{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:47:30Z","timestamp":1789440450120,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PCCA no.85\/2018"],"award-info":[{"award-number":["PCCA no.85\/2018"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Operational Programme Human Capital of the Ministry of European Funds through the Financial Agreement","award":["51668\/09.07.2019, SMIS code 124705"],"award-info":[{"award-number":["51668\/09.07.2019, SMIS code 124705"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>This study evidenced the nanoconfinement effect on polyphenolic extracts prepared from Salvia officinalis L. and Thymus serpyllum L. into the mesopores of silica and titania nanomaterials on their radical scavenging capacity and antimicrobial potential. The ethanolic and hydroalcoholic extracts obtained either by conventional or microwave-assisted extraction were characterized in terms of total polyphenols, total flavonoids, and chlorophyll content, as well as radical scavenging activity by consecrated spectrometric determinations. The phytochemical fingerprint of extracts was analyzed by high-performance liquid chromatography-photodiode array detector. Salvia officinalis extracts exhibited better radical scavenging capacity and antimicrobial potential than Thymus serpyllum extracts. The mesoporous MCM-41 silica and titania nanomaterials, prepared by the sol\u2013gel method, were characterized by small- and wide-angle powder diffraction, FTIR spectroscopy, nitrogen adsorption\u2013desorption isotherms, scanning electron microscopy and transmission electron microscopy, while the materials containing embedded extracts were analyzed through Fourier-transform infrared spectroscopy, N2 sorption measurements, and thermal analysis. All extracts free and embedded in mesoporous matrix exhibited high radical scavenger properties and good bactericidal activity against several reference strains. It was proved that by embedding the polyphenolic extracts into mesopores of silica or titania nanoparticles, the phytochemicals stability was enhanced as the materials containing extract exhibited higher radical scavenger activity after 3\u20136 months storage than that of the free extracts. Additionally, the extract-loaded material showed mild improved antimicrobial activity in comparison with the corresponding free extract.<\/jats:p>","DOI":"10.3390\/nano10050820","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T04:15:29Z","timestamp":1587960929000},"page":"820","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Properties of Salvia officinalis L. and Thymus serpyllum L. Extracts Free and Embedded into Mesopores of Silica and Titania Nanomaterials"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4373-295X","authenticated-orcid":false,"given":"Ana-Maria","family":"Brezoiu","sequence":"first","affiliation":[{"name":"Department of Inorganic Chemistry, Physical-Chemistry &amp; Electrochemistry, Faculty of Applied Chemistry and Materials Science, University \u201cPolitehnica\u201d of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mioara","family":"Prundeanu","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Physical-Chemistry &amp; Electrochemistry, Faculty of Applied Chemistry and Materials Science, University \u201cPolitehnica\u201d of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-7540","authenticated-orcid":false,"given":"Daniela","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Physical-Chemistry &amp; Electrochemistry, Faculty of Applied Chemistry and Materials Science, University \u201cPolitehnica\u201d of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-8401","authenticated-orcid":false,"given":"Mihaela","family":"Deaconu","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Physical-Chemistry &amp; Electrochemistry, Faculty of Applied Chemistry and Materials Science, University \u201cPolitehnica\u201d of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9830-8246","authenticated-orcid":false,"given":"Cristian","family":"Matei","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Physical-Chemistry &amp; Electrochemistry, Faculty of Applied Chemistry and Materials Science, University \u201cPolitehnica\u201d of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-1094","authenticated-orcid":false,"given":"Ovidiu","family":"Oprea","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Physical-Chemistry &amp; Electrochemistry, Faculty of Applied Chemistry and Materials Science, University \u201cPolitehnica\u201d of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeniu","family":"Vasile","sequence":"additional","affiliation":[{"name":"Department of Oxide Materials Science and Engineering, Faculty of Applied Chemistry and Materials Science, University \u201cPolitehnica\u201d of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9254-1047","authenticated-orcid":false,"given":"Ticu\u021ba","family":"Negreanu-P\u00eerjol","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, \u201cOvidius\u201d University of Constanta, Aleea Universitatii No. 1, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9100-4530","authenticated-orcid":false,"given":"Delia","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Danciu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tohma, H., K\u00f6ksal, E., Kilic, \u00d6., Alan, Y., Yilmaz, M., Gulcin, I., Bursal, E., and Harrath, A.H. (2016). RP-HPLC\/MS\/MS analysis of the phenolic compounds, antioxidant and antimicrobial activities of Salvia L. species. Antioxidants, 5.","DOI":"10.3390\/antiox5040038"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"P\u0103v\u0103loiu, R.