{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:10:01Z","timestamp":1784617801037,"version":"3.55.0"},"reference-count":158,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology (FCT)","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}]},{"name":"Foundation for Science and Technology (FCT)","award":["CENTRO-01-0145-FEDER-028989"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-028989"]}]},{"name":"Foundation for Science and Technology (FCT)","award":["POCI-01-0145-FEDER-031462"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031462"]}]},{"name":"European Regional Development Fund (ERDF)","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}]},{"name":"European Regional Development Fund (ERDF)","award":["CENTRO-01-0145-FEDER-028989"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-028989"]}]},{"name":"European Regional Development Fund (ERDF)","award":["POCI-01-0145-FEDER-031462"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031462"]}]},{"DOI":"10.13039\/501100001871","name":"Regional Operational Program of the Center (Centro2020)","doi-asserted-by":"publisher","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Regional Operational Program of the Center (Centro2020)","doi-asserted-by":"publisher","award":["CENTRO-01-0145-FEDER-028989"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-028989"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Regional Operational Program of the Center (Centro2020)","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-031462"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031462"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Metallic-based nanoparticles present a unique set of physicochemical properties that support their application in different fields, such as electronics, medical diagnostics, and therapeutics. Particularly, in cancer therapy, the plasmonic resonance, magnetic behavior, X-ray attenuation, and radical oxygen species generation capacity displayed by metallic nanoparticles make them highly promising theragnostic solutions. Nevertheless, metallic-based nanoparticles are often associated with some toxicological issues, lack of colloidal stability, and establishment of off-target interactions. Therefore, researchers have been exploiting the combination of metallic nanoparticles with other materials, inorganic (e.g., silica) and\/or organic (e.g., polymers). In terms of biological performance, metal-polymer conjugation can be advantageous for improving biocompatibility, colloidal stability, and tumor specificity. In this review, the application of metallic-polymer nanoconjugates\/nanohybrids as a multifunctional all-in-one solution for cancer therapy will be summarized, focusing on the physicochemical properties that make metallic nanomaterials capable of acting as imaging and\/or therapeutic agents. Then, an overview of the main advantages of metal-polymer conjugation as well as the most common structural arrangements will be provided. Moreover, the application of metallic-polymer nanoconjugates\/nanohybrids made of gold, iron, copper, and other metals in cancer therapy will be discussed, in addition to an outlook of the current solution in clinical trials.<\/jats:p>","DOI":"10.3390\/nano12183166","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T04:05:41Z","timestamp":1663041941000},"page":"3166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Metal-Polymer Nanoconjugates Application in Cancer Imaging and Therapy"],"prefix":"10.3390","volume":"12","author":[{"given":"Andr\u00e9 Q.","family":"Figueiredo","sequence":"first","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina F.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7737-9288","authenticated-orcid":false,"given":"Natanael","family":"Fernandes","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duarte","family":"de Melo-Diogo","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1613-9675","authenticated-orcid":false,"given":"Il\u00eddio J.","family":"Correia","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0604-2506","authenticated-orcid":false,"given":"Andr\u00e9 F.","family":"Moreira","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"CPIRN-UDI\/IPG\u2014Centro de Potencial e Inova\u00e7\u00e3o em Recursos Naturais, Unidade de Investiga\u00e7\u00e3o para o Desenvolvimento do Interior do Instituto Polit\u00e9cnico da Guarda, Avenida Dr. Francisco de S\u00e1 Carneiro, No. 50, 6300-559 Guarda, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/jcp.29126","article-title":"Nanoparticles and cancer therapy: Perspectives for application of nanoparticles in the treatment of cancers","volume":"235","author":"Dolati","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.actbio.2020.09.008","article-title":"Strategies to improve the photothermal capacity of gold-based nanomedicines","volume":"116","author":"Goncalves","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104742","DOI":"10.1016\/j.phrs.2020.104742","article-title":"Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery","volume":"155","author":"Guimaraes","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1021\/acsnano.9b08460","article-title":"Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2\/3 Signaling","volume":"14","author":"Huang","year":"2020","journal-title":"ACS Nano"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rodrigues, C.F., Alves, C.G., Lima-Sousa, R., Moreira, A.F., de Melo-Diogo, D., and Correia, I.J. (2020). Inorganic-based drug delivery systems for cancer therapy. Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents, Academic Press.","DOI":"10.1016\/B978-0-12-819666-3.00010-9"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1021\/acsnano.9b08320","article-title":"Graphene Oxide-Grafted Magnetic Nanorings Mediated Magnetothermodynamic Therapy Favoring Reactive Oxygen Species-Related Immune Response for Enhanced Antitumor Efficacy","volume":"14","author":"Liu","year":"2020","journal-title":"ACS Nano"},{"key":"ref_7","first-page":"409","article-title":"Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy","volume":"8","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1039\/C5BM00277J","article-title":"Utilising inorganic nanocarriers for gene delivery","volume":"4","author":"Loh","year":"2016","journal-title":"Biomater. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive oxygen species in cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1002\/anie.200903801","article-title":"Semiconductor gas sensors: Dry synthesis and application","volume":"49","author":"Tricoli","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Huynh, K.H., Pham, X.H., Kim, J., Lee, S.H., Chang, H., Rho, W.Y., and Jun, B.H. (2020). Synthesis, Properties, and Biological Applications of Metallic Alloy Nanoparticles. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145174"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1039\/b900654k","article-title":"Laser ablation synthesis in solution and size manipulation of noble metal nanoparticles","volume":"11","author":"Amendola","year":"2009","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"134184","DOI":"10.1016\/j.chemosphere.2022.134184","article-title":"Synthesis of various dimensional metal organic frameworks (MOFs) and their hybrid composites for emerging applications\u2014A review","volume":"298","author":"Annamalai","year":"2022","journal-title":"Chemosphere"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1021\/acs.accounts.6b00377","article-title":"Surface Functionalization of Metal Nanoparticles by Conjugated Metal-Ligand Interfacial Bonds: Impacts on Intraparticle Charge Transfer","volume":"49","author":"Hu","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1080\/17425247.2021.1912008","article-title":"Metallic nanoparticles as drug delivery system for the treatment of cancer","volume":"18","author":"Neha","year":"2021","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1080\/10717544.2022.2039804","article-title":"Metal nanoparticles as a promising technology in targeted cancer treatment","volume":"29","author":"Xu","year":"2022","journal-title":"Drug Deliv."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1208\/s12248-015-9780-2","article-title":"A Review of Clinical Translation of Inorganic Nanoparticles","volume":"17","author":"Anselmo","year":"2015","journal-title":"AAPS J."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Canaparo, R., Foglietta, F., Limongi, T., and Serpe, L. (2020). Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles. Materials, 14.","DOI":"10.3390\/ma14010053"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1021\/acs.accounts.6b00041","article-title":"Reshaping, Fragmentation, and Assembly of Gold Nanoparticles Assisted by Pulse Lasers","volume":"49","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Bhatia, S. (2016). Natural Polymers vs Synthetic Polymer. Natural Polymer Drug Delivery Systems, Springer.","DOI":"10.1007\/978-3-319-41129-3"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"128599","DOI":"10.1016\/j.molstruc.2020.128599","article-title":"Metallic nanoparticles as X-ray computed tomography (CT) contrast agents: A review","volume":"1219","author":"Aslan","year":"2020","journal-title":"J. Mol. Struct."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1021\/ar300150c","article-title":"Nanoparticulate X-ray computed tomography contrast agents: From design validation to in vivo applications","volume":"45","author":"Liu","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biomaterials.2016.06.015","article-title":"Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging","volume":"102","author":"Cheheltani","year":"2016","journal-title":"Biomaterials"},{"key":"ref_24","first-page":"1250360","article-title":"Comparison of Rhenium and Iodine as Contrast Agents in X-ray Imaging","volume":"2021","author":"Esquinas","year":"2021","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.1021\/acs.inorgchem.7b00359","article-title":"Hafnium-Based Contrast Agents for X-ray Computed Tomography","volume":"56","author":"Berger","year":"2017","journal-title":"Inorg. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1076-6332(03)00536-1","article-title":"Gadolinium-enhanced computed tomography angiography in multi-detector row computed tomography","volume":"11","author":"Bae","year":"2004","journal-title":"Acad. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1109\/JSTQE.2013.2284549","article-title":"Manipulation and Optical Detection of Colloidal Functional Plasmonic Nanostructures in Microfluidic Systems","volume":"20","author":"Werts","year":"2014","journal-title":"IEEE J. Sel. Top. Quantum Electron."