{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:02:54Z","timestamp":1784689374187,"version":"3.55.0"},"reference-count":44,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Titanium-zirconium dioxide nanostructures loaded by hydroxyapatite were produced on the surface of Ti65Zr alloy. The alloy was treated by anodization with the subsequent immersion in calcium glycerophosphate (CG) solutions. The resulting surfaces present TiO2-ZrO2 nanotubular (TiZr-NT) structures enriched with hydroxyapatite (HAP). The nanotube texture is expected to enhance the surface\u2019s corrosion resistance and promote integration with bone tissue in dental implants. The TiZr-NT structure had a diameter of 73 \u00b1 2.2 nm and a length of 10.1 \u00b1 0.5 \u03bcm. The most favorable result for the growth of HAP in Hanks\u2019 balanced salt solution (Hanks\u2019 BSS) was obtained at a CG concentration of 0.5 g\/L. Samples soaked in CG at a concentration of 0.5 g\/L demonstrated in a decrease of the contact angles to 25.2\u00b0; after 3 days of exposure to Hanks\u2019 BSS, the contact angles further reduced to 18.5\u00b0. The corrosion studies also showed that the TiZr-NT structure soaked in the CG = 0.5 g\/L solution exhibited the best corrosion stability.<\/jats:p>","DOI":"10.3390\/nano14010015","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T03:47:56Z","timestamp":1703044076000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Surface Properties of Ti65Zr Alloy Modified with TiZr Oxide and Hydroxyapatite"],"prefix":"10.3390","volume":"14","author":[{"given":"Elinor Zadkani","family":"Nahum","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Ariel University, Ariel 4070000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Lugovskoy","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Ariel University, Ariel 4070000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Lugovskoy","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Ariel University, Ariel 4070000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0214-3059","authenticated-orcid":false,"given":"Alexander","family":"Sobolev","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Ariel University, Ariel 4070000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Silva, R.C.S., Agrelli, A., Andrade, A.N., Mendes-Marques, C.L., Arruda, I.R.S., Santos, L.R.L., Vasconcelos, N.F., and Machado, G. (2022). Titanium Dental Implants: An Overview of Applied Nanobiotechnology to Improve Biocompatibility and Prevent Infections. Materials, 15.","DOI":"10.3390\/ma15093150"},{"key":"ref_2","unstructured":"Buser, D. (2010). 20 Years of Guided Bone Regeneration in Implant Dentistry, Nature Publishing Group. [2nd ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1016\/j.heliyon.2022.e11300","article-title":"Titanium and titanium alloys in dentistry: Current trends, recent developments, and future prospects","volume":"8","author":"Hoque","year":"2022","journal-title":"Heliyon"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"140698","DOI":"10.1016\/j.msea.2020.140698","article-title":"Enhancing low-cycle fatigue life of commercially-pure Ti by deformation at cryogenic temperature","volume":"803","author":"Kim","year":"2021","journal-title":"Mater. Sci. Eng. A"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mystkowska, J., Niemirowicz-Laskowska, K., \u0141ysik, D., Tokajuk, G., D\u0105browski, J.R., and Bucki, R. (2018). The Role of Oral Cavity Biofilm on Metallic Biomaterial Surface Destruction\u2013Corrosion and Friction Aspects. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030743"},{"key":"ref_6","first-page":"3398","article-title":"Microstructural and mechanical properties, surface and electrochemical characterization of a new Ti-Zr-Nb alloy for implant applications","volume":"612","author":"Vasilescu","year":"2014","journal-title":"J. Alloys Compd."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1016\/j.electacta.2006.11.023","article-title":"Control of morphology and composition of self-organized zirconium titanate nanotube in (NH4)2SO4\/NH4F electrolytes","volume":"52","author":"Yasuda","year":"2007","journal-title":"Electrochim. Acta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.3390\/ma5081348","article-title":"A review of titanium zirconium (TiZr) alloys for use in endosseous dental implants","volume":"5","author":"Grandin","year":"2012","journal-title":"Materials"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.jmrt.2023.03.128","article-title":"The study of hydroxyapatite growth kinetics on CP\u2014Ti and Ti65Zr treated by Plasma electrolytic oxidation process","volume":"24","author":"Nahum","year":"2023","journal-title":"J. Mater. Res. Technol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbm.b.30073","article-title":"Hydroxyapatite and titania sol\u2013gel composite coatings on titanium for hard tissue implants; mechanical and in vitro biological performance","volume":"72","author":"Kim","year":"2005","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/jbm.a.32303","article-title":"The effect on bone growth enhancement of implant coatings with hydroxyapatite and collagen deposited electrochemically and by plasma spray","volume":"92","author":"Daugaard","year":"2010","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1177\/0954411919858018","article-title":"Surface nano-modification by ion beam\u2013assisted deposition alters the expression of osteogenic genes in osteoblasts","volume":"233","author":"Miralami","year":"2019","journal-title":"Proc. Inst. Mech. Eng."