{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:59:50Z","timestamp":1791230390401,"version":"4.1.0"},"reference-count":65,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Higher Education and Scientific Research of Tunisia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Candida and dermatophyte infections are difficult to treat due to increasing antifungal drugs resistance such as fluconazole, as well as the emergence of multi-resistance in clinical bacteria. Here, we first synthesized silver nanoparticles using aqueous fruit extracts from Scabiosa atropurpurea subsp. maritima (L.). The characterization of the AgNPs by means of UV, XRD, FTIR, and TEM showed that the AgNPs had a uniform spherical shape with average sizes of 40\u201350 nm. The biosynthesized AgNPs showed high antioxidant activity when investigated using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The AgNPs displayed strong antibacterial potential expressed by the maximum zone inhibition and the lowest MIC and MBC values. The AgNPs revealed a significant antifungal effect against the growth and biofilm of Candida species. In fact, the AgNPs were efficient against Trichophyton rubrum, Trichophyton interdigitale, and Microsporum canis. The antifungal mechanisms of action of the AgNPs seem to be due to the disruption of membrane integrity and a reduction in virulence factors (biofilm and hyphae formation and a reduction in germination). Finally, the silver nanoparticles also showed important cytotoxic activity against the human multiple myeloma U266 cell line and the human breast cancer cell line MDA-MB-231. Therefore, we describe new silver nanoparticles with promising biomedical application in the development of novel antimicrobial and anticancer agents.<\/jats:p>","DOI":"10.3390\/nano12091585","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T21:31:20Z","timestamp":1652045480000},"page":"1585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["First Report of the Biosynthesis and Characterization of Silver Nanoparticles Using Scabiosa atropurpurea subsp. maritima Fruit Extracts and Their Antioxidant, Antimicrobial and Cytotoxic Properties"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-7896","authenticated-orcid":false,"given":"Badiaa","family":"Essghaier","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Sciences, University of Tunis El-Manar II, Tunis 2092, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4887-5466","authenticated-orcid":false,"given":"Nourch\u00e9ne","family":"Toukabri","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Mycologie, Laboratoire de Recherche Infections et Sant\u00e9 Publique LR18SP01, Service de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie, H\u00f4pital La Rabta Jebbari, Tunis 1007, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-8225","authenticated-orcid":false,"given":"Rihab","family":"Dridi","sequence":"additional","affiliation":[{"name":"Laboratoire de Mat\u00e9riaux, Cristallochimie et Thermodynamique Appliqu\u00e9e, Department of Chimie, Faculty of Sciences, University of Tunis El-Manar II, Tunis 2092, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9dia","family":"Hannachi","sequence":"additional","affiliation":[{"name":"Laboratory of Vegetable Productivity and Environmental Constraint LR18ES04, Department of Biology, Faculty of Science, University of Tunis El Manar II, Tunis 2092, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e8s","family":"Limam","sequence":"additional","affiliation":[{"name":"Laboratory of Oncohematology, PRF of Oncohematology, Faculty of Medicine of Tunis, Tunis El Manar University, Tunis 1006, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-9398","authenticated-orcid":false,"given":"Filomena","family":"Mottola","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), University of Campania \u201cL. Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1180-3442","authenticated-orcid":false,"given":"Mourad","family":"Mokni","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Mycologie, Laboratoire de Recherche Infections et Sant\u00e9 Publique LR18SP01, Service de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie, H\u00f4pital La Rabta Jebbari, Tunis 1007, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Faouzi","family":"Zid","sequence":"additional","affiliation":[{"name":"Laboratoire de Mat\u00e9riaux, Cristallochimie et Thermodynamique Appliqu\u00e9e, Department of Chimie, Faculty of Sciences, University of Tunis El-Manar II, Tunis 2092, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6250-4798","authenticated-orcid":false,"given":"Lucia","family":"Rocco","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), University of Campania \u201cL. Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelkarim","sequence":"additional","affiliation":[{"name":"Laboratory of Oncohematology, PRF of Oncohematology, Faculty of Medicine of Tunis, Tunis El Manar University, Tunis 1006, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, X.F., Liu, Z.G., Shen, W., and Gurunathan, S. (2016). Silver nanoparticles: Synthesis, characterization, properties, applications, and therapeutic approaches. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17091534"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Robinson, J.R., Isikhuemhen, O.S., and Anike, F.N. (2021). Fungal metal interactions: A review of toxicity and homeostasis. J. 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