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2005400","DOI":"10.1002\/adfm.202005400","article-title":"Optical Properties and Applications of Plasmonic-Metal Nanoparticles","volume":"30","author":"Wang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1021\/jp066539m","article-title":"Surface Plasmons on Metal Nanoparticles:\u2009 The Influence of Shape and Physical Environment","volume":"111","author":"Noguez","year":"2007","journal-title":"J. Phys. Chem. C"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/la0513353","article-title":"Tailoring Surface Plasmons through the Morphology and Assembly of Metal Nanoparticles","volume":"22","year":"2006","journal-title":"Langmuir"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1515\/nanoph-2019-0039","article-title":"Plasmon-enhanced solar vapor generation","volume":"8","author":"Liang","year":"2019","journal-title":"Nanophotonics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bios.2018.04.007","article-title":"Metal enhanced fluorescence (MEF) for biosensors: General approaches and a review of recent developments","volume":"111","author":"Jeong","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"738630","DOI":"10.3389\/fphar.2021.738630","article-title":"Upper-Critical-Solution-Temperature Polymer Modified Gold Nanorods for Laser Controlled Drug Release and Enhanced Anti-Tumour Therapy","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Pharm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1700073","DOI":"10.1002\/adhm.201700073","article-title":"Strategies to Improve Cancer Photothermal Therapy Mediated by Nanomaterials","volume":"6","author":"Dias","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bettaieb, A., Wrzal, K.P., and Averill-Bates, D.A. (2013). Hyperthermia: Cancer Treatment and Beyond. Cancer Treat. Conv. Innov. Approaches, 257\u2013283.","DOI":"10.5772\/55795"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8720","DOI":"10.1038\/s41598-018-26978-1","article-title":"Temperature-dependent cell death patterns induced by functionalized gold nanoparticle photothermal therapy in melanoma cells","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1039\/D0BM00222D","article-title":"Overview of the application of inorganic nanomaterials in cancer photothermal therapy","volume":"8","author":"Fernandes","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10900","DOI":"10.1039\/C9SC04389F","article-title":"Raman observation of a molecular signaling pathway of apoptotic cells induced by photothermal therapy","volume":"10","author":"Xing","year":"2019","journal-title":"Chem. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ajps.2021.10.001","article-title":"Nanomedicine potentiates mild photothermal therapy for tumor ablation","volume":"16","author":"Jiang","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jmmm.2018.10.016","article-title":"Magnetic properties of transition metal nanoparticles enclosed in carbon nanocages","volume":"472","author":"Rudakov","year":"2019","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8267","DOI":"10.1021\/acs.langmuir.5b01458","article-title":"Toward Accumulation of Magnetic Nanoparticles into Tissues of Small Porosity","volume":"31","author":"Soheilian","year":"2015","journal-title":"Langmuir"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"16581","DOI":"10.1021\/acsami.6b16513","article-title":"External Magnetic Field-Enhanced Chemo-Photothermal Combination Tumor Therapy via Iron Oxide Nanoparticles","volume":"9","author":"Guo","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e1901058","DOI":"10.1002\/adhm.201901058","article-title":"Magnetic Nanoparticles in Cancer Therapy and Diagnosis","volume":"9","author":"Farzin","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s10311-020-01033-6","article-title":"Toxicity of metal and metal oxide nanoparticles: A review","volume":"18","author":"Sengul","year":"2020","journal-title":"Environ. Chem. Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jfda.2014.01.007","article-title":"Reactive oxygen species-related activities of nano-iron metal and nano-iron oxides","volume":"22","author":"Wu","year":"2014","journal-title":"J. Food Drug Anal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1701392","DOI":"10.1002\/adhm.201701392","article-title":"Metal Nanoparticles for Diagnosis and Therapy of Bacterial Infection","volume":"7","author":"Yuan","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12094-008-0172-2","article-title":"Photodynamic therapy of cancer. Basic principles and applications","volume":"10","author":"Juarranz","year":"2008","journal-title":"Clin. Transl. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"743109","DOI":"10.1155\/2002\/743109","article-title":"Photodynamic Therapy for Cancer: Principles","volume":"16","author":"Wilson","year":"2002","journal-title":"Can. J. Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"70787","DOI":"10.1039\/C5RA14100A","article-title":"Does surface coating of metallic nanoparticles modulate their interference with in vitro assays?","volume":"5","author":"Lovric","year":"2015","journal-title":"RSC Adv."