{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:24:37Z","timestamp":1793118277950,"version":"4.5.0"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L222064"],"award-info":[{"award-number":["L222064"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["2021GQG0004"],"award-info":[{"award-number":["2021GQG0004"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guoqiang Institute, Tsinghua University","award":["L222064"],"award-info":[{"award-number":["L222064"]}]},{"name":"Guoqiang Institute, Tsinghua University","award":["2021GQG0004"],"award-info":[{"award-number":["2021GQG0004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Chronic lateral ankle instability (CLAI) is commonly secondary to prior lateral ankle ligament injury, and the concomitant latent syndesmosis injury would prolong recovery time and increase the risk of substantial traumatic arthritis. However, differentiating syndesmotic injury from isolated lateral ankle ligament injury in CLAI cases is difficult by conventional physical and radiological examinations. To improve the accuracy of syndesmotic injury diagnosis, a shoe-integrated sensor system (SISS) is proposed. This system measures plantar pressure during walking to detect the presence of syndesmotic injury. The study included 27 participants who had ankle sprains and underwent an examination. Plantar pressure in eight regions of interest was measured for both limbs, and syndesmotic injuries were examined using arthroscopy. The width of the syndesmosis was measured to evaluate its severity. The characteristics of plantar pressure were compared between patients with normal and injured syndesmosis. The results indicated that peak plantar pressure ratios with logistic regression predicted value &gt; 0.51 accurately distinguished concomitant syndesmotic injury during walking, with high sensitivity (80%) and specificity (75%). The post-test probability of having a syndesmotic injury was positively 80% and negatively 25%. These findings demonstrate the effectiveness of cost-effective wearable sensors in objectively diagnosing concomitant syndesmotic injuries in cases of CLAI.<\/jats:p>","DOI":"10.3390\/nano13091539","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T01:33:36Z","timestamp":1683164016000},"page":"1539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Shoe-Integrated Sensor System for Diagnosis of the Concomitant Syndesmotic Injury in Chronic Lateral Ankle Instability: A Prospective Double-Blind Diagnostic Test"],"prefix":"10.3390","volume":"13","author":[{"given":"Yanzhang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing 100191, China"},{"name":"Beijing Key Laboratory of Sports Injuries, Beijing 100191, China"},{"name":"Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4464-8063","authenticated-orcid":false,"given":"Rui","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing National Research Center for Information Science and Technology (BNRist), School of Integrated Circuits, Tsinghua University, Beijing 100084, China"},{"name":"Tsingyan Micro Technology Co., Ltd., Shaoxing 312099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7275-8763","authenticated-orcid":false,"given":"Yuchen","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing National Research Center for Information Science and Technology (BNRist), School of Integrated Circuits, Tsinghua University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing National Research Center for Information Science and Technology (BNRist), School of Integrated Circuits, Tsinghua University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing 100191, China"},{"name":"Beijing Key Laboratory of Sports Injuries, Beijing 100191, China"},{"name":"Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing 100191, China"},{"name":"Beijing Key Laboratory of Sports Injuries, Beijing 100191, China"},{"name":"Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing 100191, China"},{"name":"Beijing Key Laboratory of Sports Injuries, Beijing 100191, China"},{"name":"Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing National Research Center for Information Science and Technology (BNRist), School of Integrated Circuits, Tsinghua University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianling","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing National Research Center for Information Science and Technology (BNRist), School of Integrated Circuits, Tsinghua University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing 100191, China"},{"name":"Beijing Key Laboratory of Sports Injuries, Beijing 100191, China"},{"name":"Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s40279-013-0102-5","article-title":"The incidence and prevalence of ankle sprain injury: A systematic review and meta-analysis of prospective epidemiological studies","volume":"44","author":"Doherty","year":"2014","journal-title":"Sport. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.4085\/1062-6050-447-17","article-title":"Epidemiology of Ankle Sprains and Chronic Ankle Instability","volume":"54","author":"Herzog","year":"2019","journal-title":"J. Athl. Train."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s40279-017-0781-4","article-title":"Factors Contributing to Chronic Ankle Instability: A Systematic Review and Meta-Analysis of Systematic Reviews","volume":"48","author":"Thompson","year":"2018","journal-title":"Sport. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s00167-014-3399-1","article-title":"Magnetic resonance imaging characterization of individual ankle syndesmosis structures in asymptomatic and surgically treated cohorts","volume":"24","author":"Clanton","year":"2016","journal-title":"Knee Surg. Sport. Traumatol. Arthrosc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1302\/0301-620X.85B3.13174","article-title":"Diagnosis of a tear of the tibiofibular syndesmosis. The role of arthroscopy of the ankle","volume":"85","author":"Takao","year":"2003","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S275","DOI":"10.1016\/j.otsr.2019.09.014","article-title":"Diagnosis and treatment of tibiofibular syndesmosis lesions","volume":"105","author":"Molinier","year":"2019","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/bjsports-2013-092787","article-title":"Diagnostic accuracy of clinical tests for ankle syndesmosis injury","volume":"49","author":"Sman","year":"2015","journal-title":"Br. J. Sport. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/JSM.0b013e318234be7d","article-title":"The clinical features of ankle syndesmosis injuries: A general review","volume":"21","author":"Kellett","year":"2011","journal-title":"Clin. J. Sport. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3113\/FAI.2007.0336","article-title":"Chronic tibiofibular syndesmosis injury: The diagnostic efficiency of magnetic resonance imaging and comparative analysis of operative treatment","volume":"28","author":"Han","year":"2007","journal-title":"Foot Ankle Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"23259671211021056","DOI":"10.1177\/23259671211021057","article-title":"APKASS Consensus Statement on Chronic Syndesmosis Injury, Part 1: Clinical Manifestation, Radiologic Examination, Diagnosis Criteria, Classification, and Nonoperative Treatment","volume":"9","author":"Jiao","year":"2021","journal-title":"Orthop. J. Sport. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1460-9584.1997.00043.x","article-title":"Plantar pressure distribution measurements. Technical background and clinical applications","volume":"3","author":"Rosenbaum","year":"1997","journal-title":"Foot Ankle Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1136\/bjsm.37.6.495","article-title":"Dynamic force distribution during level walking under the feet of patients with chronic ankle instability","volume":"37","author":"Nyska","year":"2003","journal-title":"Br. J. Sport. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00167-005-0023-4","article-title":"A new ambulatory system for comparative evaluation of the three-dimensional knee kinematics, applied to anterior cruciate ligament injuries","volume":"14","author":"Favre","year":"2006","journal-title":"Knee Surg. Sport. Traumatol. Arthrosc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3390\/s140100887","article-title":"An ambulatory method of identifying anterior cruciate ligament reconstructed gait patterns","volume":"14","author":"Patterson","year":"2014","journal-title":"Sensors"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.gaitpost.2017.10.005","article-title":"Mobile assessment of the lower limb kinematics in healthy persons and in persons with degenerative knee disorders: A systematic review","volume":"59","author":"Jonkers","year":"2018","journal-title":"Gait Posture"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10104","DOI":"10.1021\/acsnano.0c03294","article-title":"Triode-Mimicking Graphene Pressure Sensor with Positive Resistance Variation for Physiology and Motion Monitoring","volume":"14","author":"Wu","year":"2020","journal-title":"ACS Nano"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1056\/NEJM197211302872228","article-title":"The D.C. heroin epidemic: Progress report","volume":"287","author":"DuPont","year":"1972","journal-title":"N. Engl. J. Med."},{"key":"ref_18","unstructured":"Portney, L., and Watkins, M. (2009). Foundations of Clinical Research: Applications to Practice, Pearson Prentice Hall. [3rd ed.]."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/bmj.329.7458.168","article-title":"Diagnostic tests 4: Likelihood ratios","volume":"329","author":"Deeks","year":"2004","journal-title":"BMJ"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/bmj.323.7305.157","article-title":"Systematic reviews in health care: Systematic reviews of evaluations of diagnostic and screening tests","volume":"323","author":"Deeks","year":"2001","journal-title":"BMJ"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/ptj\/79.10.939","article-title":"Interpreting validity indexes for diagnostic tests: An illustration using the Berg balance test","volume":"79","author":"Riddle","year":"1999","journal-title":"Phys. