{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:28:26Z","timestamp":1770629306781,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["18-13-00413"],"award-info":[{"award-number":["18-13-00413"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State task of GEOKHI RAS","award":["0137-2019-0022"],"award-info":[{"award-number":["0137-2019-0022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>In present work, carbon nanomaterials (CNMs) are investigated as potential carriers of 68Ga, which is widely used in positron emission tomography (PET) in nuclear medicine. Sorption behavior of 68Ga was studied onto CNMs of various structures and chemical compositions: nanodiamonds (ND), reduced graphite oxide (rGiO) and multi-walled carbon nanotubes (MWCNT), as well as their oxidized (ND\u2013COOH) or reduced (rGiO\u2013H, MWCNT\u2013H) forms. The physicochemical properties of the nanoparticles were determined by high resolution transmission electron microscopy, x-ray photoelectron spectroscopy, dynamic light scattering and potentiometric titration. The content of 68Ga in the solutions during the study of sorption was determined by gamma-ray spectrometry. The highest degree of 68Ga sorption was observed on ND and ND\u2013COOH samples, and the optimal sorption conditions were determined: an aqueous solution with a pH of 5\u20137, m\/V ratio of 50 \u03bcg\/mL and a room temperature (25 \u00b0C). The 68Ga@ND and 68Ga@ND\u2013COOH conjugates were found to be stable in a model blood solution\u2014phosphate-buffered saline with a pH of 7.3, containing 40 g\/L of bovine serum albumin: 68Ga desorption from these samples in 90 minutes was no more than 20% at 25 \u00b0C and up to 30% at 37 \u00b0C. Such a quantity of desorbed 68Ga does not harm the body and does not interfere with the PET imaging process. Thus, ND and ND\u2013COOH are promising CNMs for using as carriers of 68Ga for PET diagnostics.<\/jats:p>","DOI":"10.3390\/nano10061090","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T04:09:03Z","timestamp":1591070943000},"page":"1090","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Carbon Nanomaterials for Sorption of 68Ga for Potential Using in Positron Emission Tomography"],"prefix":"10.3390","volume":"10","author":[{"given":"Andrey G.","family":"Kazakov","sequence":"first","affiliation":[{"name":"Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences, Radiochemistry Laboratory, 19 Kosygin St., Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan L.","family":"Garashchenko","sequence":"additional","affiliation":[{"name":"Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences, Radiochemistry Laboratory, 19 Kosygin St., Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milana K.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences, Radiochemistry Laboratory, 19 Kosygin St., Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey E.","family":"Vinokurov","sequence":"additional","affiliation":[{"name":"Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences, Radiochemistry Laboratory, 19 Kosygin St., Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris F.","family":"Myasoedov","sequence":"additional","affiliation":[{"name":"Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences, Radiochemistry Laboratory, 19 Kosygin St., Moscow 119991, Russia"},{"name":"Interdepartmental Center for Analytical Research on Problems in the Field of Physics, Chemistry, and Biology, of the Russian Academy of Sciences, Bld. 6, Profsoyuznaya St. 65,  Moscow 117342, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/ma5020350","article-title":"Carbon Nanomaterials: Efficacy and Safety for Nanomedicine","volume":"5","author":"Yamashita","year":"2012","journal-title":"Materials"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/ncomms1698","article-title":"Three-dimensional imaging of single nanotube molecule endocytosis on plasmonic substrates","volume":"3","author":"Hong","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1039\/C2TB00085G","article-title":"Carbon nanostructures as multi-functional drug delivery platforms","volume":"1","author":"Mendes","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","article-title":"Nanocarriers as an emerging platform for cancer therapy","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chow, E.K., Zhang, X.Q., Chen, M., Lam, R., Robinson, E., Huang, H., Schaffer, D., Osawa, E., Goga, A., and Ho, D. (2011). Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment. Sci. Transl. Med., 3.","DOI":"10.1126\/scitranslmed.3001713"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cmmi.1633","article-title":"Ultrasmall particles for Gd-MRI and 68 Ga-PET dual imaging","volume":"10","author":"Truillet","year":"2015","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Huclier-Markai, S., Alliot, C., Tillement, O., Cutler, C.S., Ntsiba, E., Thomas, E., and Lux, F. (2019). Multimodal AGuIX\u00ae Nanoparticles: Size Characterization by HF5 and Optimization of the Radiolabeling with Various SPECT\/PET\/Theranostic Tracers. Int. J. Med. Nano Res., 6.","DOI":"10.23937\/2378-3664.1410027"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2967\/jnumed.116.187419","article-title":"Advanced Methods for Radiolabeling Multimodality Nanomedicines for SPECT\/MRI and PET\/MRI","volume":"59","author":"Lamb","year":"2018","journal-title":"J. Nucl. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"15910","DOI":"10.3390\/ijms140815910","article-title":"Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer","volume":"14","author":"Thomas","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1603121","DOI":"10.1002\/smll.201603121","article-title":"Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery","volume":"13","author":"Xie","year":"2017","journal-title":"Small"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jconrel.2015.04.021","article-title":"Theranostic applications of carbon nanomaterials in cancer: Focus on imaging and cargo delivery","volume":"210","author":"Chen","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.biomaterials.2015.06.043","article-title":"Radionuclide 131I labeled reduced graphene oxide for nuclear imaging guided combined radio- and photothermal therapy of cancer","volume":"66","author":"Chen","year":"2015","journal-title":"Biomaterials"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1016\/j.carbon.2011.05.056","article-title":"In vitro and in vivo behaviors of dextran functionalized graphene","volume":"49","author":"Zhang","year":"2011","journal-title":"Carbon N. Y."