{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:23:04Z","timestamp":1790018584648,"version":"4.0.1"},"reference-count":160,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1D1A1B07048459"],"award-info":[{"award-number":["2018R1D1A1B07048459"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Osteoarthritis (OA) is a common chronic joint disease that is characterized by joint pain and stiffness, and limitation of motion and the major cause of disability, which reduces life quality of patients and brings a large economic burden to the family and society. Current clinical treatment is mostly limited to symptomatic treatment aimed at pain alleviation and functional improvement, rather than suppressing the progression of OA. Nanotechnology is a promising strategy for the treatment of OA. In this review, we summarize the current experimental progress that focuses on technologies such as liposomes, micelles, dendrimers, polymeric nanoparticles (PNPs), exosomes, and inorganic nanoparticles (NPs) for their potential treatment of OA.<\/jats:p>","DOI":"10.3390\/nano10122368","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T21:00:57Z","timestamp":1606683657000},"page":"2368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Current Nanoparticle-Based Technologies for Osteoarthritis Therapy"],"prefix":"10.3390","volume":"10","author":[{"given":"Guang-Zhen","family":"Jin","sequence":"first","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea"},{"name":"Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Korea"},{"name":"Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Korea"},{"name":"Cell &amp; Matter Institute, Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1097\/01.NAJ.0000412646.80054.21","article-title":"The impact of osteoarthritis in the United States: A population-health perspective","volume":"112","author":"Murphy","year":"2012","journal-title":"Am. J. Nurs."},{"key":"ref_2","first-page":"205","article-title":"Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I","volume":"2","author":"Heidari","year":"2011","journal-title":"Caspian J. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrrheum.2014.46","article-title":"Mouse models of osteoarthritis: Modelling risk factors and assessing outcomes","volume":"10","author":"Fang","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Palmer","year":"2015","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: An update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/1941738111429419","article-title":"The basic science of human knee menisci: Structure, composition, and function","volume":"4","author":"Fox","year":"2012","journal-title":"Sports Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.matbio.2014.08.010","article-title":"How best to preserve and reveal the structural intricacies of cartilaginous tissue","volume":"39","author":"Hunziker","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.nano.2015.09.013","article-title":"Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy","volume":"12","author":"Bottini","year":"2016","journal-title":"Nanomedicine"},{"key":"ref_9","first-page":"37","article-title":"Osteoarthritis pathogenesis\u2014A complex process that involves the entire joint","volume":"7","author":"Man","year":"2014","journal-title":"J. Med. Life"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.berh.2011.11.010","article-title":"Emerging Frontiers in cartilage and chondrocyte biology","volume":"25","author":"Fosang","year":"2011","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/ar4133","article-title":"MMP13 is a critical target gene during the progression of osteoarthritis","volume":"15","author":"Wang","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11926-013-0375-6","article-title":"Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis","volume":"15","author":"Houard","year":"2013","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: A disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrrheum.2014.162","article-title":"Emerging regulators of the inflammatory process in osteoarthritis","volume":"11","author":"Terkeltaub","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138945010791011938","article-title":"NF-kappaB signaling: Multiple angles to target OA","volume":"11","author":"Marcu","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","article-title":"NF-\u03baB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis","volume":"14","author":"Jimenez","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13075-015-0908-7","article-title":"Targeting oxidative stress to reduce osteoarthritis","volume":"18","author":"Poulet","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fcell.2019.00172","article-title":"The Mitochondria-Endoplasmic Reticulum Contacts and Their Critical Role in Aging and Age-Associated Diseases","volume":"7","author":"Moltedo","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.joca.2009.09.008","article-title":"Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes","volume":"18","author":"Kim","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/jor.21091","article-title":"Rotenone prevents impact-induced chondrocyte death","volume":"28","author":"Goodwin","year":"2010","journal-title":"J. Orthop. