{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:31:40Z","timestamp":1787239900091,"version":"build-2736575974"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Tetracycline (TC) and oxytetracycline (OTC) are the most widely used broad-spectrum antimicrobial agents in tetracycline drugs, and their structures and properties are very similar, so it is a great challenge to distinguish and detect these two antibiotics with a single probe at the same time. Herein, a dual-channel fluorescence probe (SiCDs@mMIPs-cit-Eu) was developed by integrating two independent reaction sites with SiCDs-doped mesoporous silica molecular imprinting group and europium complex group into a nanomaterial. The synergistic influence of inner filter effect and \u201cantenna effect\u201d can be guaranteed to solve the distinction between TC and OTC. Moreover, this novel strategy can also sequentially detect TC and OTC in buffer solution and real samples with high sensitivity and selectivity. This method revealed good responses to TC and OTC ranging from 0 to 5.5 \u03bcM with a detection limit of 5 and 16 nM, respectively. Combined with the smartphone color-scanning application, the portable and cheap paper-based sensor was designed to realize the multi-color visual on-site detection of TC and OTC. In addition, the logic gate device was constructed according to the fluorescence color change of the probe for TC and OTC, which provided the application possibility for the intelligent detection of the probe.<\/jats:p>","DOI":"10.3390\/nano12010128","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T23:29:07Z","timestamp":1640906947000},"page":"128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dual-Channel Probe of Carbon Dots Cooperating with Lanthanide Complex Employed for Simultaneously Distinguishing and Sequentially Detecting Tetracycline and Oxytetracycline"],"prefix":"10.3390","volume":"12","author":[{"given":"Lei","family":"Jia","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujie","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhen","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11750","DOI":"10.1021\/ac503212q","article-title":"Feasibility of Terahertz Time-Domain Spectroscopy to Detect Tetracyclines Hydrochloride in Infant Milk Powder","volume":"86","author":"Qin","year":"2014","journal-title":"Anal. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1021\/acsami.6b13949","article-title":"Conjugated polyelectrolyte based sensitive detection and removal of antibiotics tetracycline from water","volume":"9","author":"Malik","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121630","DOI":"10.1016\/j.jhazmat.2019.121630","article-title":"Metal-Enhanced fluorescence detection and degradation of tetracycline by silver nanoparticle-encapsulated halloysite nanolumen","volume":"386","author":"Xu","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.bios.2013.07.011","article-title":"Determination of tetracycline in milk by using nucleotide\/lanthanide coordination polymer-based ternary complex","volume":"50","author":"Tan","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.aca.2008.08.003","article-title":"Quantitative detection of tetracycline residues in honey by a simple sensitive immunoassay","volume":"626","author":"Jeon","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1021\/es104009s","article-title":"Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China","volume":"45","author":"Luo","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jchromb.2012.12.036","article-title":"High-performance liquid chromatography using pressurized liquid extraction for the determination of seven tetracyclines in egg, fish and shrimp","volume":"917","author":"Liu","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1021\/ac3037574","article-title":"Aptamer-Based Cantilever Array Sensors for Oxytetracycline Detection","volume":"85","author":"Hou","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.1220761","article-title":"The shared antibiotic Resistome of soil bacteria and human pathogens","volume":"337","author":"Forsberg","year":"2012","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.aca.2018.03.018","article-title":"Ratiometric system based on graphene quantum dots and Eu3+ for selective detection of tetracyclines","volume":"1022","author":"Li","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.chroma.2011.12.108","article-title":"Synthesis and application of molecularly imprinted poly(methacrylic acid)\u2013silica hybrid composite material for selective solid-phase extraction and high-performance liquid chromatography determination of oxytetracycline residues in milk","volume":"1227","author":"Lv","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.bios.2010.08.046","article-title":"A novel colorimetric aptasensor using gold nanoparticle for a highly sensitive and specific detection of oxytetracycline","volume":"26","author":"Kim","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/elps.201500440","article-title":"Trace determination of tetracyclines in water samples by capillary zone electrophoresis combining off-line and on-line sample preconcentration","volume":"37","year":"2016","journal-title":"Electrophoresis"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s12161-015-0262-z","article-title":"Development of an ELISA and Immunochromatographic Assay for Tetracycline, Oxytetracycline, and Chlortetracycline Residues in Milk and Honey Based on the Class-Specific Monoclonal Antibody","volume":"9","author":"Chen","year":"2016","journal-title":"Food Anal. Methods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.1039\/C9TC02738F","article-title":"A facile strategy for the synthesis of water-soluble fluorescent nonconjugated polymer dots and their application in tetracycline detection","volume":"7","author":"Chen","year":"2019","journal-title":"J. Mater. Chem. C"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"123776","DOI":"10.1016\/j.jhazmat.2020.123776","article-title":"A smartphone-integrated multicolor fluorescence probe of bacterial spore biomarker: The combination of natural clay material and metal-organic frameworks","volume":"402","author":"Jia","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1021\/ac100021m","article-title":"Development of a visible-light-sensitized europium complex for time-resolved fluorometric application","volume":"82","author":"Jiang","year":"2010","journal-title":"Anal. