{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:33Z","timestamp":1787029173279,"version":"build-2736575974"},"reference-count":49,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Ciencia y Tecnologia (CONACyT)","award":["CB-2014-1-241458"],"award-info":[{"award-number":["CB-2014-1-241458"]}]},{"name":"the Nano-Sensors and Devices Group of Tecnologico de Monterrey","award":["CB-2014-1-241458"],"award-info":[{"award-number":["CB-2014-1-241458"]}]},{"name":"Tecnologico de Monterrey Grants for Scientific Papers Publication","award":["CB-2014-1-241458"],"award-info":[{"award-number":["CB-2014-1-241458"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>This study investigates electrospun fibers of metal-organic frameworks (MOFs), particularly CuBTC and ZIF-8, in polyacrylonitrile (PAN) for the solid-phase extraction (SPE) of Tamoxifen (TAM) and its metabolites (NDTAM, ENDO, and 4OHT) from human blood plasma. The focus is on the isolation, pre-concentration, and extraction of the analytes, aiming to provide a more accessible and affordable breast cancer patient-monitoring technology. The unique physicochemical properties of MOFs, such as high porosity and surface area, combined with PAN\u2019s stability and low density, are leveraged to improve SPE efficiency. The study meticulously examines the interactions of these MOFs with the analytes under various conditions, including elution solvents and protein precipitators. Results reveal that ZIF-8\/PAN composites outperform CuBTC\/PAN and PAN alone, especially when methanol is used as the protein precipitator. This superior performance is attributed to the physicochemical compatibility between the analytes\u2019 properties, like solubility and polarity, and the MOFs\u2019 structural features, including pore flexibility, active site availability, surface polarity, and surface area. The findings underscore MOFs\u2019 potential in SPE applications and provide valuable insights into the selectivity and sensitivity of different MOFs towards specific analytes, advancing more efficient targeted extraction methods in biomedical analysis.<\/jats:p>","DOI":"10.3390\/nano14010073","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T07:45:32Z","timestamp":1703663132000},"page":"73","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Enhancing Solid-Phase Extraction of Tamoxifen and Its Metabolites from Human Plasma Using MOF-Integrated Polyacrylonitrile Composites: A Study on CuBTC and ZIF-8 Efficacy"],"prefix":"10.3390","volume":"14","author":[{"given":"Domingo R.","family":"Flores-Hernandez","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Ingenier\u00eda y Ciencias, Ave. Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor Manuel","family":"Leija Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Leon, CICFM-FCFM. 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Universidad S\/N, Ciudad Universitaria, San Nicolas de los Garza 66451, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4556-7257","authenticated-orcid":false,"given":"Jose A.","family":"Hernandez-Hernandez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-4383","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"S\u00e1nchez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Procesos de Polimerizaci\u00f3n, Centro de Investigaci\u00f3n en Qu\u00edmica Aplicada, Blvd. Enrique Reyna No. 140, Saltillo 25294, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Bonilla-Rios","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Ingenier\u00eda y Ciencias, Ave. Eugenio Garza Sada 2501, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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