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.joca.2006.01.005","article-title":"Cytokines, tumor necrosis factor-alpha and interleukin-1beta, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes","volume":"14","author":"Galdo","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.joca.2007.10.006","article-title":"Differential effects of tumor necrosis factor-alpha and interleukin-1beta on cell death in human articular chondrocytes","volume":"16","author":"Vaamonde","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jbspin.2007.02.002","article-title":"Reactive oxygen species and superoxide dismutases: Role in joint diseases","volume":"74","author":"Afonso","year":"2007","journal-title":"Jt. Bone Spine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1056\/NEJM199107113250203","article-title":"Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee","volume":"325","author":"Bradley","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJM199507203330302","article-title":"The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The Arthritis and Rheumatism Council Low-Dose Glucocorticoid Study Group","volume":"333","author":"Kirwan","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/clpt.1986.45","article-title":"Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra-articular administration","volume":"39","author":"Derendorf","year":"1986","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3762\/bjnano.9.98","article-title":"Review on nanoparticles and nanostructured materials: History, sources, toxicity and regulations","volume":"9","author":"Jeevanandam","year":"2018","journal-title":"Beilstein J. Nanotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.cis.2011.11.001","article-title":"Advances in top-down and bottom-up surface nanofabrication: Techniques, applications & future prospects","volume":"170","author":"Biswas","year":"2012","journal-title":"Adv. Colloid. Interface Sci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lawson, T.B., M\u00e4kel\u00e4, J.T.A., Klein, T., Snyder, B.D., and Grinstaff, M.W. (2020). Nanotechnology and osteoarthritis; part 1: Clinical landscape and opportunities for advanced diagnostics. J. Orthop. Res.","DOI":"10.1002\/jor.24817"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.2147\/IJN.S44393","article-title":"Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration","volume":"8","author":"Gu","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"13477","DOI":"10.1038\/s41598-020-68302-w","article-title":"Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis","volume":"10","author":"Corciulo","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.2147\/IJN.S252223","article-title":"Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound","volume":"15","author":"Chen","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2217\/nnm-2018-0221","article-title":"Liposome-encapsulated fish oil protein-tagged gold nanoparticles for intra-articular therapy in osteoarthritis","volume":"14","author":"Sarkar","year":"2019","journal-title":"Nanomedicine"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41598-018-36909-9","article-title":"Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation","volume":"9","author":"Sun","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12951-020-00666-7","article-title":"MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis","volume":"18","author":"Lan","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"102104","DOI":"10.1016\/j.nano.2019.102104","article-title":"Acid-activatable polymeric curcumin nanoparticles as therapeutic agents for osteoarthritis","volume":"23","author":"Kang","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1089\/ten.tea.2016.0524","article-title":"Hyaluronic Acid Hydrogel Functionalized with Self-Assembled Micelles of Amphiphilic PEGylated Kartogenin for the Treatment of Osteoarthritis","volume":"23","author":"Kang","year":"2017","journal-title":"Tissue Eng. Part A"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"eaat8800","DOI":"10.1126\/scitranslmed.aat8800","article-title":"Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis","volume":"10","author":"Geiger","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Schneider, T., Welker, P., Licha, K., Haag, R., and Schulze-Tanzil, G. (2015). Influence of dendritic polyglycerol sulfates on knee osteoarthritis: An experimental study in the rat osteoarthritis model. BMC Musculoskelet. Disord., 16.","DOI":"10.1186\/s12891-015-0844-3"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.2147\/IJN.S234198","article-title":"p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis","volume":"15","author":"Shin","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Shin, H.J., Park, H., Shin, N., Kwon, H.H., Yin, Y., Hwang, J.A., Kim, S.I., Kim, S.R., Kim, S., and Joo, Y. (2020). p47phox siRNA-Loaded PLGA Nanoparticles Suppress ROS\/Oxidative Stress-Induced Chondrocyte Damage in Osteoarthritis. Polymers, 12.","DOI":"10.3390\/polym12020443"},{"key":"ref_43","first-page":"6775","article-title":"Intra-articular injection of etoricoxib-loaded PLGA-PEG-PLGA triblock copolymeric nanoparticles