{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:24:27Z","timestamp":1760149467641,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agence Nationale de la Recherche","award":["ANR-20-CE09-0004","ANR-19-CE09 APMJ","ANR-10-LABX-0096"],"award-info":[{"award-number":["ANR-20-CE09-0004","ANR-19-CE09 APMJ","ANR-10-LABX-0096"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Barbituric acid derivative (TDPT) is an achiral molecule, and its adsorption on a surface results in two opposite enantiomerically oriented motifs, namely TDPT-Sp and Rp. Two types of building blocks can be formed; block I is enantiomer-pure and is built up of the same motifs (format SpSp or RpRp) whereas block II is enantiomer-mixed and composes both motifs (format SpRp), respectively. The organization of the building blocks determines the formation of different nanoarchitectures which are investigated using scanning tunneling microscopy at a liquid\/HOPG interface. Sophisticated, highly symmetric \u201cnanowaves\u201d are first formed from both building blocks I and II and are heterochiral. The \u201cnanowaves\u201d are metastable and evolve stepwisely into more close-packed \u201cnanowires\u201d which are formed from enantiomer-pure building block I and are homochiral. A dynamic hetero- to homochiral transformation and simultaneous multi-scale phase transitions are demonstrated at the single-molecule level. Our work provides novel insights into the control and the origin of chiral assemblies and chiral transitions, revealing the various roles of enantiomeric selection and chiral competition, driving forces, stability and molecular coverage.<\/jats:p>","DOI":"10.3390\/nano13162304","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T10:24:47Z","timestamp":1691663087000},"page":"2304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two-Dimensional Hetero- to Homochiral Phase Transition from Dynamic Adsorption of Barbituric Acid Derivatives"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6782-9268","authenticated-orcid":false,"given":"Fabien","family":"Silly","sequence":"first","affiliation":[{"name":"TITANS, SPEC, CEA, CNRS, Universit\u00e9 Paris-Saclay, 91191 Gif sur Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changzhi","family":"Dong","sequence":"additional","affiliation":[{"name":"ITODYS, CNRS UMR 7086, Universit\u00e9 Paris Cit\u00e9, 15 rue Jean Antoine de Ba\u00eff, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4768-1902","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Maurel","sequence":"additional","affiliation":[{"name":"ITODYS, CNRS UMR 7086, Universit\u00e9 Paris Cit\u00e9, 15 rue Jean Antoine de Ba\u00eff, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Sun","sequence":"additional","affiliation":[{"name":"ITODYS, CNRS UMR 7086, Universit\u00e9 Paris Cit\u00e9, 15 rue Jean Antoine de Ba\u00eff, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0167-5729(03)00015-3","article-title":"Complex organic molecules at metal surfaces: Bonding, organisation and chirality","volume":"50","author":"Barlow","year":"2003","journal-title":"Surf. 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