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"82688","DOI":"10.1039\/C6RA08922D","article-title":"Enhanced osteoblast adhesion on amino-functionalized titanium surfaces through combined plasma enhanced chemical vapor deposition (PECVD) method","volume":"6","author":"Lu","year":"2016","journal-title":"RSC Adv."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Schwartz, A., Kossenko, A., Zinigrad, M., Danchuk, V., and Sobolev, A. (2023). Cleaning Strategies of Synthesized Bioactive Coatings by PEO on Ti-6Al-4V Alloys of Organic Contaminations. Materials, 16.","DOI":"10.3390\/ma16134624"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"110653","DOI":"10.1016\/j.matdes.2022.110653","article-title":"A review of techniques for the application of bioactive coatings on metal-based implants to achieve controlled release of active ingredients","volume":"217","author":"Kravanja","year":"2022","journal-title":"Mater. Des."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1016\/j.jmrt.2022.06.055","article-title":"Formation of self-organized ZrO2\u2013TiO2 and ZrTiO4\u2013TiO2 nanotube arrays by anodization of Ti\u201340Zr foil for Cr(VI) removal","volume":"19","author":"Bashirom","year":"2022","journal-title":"J. Mater. Res. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"144661","DOI":"10.1016\/j.apsusc.2019.144661","article-title":"Understanding surface and interface properties of modified Ti50Zr with nanotubes","volume":"506","author":"Pantazi","year":"2020","journal-title":"Appl. Surf. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.memsci.2008.03.050","article-title":"Fabrication of mechanically robust, large area, polycrystalline nanotubular\/porous TiO2 membranes","volume":"319","author":"Paulose","year":"2018","journal-title":"J. Membr. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"112322","DOI":"10.1016\/j.msec.2021.112322","article-title":"Mg\/Cu-doped TiO2 nanotube array: A novel dual-function system with self-antibacterial activity and excellent cell compatibility","volume":"128","author":"Wang","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Park, J., Cimpean, A., Tesler, A.B., and Mazare, A. (2021). Anodic TiO2 Nanotubes: Tailoring Osteoinduction via Drug Delivery. Nanomaterials, 11.","DOI":"10.3390\/nano11092359"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7082","DOI":"10.1039\/c0jm04307a","article-title":"Polymeric micelles in porous and nanotubular implants as a new system for extended delivery of poorly soluble drugs","volume":"21","author":"Aw","year":"2011","journal-title":"J. Mater. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1517\/17425240903300857","article-title":"Self-ordered nanopore and nanotube platforms for drug delivery applications","volume":"6","author":"Losic","year":"2009","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.actbio.2009.02.032","article-title":"Bioactivation of titanium surfaces using coatings of TiO2 nanotubes rapidly pre-loaded with synthetic hydroxyapatite","volume":"5","author":"Kodama","year":"2009","journal-title":"Acta Biomater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1021\/acs.langmuir.6b00297","article-title":"Photocatalytic Deposition of Hydroxyapatite onto a Titanium Dioxide Nanotubular Layer with Fine Tuning of Layer Nanoarchitecture","volume":"32","author":"Ulasevich","year":"2016","journal-title":"Langmuir"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"126934","DOI":"10.1016\/j.matchemphys.2022.126934","article-title":"Evaluation of sodium alendronate drug released from TiO2 nanoparticle doped with hydroxyapatite and silver\u2013strontium for enhancing antibacterial effect and osteoinductivity","volume":"295","author":"Aryan","year":"2023","journal-title":"Mater. Chem. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijpharm.2016.11.062","article-title":"Activity of vancomycin release from bioinspired coatings of hydroxyapatite or TiO2 nanotubes","volume":"517","author":"Ionita","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Nahum, E.Z., Lugovskoy, A., Lugovskoy, S., and Sobolev, A. (2023). Synthesis of Titanium Oxide Nanotubes Loaded with Hydroxyapatite. Nanomaterials, 13.","DOI":"10.3390\/nano13202743"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/app.1969.070130815","article-title":"Estimation of the surface free energy of polymers","volume":"13","author":"Owens","year":"1969","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s12598-015-0675-2","article-title":"Fabrication and characterization of anodic oxide nanotubes on TiNb alloys","volume":"35","author":"Jin","year":"2016","journal-title":"Rare Met."