attenuates osteoarthritis progression","volume":"11","author":"Liu","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1038\/s41598-019-43834-y","article-title":"Adenosine-Functionalized Biodegradable PLA-b-PEG Nanoparticles Ameliorate Osteoarthritis in Rats","volume":"9","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1080\/10717544.2018.1461279","article-title":"Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis","volume":"25","author":"Fan","year":"2018","journal-title":"Drug Deliv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1703108","DOI":"10.1002\/smll.201703108","article-title":"Nanocrystal-Polymer Particles: Extended Delivery Carriers for Osteoarthritis Treatment","volume":"14","author":"Maudens","year":"2018","journal-title":"Small"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.biomaterials.2018.08.045","article-title":"A hyaluronic acid binding peptide-polymer system for treating osteoarthritis","volume":"183","author":"Faust","year":"2018","journal-title":"Biomaterials"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.intimp.2015.05.014","article-title":"In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis","volume":"28","author":"Zhou","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_49","first-page":"2604","article-title":"Therapeutic potential of hyaluronic acid\/chitosan nanoparticles for the delivery of curcuminoid in knee osteoarthritis and an in vitro evaluation in chondrocytes","volume":"42","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1159\/000490217","article-title":"Chondroprotective Effects of Hyaluronic Acid-Chitosan Nanoparticles Containing Plasmid DNA Encoding Cytokine Response Modifier A in a Rat Knee Osteoarthritis Model","volume":"47","author":"Zhou","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"36938","DOI":"10.1021\/acsami.0c10458","article-title":"Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy","volume":"12","author":"Liang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00441-020-03193-x","article-title":"Exosomal miR-9-5p secreted by bone marrow-derived mesenchymal stem cells alleviates osteoarthritis by inhibiting syndecan-1","volume":"381","author":"Jin","year":"2020","journal-title":"Cell Tissue Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biomaterials.2019.03.022","article-title":"miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis","volume":"206","author":"Wu","year":"2019","journal-title":"Biomaterials"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1080\/15384101.2018.1556063","article-title":"TGF-\u03b21 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b","volume":"17","author":"Wang","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7150\/thno.17133","article-title":"Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1042\/BCJ20180675","article-title":"Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis","volume":"475","author":"Liu","year":"2018","journal-title":"Biochem. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1080\/15384101.2018.1526603","article-title":"MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1\/miR-206\/GIT1 axis in osteoarthritis","volume":"17","author":"Liu","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","article-title":"Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis","volume":"11","author":"He","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"16214","DOI":"10.1038\/s41598-017-15376-8","article-title":"Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis","volume":"7","author":"Cosenza","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13287-017-0632-0","article-title":"Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix","volume":"8","author":"Wang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13287-017-0510-9","article-title":"Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis","volume":"8","author":"Zhu","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrd1632","article-title":"Recent advances with liposomes as pharmaceutical carriers","volume":"4","author":"Torchilin","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/jac\/49.suppl_1.21","article-title":"AmBisome: Liposomal formulation, structure, mechanism of action and pre-clinical experience","volume":"49","author":"Proffitt","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/j.1552-4604.1998.tb04464.x","article-title":"AmBisome (liposomal amphotericin B): A comparative review","volume":"38","author":"Boswell","year":"1998","journal-title":"J. Clin. Pharmacol."},{"key":"ref_65","first-page":"987","article-title":"Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes","volume":"54","author":"Gabizon","year":"1994","journal-title":"Cancer Res."