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1001\/jama.1994.03510330081039","article-title":"Users\u2019 guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group","volume":"271","author":"Jaeschke","year":"1994","journal-title":"JAMA"},{"key":"ref_23","unstructured":"Fetters, L., and Tilson, J. (2018). Evidence Based Physical Therapy, FA Davis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Luczak, T., Burch, V.R.F., Smith, B.K., Carruth, D.W., Lamberth, J., Chander, H., Knight, A., Ball, J., and Prabhu, R. (2019). Closing the Wearable Gap-Part V: Development of a Pressure-Sensitive Sock Utilizing Soft Sensors. Sensors, 20.","DOI":"10.3390\/s20010208"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1177\/1071100721996714","article-title":"Quantitative Evaluation of Ankle Instability Using a Capacitance-Type Strain Sensor","volume":"42","author":"Teramoto","year":"2021","journal-title":"Foot Ankle Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2113008","DOI":"10.1002\/adfm.202113008","article-title":"Active-Matrix Sensing Array Assisted with Machine-Learning Approach for Lumbar Degenerative Disease Diagnosis and Postoperative Assessment","volume":"32","author":"Liu","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"ref_27","unstructured":"Goh, G.L., Agarwala, S., and Yeong, W.Y. (2018, January 14\u201317). High resolution aerosol jet printing of conductive ink for stretchable electronics. Proceedings of the 3rd International Conference on Progress in Additive Manufacturing (PRO-AM), Singapore."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1900717","DOI":"10.1002\/admt.201900717","article-title":"Inkjet-Printed Soft Resistive Pressure Sensor Patch for Wearable Electronics Applications","volume":"5","author":"Lo","year":"2020","journal-title":"Adv. Mater. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.carbon.2022.04.021","article-title":"A novel pre-deposition assisted strategy for inkjet printing graphene-based flexible pressure sensor with enhanced performance","volume":"196","author":"Sun","year":"2022","journal-title":"Carbon"},{"key":"ref_30","unstructured":"Goh, G.L., Agarwala, S., and Yong, W.Y. (2016, January 16\u201319). 3D printing of microfludic sensor for soft robots: A preliminary study in design and fabrication. Proceedings of the 2nd International Conference on Progress in Additive Manufacturing (Pro-AM 2016), Singapore."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2201272","DOI":"10.1002\/admt.202201272","article-title":"Aerosol Jet Printing of Multi-Dimensional OECT Force Sensor with High Sensitivity and Large Measuring Range","volume":"8","author":"Zhou","year":"2023","journal-title":"Adv. Mater. Technol."},{"key":"ref_32","first-page":"118","article-title":"Conformal printing of sensors on 3D and flexible surfaces using aerosol jet deposition","volume":"Volume 8691","author":"Blumenthal","year":"2013","journal-title":"Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2013"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3113\/FAI.2011.1110","article-title":"Comparison of magnetic resonance imaging to physical examination for syndesmotic injury after lateral ankle sprain","volume":"32","author":"Avila","year":"2011","journal-title":"Foot Ankle Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1007\/s00167-015-3604-x","article-title":"Isolated syndesmotic injuries in acute ankle sprains: Diagnostic significance of clinical examination and MRI","volume":"24","author":"Hartel","year":"2016","journal-title":"Knee Surg. Sport. Traumatol. Arthrosc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S1067-2516(98)80063-X","article-title":"Sprained ankle syndrome: Prevalence and analysis of 639 acute injuries","volume":"37","author":"Fallat","year":"1998","journal-title":"J. Foot Ankle Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.3928\/01477447-20140225-53","article-title":"Incidence of syndesmotic injury","volume":"37","author":"Vosseller","year":"2014","journal-title":"Orthopedics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/036354659101900315","article-title":"Syndesmotic ankle sprains","volume":"19","author":"Boytim","year":"1991","journal-title":"Am. J. Sport. Med."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/13\/9\/1539\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:28:51Z","timestamp":1760124531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/13\/9\/1539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":37,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["nano13091539"],"URL":"https:\/\/doi.org\/10.3390\/nano13091539","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]}}}