial of an Integrated Perioperative Care and Safe-Discharge Pathway in Oncological and Older Surgical Patients"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-5762","authenticated-orcid":false,"given":"Natalia","family":"J\u0119druchniewicz","sequence":"first","affiliation":[{"name":"Research and Development Centre, Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-9040","authenticated-orcid":false,"given":"Hanna","family":"Klimza","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Regional Specialist Hospital in Wroc\u0142aw, Research and Development Centre, 51-124 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Zawadzki","sequence":"additional","affiliation":[{"name":"Research and Development Centre, Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland"},{"name":"Department of Clinical Surgical Sciences, Faculty of Medicine, Wroclaw University of Science and Technology, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola","family":"Dwornikowska-D\u0105browska","sequence":"additional","affiliation":[{"name":"Research and Development Centre, Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland"},{"name":"Department of Public Health, Faculty of Health Sciences, Medical University of Silesia, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Zaj\u0105c","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1283-8187","authenticated-orcid":false,"given":"Tomasz","family":"Klimek","sequence":"additional","affiliation":[{"name":"Research and Development Centre, Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Kiszka","sequence":"additional","affiliation":[{"name":"Innovation and Education Center, 4th Military Clinical Hospital, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-4525","authenticated-orcid":false,"given":"Mariusz","family":"Chabowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgical Sciences, Faculty of Medicine, Wroclaw University of Science and Technology, 51-124 Wroclaw, Poland"},{"name":"Department of Surgery, 4th Military Clinical Hospital, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-9328","authenticated-orcid":false,"given":"Dorota","family":"Kami\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Surgery, 4th Military Clinical Hospital, 51-124 Wroclaw, Poland"},{"name":"Department of Non-Procedural Clinical Sciences, Faculty of Medicine, Wroclaw University of Science and Technology, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Jankowska-Pola\u0144ska","sequence":"additional","affiliation":[{"name":"Innovation and Education Center, 4th Military Clinical Hospital, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Witkiewicz","sequence":"additional","affiliation":[{"name":"Research and Development Centre, Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-6352","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Wierzbicka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Regional Specialist Hospital in Wroc\u0142aw, Research and Development Centre, 51-124 Wroc\u0142aw, Poland"},{"name":"Department of Clinical Surgical Sciences, Faculty of Medicine, Wroclaw University of Science and Technology, 51-124 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"ref_1","first-page":"CD013259","article-title":"Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery","volume":"5","author":"Molenaar","year":"2022","journal-title":"Cochrane Database Syst. 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