},{"key":"ref_66","first-page":"49","article-title":"Clinical development of liposome-based drugs: Formulation, characterization, and therapeutic efficacy","volume":"7","author":"Chang","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrrheum.2013.159","article-title":"Progress in intra-articular therapy","volume":"10","author":"Evans","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1038\/ncomms15019","article-title":"Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression","volume":"8","author":"Corciulo","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s40268-015-0082-z","article-title":"mTOR: A potential therapeutic target in osteoarthritis?","volume":"15","author":"Pal","year":"2015","journal-title":"Drugs R D"},{"key":"ref_70","first-page":"91","article-title":"Effect of gold nanoparticles in the treatment of established collagen arthritis in rats","volume":"48","author":"Vasiliauskas","year":"2012","journal-title":"Medicina"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1080\/21691401.2018.1446968","article-title":"Nano-gold displayed anti-inflammatory property via NF-kB pathways by suppressing COX-2 activity","volume":"46","author":"Khan","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Sun, A.R., Panchal, S.K., Friis, T., Sekar, S., Crawford, R., Brown, L., Xiao, Y., and Prasadam, I. (2017). Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183693"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"G22","DOI":"10.1152\/ajpgi.00229.2017","article-title":"Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM\/DSS mouse model of colon cancer","volume":"314","author":"Bader","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/2156587216636747","article-title":"Efficacy of Curcuma for Treatment of Osteoarthritis","volume":"22","author":"Perkins","year":"2017","journal-title":"J. Evid. Based Complementary Altern. Med."},{"key":"ref_75","first-page":"2285","article-title":"Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis","volume":"9","author":"Yeh","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s11095-010-0233-4","article-title":"Polymeric micelles in anticancer therapy: Targeting, imaging and triggered release","volume":"27","author":"Oerlemans","year":"2010","journal-title":"Pharm. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0939-6411(99)00039-9","article-title":"Polymeric micelles\u2014A new generation of colloidal drug carriers","volume":"48","author":"Jones","year":"1999","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s13346-015-0234-2","article-title":"Particle-based technologies for osteoarthritis detection and therapy","volume":"6","author":"Kavanaugh","year":"2016","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/wnan.1332","article-title":"Applications of polymer micelles for imaging and drug delivery","volume":"7","author":"Movassaghian","year":"2015","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/jps.10397","article-title":"Amphiphilic block copolymers for drug delivery","volume":"92","author":"Adams","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejps.2015.12.031","article-title":"Recent advances in polymeric micelles for anti-cancer drug delivery","volume":"83","author":"Biswas","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"12462","DOI":"10.1021\/jacs.5b08057","article-title":"Controlled Release of an Anti-inflammatory Drug Using an Ultrasensitive ROS-Responsive Gas-Generating Carrier for Localized Inflammation Inhibition","volume":"137","author":"Chung","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1172\/JCI10564","article-title":"Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice","volume":"107","author":"Neuhold","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7150\/ijbs.28830","article-title":"Psoralen Protects Chondrocytes, Exhibits Anti-Inflammatory Effects on Synoviocytes, and Attenuates Monosodium Iodoacetate-Induced Osteoarthritis","volume":"15","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_85","first-page":"3418","article-title":"Protective effects of psoralidin on IL-1\u03b2-induced chondrocyte apoptosis","volume":"17","author":"Rao","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijpharm.2012.01.052","article-title":"Controlled synergistic delivery of paclitaxel and heat from poly(\u03b2-amino ester)\/iron oxide-based hydrogel nanocomposites","volume":"427","author":"Meenach","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.1039\/c0cc01413c","article-title":"In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles","volume":"46","author":"Koo","year":"2010","journal-title":"Chem. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.nano.2016.10.001","article-title":"Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage","volume":"13","author":"Perni","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1126\/science.1215157","article-title":"A stem cell-based approach to cartilage repair","volume":"336","author":"Johnson","year":"2012","journal-title":"Science"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/1556-276X-9-247","article-title":"Dendrimers: Synthesis, applications, and properties","volume":"9","author":"Abbasi","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijpharm.2018.05.045","article-title":"Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA\/siRNA for cancer therapy","volume":"546","author":"Li","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.apmt.2018.05.002","article-title":"PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy","volume":"12","author":"Dehghan","year":"2018","journal-title":"Appl. Mater. Today"},{"key":"ref_93","first-page":"561","article-title":"VivaGel (SPL7013 Gel): A candidate dendrimer--microbicide for the prevention of HIV and HSV infection","volume":"2","author":"Rupp","year":"2007","journal-title":"Int. J. Nanomed."