{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:19:00Z","timestamp":1790824740051,"version":"4.1.0"},"reference-count":110,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871492, 81901053"],"award-info":[{"award-number":["81871492, 81901053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Extensive bone defect repair remains a clinical challenge, since ideal implantable scaffolds require the integration of excellent biocompatibility, sufficient mechanical strength and high biological activity to support bone regeneration. The inorganic nanomaterial-based therapy is of great significance due to their excellent mechanical properties, adjustable biological interface and diversified functions. Calcium\u2013phosphorus compounds, silica and metal-based materials are the most common categories of inorganic nanomaterials for bone defect repairing. Nano hydroxyapatites, similar to natural bone apatite minerals in terms of physiochemical and biological activities, are the most widely studied in the field of biomineralization. Nano silica could realize the bone-like hierarchical structure through biosilica mineralization process, and biomimetic silicifications could stimulate osteoblast activity for bone formation and also inhibit osteoclast differentiation. Novel metallic nanomaterials, including Ti, Mg, Zn and alloys, possess remarkable strength and stress absorption capacity, which could overcome the drawbacks of low mechanical properties of polymer-based materials and the brittleness of bioceramics. Moreover, the biodegradability, antibacterial activity and stem cell inducibility of metal nanomaterials can promote bone regeneration. In this review, the advantages of the novel inorganic nanomaterial-based therapy are summarized, laying the foundation for the development of novel bone regeneration strategies in future.<\/jats:p>","DOI":"10.3390\/nano11030789","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T11:18:38Z","timestamp":1616152718000},"page":"789","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-4749","authenticated-orcid":false,"given":"Yu","family":"Fu","sequence":"first","affiliation":[{"name":"Fourth Clinical Division, Peking University School and Hospital of Stomatology; National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Cui","sequence":"additional","affiliation":[{"name":"Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology; Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-6131","authenticated-orcid":false,"given":"Dan","family":"Luo","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-6729","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology; Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nmat4089","article-title":"Bioinspired structural materials","volume":"14","author":"Wegst","year":"2015","journal-title":"Nat. Mater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00590-017-2063-0","article-title":"Treatment of critical-sized bone defects: Clinical and tissue engineering perspectives","volume":"28","author":"Roddy","year":"2018","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s12018-015-9194-9","article-title":"Evolution of Bone Grafting: Bone Grafts and Tissue Engineering Strategies for Vascularized Bone Regeneration","volume":"13","author":"Griffin","year":"2015","journal-title":"Clin. Rev. Bone Miner. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1016\/j.joms.2016.06.191","article-title":"Maximum Quantity of Bone Available for Harvest From the Anterior Iliac Crest, Posterior Iliac Crest, and Proximal Tibia Using a Standardized Surgical Approach: A Cadaveric Study","volume":"74","author":"Burk","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.actbio.2016.06.023","article-title":"Nanoengineered biomaterials for repair and regeneration of orthopedic tissue interfaces","volume":"42","author":"Cross","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0167-7799(99)01309-8","article-title":"Silicon biotechnology: Harnessing biological silica production to construct new materials","volume":"17","author":"Morse","year":"1999","journal-title":"Trends Biotechnol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lee, J.W., Han, H.S., Han, K.J., Park, J., Jeon, H., Ok, M.R., Seok, H.K., Ahn, J.P., Lee, K.E., and Lee, D.H. (2016). Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy. Proc. Natl. Acad. Sci. USA, 716.","DOI":"10.1073\/pnas.1518238113"},{"key":"ref_8","unstructured":"Ljungblad, U. (2010, January 20\u201323). Statistical process control applied to additive manufacturing enables series production of orthopedic implants. Proceedings of the 21st International DAAAM Symposium, Zadar, Croatia."