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"111475","DOI":"10.1016\/j.colsurfb.2020.111475","article-title":"Toxicological evaluation of biosynthesised hematite nanoparticles in vivo","volume":"198","author":"Rajendran","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1039\/C7NR08322J","article-title":"In vivo formation of protein corona on gold nanoparticles. The effect of their size and shape","volume":"10","author":"Hadjidemetriou","year":"2018","journal-title":"Nanoscale"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1038\/s41598-020-80529-1","article-title":"An effective strategy for development of docetaxel encapsulated gold nanoformulations for treatment of prostate cancer","volume":"11","author":"Thambiraj","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"121960","DOI":"10.1016\/j.talanta.2020.121960","article-title":"Folic acid functionalized gold nanoclusters for enabling targeted fluorescence imaging of human ovarian cancer cells","volume":"225","author":"Hada","year":"2021","journal-title":"Talanta"},{"key":"ref_54","first-page":"35","article-title":"Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor","volume":"8","author":"Kim","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jcis.2020.08.059","article-title":"Combined chemo-photothermal treatment of three-dimensional head and neck squamous cell carcinomas by gold nano-architectures","volume":"582","author":"Mapanao","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"266","DOI":"10.7150\/ntno.36842","article-title":"Polydopamine-coated gold nanostar for combined antitumor and antiangiogenic therapy in multidrug-resistant breast cancer","volume":"3","author":"You","year":"2019","journal-title":"Nanotheranostics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.biomaterials.2008.12.070","article-title":"Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan","volume":"30","author":"Sheng","year":"2009","journal-title":"Biomaterials"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1002\/anie.201710068","article-title":"Mitigation of Inflammatory Immune Responses with Hydrophilic Nanoparticles","volume":"57","author":"Li","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1039\/C4PY01356E","article-title":"Antibiofouling polymer interfaces: Poly(ethylene glycol) and other promising candidates","volume":"6","author":"Lowe","year":"2015","journal-title":"Polym. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.ijbiomac.2022.03.105","article-title":"Dynamic process, mechanisms, influencing factors and study methods of protein corona formation","volume":"205","author":"Yu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1116\/1.2187495","article-title":"Protein resistant surfaces: Comparison of acrylate graft polymers bearing oligo-ethylene oxide and phosphorylcholine side chains","volume":"1","author":"Feng","year":"2006","journal-title":"Biointerphases"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.actbio.2016.03.038","article-title":"Zwitterionic materials for antifouling membrane surface construction","volume":"40","author":"He","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"403001","DOI":"10.1088\/1361-6463\/ab2cbc","article-title":"Fundamentals and applications of zwitterionic antifouling polymers","volume":"52","author":"Zhang","year":"2019","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/adhm.201300617","article-title":"Mixed-Charge Nanoparticles for Long Circulation, Low Reticuloendothelial System Clearance, and High Tumor Accumulation","volume":"3","author":"Liu","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.actbio.2019.01.026","article-title":"Enzyme-responsive multifunctional peptide coating of gold nanorods improves tumor targeting and photothermal therapy efficacy","volume":"86","author":"Wu","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12951-021-00883-8","article-title":"Hierarchical drug release designed Au @PDA-PEG-MTX NPs for targeted delivery to breast cancer with combined photothermal-chemotherapy","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"117907","DOI":"10.1016\/j.carbpol.2021.117907","article-title":"pH-controlled nucleolin targeted release of dual drug from chitosan-gold based aptamer functionalized nano drug delivery system for improved glioblastoma treatment","volume":"262","author":"Sathiyaseelan","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"119327","DOI":"10.1016\/j.biomaterials.2019.119327","article-title":"Time-staggered delivery of erlotinib and doxorubicin by gold nanocages with two smart polymers for reprogrammable release and synergistic with photothermal therapy","volume":"217","author":"Feng","year":"2019","journal-title":"Biomaterials"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"599740","DOI":"10.3389\/fchem.2020.599740","article-title":"Design of DOX-GNRs-PNIPAM@PEG-PLA Micelle With Temperature and Light Dual-Function for Potent Melanoma Therapy","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2000605","DOI":"10.1002\/adhm.202000605","article-title":"Redox-Responsive Self-Assembled Nanoparticles for Cancer Therapy","volume":"9","author":"Li","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.7150\/thno.49577","article-title":"The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy","volume":"10","author":"Shi","year":"2020","journal-title":"Theranostics"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.addr.2010.10.008","article-title":"PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect","volume":"63","author":"Acharya","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"355101","DOI":"10.1088\/1361-6528\/ab9395","article-title":"Folic acid-modified methotrexate-conjugated gold nanoparticles as nano-sized trojans for drug delivery to folate receptor-positive cancer cells","volume":"31","author":"Yucel","year":"2020","journal-title":"Nanotechnology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1021\/acsnano.0c10276","article-title":"Tumor-Selective