{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:54:25Z","timestamp":1789829665169,"version":"4.0.1"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"Research Project Unit of Tanta University","doi-asserted-by":"publisher","award":["AI162182"],"award-info":[{"award-number":["AI162182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Research Project Unit of Tanta University","doi-asserted-by":"publisher","award":["F-089\/26-AUG-2014"],"award-info":[{"award-number":["F-089\/26-AUG-2014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Research Project Unit of Tanta University","doi-asserted-by":"publisher","award":["AI162182"],"award-info":[{"award-number":["AI162182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Research Project Unit of Tanta University","doi-asserted-by":"publisher","award":["DK125126"],"award-info":[{"award-number":["DK125126"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of International Cooperation\u2014Arab Republic of Egypt","award":["AI162182"],"award-info":[{"award-number":["AI162182"]}]},{"name":"Ministry of International Cooperation\u2014Arab Republic of Egypt","award":["F-089\/26-AUG-2014"],"award-info":[{"award-number":["F-089\/26-AUG-2014"]}]},{"name":"Ministry of International Cooperation\u2014Arab Republic of Egypt","award":["AI162182"],"award-info":[{"award-number":["AI162182"]}]},{"name":"Ministry of International Cooperation\u2014Arab Republic of Egypt","award":["DK125126"],"award-info":[{"award-number":["DK125126"]}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["AI162182"],"award-info":[{"award-number":["AI162182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["F-089\/26-AUG-2014"],"award-info":[{"award-number":["F-089\/26-AUG-2014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["AI162182"],"award-info":[{"award-number":["AI162182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["DK125126"],"award-info":[{"award-number":["DK125126"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>The widespread biomedical and commercial applications of silver nanoparticles (AgNPs) have increased their potential for human and environmental exposure and toxicity to human health. The bio-distribution and toxicity of AgNPs in rodents following inhalation, intratracheal instillation, and oral ingestion are well documented; however, little is known about the bio-distribution of intravenously (IV)-administered AgNPs and their organ-specific pathophysiological effects. Here, we investigate the pharmacokinetic pattern and tissue distribution of AgNPs in male rats following IV administration. The animals were humanely sacrificed after 10 min, 1 h, 6 h, 12 h, 24 h, and 168 h of AgNP administration, and the silver (Ag) content was measured from blood samples and various tissues following acid digestion. The AgNPs were readily absorbed and subsequently distributed into most organs predominantly in the colon, small intestine, kidney, and heart after 6 h; however, they were the highest in the spinal cord after 168 h. White blood cells (WBCs) were significantly increased (42\u201360%) in AgNP-administered animals at all time points except 10 min. Regarding platelets, all AgNP-administered animals showed counts 7.8\u201339.2% lower, with the lowest count at 168 h post-administration. In the case of lymphocytes (LYMs), the AgNP-treated animals exhibited a count 19.5\u201341% lower at 10 min and 1 h post-administration; however, the animals at 168 h post-administration showed a count 30.5% more. The mean corpuscular hemoglobin (MCH) counts from the AgNP-treated animals were decreased by 50\u201362%. The concentrations of aspartate transaminase (AST), urea, and creatinine were increased in the AgNP-treated animals. Taken together, the results suggest that the acute IV administration of AgNPs alters metabolic and hematological parameters in animals and may pose a health risk to humans.<\/jats:p>","DOI":"10.3390\/nano14010029","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T10:53:52Z","timestamp":1703156032000},"page":"29","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Tissue Distribution, Pharmacokinetics, and Effect of Hematological and Biochemical Parameters of Acute Intravenous Administration of Silver Nanoparticles in Rats"],"prefix":"10.3390","volume":"14","author":[{"given":"Elsayed I.","family":"Salim","sequence":"first","affiliation":[{"name":"Research Laboratory of Molecular Carcinogenesis, Department of Zoology, Faculty of Science, Tanta University, Tanta 31527, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled Y.","family":"Abdel-Halim","sequence":"additional","affiliation":[{"name":"Mammalian & Aquatic Toxicology Department, Central Agricultural Pesticides Laboratory (CAPL), Agricultural Research Center (ARC), Dokki, Giza 12618, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa E.","family":"El-Mahalawy","sequence":"additional","affiliation":[{"name":"Research Laboratory of Molecular Carcinogenesis, Department of Zoology, Faculty of Science, Tanta University, Tanta 31527, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitham A.","family":"Badr","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"GlycoMantra Inc., 1450 South Rolling Road, Baltimore, MD 21227, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ferdous, Z., and Nemmar, A. 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