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.msec.2017.05.017","article-title":"Scaffolds for Bone Tissue Engineering: State of the art and new perspectives","volume":"78","author":"Roseti","year":"2017","journal-title":"Mat. Sci Eng. C Mater."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1806445","DOI":"10.1002\/adfm.201806445","article-title":"Thermodynamically Controlled Self-Assembly of Hierarchically Staggered Architecture as an Osteoinductive Alternative to Bone Autografts","volume":"29","author":"Liu","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.actbio.2019.10.034","article-title":"Additively manufactured biodegradable porous zinc","volume":"101","author":"Li","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.actbio.2018.11.045","article-title":"Biomimetic porous Mg with tunable mechanical properties and biodegradation rates for bone regeneration","volume":"84","author":"Kang","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.actbio.2015.04.019","article-title":"Stimulation of osteogenesis and angiogenesis of hBMSCs by delivering Si ions and functional drug from mesoporous silica nanospheres","volume":"21","author":"Shi","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2041731420965797","DOI":"10.1177\/2041731420965797","article-title":"The combination of multi-functional ingredients-loaded hydrogels and three-dimensional printed porous titanium alloys for infective bone defect treatment","volume":"11","author":"Qiao","year":"2020","journal-title":"J. Tissue Eng."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Koons, G.L., Diba, M., and Mikos, A.G. (2020). Materials design for bone-tissue engineering. Nat. Rev. Mater.","DOI":"10.1038\/s41578-020-0204-2"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/adfm.201201611","article-title":"Hierarchical Intrafibrillar Nanocarbonated Apatite Assembly Improves the Nanomechanics and Cytocompatibility of Mineralized Collagen","volume":"23","author":"Liu","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Fu, Y., Liu, S., Cui, S.J., Kou, X.X., Wang, X.D., Liu, X.M., Sun, Y., Wang, G.N., Liu, Y., and Zhou, Y.H. (2016). The surface chemistry of nanoscale mineralized collagen regulates periodontal ligament stem cell fate. ACS Appl. Mater. Interfaces, 15958.","DOI":"10.1021\/acsami.6b04951"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1002\/adma.201602628","article-title":"Hierarchically Staggered Nanostructure of Mineralized Collagen as a Bone-Grafting Scaffold","volume":"28","author":"Liu","year":"2016","journal-title":"Adv. Mater."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.ijbiomac.2017.03.196","article-title":"Preparation and characterization of composites based on the blends of collagen, chitosan and hyaluronic acid with nano-hydroxyapatite","volume":"102","author":"Sionkowska","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.carbpol.2017.07.054","article-title":"Intercalated chitosan\/hydroxyapatite nanocomposites: Promising materials for bone tissue engineering applications","volume":"175","author":"Nazeer","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.msec.2016.06.089","article-title":"Injectable porous nano-hydroxyapatite\/chitosan\/tripolyphosphate scaffolds with improved compressive strength for bone regeneration","volume":"69","author":"Uswatta","year":"2016","journal-title":"Mater. Sci Eng. C"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.biomaterials.2015.01.017","article-title":"Composite scaffolds of nano-hydroxyapatite and silk fibroin enhance mesenchymal stem cell-based bone regeneration via the interleukin 1 alpha autocrine\/paracrine signaling loop","volume":"49","author":"Liu","year":"2015","journal-title":"Biomaterials"},{"key":"ref_23","first-page":"146","article-title":"In-situ solvothermal processing of polycaprolactone\/hydroxyapatite nanocomposites with enhanced mechanical and biological performance for bone tissue engineering","volume":"2","author":"Moeini","year":"2017","journal-title":"Bioact. Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1021\/acs.biomac.7b01222","article-title":"Three-Dimensional Printing of Nano Hydroxyapatite\/Poly(ester urea) Composite Scaffolds with Enhanced Bioactivity","volume":"18","author":"Yu","year":"2017","journal-title":"Biomacromolecules"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Higuchi, J., Fortunato, G., Wozniak, B., Chodara, A., Domaschke, S., Meczynska-Wielgosz, S., Kruszewski, M., Dommann, A., and Lojkowski, W. (2019). Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration. Nanomaterials, 9.","DOI":"10.3390\/nano9111625"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2020.01.035","article-title":"Fabrication and in-vitro biocompatibility of freeze-dried CTS-nHA and CTS-nBG scaffolds for bone regeneration applications","volume":"149","author":"Kumar","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Bohner, M., and Miron, R.J. (2019). A proposed mechanism for material-induced heterotopic ossification. Mater. Today.","DOI":"10.1016\/j.mattod.2018.10.036"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.actbio.2018.10.023","article-title":"Osteoblast responses to injectable bone substitutes of kappa-carrageenan and nano hydroxyapatite","volume":"83","author":"Bassous","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Feng, C., Xue, J., Yu, X., Zhai, D., Lin, R., Zhang, M., Xia, L., Wang, X., Yao, Q., and Chang, J. (2020). Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration. Acta Biomater.","DOI":"10.1016\/j.actbio.2020.11.010"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Kim, J.W., Yang, B.E., Hong, S.J., Choi, H.G., Byeon, S.J., Lim, H.K., Chung, S.M., Lee, J.H., and Byun, S.H. (2020). Bone Regeneration Capability of 3D Printed Ceramic Scaffolds. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144837"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kim, Y., Lee, E.J., Davydov, A.V., Frukhbeyen, S., Seppala, J.E., Takagi, S., Chow, L., and Alimperti, S. (2020). Biofabrication of 3D printed hydroxyapatite composite scaffolds for bone regeneration. Biomed. Mater.","DOI":"10.1088\/1748-605X\/abcf03"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1021\/acsabm.0c00049","article-title":"In Situ Formation of Hexagon-like Column Array Hydroxyapatite on 3D-Plotted Hydroxyapatite Scaffolds by Hydrothermal Method and Its Effect on Osteogenic Differentiation","volume":"3","author":"Wei","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wei, Y., Gao, H., Hao, L., Shi, X., and Wang, Y. (2020). Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation. Nanomaterials, 10.","DOI":"10.3390\/nano10091672"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.2147\/IJN.S259678","article-title":"3D-HA Scaffold Functionalized by Extracellular Matrix of Stem Cells Promotes Bone Repair","volume":"15","author":"Chi","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Lim, H.K., Hong, S.J., Byeon, S.J., Chung, S.M., On, S.W., Yang, B.E., Lee, J.H., and Byun, S.H. (2020). 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186942"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kresge, C.T., Leonowicz, M.E., Roth, W.J., Vartuli, J.C., and Beck, J.S. (1992). Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism. Nature.","DOI":"10.1038\/359710a0"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1021\/nn200809t","article-title":"Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model","volume":"5","author":"Meng","year":"2011","journal-title":"Acs Nano"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.msec.2015.05.027","article-title":"Bone tissue engineering using silica-based mesoporous nanobiomaterials: Recent progress","volume":"55","author":"Shadjou","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.actbio.2015.11.033","article-title":"Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis","volume":"30","author":"Shi","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijbiomac.2020.01.237","article-title":"Incorporation of dexamethasone-loaded mesoporous silica nanoparticles into mineralized porous biocomposite scaffolds for improving osteogenic activity","volume":"149","author":"Zhou","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2174\/138920101607150427113355","article-title":"Synthesis and Characterization of Ibandronate-Loaded Silica Nanoparticles and Collagen Nanocomposites","volume":"16","author":"Alvarez","year":"2015","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.7150\/thno.37599","article-title":"EDTA-Modified 17beta-Estradiol-Laden Upconversion Nanocomposite for Bone-Targeted Hormone Replacement Therapy for Osteoporosis","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lei, L., Liu, Z., Yuan, P., Jin, R., Wang, X., Jiang, T., and Chen, X. (2019). Injectable colloidal hydrogel with mesoporous silica nanoparticles for sustained co-release of microRNA-222 and aspirin to achieve innervated bone regeneration in rat mandibular defects. J. Mater. Chem. B.","DOI":"10.1039\/C9TB00025A"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/wnan.1157","article-title":"Recent