{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:38:57Z","timestamp":1773891537330,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of science, technological development and innovation of Republic of Serbia","award":["451-03-47\/2023-01\/200017"],"award-info":[{"award-number":["451-03-47\/2023-01\/200017"]}]},{"name":"Ministry of science, technological development and innovation of Republic of Serbia","award":["E!13303"],"award-info":[{"award-number":["E!13303"]}]},{"name":"EUREKA","award":["451-03-47\/2023-01\/200017"],"award-info":[{"award-number":["451-03-47\/2023-01\/200017"]}]},{"name":"EUREKA","award":["E!13303"],"award-info":[{"award-number":["E!13303"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Partial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior for desired technological application. Using the polyol synthesis procedure, a series of yttrium-substituted iron oxide nanoconstructs, \u03b3-Fe2\u2212xYxO3 (YIONs), was prepared. It was found that Y3+ could substitute Fe3+ in the crystal structures of maghemite (\u03b3-Fe2O3) up to a limited concentration of ~1.5% (\u03b3-Fe1.969Y0.031O3). Analysis of TEM micrographs showed that crystallites or particles were aggregated in flower-like structures with diameters from 53.7 \u00b1 6.2 nm to 97.3 \u00b1 37.0 nm, depending on yttrium concentration. To be investigated for potential applications as magnetic hyperthermia agents, YIONs were tested twice: their heating efficiency was tested and their toxicity was investigated. The Specific Absorption Rate (SAR) values were in the range of 32.6 W\/g to 513 W\/g and significantly decreased with increased yttrium concentration in the samples. Intrinsic loss power (ILP) for \u03b3-Fe2O3 and \u03b3-Fe1.995Y0.005O3 were ~8\u20139 nH\u00b7m2\/Kg, which pointed to their excellent heating efficiency. IC50 values of investigated samples against cancer (HeLa) and normal (MRC-5) cells decreased with increased yttrium concentration and were higher than ~300 \u03bcg\/mL. The samples of \u03b3-Fe2\u2212xYxO3 did not show a genotoxic effect. The results of toxicity studies show that YIONs are suitable for further in vitro\/in vivo studies toward to their potential medical applications, while results of heat generation point to their potential use in magnetic hyperthermia cancer treatment or use as self-heating systems for other technological applications such as catalysis.<\/jats:p>","DOI":"10.3390\/nano13050870","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T04:13:16Z","timestamp":1677471196000},"page":"870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-4416","authenticated-orcid":false,"given":"Milo\u0161","family":"Ognjanovi\u0107","sequence":"first","affiliation":[{"name":"VIN\u010cA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovi\u0107a Alasa 12-14, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2905-4526","authenticated-orcid":false,"given":"\u017deljko","family":"Ja\u0107imovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Metallurgy and Technology, University of Montenegro, Cetinjski put bb, 81000 Podgorica, Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Kosovi\u0107-Perutovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Metallurgy and Technology, University of Montenegro, Cetinjski put bb, 81000 Podgorica, Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Besu \u017di\u017eak","sequence":"additional","affiliation":[{"name":"Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Stanojkovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017deljko","family":"\u017di\u017eak","sequence":"additional","affiliation":[{"name":"Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1479-8060","authenticated-orcid":false,"given":"Biljana","family":"Doj\u010dinovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, Njego\u0161eva 12, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-1373","authenticated-orcid":false,"given":"Dalibor M.","family":"Stankovi\u0107","sequence":"additional","affiliation":[{"name":"VIN\u010cA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovi\u0107a Alasa 12-14, 11000 Belgrade, Serbia"},{"name":"Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bratislav","family":"Anti\u0107","sequence":"additional","affiliation":[{"name":"VIN\u010cA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovi\u0107a Alasa 12-14, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mokhosi, S.R., Mdlalose, W., Nhlapo, A., and Singh, M. 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