{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:34:21Z","timestamp":1790966061471,"version":"4.1.0"},"reference-count":95,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vice-Chancellor for Research at Tabriz University of Medical Sciences","award":["68663"],"award-info":[{"award-number":["68663"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Curcumin has multiple properties that are used to cure different diseases such as cancer, infections, inflammatory, arthritic disease, etc. Despite having many effects, the inherent physicochemical properties\u2014such as poor water solubility, chemical instability, low bioavailability, photodegradation, fast metabolism, and short half-life\u2014of curcumin\u2019s derivatives have limited its medical importance. Recently, unprecedented advances in biomedical nanotechnology have led to the development of nanomaterial-based drug delivery systems in the treatment of diseases and diagnostic goals that simultaneously enhance therapeutic outcomes and avoid side effects. Mesoporous silica nanoparticles (MSNs) are promising drug delivery systems for more effective and safer treatment of several diseases, such as infections, cancers, and osteoporosis. Achieving a high drug loading in MSNs is critical to the success of this type of treatment. Their notable inherent properties\u2014such as adjustable size and porosity, high pore volume, large surface area, functionality of versatile surfaces, as well as biocompatibility\u2014have prompted extraordinary research on MSNs as multi-purpose delivery platforms. In this review, we focused on curcumin-loaded silica nanoparticles and their effects on the diagnosis and treatment of infections as well as their use in food packaging.<\/jats:p>","DOI":"10.3390\/nano12162848","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T23:28:41Z","timestamp":1660865321000},"page":"2848","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Curcumin-Loaded Silica Nanoparticles: Applications in Infectious Disease and Food Industry"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4759-7222","authenticated-orcid":false,"given":"Solmaz","family":"Maleki Dizaj","sequence":"first","affiliation":[{"name":"Department of Dental Biomaterials, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"},{"name":"Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3020-3779","authenticated-orcid":false,"given":"Simin","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-5465","authenticated-orcid":false,"given":"Fatemeh","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-6720","authenticated-orcid":false,"given":"Yaseen","family":"Hussain","sequence":"additional","affiliation":[{"name":"Lab of Controlled Release and Drug Delivery System, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleh","family":"Forouhandeh","sequence":"additional","affiliation":[{"name":"Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4544-2254","authenticated-orcid":false,"given":"Seyed Mahdi","family":"Hosseiniyan Khatibi","sequence":"additional","affiliation":[{"name":"Kidney Research Center, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Yousef","family":"Memar","sequence":"additional","affiliation":[{"name":"Kidney Research Center, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Yekani","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran"},{"name":"Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan 8715988141, Iran"},{"name":"Student Research Committee, Kashan University of Medical Sciences, Kashan 8715988141, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6686-7019","authenticated-orcid":false,"given":"Khang Wen","family":"Goh","sequence":"additional","affiliation":[{"name":"Faculty of Data Science and Information Technology, INTI International University, Nilai 78100, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-1383","authenticated-orcid":false,"given":"Long Chiau","family":"Ming","sequence":"additional","affiliation":[{"name":"PAP Rashidah Sa\u2019adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan BE 1410, Brunei"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1039\/c1cs15246g","article-title":"Mesoporous silica nanoparticles in biomedical applications","volume":"41","author":"Li","year":"2012","journal-title":"Chem. 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