advances in stealth coating of nanoparticle drug delivery systems","volume":"4","author":"Amoozgar","year":"2012","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1021\/acsami.9b20697","article-title":"Development of Optimized Strategies for Growth Factor Incorporation onto Electrospun Fibrous Scaffolds To Promote Prolonged Release","volume":"12","author":"Karpov","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9824827","DOI":"10.1155\/2016\/9824827","article-title":"Synergistic Effect of Mesoporous Silica and Hydroxyapatite in Loaded Poly(DL-lactic-co-glycolic acid) Microspheres on the Regeneration of Bone Defects","volume":"2016","author":"He","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09205063.2019.1622221","article-title":"Co-enhance bioactive of polymer scaffold with mesoporous silica and nano-hydroxyapatite","volume":"30","author":"Shuai","year":"2019","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1007\/s10856-014-5273-6","article-title":"An in situ synthesis of mesoporous SBA-16\/hydroxyapatite for ciprofloxacin release: In vitro stability and cytocompatibility studies","volume":"25","author":"Andrade","year":"2014","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Tamburaci, S., Kimna, C., and Tihminlioglu, F. (2019). Bioactive diatomite and POSS silica cage reinforced chitosan\/Na-carboxymethyl cellulose polyelectrolyte scaffolds for hard tissue regeneration. Mater. Sci. Eng. C.","DOI":"10.1016\/j.msec.2019.02.104"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Gaihre, B., Lecka-Czernik, B., and Jayasuriya, A.C. (2017). Injectable nanosilica-chitosan microparticles for bone regeneration applications. J. Biomater. Appl.","DOI":"10.1177\/0885328217741523"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Khatami, N., Khoshfetrat, A.B., Khaksar, M., Zamani, A.R.N., and Rahbarghazi, R. (2019). Collagen-alginate-nano-silica microspheres improved the osteogenic potential of human osteoblast-like MG-63 cells. J. Cell. Biochem.","DOI":"10.1002\/jcb.28768"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sun, J.L., Jiao, K., Song, Q., Ma, C.F., Ma, C., Tay, F.R., Niu, L.N., and Chen, J.H. (2017). Intrafibrillar silicified collagen scaffold promotes in-situ bone regeneration by activating the monocyte p38 signaling pathway. Acta Biomater., 354\u2013365.","DOI":"10.1016\/j.actbio.2017.12.022"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8506","DOI":"10.1016\/j.biomaterials.2011.07.090","article-title":"Osteogenic evaluation of calcium\/magnesium-doped mesoporous silica scaffold with incorporation of rhBMP-2 by synchrotron radiation-based muCT","volume":"32","author":"Dai","year":"2011","journal-title":"Biomaterials"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1039\/C8BM01498A","article-title":"La-Doped mesoporous calcium silicate\/chitosan scaffolds for bone tissue engineering","volume":"7","author":"Peng","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Shi, M., Xia, L., Chen, Z., Lv, F., Zhu, H., Wei, F., Han, S., Chang, J., Xiao, Y., and Wu, C. (2017). Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis\/angiogenesis agent. Biomaterials, 176\u2013187.","DOI":"10.1016\/j.biomaterials.2017.08.027"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"109999","DOI":"10.1016\/j.msec.2019.109999","article-title":"Gadolinium-doped mesoporous calcium silicate\/chitosan scaffolds enhanced bone regeneration ability","volume":"104","author":"Liao","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2014.04.001","article-title":"Biomimetic porous scaffolds for bone tissue engineering","volume":"80","author":"Wu","year":"2014","journal-title":"Mater. Sci. Eng. R Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1016\/j.biomaterials.2005.02.002","article-title":"Porosity of 3D biomaterial scaffolds and osteogenesis","volume":"26","author":"Karageorgiou","year":"2005","journal-title":"Biomaterials"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tibtech.2009.12.003","article-title":"Classification of osseointegrated implant surfaces: Materials, chemistry and topography","volume":"28","author":"Coelho","year":"2010","journal-title":"Trends Biotechnol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"110851","DOI":"10.1016\/j.msec.2020.110851","article-title":"Fabrication of strontium-incorporated protein supramolecular nanofilm on titanium substrates for promoting osteogenesis","volume":"111","author":"Ding","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.2147\/IJN.S245608","article-title":"Involvement