{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:15:10Z","timestamp":1791555310068,"version":"4.3.4"},"reference-count":72,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51690150, 51690154, 51722307, 51673179, 51773190,and U19A2094"],"award-info":[{"award-number":["51690150, 51690154, 51722307, 51673179, 51773190,and U19A2094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["WK3450000003"],"award-info":[{"award-number":["WK3450000003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology","award":["CE140100036"],"award-info":[{"award-number":["CE140100036"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1158755"],"award-info":[{"award-number":["APP1158755"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Metal\u2013organic frameworks (MOFs) comprising metal ions or clusters coordinated to organic ligands have become a class of emerging materials in the field of biomedical research due to their bespoke compositions, highly porous nanostructures, large surface areas, good biocompatibility, etc. So far, many MOFs have been developed for imaging and therapy purposes. The unique porous nanostructures render it possible to adsorb and store various substances, especially for gaseous molecules, which is rather challenging for other types of delivery vectors. In this review, we mainly focus on the recent development of MOFs for controlled release of three gaseous transmitters, namely, nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Although these gaseous molecules have been known as air pollutants for a long time, much evidence has been uncovered regarding their important physiological functions as signaling molecules. These signaling molecules could be either physically absorbed onto or covalently linked to MOFs, allowing for the release of loaded signaling molecules in a spontaneous or controlled manner. We highlight the designing concept by selective examples and display their potential applications in many fields such as cancer therapy, wound healing, and anti-inflammation. We hope more effort could be devoted to this emerging fields to develop signaling molecule-releasing MOFs with practical applications.<\/jats:p>","DOI":"10.3390\/nano10061134","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T04:19:39Z","timestamp":1591676379000},"page":"1134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Engineering Metal\u2013Organic Frameworks (MOFs) for Controlled Delivery of Physiological Gaseous Transmitters"],"prefix":"10.3390","volume":"10","author":[{"given":"Mengdan","family":"Zhang","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Science at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Qiao","sequence":"additional","affiliation":[{"name":"ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-1343","authenticated-orcid":false,"given":"Jinming","family":"Hu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Science at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1021\/ja061716i","article-title":"Microporous metal\u2212organic frameworks incorporating 1,4-benzeneditetrazolate:\u2009 Syntheses, structures, and hydrogen storage properties","volume":"128","author":"Yu","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8136","DOI":"10.1021\/ja061681m","article-title":"Hydrogen storage in metal\u2212organic frameworks by bridged hydrogen spillover","volume":"128","author":"Li","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1021\/jp109541n","article-title":"Theoretical explanation of hydrogen spillover in metal\u2212organic frameworks","volume":"115","author":"Psofogiannakis","year":"2011","journal-title":"J. Phys. Chem. C"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1039\/b802426j","article-title":"Selective gas adsorption and separation in metal\u2013organic frameworks","volume":"38","author":"Li","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1021\/ja111411q","article-title":"Metal\u2212organic frameworks as adsorbents for hydrogen purification and precombustion carbon dioxide capture","volume":"133","author":"Herm","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17998","DOI":"10.1021\/ja0570032","article-title":"Metal\u2212organic frameworks with exceptionally high capacity for storage of carbon dioxide at room temperature","volume":"127","author":"Millward","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1002\/anie.200703934","article-title":"Gas storage in nanoporous materials","volume":"47","author":"Morris","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cclet.2016.06.006","article-title":"Impact of the flexibility of pillar linkers on the structure and CO2 adsorption property of \u201cpillar-layered\u201d MOFs","volume":"28","author":"Xu","year":"2017","journal-title":"Chin. Chem. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1021\/ja900203f","article-title":"A catalytically active, permanently microporous MOF with metalloporphyrin struts","volume":"131","author":"Shultz","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1021\/cm703339h","article-title":"Loading of MOF-5 with Cu and ZnO nanoparticles by gas-phase infiltration with organometallic precursors: Properties of Cu\/ZnO@MOF-5 as catalyst for methanol synthesis","volume":"20","author":"Hermes","year":"2008","journal-title":"Chem. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.carbon.2020.02.047","article-title":"Tailoring MOF-based materials to tune electromagnetic property for great microwave absorbers and devices","volume":"162","author":"Shu","year":"2020","journal-title":"Carbon"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cej.2019.123096","article-title":"Magnetic CoFe alloy@C nanocomposites derived from ZnCo-MOF for electromagnetic wave absorption","volume":"383","author":"Wang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"152952","DOI":"10.1016\/j.jallcom.2019.152952","article-title":"Fe@NPC@CF nanocomposites derived from Fe-MOFs\/biomass cotton for lightweight and high-performance electromagnetic wave absorption applications","volume":"819","author":"Li","year":"2020","journal-title":"J. Alloys Compd."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1021\/cr200256v","article-title":"Metal\u2013organic frameworks in biomedicine","volume":"112","author":"Horcajada","year":"2012","journal-title":"Chem. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1021\/ie101312k","article-title":"Biomedical applications of metal organic frameworks","volume":"50","author":"Keskin","year":"2011","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two\u2019s company, three\u2019s a crowd: Can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1016\/S0021-9258(18)38112-2","article-title":"N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine","volume":"266","author":"Stuehr","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1021\/ja066098k","article-title":"High-capacity hydrogen and nitric oxide adsorption and storage in a metal\u2013organic framework","volume":"129","author":"Bo","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cclet.2008.11.012","article-title":"Synthesis and antitumor activity of nitric oxide releasing derivatives of AT1 antagonist","volume":"20","author":"Zhang","year":"2009","journal-title":"Chin. Chem. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1039\/C9SC04039K","article-title":"Light-triggered nitric oxide (NO) release from photoresponsive polymersomes for corneal wound healing","volume":"11","author":"Duan","year":"2019","journal-title":"Chem. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3389\/fchem.2019.00530","article-title":"Nitric oxide (NO)-releasing macromolecules: Rational design and biomedical applications","volume":"7","author":"Cheng","year":"2019","journal-title":"Front. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.micromeso.2009.04.031","article-title":"Metal organic frameworks as NO delivery materials for biological applications","volume":"129","author":"Hinks","year":"2010","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1039\/c2cs15273h","article-title":"Nitric oxide release: Part II. Therapeutic applications","volume":"41","author":"Carpenter","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1002\/anie.201913135","article-title":"Tuning cellular biological functions through the controlled release of NO from a porous Ti-MOF","volume":"59","author":"Pinto","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"10440","DOI":"10.1021\/ja801997r","article-title":"Exceptional behavior over the whole adsorption\u2212storage\u2212delivery cycle for NO in porous metal organic frameworks","volume":"130","author":"McKinlay","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.actbio.2017.01.039","article-title":"Vitamin B3 metal\u2013organic frameworks as potential delivery vehicles for therapeutic nitric oxide","volume":"51","author":"Pinto","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1039\/C5DT03955J","article-title":"Water based scale-up of CPO-27 synthesis for nitric oxide delivery","volume":"45","author":"Cattaneo","year":"2016","journal-title":"Dalton Trans."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"14059","DOI":"10.1039\/C5RA24023A","article-title":"Tuning the nitric oxide release from CPO-27 MOFs","volume":"6","author":"Cattaneo","year":"2016","journal-title":"RSC Adv."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1002\/chem.201405380","article-title":"Synthesis, culture medium stability, and in vitro and in vivo zebrafish embryo toxicity of metal\u2013organic framework nanoparticles","volume":"21","author":"Ruyra","year":"2015","journal-title":"Chem. Eur. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0039-6060(97)90105-7","article-title":"Diabetes-impaired healing and reduced wound nitric oxide synthesis: A possible pathophysiologic correlation","volume":"121","author":"Tantry","year":"1997","journal-title":"Surgery"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1046\/j.1365-2168.2002.02263.x","article-title":"Nitric oxide enhances experimental wound healing in diabetes","volume":"89","author":"Witte","year":"2002","journal-title":"Br. J. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1161\/01.CIR.0000137969.87365.05","article-title":"Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice","volume":"110","author":"Luo","year":"2004","journal-title":"Circulation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1021\/acsnano.8b09417","article-title":"Enhancing microcirculation on multitriggering manner facilitates angiogenesis and collagen deposition on wound healing by photoreleased NO from hemin-derivatized colloids","volume":"13","author":"Su","year":"2019","journal-title":"ACS Nano"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"18319","DOI":"10.1021\/acsami.0c01792","article-title":"Copper-based metal\u2013organic framework as a controllable nitric oxide-releasing vehicle for enhanced diabetic wound healing","volume":"12","author":"Zhang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.1021\/ja200663e","article-title":"Slow release of NO by microporous titanosilicate ETS-4","volume":"133","author":"Pinto","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jconrel.2019.12.040","article-title":"Modulating intracellular oxidative stress via engineered nanotherapeutics","volume":"319","author":"Hu","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1039\/c000154f","article-title":"Postsynthetic diazeniumdiolate formation and NO release from MOFs","volume":"12","author":"Nguyen","year":"2010","journal-title":"Crystengcomm"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.micromeso.2013.07.017","article-title":"Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework","volume":"181","author":"Lowe","year":"2013","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1038\/ncomms3684","article-title":"Localized cell stimulation by nitric oxide using a photoactive porous coordination polymer platform","volume":"4","author":"Diring","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1039\/C5DT01418B","article-title":"Light-induced nitric oxide release from physiologically stable porous coordination polymers","volume":"44","author":"Kim","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"28390","DOI":"10.1021\/acsami.8b09680","article-title":"Theranostic Mn-porphyrin metal\u2013organic frameworks for magnetic resonance imaging-guided nitric oxide and photothermal synergistic therapy","volume":"10","author":"Zhang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"14690","DOI":"10.1021\/acsami.9b20910","article-title":"The effect of surface hydroxylation on MOF formation on ALD metal oxides: MOF-525 on TiO2\/polypropylene for catalytic hydrolysis of chemical warfare agent simulants","volume":"12","author":"Barton","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1021\/ja210771m","article-title":"Metal organic frameworks as nitric oxide catalysts","volume":"134","author":"Harding","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"19343","DOI":"10.1021\/acsami.6b05948","article-title":"Water-stable metal\u2013organic framework\/polymer composites compatible with human hepatocytes","volume":"8","author":"Neufeld","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"26742","DOI":"10.1021\/acsami.5b08773","article-title":"Immobilization of metal\u2013organic framework copper(II) benzene-1,3,5-tricarboxylate (CuBTC) onto cotton fabric as a nitric oxide release catalyst","volume":"7","author":"Neufeld","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.colsurfb.2013.10.036","article-title":"Nitric oxide-releasing poly(vinyl alcohol) film for increasing dermal vasodilation","volume":"116","author":"Marcilli","year":"2014","journal-title":"Colloids Surf. B"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1524-475X.2002.10503.x","article-title":"Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice","volume":"10","author":"Masters","year":"2002","journal-title":"Wound Repair Regen."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.colsurfb.2015.04.007","article-title":"Combined nitric oxide-releasing poly(vinyl alcohol) film\/F127 hydrogel for accelerating wound healing","volume":"130","author":"Schanuel","year":"2015","journal-title":"Colloids Surf. B"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"35628","DOI":"10.1021\/acsami.7b11846","article-title":"Nitric oxide generation from endogenous substrates using metal\u2013organic frameworks: Inclusion within Poly(vinyl alcohol) membranes to investigate reactivity and therapeutic potential","volume":"9","author":"Neufeld","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7872","DOI":"10.1021\/acsami.8b22731","article-title":"Copper-based SURMOFs for nitric oxide generation: Hemocompatibility, vascular cell growth, and tissue response","volume":"11","author":"Zhao","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8054","DOI":"10.1021\/ja0701208","article-title":"Oriented growth of the metal organic framework Cu3(BTC)2(H2O)3\u00b7xH2O tunable with functionalized self-assembled monolayers","volume":"129","author":"Biemmi","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s11426-011-4406-8","article-title":"Liquid-phase epitaxy of metal organic framework thin films","volume":"54","author":"Liu","year":"2011","journal-title":"Sci. China Chem."