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1149\/1.2428496","article-title":"A Theoretical Analysis of the Shape of Polarization Curves","volume":"104","author":"Stern","year":"1957","journal-title":"J. Electrochem. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.electacta.2013.11.108","article-title":"Effect of electrolyte composition on TiO2 nanotubular structure formation and its electrochemical evaluation","volume":"117","author":"Deen","year":"2014","journal-title":"Electrochim. Acta"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"24182","DOI":"10.1021\/acs.jpcc.5b08403","article-title":"Heat Treatment Effect on Crystalline Structure and Photoelectrochemical Properties of Anodic TiO2 Nanotube Arrays Formed in Ethylene Glycol and Glycerol Based Electrolytes","volume":"119","author":"Jarosz","year":"2015","journal-title":"J. Phys. Chem. C"},{"key":"ref_33","first-page":"87","article-title":"Biodegradable\/biocompatible coated metal implants for orthopedic applications","volume":"27","author":"Saleh","year":"2016","journal-title":"Biomed. Mater. Eng."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"146311","DOI":"10.1016\/j.apsusc.2020.146311","article-title":"Surface functionalization of dual growth factor on hydroxyapatite-coated nanofibers for bone tissue engineering","volume":"520","author":"Udomluck","year":"2020","journal-title":"Appl. Surf. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6216","DOI":"10.1016\/j.matpr.2022.05.096","article-title":"Growth mechanism of aligned porous oxide layers on titanium by anodization in electrolyte containing Cl\u2212","volume":"62","author":"Praharaj","year":"2022","journal-title":"Mater. Today Proc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.ceramint.2012.08.026","article-title":"Crystallization of hydroxyapatite during hydrothermal treatment on amorphous calcium phosphate layer coated by PEO technique","volume":"39","author":"Arbabi","year":"2013","journal-title":"Ceram Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.wear.2010.12.039","article-title":"Wear properties of micro-arc oxidized and hydrothermally treated Ti6Al4V alloy in simulated body fluid","volume":"271","author":"Vangolu","year":"2011","journal-title":"Wear"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1021\/cg400498j","article-title":"Structure of clusters and formation of amorphous calcium phosphate and hydroxyapatite: From the perspective of coordination chemistry","volume":"13","author":"Du","year":"2013","journal-title":"Cryst. Growth Des."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.apsusc.2015.08.017","article-title":"Influence of crystallite size and surface morphology on electrochemical properties of annealed TiO2 nanotubes","volume":"355","author":"Munirathinam","year":"2015","journal-title":"Appl. Surf. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.actbio.2014.03.032","article-title":"A review on the wettability of dental implant surfaces II: Biological and clinical aspects","volume":"10","author":"Gittens","year":"2014","journal-title":"Acta Biomater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"21823","DOI":"10.1039\/C8RA02744G","article-title":"MoO3\u2212x-deposited TiO2 nanotubes for stable and high-capacitance supercapacitor electrodes","volume":"8","author":"Sun","year":"2018","journal-title":"RSC Adv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"035004","DOI":"10.1143\/JJAP.48.035004","article-title":"Monitoring the effects of growing titania nanotubes on titanium substrate by electrochemical impedance spectroscopy measurement","volume":"48","author":"Say","year":"2009","journal-title":"Jpn. J. Appl. Phys."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.electacta.2018.04.206","article-title":"One-step facile preparation of ZnO nanorods as high-performance photoanodes for photoelectrochemical cathodic protection","volume":"276","author":"Yang","year":"2018","journal-title":"Electrochim. Acta"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"110604","DOI":"10.1016\/j.corsci.2022.110604","article-title":"Kinetics and mechanism of corrosion of oxide coating fabricated on aluminum alloy by the plasma electrolytic oxidation in molten salt","volume":"208","author":"Sobolev","year":"2022","journal-title":"Corros. Sci."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/14\/1\/15\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:41:57Z","timestamp":1760132517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/14\/1\/15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,20]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["nano14010015"],"URL":"https:\/\/doi.org\/10.3390\/nano14010015","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,20]]}}}