of FAK\/P38 Signaling Pathways in Mediating the Enhanced Osteogenesis Induced by Nano-Graphene Oxide Modification on Titanium Implant Surface","volume":"15","author":"Li","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"8261","DOI":"10.2147\/IJN.S267632","article-title":"Lanthanides-Substituted Hydroxyapatite\/Aloe vera Composite Coated Titanium Plate for Bone Tissue Regeneration","volume":"15","author":"Prabakaran","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"46183","DOI":"10.1021\/acsami.9b17015","article-title":"Self-Assembled Human Adipose-Derived Stem Cell-Derived Extracellular Vesicle-Functionalized Biotin-Doped Polypyrrole Titanium with Long-Term Stability and Potential Osteoinductive Ability","volume":"11","author":"Chen","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.actbio.2020.07.024","article-title":"Bio-surface coated titanium scaffolds with cancellous bone-like biomimetic structure for enhanced bone tissue regeneration","volume":"114","author":"Zhang","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.actbio.2019.09.030","article-title":"Activating macrophages for enhanced osteogenic and bactericidal performance by Cu ion release from micro\/nano-topographical coating on a titanium substrate","volume":"100","author":"Huang","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"30044","DOI":"10.1021\/acsami.0c05413","article-title":"Tremella-Like ZnO@Col-I-Decorated Titanium Surfaces with Dual-Light-Defined Broad-Spectrum Antibacterial and Triple Osteogenic Properties","volume":"12","author":"Zhao","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.2147\/IJN.S252936","article-title":"Effects of Nanotopography Regulation and Silicon Doping on Angiogenic and Osteogenic Activities of Hydroxyapatite Coating on Titanium Implant","volume":"15","author":"Fu","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0142-9612(97)00146-4","article-title":"Titanium alloys in total joint replacement\u2014A materials science perspective","volume":"19","author":"Long","year":"1998","journal-title":"Biomaterials"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1016\/j.actbio.2012.04.001","article-title":"The effect of pore geometry on the in vitro biological behavior of human periosteum-derived cells seeded on selective laser-melted Ti6Al4V bone scaffolds","volume":"8","author":"Chai","year":"2012","journal-title":"Acta Biomater."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.actamat.2014.01.018","article-title":"Microstructure and mechanical properties of a novel \u03b2 titanium metallic composite by selective laser melting","volume":"68","author":"Vrancken","year":"2014","journal-title":"Acta Mater."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.msea.2019.06.001","article-title":"Selective laser melting of Ti\u201335Nb composite from elemental powder mixture: Microstructure, mechanical behavior and corrosion behavior","volume":"760","author":"Wang","year":"2019","journal-title":"Mater. Sci. Eng."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ijrmhm.2018.08.006","article-title":"Selective laser melting of titanium alloy with 50 wt% tantalum: Effect of laser process parameters on part quality","volume":"77","author":"Leong","year":"2018","journal-title":"Int. J. Refract. Met. Hard Mater."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Cho, H.R., Roh, T.S., Shim, K.W., Kim, Y.O., Lew, D.H., and Yun, I.S. (2015). Skull Reconstruction with Custom Made Three-Dimensional Titanium Implant. Arch. Craniofac.Surg., 16.","DOI":"10.7181\/acfs.2015.16.1.11"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1097\/SCS.0000000000002656","article-title":"Cranioplasty Enhanced by Three-Dimensional Printing: Custom-Made Three-Dimensional-Printed Titanium Implants for Skull Defects","volume":"27","author":"Park","year":"2016","journal-title":"J. Craniofac. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Lee, Y.W., You, H.J., Jung, J.A., and Kim, D.W. (2018). Mandibular reconstruction using customized three-dimensional titanium implant. Arch. Craniofac. Surg., 19.","DOI":"10.7181\/acfs.2018.01830"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/1071100715620895","article-title":"Salvage of Severe Foot and Ankle Trauma With a 3D Printed Scaffold","volume":"37","author":"Hamid","year":"2016","journal-title":"Foot Ankle Int."