},{"key":"ref_14","first-page":"40301","article-title":"Study on technetium-99m labeling of graphene oxide nanosheets through click chemistry-99mTc labeling of graphene oxide nanosheets","volume":"26","author":"Jiang","year":"2015","journal-title":"Nucl. Sci. Tech."},{"key":"ref_15","first-page":"5361","article-title":"Functionalized carbon nanotubes: Biomedical applications","volume":"7","author":"Vardharajula","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/smll.200700153","article-title":"211AtCl@US-tube nanocapsules: A new concept in radiotherapeutic-agent design","volume":"3","author":"Hartman","year":"2007","journal-title":"Small"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nmat2766","article-title":"Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging","volume":"9","author":"Hong","year":"2010","journal-title":"Nat. Mater."},{"key":"ref_18","first-page":"1","article-title":"Biodistribution of co-exposure to multi-walled carbon nanotubes and nanodiamonds in mice","volume":"7","author":"Qi","year":"2012","journal-title":"Nanoscale Res. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1021\/nn200986z","article-title":"Biodistribution of amino-functionalized diamond nanoparticles. in vivo studies based on 18F radionuclide emission","volume":"5","author":"Rojas","year":"2011","journal-title":"ACS Nano"},{"key":"ref_20","first-page":"783","article-title":"Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes","volume":"5","author":"Ruggiero","year":"2010","journal-title":"Int. J. Nanomed."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev-bioeng-071114-040723","article-title":"Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems","volume":"17","author":"Vaquero","year":"2015","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Challapalli, A., and Aboagye, E.O. (2016). Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring. Front. Oncol., 6.","DOI":"10.3389\/fonc.2016.00044"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1039\/C4DT02846E","article-title":"A nuclear chocolate box: The periodic table of nuclear medicine","volume":"44","author":"Blower","year":"2015","journal-title":"Dalt. Trans."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Edem, P.E., J\u00f8rgensen, J.T., N\u00f8rregaard, K., Rossin, R., Yazdani, A., Valliant, J.F., Robillard, M., Herth, M.M., and Kjaer, A. (2020). Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging. Molecules, 25.","DOI":"10.3390\/molecules25030463"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"J\u00f8dal, L., Roivainen, A., Oikonen, V., Jalkanen, S., Hansen, S.B., Afzelius, P., Alstrup, A.K.O., Nielsen, O.L., and Jensen, S.B. (2019). Kinetic Modelling of [68Ga]Ga-DOTA-Siglec-9 in Porcine Osteomyelitis and Soft Tissue Infections. Molecules, 24.","DOI":"10.3390\/molecules24224094"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.2967\/jnumed.111.093344","article-title":"68Ga PET\/CT Ventilation-Perfusion Imaging for Pulmonary Embolism: A Pilot Study with Comparison to Conventional Scintigraphy","volume":"52","author":"Hofman","year":"2011","journal-title":"J. Nucl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"107752","DOI":"10.1016\/j.diamond.2020.107752","article-title":"An experimental study of sorption\/desorption of selected radionuclides on carbon nanomaterials: A quest for possible applications in future nuclear medicine","volume":"104","author":"Kazakov","year":"2020","journal-title":"Diam. Relat. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0003-2670(00)89989-4","article-title":"Dosage polarographique du germanium dans des minerals et concentr\u00e9s germanif\u00e8res","volume":"16","author":"Sauvenier","year":"1957","journal-title":"Anal. Chim. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/ten.tec.2018.0024","article-title":"In Vitro and In Vivo Correlation of Bone Morphogenetic Protein-2 Release Profiles from Complex Delivery Vehicles","volume":"24","author":"Olthof","year":"2018","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5650\/jos.ess16194","article-title":"Fabrication and functionalization of inorganic materials using amphiphilic molecules","volume":"66","author":"Shibata","year":"2017","journal-title":"J. Oleo Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"13058","DOI":"10.1002\/chem.201701884","article-title":"An Exceptionally Water Stable Metal\u2013Organic Framework with Amide-Functionalized Cages: Selective CO2\/CH4 Uptake and Removal of Antibiotics and Dyes from Water","volume":"23","author":"Jin","year":"2017","journal-title":"Chem. A Eur. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.actbio.2018.10.014","article-title":"Effects of bisphosphonate ligands and PEGylation on targeted delivery of gold nanoparticles for contrast-enhanced radiographic detection of breast microcalcifications","volume":"82","author":"Cole","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2217\/nnm.11.19","article-title":"Nanoparticle PEGylation for imaging and therapy","volume":"6","author":"Jokerst","year":"2011","journal-title":"Nanomedicine"}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/6\/1090\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:34:31Z","timestamp":1760175271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/6\/1090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["nano10061090"],"URL":"https:\/\/doi.org\/10.3390\/nano10061090","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]}}}