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"19853","DOI":"10.1039\/C4RA16456C","article-title":"Carbon dots based turn-on fluorescent probes for oxytetracycline hydrochloride sensing","volume":"5","author":"An","year":"2015","journal-title":"RSC Adv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1021\/acs.analchem.9b00319","article-title":"Metal\u2013Organic Framework Enhances Aggregation-Induced Fluorescence of Chlortetracycline and the Application for Detection","volume":"91","author":"Yu","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1080\/19440049.2011.589037","article-title":"Rapid and sensitive enzyme-linked immunosorbent assay and immunochromatographic assay for the detection of chlortetracycline residues in edible animal tissues","volume":"28","author":"Le","year":"2011","journal-title":"Food Addit. Contam. Part A"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.1039\/c3cc44627a","article-title":"Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals","volume":"49","author":"Kim","year":"2013","journal-title":"Chem. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.bios.2014.05.058","article-title":"Comparative syntheses of tetracycline-imprinted polymeric silicate and acrylate on CdTe quantum dots as fluorescent sensors","volume":"61","author":"Chao","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1039\/C9CC09223D","article-title":"Low-toxicity carbon quantum dots derived from gentamicin sulfate to combat antibiotic resistance and eradicate mature biofilms","volume":"56","author":"Li","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1039\/C4NR01585A","article-title":"Carbon dots obtained using hydrothermal treatment of formaldehyde. Cell imaging in vitro","volume":"6","author":"Algarra","year":"2014","journal-title":"Nanoscale"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bios.2017.01.014","article-title":"Dual-channel probe of carbon dots cooperating with gold nanoclusters employed for assaying multiple targets","volume":"91","author":"Yang","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1039\/C2CC16791C","article-title":"Carbon nanodots as fluorescence probes for rapid, sensitive, and label-free detection of Hg2+ and biothiols in complex matrices","volume":"48","author":"Zhou","year":"2012","journal-title":"Chem. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1007\/s11356-019-06779-3","article-title":"Facile synthesis of highly efficient fluorescent carbon dots for tetracycline detection","volume":"27","author":"Guo","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1021\/acsabm.0c01104","article-title":"Applications of N-Doped carbon dots as antimicrobial agents, antibiotic carriers, and selective fluorescent probes for nitro explosives","volume":"3","author":"Arumugam","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11777","DOI":"10.1021\/acsanm.0c02305","article-title":"Carbon dots for heavy-metal sensing, pH-sensitive cargo delivery, and antibacterial applications","volume":"3","author":"Das","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9636","DOI":"10.1039\/C8TC02982B","article-title":"Microwave-assisted synthesis of cyclen functional carbon dots to construct a ratiometric fluorescent probe for tetracycline detection","volume":"6","author":"Shen","year":"2018","journal-title":"J. Mater. Chem. C"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jiec.2018.10.007","article-title":"A facile, green synthesis of biomass carbon dots coupled with molecularly imprinted polymers for highly selective detection of oxytetracycline","volume":"69","author":"Liu","year":"2019","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"39056","DOI":"10.1021\/acsami.8b14472","article-title":"Novel Fluorescence Sensor Based on All-Inorganic Perovskite Quantum Dots Coated with Molecularly Imprinted Polymers for Highly Selective and Sensitive Detection of Omethoate","volume":"10","author":"Huang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11827","DOI":"10.1021\/acs.analchem.8b01291","article-title":"Rotational Paper-Based Microfluidic-Chip Device for Multiplexed and Simultaneous Fluorescence Detection of Phenolic Pollutants Based on a Molecular-Imprinting Technique","volume":"90","author":"Qi","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8866","DOI":"10.1021\/acs.inorgchem.8b00788","article-title":"Ratiometric fluorescence platform based on modified silicon quantum dots and its logic gate performance","volume":"57","author":"Li","year":"2018","journal-title":"Inorg. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"121929","DOI":"10.1016\/j.jhazmat.2019.121929","article-title":"A long lifetime ratiometrically luminescent tetracycline nanoprobe based on Ir(III) complex-doped and Eu3+ -functionalized silicon nanoparticles","volume":"386","author":"Li","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/anie.200353169","article-title":"Fluorescent imaging of citrate and other intermediates in the citric Acid cycle","volume":"43","author":"Lin","year":"2010","journal-title":"Angew. Chem. Int. Edit"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.carbon.2015.05.107","article-title":"Imaging two targets in live cells based on rational design of lanthanide organic structure appended carbon dots","volume":"93","author":"Zhou","year":"2015","journal-title":"Carbon"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1007\/s00216-015-8632-3","article-title":"Magnetic-nanobead-based competitive enzyme-linked aptamer assay for the analysis of oxytetracycline in food","volume":"407","author":"Lu","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"11022","DOI":"10.1039\/C5CC02889B","article-title":"Luminescent lanthanide graphene for detection of bacterial spores and cysteine","volume":"51","author":"Wang","year":"2015","journal-title":"Chem. Comm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jhazmat.2018.10.083","article-title":"Adsorption of Sr (II) from water by mercerized bacterial cellulose membrane modified with EDTA","volume":"364","author":"Cheng","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s11051-012-1191-z","article-title":"Application of Core-shell-structured CdTe@SiO2 quantum dots synthesized via a facile solution method for improving latent fingerprint detection","volume":"14","author":"Gao","year":"2012","journal-title":"J. Nanopart. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bios.2017.04.045","article-title":"Molecularly imprinted mesoporous silica embedded with carbon dots and semiconductor quantum dots as a ratiometric fluorescent sensor for diniconazole","volume":"96","author":"Amjadi","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.talanta.2019.06.036","article-title":"Ratiometric method based on silicon nanodots and Eu3+ system for highly-sensitive detection of tetracyclines","volume":"204","author":"Wei","year":"2019","journal-title":"Talanta"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1039\/C7TB00886D","article-title":"Large-pore, silica particles with antibody-like, biorecognition sites for efficient protein separation","volume":"5","author":"Zhang","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1039\/C8AN00734A","article-title":"Molecularly imprinted electrospun nanofibers for adsorption of 2,4-dinitrotoluene in water","volume":"143","author":"Xue","year":"2018","journal-title":"Analyst"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.saa.2019.01.033","article-title":"Electronic structure and optical properties of Ln(III) nitrate adducts with 1,10-phenanthroline","volume":"213","author":"Shurygin","year":"2019","journal-title":"Spectrochim. Acta A"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"16248","DOI":"10.1021\/acsami.6b04381","article-title":"Fluorescence Probe Based on Hybrid Mesoporous Silica\/Quantum Dot\/Molecularly Imprinted Polymer for Detection of Tetracycline","volume":"8","author":"Zhang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jphotobiol.2012.07.002","article-title":"Interaction of multitryptophan protein with drug: An insight into the binding mechanism and the binding domain by time resolved emission, anisotropy, phosphorescence and docking","volume":"115","author":"Mukherjee","year":"2012","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1021\/ic990597n","article-title":"Displacement of Inner-Sphere Water Molecules from Eu3+ Analogues of Gd3+ MRI Contrast Agents by Carbonate and Phosphate Anions:\u2009 Dissociation Constants from Luminescence Data in the Rapid-Exchange Limit","volume":"38","author":"Supkowski","year":"1999","journal-title":"Inorg. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s00604-017-2318-9","article-title":"The quenching of the fluorescence of carbon dots: A review on mechanisms and applications","volume":"184","author":"Zu","year":"2017","journal-title":"Microchim. Acta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.saa.2016.08.018","article-title":"Interaction between fluorescein isothiocyanate and carbon dots: Inner filter effect and fluorescence resonance energy transfer","volume":"171","author":"Liu","year":"2017","journal-title":"Spectrochim. Acta A"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.foodchem.2010.03.032","article-title":"Visual detection of melamine in raw milk using gold nanoparticles as colorimetric probe","volume":"122","author":"Li","year":"2010","journal-title":"Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"111791","DOI":"10.1016\/j.bios.2019.111791","article-title":"Smartphone-integrated ratiometric fluorescence sensing platform for visual and quantitative point-of-care testing of tetracycline","volume":"148","author":"Wang","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bios.2016.09.070","article-title":"Facile ratiometric fluorapatite nanoprobes for rapid and sensitive bacterial spore biomarker detection","volume":"87","author":"Xu","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"127741","DOI":"10.1016\/j.cej.2020.127741","article-title":"A smartphone-integrated method for visual detection of tetracycline","volume":"416","author":"Xu","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1021\/jf9911794","article-title":"A group-specific microbiological test for the detection of tetracycline residues in raw milk","volume":"48","author":"Kurittu","year":"2000","journal-title":"J. Agric. Food Chem."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/12\/1\/128\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:56:26Z","timestamp":1760169386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/12\/1\/128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,31]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["nano12010128"],"URL":"https:\/\/doi.org\/10.3390\/nano12010128","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,31]]}}}