{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:28:00Z","timestamp":1780331280105,"version":"3.54.1"},"reference-count":78,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Silver nanoparticles (AgNPs) are increasingly used in various consumer products, leading to their inadvertent release in aquatic ecosystems. The toxicity of AgNPs could be associated with the leaching of ionic Ag but also with the size, shape and surface properties. The purpose of this study was to test the null hypothesis that toxicity of AgNPs was independent of shape in the invertebrate Hydra vulgaris. The hydranths were exposed to increasing concentrations of ionic Ag and AgNPs of three different shapes (spherical, cubic and prismatic) with the same size and coating (polyvinylpyrrolidone). The data revealed that between 68% and 75% of total Ag remained in solution after the 96 h exposure period, while 85\u201390% of ionic Ag remained in solution. The 96 h lethal concentration (LC50) was lower with ionic (4 \u00b5g\/L) and spherical AgNPs (56 \u00b5g\/L), based on irreversible morphological changes such as loss of tentacles and body disintegration. Cubic and prismatic AgNPs were not toxic at a concentration of &lt;100 \u00b5g\/L. The sublethal toxicity was also determined at 96 h based on characteristic morphological changes (clubbed and\/or shortened tentacles) and showed the following toxicity: ionic (2.6 \u00b5g\/L), spherical (22 \u00b5g\/L) and prismatic (32.5 \u00b5g\/L) AgNPs. The nanocube was not toxic at this level. The data indicated that toxicity was shape-dependent where nanoparticles with a low aspect ratio in addition to high circularity and elongation properties were more toxic at both the lethal and sublethal levels. In conclusion, the shape of AgNPs could influence toxicity and warrants further research to better understand the mechanisms of action at play.<\/jats:p>","DOI":"10.3390\/nano12183107","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T01:40:13Z","timestamp":1662601213000},"page":"3107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Shape-Dependent Toxicity of Silver Nanoparticles on Freshwater Cnidarians"],"prefix":"10.3390","volume":"12","author":[{"given":"Joelle","family":"Auclair","sequence":"first","affiliation":[{"name":"Aquatic Contaminants Research Division, Environment and Climate Change Canada, 105 McGill, Montreal, QC H2Y 2E7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-5967","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Gagn\u00e9","sequence":"additional","affiliation":[{"name":"Aquatic Contaminants Research Division, Environment and Climate Change Canada, 105 McGill, Montreal, QC H2Y 2E7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"498420","DOI":"10.1155\/2014\/498420","article-title":"Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations","volume":"2014","author":"Gatoo","year":"2014","journal-title":"Biomed Res. 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