Immune-Active Mild Hyperthermia Associated with Chemotherapy in Colon Peritoneal Metastasis by Photoactivation of Fluorouracil-Gold Nanoparticle Complexes","volume":"15","author":"Pinto","year":"2021","journal-title":"ACS Nano"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.2147\/IJN.S140772","article-title":"Gold nanoparticles enlighten the future of cancer theranostics","volume":"12","author":"Guo","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2217\/nnm.14.171","article-title":"Gold nanoparticles as contrast agents in x-ray imaging and computed tomography","volume":"10","author":"Cole","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"12515","DOI":"10.1039\/c2ra21263c","article-title":"Gold nanoparticles as computerized tomography (CT) contrast agents","volume":"2","author":"Xi","year":"2012","journal-title":"RSC Adv."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cis.2017.01.007","article-title":"Polymer decorated gold nanoparticles in nanomedicine conjugates","volume":"249","author":"Capek","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1039\/C4RA11051J","article-title":"Gold nanoparticle-doped silk film as biocompatible SERS substrate","volume":"5","author":"Guo","year":"2015","journal-title":"RSC Adv."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Fernandes, N., Rodrigues, C.F., de Melo-Diogo, D., Correia, I.J., and Moreira, A.F. (2021). Optimization of the GSH-Mediated Formation of Mesoporous Silica-Coated Gold Nanoclusters for NIR Light-Triggered Photothermal Applications. Nanomaterials, 11.","DOI":"10.3390\/nano11081946"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Fernandes, J., and Kang, S. (2021). Numerical Study on the Surface Plasmon Resonance Tunability of Spherical and Non-Spherical Core-Shell Dimer Nanostructures. Nanomaterials, 11.","DOI":"10.3390\/nano11071728"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0925-4005(02)00243-5","article-title":"Modeling the optical response of nanoparticle-based surface plasmon resonance sensors","volume":"87","author":"Xu","year":"2002","journal-title":"Sens. Actuators B Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"267405","DOI":"10.1103\/PhysRevLett.95.267405","article-title":"Surface plasmon characteristics of tunable photoluminescence in single gold nanorods","volume":"95","author":"Bouhelier","year":"2005","journal-title":"Phys. Rev. Lett"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1039\/C5NR07831H","article-title":"Tumor cell-specific photothermal killing by SELEX-derived DNA aptamer-targeted gold nanorods","volume":"8","author":"Chandrasekaran","year":"2016","journal-title":"Nanoscale"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"659043","DOI":"10.5402\/2012\/659043","article-title":"Synthesis and Characterization of Gold Nanoparticles with Plasmon Absorbance Wavelength Tunable from Visible to Near Infrared Region","volume":"2012","author":"Shi","year":"2012","journal-title":"ISRN Nanomater."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"110778","DOI":"10.1016\/j.colsurfb.2020.110778","article-title":"Hyaluronic acid and vitamin E polyethylene glycol succinate functionalized gold-core silica shell nanorods for cancer targeted photothermal therapy","volume":"188","author":"Jacinto","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.2217\/nnm-2021-0270","article-title":"HA\/PEI-coated acridine orange-loaded gold-core silica shell nanorods for cancer-targeted photothermal and chemotherapy","volume":"16","author":"Fernandes","year":"2021","journal-title":"Nanomedicine"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1021\/acsnano.1c05452","article-title":"Retinoic Acid-Loaded Dendritic Polyglycerol-Conjugated Gold Nanostars for Targeted Photothermal Therapy in Breast Cancer Stem Cells","volume":"15","author":"Pan","year":"2021","journal-title":"ACS Nano"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"102192","DOI":"10.1016\/j.nano.2020.102192","article-title":"CD133 antibody targeted delivery of gold nanostars loading IR820 and docetaxel for multimodal imaging and near-infrared photodynamic\/photothermal\/chemotherapy against castration resistant prostate cancer","volume":"27","author":"Tan","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"120162","DOI":"10.1016\/j.ijpharm.2020.120162","article-title":"Microwave-triggered\/HSP-targeted gold nano-system for triple-negative breast cancer photothermal therapy","volume":"593","author":"Cheng","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.biomaterials.2011.10.052","article-title":"PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography","volume":"33","author":"Peng","year":"2012","journal-title":"Biomaterials"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1039\/C5TB01619C","article-title":"Hybrid polymeric nano-capsules loaded with gold nanoclusters and indocyanine green for dual-modal imaging and photothermal therapy","volume":"4","author":"Gu","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Alkhayal, A., Fathima, A., Alhasan, A.H., and Alsharaeh, E.H. (2021). PEG Coated Fe3O4\/RGO Nano-Cube-Like Structures for Cancer Therapy via Magnetic Hyperthermia. Nanomaterials, 11.","DOI":"10.3390\/nano11092398"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s12033-017-0053-4","article-title":"Plant-Mediated Synthesis and Applications of Iron Nanoparticles","volume":"60","author":"Ebrahiminezhad","year":"2018","journal-title":"Mol. Biotechnol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.actbio.2019.11.027","article-title":"Targeting strategies for superparamagnetic iron oxide nanoparticles in cancer therapy","volume":"102","author":"Zhi","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"9490","DOI":"10.1039\/C9DT00459A","article-title":"Superparamagnetic iron oxide nanoparticulate system: Synthesis, targeting, drug delivery and therapy in cancer","volume":"48","author":"Palanisamy","year":"2019","journal-title":"Dalton Trans."