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In this paper, the cause and internal mechanism of Fano resonance are investigated by the finite element method (FEM), and the transport characteristics are optimized by changing various parameters of the structure. The results show that the structure can achieve double Fano resonance. Due to the destructive disturbance between the wideband mode of the inverted rectangle on the bus waveguide and the narrowband mode of the SRRDR, the output spectrum of the system shows an obvious asymmetric Fano diagram, and the structural parameters of the sensor have a great influence on the Fano resonance. By changing the sensitive parameters, the optimal sensitivity of the refractive index nanosensor is 2280 nm\/RIU, and the coefficient of excellence (FOM) is 76.7. In addition, the proposed high-sensitivity nanosensor will be used to detect hemoglobin concentration in blood, which has positive applications for biosensors and has great potential for future nanosensing and optical integration systems.<\/jats:p>","DOI":"10.3390\/nano12213784","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T22:36:17Z","timestamp":1666910177000},"page":"3784","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Nano Refractive Index Sensing Structure for Monitoring Hemoglobin Concentration in Human Body"],"prefix":"10.3390","volume":"12","author":[{"given":"Guoquan","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Electrical and Control Engineering, North University of China, Taiyuan 030051, China"},{"name":"School of Electrical Engineering, Zhejiang University of Water Resources and Electric Power, Hangzhou 310018, 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Electrical and Control Engineering, North University of China, Taiyuan 030051, China"},{"name":"School of Electrical Engineering, Zhejiang University of Water Resources and Electric Power, Hangzhou 310018, China"},{"name":"Joint Laboratory of Intelligent Equipment and System for Water Conservancy and Hydropower Safety Monitoring of Zhejiang Province and Belarus, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering, Zhejiang University of Water Resources and Electric Power, Hangzhou 310018, China"},{"name":"Joint Laboratory of Intelligent Equipment and System for Water Conservancy and Hydropower Safety Monitoring of Zhejiang Province and Belarus, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-4218","authenticated-orcid":false,"given":"Pengwei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Electrical and Control Engineering, North University of China, Taiyuan 030051, China"},{"name":"School of Electrical Engineering, Zhejiang University of Water Resources and Electric Power, Hangzhou 310018, China"},{"name":"Joint Laboratory of Intelligent Equipment and System for Water Conservancy and Hydropower Safety Monitoring of Zhejiang Province and Belarus, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering, Zhejiang University of Water Resources and Electric Power, Hangzhou 310018, China"},{"name":"Joint Laboratory of Intelligent Equipment and System for Water Conservancy and Hydropower Safety Monitoring of Zhejiang 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