{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:45:38Z","timestamp":1788018338861,"version":"build-2784847793"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP 18K17068"],"award-info":[{"award-number":["JP 18K17068"]}]},{"name":"JSPS KAKENHI","award":["16im0210805"],"award-info":[{"award-number":["16im0210805"]}]},{"name":"AMED project ACT MS","award":["JP 18K17068"],"award-info":[{"award-number":["JP 18K17068"]}]},{"name":"AMED project ACT MS","award":["16im0210805"],"award-info":[{"award-number":["16im0210805"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Despite being able to adhesively restore teeth, adhesives and cement do not possess any anticariogenic protection potential, by which caries recurrence may still occur and reduce the clinical lifetime of adhesive restorations. Several antibacterial agents have been incorporated into dental adhesives and cement to render them anticariogenic. Due to an additional therapeutic effect, such materials are classified as \u2018dental combination products\u2019 with more strict market regulations. We incorporated cetylpyridinium chloride (CPC), often used for oral hygiene applications, into montmorillonite (CPC-Mont), the latter to serve as a carrier for controlled CPC release. CPC-Mont incorporated into tissue conditioner has been approved by the Pharmaceuticals and Medical Devices Agency (PmontMDA) in Japan. To produce a clinically effective dental cement with the antibacterial potential to prevent secondary caries, we incorporated CPC-Mont into PMMA resin cement. We measured the flexural strength, shear bond strength onto dentin, CPC release, and the biofilm-inhibition potential of the experimental CPC-Mont-containing PMMA cement. An 8 and 10 wt% CPC-Mont concentration revealed the antibacterial potential without reducing the mechanical properties of the PMMA cement.<\/jats:p>","DOI":"10.3390\/nano13091495","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T01:33:40Z","timestamp":1682645620000},"page":"1495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-6012","authenticated-orcid":false,"given":"Kumiko","family":"Yoshihara","sequence":"first","affiliation":[{"name":"National Institute of Advanced Industrial Science and Technology (AIST), Health and Medical Research Institute, 2217-14 Hayashi-cho, Takamatsu 761-0395, Kagawa, Japan"},{"name":"Department of Pathology & Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Nagaoka","sequence":"additional","affiliation":[{"name":"Advanced Research Center for Oral and Craniofacial Science, Okayama University Dental School, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-8364","authenticated-orcid":false,"given":"Yoji","family":"Makita","sequence":"additional","affiliation":[{"name":"National Institute of Advanced Industrial Science and Technology (AIST), Health and Medical Research Institute, 2217-14 Hayashi-cho, Takamatsu 761-0395, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-5836","authenticated-orcid":false,"given":"Bart","family":"Van Meerbeek","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, BIOMAT & UZ Leuven (University Hospitals Leuven), Dentistry, KU Leuven (University of Leuven), Kapucijnenvoer 7, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s00784-020-03268-7","article-title":"Secondary caries: What is it and how it can be controlled detected and managed?","volume":"24","author":"Askar","year":"2020","journal-title":"Clin. 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