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Habra, K., McArdle, S.E.B., Morris, R.H., and Cave, G.W.V. (2021). Synthesis and Functionalisation of Superparamagnetic Nano-Rods towards the Treatment of Glioblastoma Brain Tumours. Nanomaterials, 11.","DOI":"10.3390\/nano11092157"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/17425247.2019.1554647","article-title":"Magnetic iron oxide nanoparticles for drug delivery: Applications and characteristics","volume":"16","author":"Vangijzegem","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e1571","DOI":"10.1002\/wnan.1571","article-title":"Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting","volume":"11","author":"Liu","year":"2019","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jmmm.2015.03.085","article-title":"Impact of magnetic field parameters and iron oxide nanoparticle properties on heat generation for use in magnetic hyperthermia","volume":"387","author":"Shah","year":"2015","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/nano5010063","article-title":"Magnetic Properties of Magnetic Nanoparticles for Efficient Hyperthermia","volume":"5","author":"Obaidat","year":"2015","journal-title":"Nanomaterials"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/asiamat.2010.6","article-title":"The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications","volume":"2","author":"Boyer","year":"2010","journal-title":"NPG Asia Mater."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1021\/acs.nanolett.0c04967","article-title":"Glutathione-Responsive Magnetic Nanoparticles for Highly Sensitive Diagnosis of Liver Metastases","volume":"21","author":"Xu","year":"2021","journal-title":"Nano Lett."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"35376","DOI":"10.1021\/acsami.1c08339","article-title":"NIR-Triggered Blasting Nanovesicles for Targeted Multimodal Image-Guided Synergistic Cancer Photothermal and Chemotherapy","volume":"13","author":"Xiao","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.actbio.2019.07.017","article-title":"Magnetic targeting combined with active targeting of dual-ligand iron oxide nanoprobes to promote the penetration depth in tumors for effective magnetic resonance imaging and hyperthermia","volume":"96","author":"Chen","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jconrel.2020.03.036","article-title":"A multifunctional magnetic nanosystem based on \u201ctwo strikes\u201d effect for synergistic anticancer therapy in triple-negative breast cancer","volume":"322","author":"Zhang","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"10007","DOI":"10.2147\/IJN.S271213","article-title":"Her2-Targeted Multifunctional Nano-Theranostic Platform Mediates Tumor Microenvironment Remodeling and Immune Activation for Breast Cancer Treatment","volume":"15","author":"Zheng","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"5927","DOI":"10.2147\/IJN.S254108","article-title":"Iron(II) phthalocyanine Loaded and AS1411 Aptamer Targeting Nanoparticles: A Nanocomplex for Dual Modal Imaging and Photothermal Therapy of Breast Cancer","volume":"15","author":"He","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1039\/D1TB00991E","article-title":"Redox-responsive magnetic nanovectors self-assembled from amphiphilic polymer and iron oxide nanoparticles for a remotely targeted delivery of paclitaxel","volume":"9","author":"Ding","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Lin, C.H., Chen, Y.C., and Huang, P.I. (2020). Preparation of Multifunctional Dopamine-Coated Zerovalent Iron\/Reduced Graphene Oxide for Targeted Phototheragnosis in Breast Cancer. Nanomaterials, 10.","DOI":"10.3390\/nano10101957"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1039\/D0TB00182A","article-title":"Synthesis, modification and bioapplications of nanoscale copper chalcogenides","volume":"8","author":"Yun","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1021\/acs.bioconjchem.6b00156","article-title":"Copper-Based Nanomaterials for Cancer Imaging and Therapy","volume":"27","author":"Zhou","year":"2016","journal-title":"Bioconjugate Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s10529-013-1239-x","article-title":"Biogenic nanoparticles: Copper, copper oxides, copper sulphides, complex copper nanostructures and their applications","volume":"35","author":"Rubilar","year":"2013","journal-title":"Biotechnol. Lett."