{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:22:20Z","timestamp":1790022140303,"version":"4.0.1"},"reference-count":62,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Candida spp. resistant to commercially available antifungals are often isolated from patients with oral candidiasis, a situation that points to the need for the development of new therapies. Thus, we evaluated the activity of Fusarium oxysporum-based silver nanoparticles (AgNPs) on Candida spp. isolated from denture stomatitis lesions. Candida isolates were molecularly identified and submitted to susceptibility assays using AgNPs and commercial fungicides. The interference on biofilm formation and the mechanisms of action of AgNPs on Candida spp. were also investigated. Scanning electron microscopy was used to evaluate the morphology of AgNP-treated Candida. Candida albicans was the most frequent species isolated from denture stomatitis cases. All Candida spp. were susceptible to AgNPs at low concentrations, except Candida parapsilosis. AgNPs caused surface damage, cell disruption, and biofilm formation inhibition. The ergosterol supplementation protected C. albicans against the AgNP action. AgNPs are effective against Candida spp. and can be faced as a promising new therapeutic agent against oral candidiasis.<\/jats:p>","DOI":"10.3390\/nano12030501","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T22:16:18Z","timestamp":1643753778000},"page":"501","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Activity of Fusarium oxysporum-Based Silver Nanoparticles on Candida spp. Oral Isolates"],"prefix":"10.3390","volume":"12","author":[{"given":"Ma\u00edsa Santos","family":"Fonseca","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunologia e Biologia Molecular, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal da Bahia (UFBA), Salvador 40110-100, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2744-4368","authenticated-orcid":false,"given":"Daniela M\u00e9ria","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia e Biologia Molecular, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal da Bahia (UFBA), Salvador 40110-100, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rita","family":"Sokolonski","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica Oral, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal da Bahia (UFBA), Salvador 40110-100, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Stanisic","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Biol\u00f3gica, Instituto de Qu\u00edmica, Universidade Estadual de Campinas (UNICAMP), Campinas 13083-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Marcelo","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular e Computacional de Fungos, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-6243","authenticated-orcid":false,"given":"Arist\u00f3teles","family":"G\u00f3es-Neto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular e Computacional de Fungos, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-2280","authenticated-orcid":false,"given":"Vasco","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Celular e Molecular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Meyer","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia e Biologia Molecular, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal da Bahia (UFBA), Salvador 40110-100, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo Barral","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica Oral, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal da Bahia (UFBA), Salvador 40110-100, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-7332","authenticated-orcid":false,"given":"Ljubica","family":"Tasic","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Biol\u00f3gica, Instituto de Qu\u00edmica, Universidade Estadual de Campinas (UNICAMP), Campinas 13083-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-776X","authenticated-orcid":false,"given":"Ricardo Dias","family":"Portela","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia e Biologia Molecular, Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal da Bahia (UFBA), Salvador 40110-100, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1532-849X.2011.00698.x","article-title":"Epidemiology and Etiology of Denture Stomatitis","volume":"20","author":"Gendreau","year":"2011","journal-title":"J. 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