},{"key":"ref_53","first-page":"11911","article-title":"Toward green production of water-stable metal\u2013organic frameworks based on high-valence metals with low toxicities","volume":"7","author":"Wang","year":"2019","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1021\/ar9001685","article-title":"Heme oxygenase reveals its strategy for catalyzing three successive oxygenation reactions","volume":"43","author":"Matsui","year":"2010","journal-title":"Acc. Chem. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","article-title":"Heme oxygenase-1\/carbon monoxide: From basic science to therapeutic applications","volume":"86","author":"Ryter","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1089\/ars.2007.1811","article-title":"Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system","volume":"9","author":"Ryter","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bcp.2017.12.007","article-title":"Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1\/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain","volume":"148","author":"Riego","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1039\/b719075a","article-title":"Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex","volume":"15","author":"Niesel","year":"2008","journal-title":"Chem. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1161\/hh0202.104530","article-title":"Carbon monoxide-releasing molecules","volume":"90","author":"Motterlini","year":"2002","journal-title":"Circ. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1002\/anie.200301634","article-title":"Metal carbonyls: A new class of pharmaceuticals?","volume":"42","author":"Johnson","year":"2003","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/anie.201006598","article-title":"Acyloxybutadiene iron tricarbonyl complexes as enzyme-triggered CO-releasing molecules (ET-CORMs)","volume":"50","author":"Romanski","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1039\/D0SC00135J","article-title":"Metal-free carbon monoxide-releasing micelles undergo tandem photochemical reactions for cutaneous wound healing","volume":"11","author":"Cheng","year":"2020","journal-title":"Chem. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1021\/ol4021089","article-title":"Fluorescein analogue xanthene-9-carboxylic acid: A transition-metal-free CO releasing molecule activated by green light","volume":"15","author":"Antony","year":"2013","journal-title":"Org. Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1021\/jacs.5b10800","article-title":"Transition-metal-free CO-releasing BODIPY derivatives activatable by visible to NIR light as promising bioactive molecules","volume":"138","author":"Palao","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"6671","DOI":"10.1039\/c3ob41385c","article-title":"Visible-light activatable organic CO-releasing molecules (PhotoCORMs) that simultaneously generate fluorophores","volume":"11","author":"Peng","year":"2013","journal-title":"Org. Biomol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nmat2608","article-title":"Porous metal\u2013organic-framework nanoscale carriers as a potential platform for drug delivery and imaging","volume":"9","author":"Horcajada","year":"2010","journal-title":"Nat. Mater."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1002\/chem.201201743","article-title":"Iron metal\u2013organic frameworks MIL-88B and NH2-MIL-88B for the loading and delivery of the gasotransmitter carbon monoxide","volume":"19","author":"Ma","year":"2013","journal-title":"Chem. Eur. J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1039\/C6SC04824B","article-title":"Light responsive metal\u2013organic frameworks as controllable CO-releasing cell culture substrates","volume":"8","author":"Diring","year":"2017","journal-title":"Chem. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2009.2919","article-title":"Hydrogen sulfide: From brain to gut","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.niox.2017.10.010","article-title":"The mechanism of action and role of hydrogen sulfide in the control of vascular tone","volume":"81","author":"Dybvig","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1039\/c2dt12069k","article-title":"Metal\u2013organic frameworks for the storage and delivery of biologically active hydrogen sulfide","volume":"41","author":"Allan","year":"2012","journal-title":"Dalton Trans."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/6\/1134\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:36:43Z","timestamp":1760175403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/6\/1134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":72,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["nano10061134"],"URL":"https:\/\/doi.org\/10.3390\/nano10061134","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]}}}