{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:55:21Z","timestamp":1791924921744,"version":"4.3.4"},"reference-count":44,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian Ministry of Education and Research","award":["PN-III-P4-ID-PCE-2020-1958"],"award-info":[{"award-number":["PN-III-P4-ID-PCE-2020-1958"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>A metallomesogen based on an Zn(II) coordination complex was employed as precursor to obtain a complex matrix nanoplatform for the fabrication of a high-performance electrochemical hybrid sensor. Three representative paste electrodes, which differ by the weight ratio between Zn(II) metallomesogen and carbon nanotubes (CNT), i.e., PE_01, PE_02 and PE_03, were obtained by mixing the materials in different amounts. The composition with the largest amount of CNT with respect to Zn complex, i.e., PE_03, gives the best electrochemical signal for uric acid detection by cyclic voltammetry in an alkaline medium. The amphiphilic structure of the Zn(II) coordination complex likely induces a regular separation between the metal centers favoring the redox system through their reduction, followed by stripping, and is characterized by enhanced electrocatalytic activity towards uric acid oxidation. The comparative detection of uric acid between the PE_03 paste electrode and the commercial zinc electrode demonstrated the superiority of the former, and its great potential for the development of advanced electrochemical detection of uric acid. Advanced electrochemical techniques, such as differential-pulsed voltammetry (DPV) and square-wave voltammetry (SWV), allowed for the highly sensitive detection of uric acid in aqueous alkaline solutions. In addition, a good and fast amperometric signal for uric acid detection was achieved by multiple-pulsed amperometry, which was validated by urine analysis.<\/jats:p>","DOI":"10.3390\/nano12234215","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T04:56:25Z","timestamp":1669611385000},"page":"4215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Design of Nanostructured Hybrid Electrodes Based on a Liquid Crystalline Zn(II) Coordination Complex-Carbon Nanotubes Composition for the Specific Electrochemical Sensing of Uric Acid"],"prefix":"10.3390","volume":"12","author":[{"given":"Sorina","family":"Negrea","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry and Engineering of Inorganic Compounds and Environment, Politehnica University of Timisoara, Bvd. Vasile Parvan No. 6, 300223 Timisoara, Romania"},{"name":"National Institute of Research and Development for Industrial Ecology (INCD ECOIND), Timisoara Branch, 300431 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina A.","family":"Andelescu","sequence":"additional","affiliation":[{"name":"\u201cCoriolan Dr\u0103gulescu\u201d Institute of Chemistry, Romanian Academy, 24 Mihai Viteazu Bvd., 300223 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-8452","authenticated-orcid":false,"given":"Sorina","family":"Ilies (b. Motoc)","sequence":"additional","affiliation":[{"name":"\u201cCoriolan Dr\u0103gulescu\u201d Institute of Chemistry, Romanian Academy, 24 Mihai Viteazu Bvd., 300223 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Cretu","sequence":"additional","affiliation":[{"name":"\u201cCoriolan Dr\u0103gulescu\u201d Institute of Chemistry, Romanian Academy, 24 Mihai Viteazu Bvd., 300223 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Cseh","sequence":"additional","affiliation":[{"name":"\u201cCoriolan Dr\u0103gulescu\u201d Institute of Chemistry, Romanian Academy, 24 Mihai Viteazu Bvd., 300223 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Rastei","sequence":"additional","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg (IPCMS), CNRS-Universit\u00e9 de Strasbourg (UMR7504), 67034 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5907-7705","authenticated-orcid":false,"given":"Bertrand","family":"Donnio","sequence":"additional","affiliation":[{"name":"Institut de Physique et Chimie des Mat\u00e9riaux de Strasbourg (IPCMS), CNRS-Universit\u00e9 de Strasbourg (UMR7504), 67034 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeta I.","family":"Szerb","sequence":"additional","affiliation":[{"name":"\u201cCoriolan Dr\u0103gulescu\u201d Institute of Chemistry, Romanian Academy, 24 Mihai Viteazu Bvd., 300223 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-6634","authenticated-orcid":false,"given":"Florica","family":"Manea","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry and Engineering of Inorganic Compounds and Environment, Politehnica University of Timisoara, Bvd. Vasile Parvan No. 6, 300223 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"21406","DOI":"10.1007\/s10854-021-06644-5","article-title":"Rapid phytochemical microwave-assisted synthesis of zinc oxide nano flakes with excellent electrocatalytic activity for non-enzymatic electrochemical sensing of uric acid","volume":"32","author":"Ramya","year":"2021","journal-title":"Mater. Sci. Mater. Electron."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Pan, Y.Z., Zuo, J.L., Hou, Z.Y., Huang, Y.Z., and Huang, C.C. (2020). Preparation of Electrochemical Sensor Based on Zinc Oxide Nanoparticles for Simultaneous Determination of AA, DA, and UA. Front. 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