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ijom.2014.09.006","article-title":"Custom-made titanium cranioplasty: Early and late complications of 151 cranioplasties and review of the literature","volume":"44","author":"Williams","year":"2015","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Pei, X., Wu, L., Zhou, C., Fan, H., Gou, M., Li, Z., Zhang, B., Lei, H., Sun, H., and Liang, J. (2020). 3D printed titanium scaffolds with homogeneous diamond-like structures mimicking that of the osteocyte microenvironment and its bone regeneration study. Biofabrication.","DOI":"10.1088\/1758-5090\/abc060"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/3212594","article-title":"A Further Analysis on Ti6Al4V Lattice Structures Manufactured by Selective Laser Melting","volume":"2019","author":"Maietta","year":"2019","journal-title":"J. Healthc. Eng."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"43888","DOI":"10.1021\/acsami.9b16050","article-title":"Engineering High-Resolution Micropatterns Directly onto Titanium with Optimized Contact Guidance to Promote Osteogenic Differentiation and Bone Regeneration","volume":"11","author":"Zhu","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Saruta, J., Sato, N., Ishijima, M., Okubo, T., Hirota, M., and Ogawa, T. (2019). Disproportionate Effect of Sub-Micron Topography on Osteoconductive Capability of Titanium. Int. J. Mol. Sci., 20.","DOI":"10.20944\/preprints201908.0143.v1"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"065016","DOI":"10.1088\/1748-605X\/aba40b","article-title":"A multifunctional silk coating on additively manufactured porous titanium to prevent implant-associated infection and stimulate bone regeneration","volume":"15","author":"Jahanmard","year":"2020","journal-title":"Biomed. Mater."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Sun, P., Wang, Y., Xu, D., and Gong, K. (2020). The Calcium Phosphate Modified Titanium Implant Combined With Platelet-Rich Plasma Treatment Promotes Implant Stabilization in an Osteoporotic Model. J. Craniofac. Surg.","DOI":"10.1097\/SCS.0000000000006836"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"109879","DOI":"10.1016\/j.msec.2019.109879","article-title":"Controlled release of BMP-2 from titanium with electrodeposition modification enhancing critical size bone formation","volume":"105","author":"Teng","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.actbio.2019.06.001","article-title":"The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway","volume":"98","author":"Hung","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/0885328220928550","article-title":"High-purity magnesium pin enhances bone consolidation in distraction osteogenesis model through activation of the VHL\/HIF-1alpha\/VEGF signaling","volume":"35","author":"Hamushan","year":"2020","journal-title":"J. Biomater. Appl."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biomaterials.2016.10.017","article-title":"Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective","volume":"112","author":"Zhao","year":"2017","journal-title":"Biomaterials"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.actbio.2015.11.014","article-title":"An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloy","volume":"29","author":"Tie","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.corsci.2016.10.009","article-title":"The in vivo degradation and bone-implant interface of Mg-Nd-Zn-Zr alloy screws: 18 months post-operation results","volume":"113","author":"Niu","year":"2016","journal-title":"Corros. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"110026","DOI":"10.1016\/j.msec.2019.110026","article-title":"PEO coatings design for Mg-Ca alloy for cardiovascular stent and bone regeneration applications","volume":"105","author":"Mohedano","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"27889","DOI":"10.1021\/acsami.0c00553","article-title":"Targeting Local Osteogenic and Ancillary Cells by Mechanobiologically Optimized Magnesium Scaffolds for Orbital Bone Reconstruction in Canines","volume":"12","author":"Zhang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"102232","DOI":"10.1016\/j.nano.2020.102232","article-title":"Bilayer nanostructure coated AZ31 magnesium alloy implants: In vivo reconstruction of critical-sized rabbit femoral segmental bone defect","volume":"29","author":"Perumal","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"119372","DOI":"10.1016\/j.biomaterials.2019.119372","article-title":"A functionalized TiO2\/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection","volume":"219","author":"Lin","year":"2019","journal-title":"Biomaterials"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.actbio.2020.07.028","article-title":"Fibrinogen and magnesium