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jcis.2020.12.028","article-title":"Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy","volume":"587","author":"Tian","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1021\/nn506687t","article-title":"Plasmonic Copper Sulfide Nanocrystals Exhibiting Near-Infrared Photothermal and Photodynamic Therapeutic Effects","volume":"9","author":"Wang","year":"2015","journal-title":"ACS Nano"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1002\/anie.201603777","article-title":"Which Metals are Green for Catalysis? Comparison of the Toxicities of Ni, Cu, Fe, Pd, Pt, Rh, and Au Salts","volume":"55","author":"Egorova","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cbi.2010.06.013","article-title":"Mechanisms underlying iron and copper ions toxicity in biological systems: Pro-oxidant activity and protein-binding effects","volume":"188","author":"Letelier","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.1021\/ja401428e","article-title":"CuTe Nanocrystals: Shape and Size Control, Plasmonic Properties, and Use as SERS Probes and Photothermal Agents","volume":"135","author":"Li","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pdpdt.2017.04.001","article-title":"CuS nanoagents for photodynamic and photothermal therapies: Phenomena and possible mechanisms","volume":"19","author":"Li","year":"2017","journal-title":"Photodiagn. Photodyn."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.actbio.2018.03.035","article-title":"Tumor-targeting CuS nanoparticles for multimodal imaging and guided photothermal therapy of lymph node metastasis","volume":"72","author":"Shi","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"9613","DOI":"10.1021\/acsnano.0c00082","article-title":"All-in-One Theranostic Nanomedicine with Ultrabright Second Near-Infrared Emission for Tumor-Modulated Bioimaging and Chemodynamic\/Photodynamic Therapy","volume":"14","author":"Xu","year":"2020","journal-title":"ACS Nano"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1021\/acs.nanolett.9b01595","article-title":"Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy","volume":"19","author":"Liang","year":"2019","journal-title":"Nano Lett."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"102042","DOI":"10.1016\/j.nano.2019.102042","article-title":"Multifaceted NIR-responsive polymer-peptide-enveloped drug-loaded copper sulfide nanoplatform for chemo-phototherapy against highly tumorigenic prostate cancer","volume":"21","author":"Poudel","year":"2019","journal-title":"Nanomedicine"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/14686996.2021.1883406","article-title":"Laser-induced thermal response and controlled release of copper oxide nanoparticles from multifunctional polymeric nanocarriers","volume":"22","author":"Maor","year":"2021","journal-title":"Sci. Technol. Adv. Mater."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"117846","DOI":"10.1016\/j.carbpol.2021.117846","article-title":"Hyaluronic acid\/polyethyleneimine nanoparticles loaded with copper ion and disulfiram for esophageal cancer","volume":"261","author":"Xu","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1039\/D0NR06866G","article-title":"Using copper sulfide nanoparticles as cross-linkers of tumor microenvironment responsive polymer micelles for cancer synergistic photo-chemotherapy","volume":"13","author":"Wu","year":"2021","journal-title":"Nanoscale"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"43925","DOI":"10.1021\/acsami.1c10341","article-title":"H2O2 Self-Supplying and GSH-Depleting Nanoplatform for Chemodynamic Therapy Synergetic Photothermal\/Chemotherapy","volume":"13","author":"Xiao","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1900848","DOI":"10.1002\/advs.201900848","article-title":"Monodispersed Copper(I)-Based Nano Metal-Organic Framework as a Biodegradable Drug Carrier with Enhanced Photodynamic Therapy Efficacy","volume":"6","author":"Cai","year":"2019","journal-title":"Adv. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.colsurfb.2019.06.031","article-title":"The NIR inspired nano-CuSMn(II) composites for lactate and glycolysis attenuation","volume":"181","author":"Fang","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1002\/chem.200900204","article-title":"One-Pot Template-Free Synthesis of Monodisperse Zinc Sulfide Hollow Spheres and Their Photocatalytic Properties","volume":"15","author":"Yu","year":"2009","journal-title":"Chem. A Eur. J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1166\/jnn.2013.7177","article-title":"Phototoxicity of Zinc Oxide Nanoparticles in HaCaT Keratinocytes-Generation of Oxidative DNA Damage During UVA and Visible Light Irradiation","volume":"13","author":"Wang","year":"2013","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_132","first-page":"845","article-title":"Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species","volume":"7","author":"Akhtar","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Song, T., Qu, Y., Ren, Z., Yu, S., Sun, M., Yu, X., and Yu, X. (2021). Synthesis and Characterization of Polyvinylpyrrolidone-Modified ZnO Quantum Dots and Their In Vitro Photodynamic Tumor Suppressive Action. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158106"},{"key":"ref_134","first-page":"1","article-title":"Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions","volume":"18","author":"Riddell","year":"2018","journal-title":"Met. Ions Life Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2217\/nnm.09.85","article-title":"DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles","volume":"5","author":"Asharani","year":"2009","journal-title":"Nanomedicine"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1039\/D0CC07355E","article-title":"Pt@polydopamine nanoparticles as nanozymes for enhanced photodynamic and photothermal therapy","volume":"57","author":"Cao","year":"2021","journal-title":"Chem. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1039\/C7CS00152E","article-title":"Platinum nanoparticles in nanobiomedicine","volume":"46","author":"Pedone","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"120202","DOI":"10.1016\/j.biomaterials.2020.120202","article-title":"Porous Pt nanoparticles loaded with doxorubicin to enable synergistic Chemo-\/Electrodynamic Therapy","volume":"255","author":"Chen","year":"2020","journal-title":"Biomaterials"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1166\/jbn.2017.2446","article-title":"Hyaluronic Acid-Encapsulated Platinum Nanoparticles for Targeted Photothermal Therapy of Breast Cancer","volume":"13","author":"Zhu","year":"2017","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Zhang, X.F., Liu, Z.G., Shen, W., and Gurunathan, S. (2016). Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17091534"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jat.2792","article-title":"Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues","volume":"33","author":"Kim","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Holmila, R.J., Vance, S.A., King, S.B., Tsang, A.W., Singh, R., and Furdui, C.M. (2019). Silver Nanoparticles Induce Mitochondrial Protein Oxidation in Lung Cells Impacting Cell Cycle and Proliferation. Antioxidants, 8.","DOI":"10.3390\/antiox8110552"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.2147\/IJN.S255874","article-title":"ICG-Loaded PEGylated BSA-Silver Nanoparticles for Effective Photothermal Cancer Therapy","volume":"15","author":"Park","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"14831","DOI":"10.1021\/acsnano.0c03781","article-title":"Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy","volume":"14","author":"Zhang","year":"2020","journal-title":"ACS Nano"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1039\/C9NR10918H","article-title":"Facile synthesis of noncytotoxic PEGylated dendrimer encapsulated silver sulfide quantum dots for NIR-II biological imaging","volume":"12","author":"Awasthi","year":"2020","journal-title":"Nanoscale"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1021\/acs.bioconjchem.0c00224","article-title":"Hyaluronic Acid-Modified Au\u2013Ag Alloy Nanoparticles for Radiation\/Nanozyme\/Ag+ Multimodal Synergistically Enhanced Cancer Therapy","volume":"31","author":"Chong","year":"2020","journal-title":"Bioconjugate Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12951-018-0367-9","article-title":"A multifunctional targeting probe with dual-mode imaging and photothermal therapy used in vivo","volume":"16","author":"Zhang","year":"2018","journal-title":"J. Nanobiotechnology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.actbio.2020.04.041","article-title":"Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo\/gene\/photothermal therapy","volume":"110","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"29536","DOI":"10.1021\/acsami.9b08948","article-title":"High-Performance Worm-like Mn-Zn Ferrite Theranostic Nanoagents and the Application on Tumor Theranostics","volume":"11","author":"Sun","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jphotobiol.2019.02.007","article-title":"Facile development of biodegradable polymer-based nanotheranostics: Hydrophobic photosensitizers delivery, fluorescence imaging and photodynamic therapy","volume":"193","author":"Thakur","year":"2019","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e10246","DOI":"10.1002\/btm2.10246","article-title":"Nanoparticles in the clinic: An update post COVID-19 vaccines","volume":"6","author":"Anselmo","year":"2021","journal-title":"Bioeng. Transl. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2018.06.008","article-title":"Pharmacokinetics variability: Why nanoparticles are not just magic-bullets in oncology","volume":"129","author":"Rodallec","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrc.2016.108","article-title":"Cancer nanomedicine: Progress, challenges and opportunities","volume":"17","author":"Shi","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"18590","DOI":"10.1073\/pnas.1906929116","article-title":"Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study","volume":"116","author":"Rastinehad","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.2174\/0929867325666171229141156","article-title":"Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic","volume":"25","author":"Bayda","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"eabb3945","DOI":"10.1126\/scitranslmed.abb3945","article-title":"A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma","volume":"13","author":"Kumthekar","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1200\/JCO.2019.37.15_suppl.3012","article-title":"A phase 0 first-in-human study using NU-0129: A gold base spherical nucleic acid (SNA) nanoconjugate targeting BCL2L12 in recurrent glioblastoma patients","volume":"37","author":"Kumthekar","year":"2019","journal-title":"J. Clin. Oncol."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/12\/18\/3166\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:30:06Z","timestamp":1760142606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/12\/18\/3166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":158,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["nano12183166"],"URL":"https:\/\/doi.org\/10.3390\/nano12183166","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]}}}