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"118814","DOI":"10.1016\/j.ijpharm.2019.118814","article-title":"Dendrimers in the context of nanomedicine","volume":"573","author":"Dias","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.4155\/tde-2017-0091","article-title":"Dendritic polymers for dermal drug delivery","volume":"8","author":"Dave","year":"2017","journal-title":"Ther. Deliv."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.joca.2014.11.006","article-title":"Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: Relevance to post-traumatic osteoarthritis","volume":"23","author":"Li","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1016\/j.nano.2017.05.011","article-title":"Polyethylene glycol modified PAMAM dendrimer delivery of kartogenin to induce chondrogenic differentiation of mesenchymal stem cells","volume":"13","author":"Hu","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00011-015-0875-0","article-title":"Effects of dendritic polyglycerol sulfate on articular chondrocytes","volume":"64","author":"Schneider","year":"2015","journal-title":"Inflamm. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(00)00339-4","article-title":"Biodegradable polymeric nanoparticles as drug delivery devices","volume":"70","author":"Soppimath","year":"2001","journal-title":"J. Control. Release"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jconrel.2016.01.008","article-title":"Current applications of nanoparticles in infectious diseases","volume":"224","author":"Zazo","year":"2016","journal-title":"J. Control Release"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ejps.2012.12.006","article-title":"A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics","volume":"48","author":"Steichen","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1212\/WNL.50.3.701","article-title":"Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 Multiple Sclerosis Study Group","volume":"50","author":"Johnson","year":"1998","journal-title":"Neurology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jconrel.2014.05.001","article-title":"Polymer therapeutics: Top 10 selling pharmaceuticals\u2014What next?","volume":"190","author":"Duncan","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1093\/annonc\/mdl104","article-title":"Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer","volume":"17","author":"Green","year":"2006","journal-title":"Ann. Oncol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbabio.2010.03.005","article-title":"Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders","volume":"1797","author":"Lebiedzinska","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"44","DOI":"10.32607\/20758251-2010-2-4-44-51","article-title":"The Role of p66shc in Oxidative Stress and Apoptosis","volume":"2","author":"Galimov","year":"2010","journal-title":"Acta Nat."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"15435","DOI":"10.1074\/jbc.273.25.15435","article-title":"Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by \u201cpeptide walking\u201d","volume":"273","author":"Morozov","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2165\/00003088-200847110-00002","article-title":"Clinical pharmacokinetic and pharmacodynamic profile of etoricoxib","volume":"47","author":"Takemoto","year":"2008","journal-title":"Clin. Pharmacokinet."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jcph.1302","article-title":"Cardiovascular Risk of Nonsteroidal Anti-inflammatory Drugs and Classical and Selective Cyclooxygenase-2 Inhibitors: A Meta-analysis of Observational Studies","volume":"59","author":"Vazquez","year":"2019","journal-title":"J. Clin. Pharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/teb.2007.0133","article-title":"Biodegradable polyurethanes: Synthesis and applications in regenerative medicine","volume":"14","author":"Guelcher","year":"2008","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijpharm.2019.02.045","article-title":"scmethods and promising therapeutic applications","volume":"562","author":"Mohammad","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2015.12.015","article-title":"Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice","volume":"498","author":"Pradal","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40169-017-0180-3","article-title":"Recent advances in hyaluronic acid based therapy for osteoarthritis","volume":"7","author":"Bowman","year":"2018","journal-title":"Clin. Transl. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/art.22446","article-title":"Boundary lubrication of articular cartilage: Role of synovial fluid constituents","volume":"56","author":"Schmidt","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nmat4048","article-title":"Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid","volume":"13","author":"Singh","year":"2014","journal-title":"Nat. Mater."