{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:03:46Z","timestamp":1777507426465,"version":"3.51.4"},"reference-count":57,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MCUI\/FEDER, EU","award":["RTI2018-100910-B-C41"],"award-info":[{"award-number":["RTI2018-100910-B-C41"]}]},{"name":"MCUI\/FEDER, EU","award":["RTI2018-101599-B-C22-AR"],"award-info":[{"award-number":["RTI2018-101599-B-C22-AR"]}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["PROMETEO\/2018\/024"],"award-info":[{"award-number":["PROMETEO\/2018\/024"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["ACIF\/2016\/023"],"award-info":[{"award-number":["ACIF\/2016\/023"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>In recent decades, the versatility of mesoporous silica particles and their relevance to develop controlled release systems have been demonstrated. Within them, gated materials able to modulate payload delivery represent great advantages. However, the role played by the porous matrix in this kind of systems is scarce. In this work, different mesoporous silica materials (MCM-41, MCM-48, SBA-15 and UVM-7) are functionalized with oleic acid as a molecular gate. All systems are fully characterized and their ability to confine the entrapped cargo and release it in the presence of bile salts is validated with release assays and in vitro digestion experiments. The cargo release profile of each synthesized support is studied, paying attention to the inorganic scaffold. Obtained release profiles fit to Korsmeyer\u2013Peppas model, which explains the differences among the studied supports. Based on the results, UVM-7 material was the most appropriate system for duodenal delivery and was tested in an in vivo model of the Wistar rat. Payload confinement and its complete release after gastric emptying is achieved, establishing the possible use of mesoporous silica particles as protection and direct release agents into the duodenum and, hence, demonstrating that these systems could serve as an alternative to the administration methods employed until now.<\/jats:p>","DOI":"10.3390\/nano10071290","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T14:24:24Z","timestamp":1593527064000},"page":"1290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-5945","authenticated-orcid":false,"given":"Elisa","family":"Poyatos-Racionero","sequence":"first","affiliation":[{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 46022 Valencia, Spain"},{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM), Universitat Polit\u00e8cnica de Val\u00e8ncia, Universitat de Val\u00e8ncia. Camino de Vera s\/n, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-142X","authenticated-orcid":false,"given":"Isabel","family":"Gonz\u00e1lez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda, Secci\u00f3n de Farmacia y Tecnolog\u00eda Farmac\u00e9utica, Universidad Miguel Hern\u00e1ndez., 03550 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Gonz\u00e1lez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda, Secci\u00f3n de Farmacia y Tecnolog\u00eda Farmac\u00e9utica, Universidad Miguel Hern\u00e1ndez., 03550 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-9674","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Mart\u00ednez-M\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 46022 Valencia, Spain"},{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM), Universitat Polit\u00e8cnica de Val\u00e8ncia, Universitat de Val\u00e8ncia. Camino de Vera s\/n, 46022 Valencia, Spain"},{"name":"Unidad Mixta de Investigaci\u00f3n en Nanomedicina y Sensores, Universitat Polit\u00e8cnica de Val\u00e8ncia, Instituto de Investigaci\u00f3n Sanitaria La Fe, Av Fernando Abril Martorell 106, 46026 Valencia, Spain"},{"name":"Unidad Mixta UPV-CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Universitat Polit\u00e8cnica de Val\u00e8ncia, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, C\/ Eduardo Primo Y\u00fafera 3, 46100 Valencia, Spain"},{"name":"Departamento de Qu\u00edmica, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s\/n, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Dolores","family":"Marcos","sequence":"additional","affiliation":[{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 46022 Valencia, Spain"},{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM), Universitat Polit\u00e8cnica de Val\u00e8ncia, Universitat de Val\u00e8ncia. Camino de Vera s\/n, 46022 Valencia, Spain"},{"name":"Unidad Mixta de Investigaci\u00f3n en Nanomedicina y Sensores, Universitat Polit\u00e8cnica de Val\u00e8ncia, Instituto de Investigaci\u00f3n Sanitaria La Fe, Av Fernando Abril Martorell 106, 46026 Valencia, Spain"},{"name":"Unidad Mixta UPV-CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Universitat Polit\u00e8cnica de Val\u00e8ncia, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, C\/ Eduardo Primo Y\u00fafera 3, 46100 Valencia, Spain"},{"name":"Departamento de Qu\u00edmica, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s\/n, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-5771","authenticated-orcid":false,"given":"Andrea","family":"Bernardos","sequence":"additional","affiliation":[{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 46022 Valencia, Spain"},{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM), Universitat Polit\u00e8cnica de Val\u00e8ncia, Universitat de Val\u00e8ncia. Camino de Vera s\/n, 46022 Valencia, Spain"},{"name":"Unidad Mixta UPV-CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Universitat Polit\u00e8cnica de Val\u00e8ncia, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, C\/ Eduardo Primo Y\u00fafera 3, 46100 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-3876","authenticated-orcid":false,"given":"Elena","family":"Aznar","sequence":"additional","affiliation":[{"name":"CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 46022 Valencia, Spain"},{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM), Universitat Polit\u00e8cnica de Val\u00e8ncia, Universitat de Val\u00e8ncia. Camino de Vera s\/n, 46022 Valencia, Spain"},{"name":"Unidad Mixta de Investigaci\u00f3n en Nanomedicina y Sensores, Universitat Polit\u00e8cnica de Val\u00e8ncia, Instituto de Investigaci\u00f3n Sanitaria La Fe, Av Fernando Abril Martorell 106, 46026 Valencia, Spain"},{"name":"Unidad Mixta UPV-CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Universitat Polit\u00e8cnica de Val\u00e8ncia, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, C\/ Eduardo Primo Y\u00fafera 3, 46100 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.micromeso.2016.05.004","article-title":"Stability of different mesoporous silica particles during an in vitro digestion","volume":"230","author":"Llorca","year":"2016","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.jinorgbio.2007.12.028","article-title":"Cytotoxicity of mesoporous silica nanomaterials","volume":"102","author":"Sharma","year":"2008","journal-title":"J. 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