-D., Sha\u2019At, F., Bubueanu, C., Deaconu, M., Neagu, G., Sha\u2019At, M., Anastasescu, M., Mihailescu, M., Matei, C., and Nechifor, G. (2020). Polyphenolic extract from Sambucus ebulus L. leaves free and loaded into lipid vesicles. Nanomaterials, 10.","DOI":"10.3390\/nano10010056"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Danciu, C., Muntean, D., Alexa, E., Farcas, C., Oprean, C., Zupk\u00f3, I., Bor, A., Minda, D., Proks, M., and Buda, V. (2019). Phytochemical characterization and evaluation of the antimicrobial, antiproliferative and pro-apoptotic potential of Ephedra alata Decne. hydroalcoholic extract against the MCF-7 breast cancer cell line. Molecules, 24.","DOI":"10.3390\/molecules24010013"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Rayan, M., Abu-Farich, B., Basha, W., Rayan, A., and Abu-Lafi, S. (2020). Correlation between antibacterial activity and free-radical scavenging: In-vitro evaluation of polar\/non-polar extracts from 25 plants. Processes, 8.","DOI":"10.3390\/pr8010117"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Afonso, A.F., Pereira, O.R., Fernandes, \u00c2., Calhelha, R.C., Silva, A., Ferreira, I.C.F.R., and Cardoso, S. (2019). Phytochemical composition and bioactive effects of Salvia africana, Salvia officinalis \u2019Icterina\u2019 and Salvia mexicana aqueous extracts. Molecules, 24.","DOI":"10.3390\/molecules24234327"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biopha.2016.11.113","article-title":"Antiproliferative effects of extracts from Salvia officinalis L. and Saliva miltiorrhiza Bunge on hepatocellular carcinoma cells","volume":"85","author":"Jiang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_7","first-page":"66","article-title":"Comparative study regarding the importance of sage (salvia officinalis l.) in terms of antioxidant capacity and antimicrobial activities","volume":"2","author":"Pop","year":"2013","journal-title":"Hop Med. Plants"},{"key":"ref_8","first-page":"133","article-title":"Antioxidant phenolic compounds in Salvia officinalis L. and Salvia sclarea L.","volume":"25","author":"Poliwoda","year":"2018","journal-title":"Ecol. Chem. Eng. S"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2298\/HEMIND110412034V","article-title":"Comparison of antioxidant and antimicrobial activities of extracts obtained from Salvia glutinosa L. and Salvia officinalis L.","volume":"65","author":"Velickovic","year":"2011","journal-title":"Chem. Ind."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"102245","DOI":"10.1016\/j.ctim.2019.102245","article-title":"Efficacy of Salvia officinalis extract on the prevention of insulin resistance in euglycemic patients with polycystic ovary syndrome: A double-blinded placebo-controlled clinical trial","volume":"48","author":"Armini","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0091-3057(03)00108-4","article-title":"Salvia for dementia therapy: Review of pharmacological activity and pilot tolerability clinical trial","volume":"75","author":"Perry","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_12","first-page":"801","article-title":"Cytotoxic, Antioxidant and antimicrobial activities and phenolic contents of Eleven Salvia species from Iran","volume":"12","author":"Firuzi","year":"2013","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.3382\/ps\/pez242","article-title":"The use of bioactive properties of sage preparations to improve the storage stability of low-pressure mechanically separated meat from chickens","volume":"98","author":"Piwowarek","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.seppur.2017.01.055","article-title":"Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat-and ultrasound-assisted techniques","volume":"179","author":"Jovanovic","year":"2017","journal-title":"Sep. Purif. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.foodchem.2013.03.090","article-title":"Cytotoxic impact of phenolics from Lamiaceae species on human breast cancer cells","volume":"141","author":"Berdowska","year":"2013","journal-title":"Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"102284","DOI":"10.1016\/j.ifset.2019.102284","article-title":"Valorization of sage extracts (Salvia officinalis L.) obtained by high voltage electrical discharges: Process control and antioxidant properties","volume":"60","author":"Nutrizio","year":"2020","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.measurement.2016.04.033","article-title":"Antioxidant activity and rosmarinic acid content of ultrasound-assisted ethanolic extracts of medicinal plants","volume":"89","author":"Nicolai","year":"2016","journal-title":"Measurement"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.foodchem.2006.03.050","article-title":"Extraction of phenolics and essential oil from dried sage (Salvia officinalis) using ethanol\u2013water mixtures","volume":"101","author":"Durling","year":"2007","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6966","DOI":"10.1021\/jf3016128","article-title":"The UVA and aqueous stability of flavonoids is dependent on B-ring substitution","volume":"60","author":"Maini","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","unstructured":"Galankis, C. (2018). Technological aspects and stability of polyphenols. Polyphenols: Properties, Recovery, and Applications, Elsevier. [1st ed.]."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"32114","DOI":"10.1021\/acsami.7b09510","article-title":"Adsorption and recovery of polyphenolic flavonoids using TiO2-functionalized mesoporous silica nanoparticles","volume":"9","author":"Khan","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_22","unstructured":"(2020, March 25). Medically reviewed by Drugs.com, Silicon Dioxide Colloidal (inactive ingredient)\u2013Drug.com. Available online: https:\/\/www.drugs.com\/inactive\/silicon-dioxide-colloidal-200.html."},{"key":"ref_23","unstructured":"Rowe, R.C., Sheskey, P.J., and Weller, P.J. (2003). Handbook of Pharmaceutical Excipients, American Pharmaceutical Association. [4th ed.]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.2174\/1381612822666151106121419","article-title":"Drug release from ordered mesoporous silicas","volume":"21","author":"Doadrio","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.colsurfb.2006.06.003","article-title":"Biocidal effects of photocatalytic semiconductor TiO2","volume":"51","author":"Rajagopal","year":"2006","journal-title":"Colloids Surfaces B: Biointerfaces"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.fm.2010.07.025","article-title":"Use of titanium dioxide (TiO2) photocatalysts as alternative means for Listeria monocytogenes biofilm disinfection in food processing","volume":"28","author":"Chorianopoulos","year":"2011","journal-title":"Food Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3906\/biy-1308-43","article-title":"Photocatalytic antimicrobial effect of TiO2 anatase thin-film\u2013coated orthodontic arch wires on 3 oral pathogens","volume":"38","author":"Uzel","year":"2014","journal-title":"Turk. J. Boil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"111762","DOI":"10.1016\/j.jphotobiol.2019.111762","article-title":"Antibiofilm effect of mesoporous titania coatings on Pseudomonas aeruginosa biofilms","volume":"203","author":"Pezzoni","year":"2019","journal-title":"J. Photochem. Photobiol. B: Boil."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"110787","DOI":"10.1016\/j.fct.2019.110787","article-title":"Polyphenols extract from grape pomace. Characterization and valorization through encapsulation into mesoporous silica-type matrices","volume":"133","author":"Brezoiu","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.5194\/bg-15-1415-2018","article-title":"Revisiting chlorophyll extraction methods in biological soil crusts \u2013 methodology for determination of chlorophyll a and chlorophyll a+b as compared to previous methods","volume":"15","author":"Caesar","year":"2018","journal-title":"Biogeosciences"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.micromeso.2018.08.031","article-title":"Heteroatom modified MCM-41-silica carriers for Lomefloxacin delivery systems","volume":"275","author":"Brezoiu","year":"2019","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.2147\/IDR.S218141","article-title":"Evaluation of essential oil obtained from Mentha piperita L. against multidrug-resistant strains","volume":"12","author":"Muntean","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_33","unstructured":"Patel, J.B., Cockerill, F.R., and Bradford, P.A. (2015). Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute. Twenty-Fifth Informational Supplement. CLSI document M100-S25."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"121886","DOI":"10.1016\/j.matchemphys.2019.121886","article-title":"Norfloxacin delivery systems based on MCM-type silica carriers designed for the treatment of severe infections","volume":"238","author":"Deaconu","year":"2019","journal-title":"Mater. Chem. Phys."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/pca.1141","article-title":"Microwave-assisted water extraction of green tea polyphenols","volume":"20","author":"Nkhili","year":"2009","journal-title":"Phytochem. Anal."