{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:09:55Z","timestamp":1790762995636,"version":"4.1.0"},"reference-count":178,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dana Gas Endowed Chair for Chemical Engineering, American University of Sharjah","award":["FRG20-L-E48"],"award-info":[{"award-number":["FRG20-L-E48"]}]},{"name":"Dana Gas Endowed Chair for Chemical Engineering, American University of Sharjah","award":["eFRG18-BBRCEN-03"],"award-info":[{"award-number":["eFRG18-BBRCEN-03"]}]},{"name":"Dana Gas Endowed Chair for Chemical Engineering, American University of Sharjah","award":["MRG\/18\/2020"],"award-info":[{"award-number":["MRG\/18\/2020"]}]},{"name":"Sheikh Hamdan Award for Medical Sciences","award":["FRG20-L-E48"],"award-info":[{"award-number":["FRG20-L-E48"]}]},{"name":"Sheikh Hamdan Award for Medical Sciences","award":["eFRG18-BBRCEN-03"],"award-info":[{"award-number":["eFRG18-BBRCEN-03"]}]},{"name":"Sheikh Hamdan Award for Medical Sciences","award":["MRG\/18\/2020"],"award-info":[{"award-number":["MRG\/18\/2020"]}]},{"name":"Friends of Cancer Patients (FoCP)","award":["FRG20-L-E48"],"award-info":[{"award-number":["FRG20-L-E48"]}]},{"name":"Friends of Cancer Patients (FoCP)","award":["eFRG18-BBRCEN-03"],"award-info":[{"award-number":["eFRG18-BBRCEN-03"]}]},{"name":"Friends of Cancer Patients (FoCP)","award":["MRG\/18\/2020"],"award-info":[{"award-number":["MRG\/18\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in the suppression of tumor growth. The simultaneous delivery of multiple small-molecule chemotherapeutic drugs and genes improves the effectiveness of each treatment, thus optimizing efficacy and improving synergistic effects. Nanomedicines integrating inorganic, lipid, and polymeric-based nanoparticles have been designed to regulate the spatiotemporal release of the encapsulated drugs. Multidrug-loaded nanocarriers are a potential strategy to fight cancer and the incorporation of co-delivery systems as a feasible treatment method has projected synergistic benefits and limited undesirable effects. Moreover, the development of co-delivery systems for maximum therapeutic impact necessitates better knowledge of the appropriate therapeutic agent ratio as well as the inherent heterogeneity of the cancer cells. Co-delivery systems can simplify clinical processes and increase patient quality of life, even though such systems are more difficult to prepare than single drug delivery systems. This review highlights the progress attained in the development and design of nano carrier-based co-delivery systems and discusses the limitations, challenges, and future perspectives in the design and fabrication of co-delivery systems.<\/jats:p>","DOI":"10.3390\/nano12152672","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T02:07:22Z","timestamp":1659578842000},"page":"2672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3435-6104","authenticated-orcid":false,"given":"Rouba D.","family":"Al Bostami","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-1736","authenticated-orcid":false,"given":"Waad H.","family":"Abuwatfa","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates"},{"name":"Materials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7244-3105","authenticated-orcid":false,"given":"Ghaleb A.","family":"Husseini","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates"},{"name":"Materials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, March 05). The Global Cancer Observatory\u2014United Arab Emirates. Available online: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/784-united-arab-emirates-fact-sheets.pdf."},{"key":"ref_2","unstructured":"UAE Department of Health (2022, April 12). Cancer\u2014Chronic Diseases and Natural Disorders. 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