{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:46:11Z","timestamp":1784717171541,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Key R&amp;D Program of China","award":["2018YFA0209402"],"award-info":[{"award-number":["2018YFA0209402"]}]},{"name":"The National Key R&amp;D Program of China","award":["2018YFC1602301"],"award-info":[{"award-number":["2018YFC1602301"]}]},{"name":"The National Key R&amp;D Program of China","award":["22175132"],"award-info":[{"award-number":["22175132"]}]},{"name":"The National Key R&amp;D Program of China","award":["2017IT100121"],"award-info":[{"award-number":["2017IT100121"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018YFA0209402"],"award-info":[{"award-number":["2018YFA0209402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018YFC1602301"],"award-info":[{"award-number":["2018YFC1602301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22175132"],"award-info":[{"award-number":["22175132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017IT100121"],"award-info":[{"award-number":["2017IT100121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Foshan Science and Technology Innovation Project","award":["2018YFA0209402"],"award-info":[{"award-number":["2018YFA0209402"]}]},{"name":"The Foshan Science and Technology Innovation Project","award":["2018YFC1602301"],"award-info":[{"award-number":["2018YFC1602301"]}]},{"name":"The Foshan Science and Technology Innovation Project","award":["22175132"],"award-info":[{"award-number":["22175132"]}]},{"name":"The Foshan Science and Technology Innovation Project","award":["2017IT100121"],"award-info":[{"award-number":["2017IT100121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Mesoporous silica materials have attracted great research interest for various applications ranging from (bio)catalysis and sensing to drug delivery. It remains challenging to prepare hollow mesoporous silica nanoparticles (HMSN) with large center-radial mesopores that could provide a more efficient transport channel through the cell for guest molecules. Here, we propose a novel strategy for the preparation of HMSN with large dendritic mesopores to achieve higher enzyme loading capacity and more efficient bioreactors. The materials were prepared by combining barium sulfate nanoparticles (BaSO4 NP) as a hard template and the in situ-formed 3-aminophenol\/formaldehyde resin as a porogen for directing the dendritic mesopores\u2019 formation. HMSNs with different particle sizes, shell thicknesses, and pore structures have been prepared by choosing BaSO4 NP of various sizes and adjusting the amount of tetraethyl orthosilicate added in synthesis. The obtained HMSN-1.1 possesses a high pore volume (1.07 cm3 g\u22121), a large average pore size (10.9 nm), and dendritic mesopores that penetrated through the shell. The advantages of HMSNs are also demonstrated for enzyme (catalase) immobilization and subsequent use of catalase-loaded HMSNs as bioreactors for catalyzing the H2O2 degradation reaction. The hollow and dendritic mesoporous shell features of HMSNs provide abundant tunnels for molecular transport and more accessible surfaces for molecular adsorption, showing great promise in developing efficient nanoreactors and drug delivery vehicles.<\/jats:p>","DOI":"10.3390\/nano12111940","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:10:33Z","timestamp":1654560633000},"page":"1940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dendritic Mesoporous Silica Hollow Spheres for Nano-Bioreactor Application"],"prefix":"10.3390","volume":"12","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry, Fudan University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Fudan University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Fudan University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Deng","sequence":"additional","affiliation":[{"name":"College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Fudan University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-5883","authenticated-orcid":false,"given":"Yajun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/adma.201104763","article-title":"Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery","volume":"24","author":"Tang","year":"2012","journal-title":"Adv. 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