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6365","DOI":"10.3390\/molecules15096365","article-title":"Microwave assisted extraction of phenolic compounds from four different spices","volume":"15","author":"Gallo","year":"2010","journal-title":"Molecules"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5937\/leksir1737045J","article-title":"Polyphenols extraction from plant sources","volume":"37","author":"Jovanovic","year":"2017","journal-title":"Lek. sirovine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.foodchem.2010.07.003","article-title":"The correlation between skin-care effects and phytochemical contents in Lamiaceae plants","volume":"124","author":"Lee","year":"2011","journal-title":"Food Chem."},{"key":"ref_39","first-page":"81","article-title":"Total phenolic and total flavonoid contents, antioxidant capacity and biological contaminants in medicinal herbs","volume":"46","author":"Atanassova","year":"2011","journal-title":"Chem. Technol. Metall."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.37358\/RC.17.7.5689","article-title":"Evaluation of antioxidant activity and total phenols content in selected spices","volume":"68","author":"Stanciu","year":"2017","journal-title":"Rev. Chim."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1016\/j.chroma.2010.11.055","article-title":"Chemical composition of bioactive pressurized extracts of Romanian aromatic plants","volume":"1218","author":"Miron","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"ref_42","first-page":"1","article-title":"Total Content of Polyphenols and Antioxidant Activity of Different Melliferous Plants","volume":"73","author":"Pasca","year":"2016","journal-title":"Bull. Univ. Agric. Sci. Veter- Med. Cluj-Napoca. Anim. Sci. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3906\/tar-1711-82","article-title":"Antioxidative and antibacterial properties of organically grown thyme (Thymus sp.) and basil (Ocimum basilicum L.)","volume":"42","author":"Abramovic","year":"2018","journal-title":"Turk. J. Agric. For."},{"key":"ref_44","first-page":"76","article-title":"Comparative assessment of phenolic profile and antioxidant activity of some indigenous Salvia species","volume":"26","author":"Oniga","year":"2018","journal-title":"Hop Med. Plants"},{"key":"ref_45","first-page":"52","article-title":"Salvia officinalis of different origins. Antioxidant activity, phenolic and flavonoid content of extracts","volume":"27","author":"Alimpic","year":"2016","journal-title":"Agro. Food Ind. Hi. Tech."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.20964\/2018.08.57","article-title":"Determination of total phenolics contents, antioxidant capacity of Thymus vulgaris extracts using electrochemical and spectrophotometric methods","volume":"13","author":"Amamra","year":"2018","journal-title":"Int. J. Electrochem. Sci."},{"key":"ref_47","first-page":"63","article-title":"Spectrophotometric analysis of chlorophylls and carotenoids from commonly grown fern species by using various extracting solvents","volume":"4","author":"Sumanta","year":"2014","journal-title":"Res. J. Chem. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jcs.2016.05.003","article-title":"Antioxidant activity, phenolic profile, chlorophyll and mineral matter content of corn silk (Zea mays L): Comparison with medicinal herbs","volume":"69","year":"2016","journal-title":"J. Cereal Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.foodchem.2013.04.089","article-title":"Effects of Salvia officinalis and Thymus vulgaris on oxidant-induced DNA damage and antioxidant status in HepG2 cells","volume":"141","author":"Kozics","year":"2013","journal-title":"Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.indcrop.2014.01.001","article-title":"Antioxidant potential of Salvia officinalis L. residues as affected by the harvesting time","volume":"54","author":"Sotomayor","year":"2014","journal-title":"Ind. Crop. Prod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s13197-015-2144-1","article-title":"Characterization of aroma-active and phenolic profiles of wild thyme (Thymus serpyllum) by GC-MS-Olfactometry and LC-ESI-MS\/MS","volume":"53","author":"Sonmezdag","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s13197-015-1994-x","article-title":"Evaluation of antioxidant capacity of 13 plant extracts by three different methods: Cluster analyses applied for selection of the natural extracts with higher antioxidant capacity to replace synthetic antioxidant in lamb burgers","volume":"53","author":"Fernandes","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"10653","DOI":"10.1002\/chem.201201355","article-title":"Structure-Directing Agents for the Synthesis of TiO2-Based Drug-Delivery Systems","volume":"18","author":"Ghedini","year":"2012","journal-title":"Chem.-A Eur. J."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/5\/820\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:23:47Z","timestamp":1760361827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/5\/820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,25]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5]]}},"alternative-id":["nano10050820"],"URL":"https:\/\/doi.org\/10.3390\/nano10050820","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,25]]}}}