{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:36:49Z","timestamp":1785911809792,"version":"3.56.0"},"reference-count":97,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Subsidy","award":["16.16.130.942\/KPiEM"],"award-info":[{"award-number":["16.16.130.942\/KPiEM"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>The prospects of using biopolymer nano-containing films for wound healing were substantiated. The main components of biopolymer composites are gelatin, polyvinyl alcohol, glycerin, lactic acid, distilled water, and zinc oxide (ZnO) nanoparticles (NPs). Biopolymer composites were produced according to various technological parameters using a mould with a chrome coating. The therapeutic properties of biopolymer films were evaluated by measuring the diameter of the protective effect. Physico-mechanical properties were studied: elasticity, vapour permeability, degradation time, and swelling. To study the influence of technological parameters of the formation process of therapeutic biopolymer nanofilled films on their therapeutic and physico-mechanical properties, the planning of the experiment was used. According to the results of the experiments, mathematical models of the second-order were built. The optimal values of technological parameters of the process are determined, which provide biopolymer nanofilled films with maximum healing ability (diameter of protective action) and sufficiently high physical and mechanical properties: elasticity, vapour permeability, degradation time and swelling. The research results showed that the healing properties of biopolymer films mainly depend on the content of ZnO NPs. Degradation of these biopolymer films provides dosed drug delivery to the affected area. The products of destruction are carbon dioxide, water, and a small amount of ZnO in the bound state, which indicates the environmental safety of the developed biopolymer film.<\/jats:p>","DOI":"10.3390\/nano12142413","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T01:57:11Z","timestamp":1657850231000},"page":"2413","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7665-8058","authenticated-orcid":false,"given":"Micha\u0142","family":"Bembenek","sequence":"first","affiliation":[{"name":"Department of Manufacturing Systems, Faculty of Mechanical Engineering and Robotics, AGH University of Science and Technology, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Popadyuk","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ivano-Frankivsk National Medical University, 076000 Ivano-Frankivsk, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaer","family":"Shihab","sequence":"additional","affiliation":[{"name":"Medical Instruments Techniques Engineering Department, Technical College of Engineering, Al-Bayan University, Baghdad 10070, Iraq"},{"name":"Department of Welding, Ivano-Frankivsk National Technical University of Oil and Gas, 076019 Ivano-Frankivsk, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-2550","authenticated-orcid":false,"given":"Liubomyr","family":"Ropyak","sequence":"additional","affiliation":[{"name":"Department of Computerized Engineering, Ivano-Frankivsk National Technical University of Oil and Gas, 076019 Ivano-Frankivsk, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8832-7873","authenticated-orcid":false,"given":"Andrzej","family":"Uhry\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Machine Design and Operation, Faculty of Mechanical Engineering and Robotics, AGH University of Science and Technology, 30-059 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3682-1612","authenticated-orcid":false,"given":"Vasyl","family":"Vytvytskyi","sequence":"additional","affiliation":[{"name":"Department of Engineering and Computer Graphics, Ivano-Frankivsk National Technical University of Oil and Gas, 076019 Ivano-Frankivsk, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Bulbuk","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Ivano-Frankivsk National Medical University, 076000 Ivano-Frankivsk, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bembenek, M. 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