combination biomaterials modulate macrophage phenotype, NF-kB signaling and crosstalk with mesenchymal stem\/stromal cells","volume":"114","author":"Silva","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.actbio.2017.10.033","article-title":"Dual modulation of bone formation and resorption with zoledronic acid-loaded biodegradable magnesium alloy implants improves osteoporotic fracture healing: An in vitro and in vivo study","volume":"65","author":"Li","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"107683","DOI":"10.1016\/j.matdes.2019.107683","article-title":"Additive manufacturing of magnesium\u2013zinc\u2013zirconium (ZK) alloys via capillary-mediated binderless three-dimensional printing\u2014ScienceDirect","volume":"169","author":"Salehi","year":"2019","journal-title":"Mater. Des."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.actbio.2017.12.008","article-title":"Additively manufactured biodegradable porous magnesium","volume":"67","author":"Li","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"27453","DOI":"10.1021\/acsami.7b06654","article-title":"Biological Responses and Mechanisms of Human Bone Marrow Mesenchymal Stem Cells to Zn and Mg Biomaterials","volume":"9","author":"Zhu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/adma.201300226","article-title":"Zinc exhibits ideal physiological corrosion behavior for bioabsorbable stents","volume":"25","author":"Bowen","year":"2013","journal-title":"Adv. Mater."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.msec.2019.01.120","article-title":"Investigation on the microstructure, mechanical properties, in vitro degradation behavior and biocompatibility of newly developed Zn-0.8%Li-(Mg, Ag) alloys for guided bone regeneration","volume":"99","author":"Zhang","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Montani, M., Demir, A.G., Mostaed, E., Vedani, M., and Previtali, B. (2017). Processability of pure Zn and pure Fe by SLM for biodegradable metallic implant manufacturing. Rapid Prototyp. J.","DOI":"10.1108\/RPJ-08-2015-0100"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1039\/C9BM01904A","article-title":"Additively manufactured functionally graded biodegradable porous zinc","volume":"8","author":"Li","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.actbio.2020.04.006","article-title":"Mechanical properties and cytocompatibility of dense and porous Zn produced by laser powder bed fusion for biodegradable implant applications","volume":"110","author":"Lietaert","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Jakhmola, A., Vecchione, R., Gentile, F., Profeta, M., Manikas, A.C., Battista, E., Celentano, M., Onesto, V., and Netti, P.A. (2019). Experimental and theoretical study of biodirected green synthesis of gold nanoflowers. Mater. Today Chem., 14.","DOI":"10.1016\/j.mtchem.2019.100203"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Jakhmola, A., Vecchione, R., Onesto, V., Gentile, F., Profeta, M., Battista, E., Manikas, A.C., and Netti, P.A. (2021). A theoretical and experimental study on L-tyrosine and citrate mediated sustainable production of near infrared absorbing twisted gold nanorods. Mat. Sci. Eng. C, 118.","DOI":"10.1016\/j.msec.2020.111515"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.colsurfa.2018.09.030","article-title":"Diffusion limited green synthesis of ultra-small gold nanoparticles at room temperature","volume":"558","author":"Celentano","year":"2018","journal-title":"Colloid Surf. A"},{"key":"ref_107","first-page":"156","article-title":"Preliminary focus on the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles","volume":"2","author":"Russo","year":"2017","journal-title":"Bioact. Mater."},{"key":"ref_108","first-page":"2221","article-title":"Gold nanorods and nanohydroxyapatite hybrid hydrogel for preventing bone tumor recurrence via postoperative photothermal therapy and bone regeneration promotion","volume":"6","author":"Liao","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e2002301","DOI":"10.1002\/smll.202002301","article-title":"Dual Functional Monocytes Modulate Bactericidal and Anti-Inflammation Process for Severe Osteomyelitis Treatment","volume":"16","author":"Shi","year":"2020","journal-title":"Small"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Sanchez-Casanova, S., Martin-Saavedra, F.M., Escudero-Duch, C., Uceda, M.I.F., Prieto, M., Arruebo, M., Acebo, P., Fabiilli, M.L., Franceschi, R.T., and Vilaboa, N. (2020). Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration. 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