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.3390\/md13085156","article-title":"Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications","volume":"13","author":"Cheung","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/1061186X.2018.1512112","article-title":"Chitosan-based nanoparticles as drug delivery systems: A review on two decades of research","volume":"27","author":"Naskar","year":"2019","journal-title":"J. Drug Target."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(92)90223-Y","article-title":"Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme","volume":"69","author":"Ray","year":"1992","journal-title":"Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: Composition, biogenesis and function","volume":"2","author":"Zitvogel","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by Extracellular Vesicles: Where We Are and Where We Need to Go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1089\/ten.1995.1.345","article-title":"Repair of articular cartilage defects using mesenchymal stem cells","volume":"1","author":"Grande","year":"1995","journal-title":"Tissue Eng."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2041731420943839","DOI":"10.1177\/2041731420943839","article-title":"Mesenchymal stem cells for cartilage regeneration","volume":"11","author":"Le","year":"2020","journal-title":"J. Tissue Eng."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jot.2017.03.006","article-title":"Role of mesenchymal stem cells in osteoarthritis treatment","volume":"9","author":"Kong","year":"2017","journal-title":"J. Orthop. Translat."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.arthro.2018.07.028","article-title":"Intra-articular Mesenchymal Stem Cells in Osteoarthritis of the Knee: A Systematic Review of Clinical Outcomes and Evidence of Cartilage Repair","volume":"35","author":"Ha","year":"2019","journal-title":"Arthroscopy"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000496605","article-title":"Cell Therapy for Knee Osteoarthritis: Mesenchymal Stromal Cells","volume":"65","author":"Kim","year":"2019","journal-title":"Gerontology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fbioe.2019.00009","article-title":"Mesenchymal Stem Cell Therapy for Osteoarthritis: The Critical Role of the Cell Secretome","volume":"7","author":"Mancuso","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41413-020-0100-9","article-title":"Exosomes: Roles and therapeutic potential in osteoarthritis","volume":"8","author":"Ni","year":"2020","journal-title":"Bone Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2041731418810130","DOI":"10.1177\/2041731418810130","article-title":"The role of extracellular vesicles in biomineralisation: Current perspective and application in regenerative medicine","volume":"9","author":"Azoidis","year":"2018","journal-title":"J. Tissue Eng."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"D\u2019Arrigo, D., Roffi, A., Cucchiarini, M., Moretti, M., Candrian, C., and Filardo, G. (2019). Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review. J. Clin. Med., 8.","DOI":"10.3390\/jcm8111867"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Bousnaki, M., Bakopoulou, A., Kritis, A., and Koidis, P. (2020). The Efficacy of Stem Cells Secretome Application in Osteoarthritis: A Systematic Review of In Vivo Studies. Stem Cell Rev. Rep.","DOI":"10.1007\/s12015-020-09980-x"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3389\/fcell.2020.00619","article-title":"The Application of MSCs-Derived Extracellular Vesicles in Bone Disorders: Novel Cell-Free Therapeutic Strategy","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13075-020-02290-0","article-title":"Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment","volume":"22","author":"Duan","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/os.12690","article-title":"Role of MicroRNA, LncRNA, and Exosomes in the Progression of Osteoarthritis: A Review of Recent Literature","volume":"12","author":"Xie","year":"2020","journal-title":"Orthop. Surg."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/1566523219666190716092203","article-title":"The Therapeutic Potential and Role of miRNA, lncRNA, and circRNA in Osteoarthritis","volume":"19","author":"Wu","year":"2019","journal-title":"Curr. Gene Ther."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4172\/2167-7921.1000239","article-title":"Role of MicroRNA in Osteoarthritis","volume":"6","author":"Zhang","year":"2017","journal-title":"J. Arthritis"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e4315","DOI":"10.1097\/MD.0000000000004315","article-title":"MicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes","volume":"95","author":"Gu","year":"2016","journal-title":"Medicine"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"12775","DOI":"10.1038\/srep12775","article-title":"MiR-210 inhibits NF-\u03baB signaling pathway by targeting DR6 in osteoarthritis","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Cheleschi, S., De Palma, A., Pecorelli, A., Pascarelli, N.A., Valacchi, G., Belmonte, G., Carta, S., Galeazzi, M., and Fioravanti, A. (2017). Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt\/\u03b2-Catenin Pathway. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010133"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3892\/ijmm.2016.2618","article-title":"MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1\/p53 signaling pathway during the pathogenesis of osteoarthritis","volume":"38","author":"Yan","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.nano.2015.10.012","article-title":"Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells","volume":"12","author":"Kim","year":"2016","journal-title":"Nanomedicine"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1038\/nprot.2012.131","article-title":"Exosome-mediated delivery of siRNA in vitro and in vivo","volume":"7","author":"Lee","year":"2012","journal-title":"Nat. Protoc."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/srep01197","article-title":"Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes","volume":"3","author":"Katsuda","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s13770-018-0139-5","article-title":"Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells","volume":"15","author":"Kim","year":"2018","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1021\/nn402232g","article-title":"Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors","volume":"7","author":"Jang","year":"2013","journal-title":"ACS Nano."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41551-019-0485-1","article-title":"Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation","volume":"4","author":"Yang","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nprot.2009.197","article-title":"Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue","volume":"5","author":"Weydert","year":"2010","journal-title":"Nat. Protoc."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1039\/C8CS00457A","article-title":"Nanomaterials with enzyme-like characteristics (nanozymes): Next-generation artificial enzymes (II)","volume":"48","author":"Wu","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1007\/s11051-013-2126-z","article-title":"Titanium-doped cerium oxide nanoparticles protect cells from hydrogen peroxide-induced apoptosis","volume":"15","author":"Clark","year":"2013","journal-title":"J. Nanopart. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.talanta.2013.12.020","article-title":"Preventing UV induced cell damage by scavenging reactive oxygen species with enzyme-mimic Au-Pt nanocomposites","volume":"120","author":"Xiong","year":"2014","journal-title":"Talanta"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.actbio.2015.01.017","article-title":"Antioxidant cerium oxide nanoparticle hydrogels for cellular encapsulation","volume":"16","author":"Weaver","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1039\/C5NR08358C","article-title":"Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model","volume":"8","author":"Moglianetti","year":"2016","journal-title":"Nanoscale"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1002\/anie.201600868","article-title":"Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System","volume":"55","author":"Huang","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2041731418776514","DOI":"10.1177\/2041731418776514","article-title":"Intra-articular biomaterials-assisted delivery to treat temporomandibular joint disorders","volume":"9","author":"Dashnyam","year":"2018","journal-title":"J. Tissue Eng."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Lin, Y.W., Fang, C.H., Meng, F.Q., Ke, C.J., and Lin, F.H. (2020). Hyaluronic Acid Loaded with Cerium Oxide Nanoparticles as Antioxidant in Hydrogen Peroxide Induced Chondrocytes Injury: An In Vitro Osteoarthritis Model. Molecules, 25.","DOI":"10.3390\/molecules25194407"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1089\/ten.tea.2013.0592","article-title":"Beneficial effects of cerium oxide nanoparticles in development of chondrocyte-seeded hydrogel constructs and cellular response to interleukin insults","volume":"20","author":"Ponnurangam","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"119467","DOI":"10.1016\/j.biomaterials.2019.119467","article-title":"Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress","volume":"224","author":"Kumar","year":"2019","journal-title":"Biomaterials"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.1021\/la060873s","article-title":"Synthesis of platinum nanoparticles by reaction of filamentous cyanobacteria with platinum(IV)-chloride complex","volume":"22","author":"Lengke","year":"2006","journal-title":"Langmuir"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.saa.2015.02.037","article-title":"Bioinspired reduced graphene oxide nanosheets using Terminalia chebula seeds extract","volume":"145","author":"Maddinedi","year":"2015","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.msec.2017.04.028","article-title":"A novel chondroitin sulfate decorated nano platinum for the treatment of osteoarthritis","volume":"78","author":"Yin","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/12\/2368\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:38:51Z","timestamp":1760179131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/10\/12\/2368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,28]]},"references-count":160,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["nano10122368"],"URL":"https:\/\/doi.org\/10.3390\/nano10122368","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,28]]}}}