{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:04:21Z","timestamp":1778648661891,"version":"3.51.4"},"reference-count":126,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M670090ZX"],"award-info":[{"award-number":["2020M670090ZX"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["82072725"],"award-info":[{"award-number":["82072725"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023ZB381"],"award-info":[{"award-number":["2023ZB381"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020M670090ZX"],"award-info":[{"award-number":["2020M670090ZX"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072725"],"award-info":[{"award-number":["82072725"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023ZB381"],"award-info":[{"award-number":["2023ZB381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Funding Program for Excellent Postdoctoral Talent","award":["2020M670090ZX"],"award-info":[{"award-number":["2020M670090ZX"]}]},{"name":"Jiangsu Funding Program for Excellent Postdoctoral Talent","award":["82072725"],"award-info":[{"award-number":["82072725"]}]},{"name":"Jiangsu Funding Program for Excellent Postdoctoral Talent","award":["2023ZB381"],"award-info":[{"award-number":["2023ZB381"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Semiconductor nanomaterials have emerged as a significant factor in the advancement of tumor immunotherapy. This review discusses the potential of transition metal oxide (TMO) nanomaterials in the realm of anti-tumor immune modulation. These binary inorganic semiconductor compounds possess high electron mobility, extended ductility, and strong stability. Apart from being primary thermistor materials, they also serve as potent agents in enhancing the anti-tumor immunity cycle. The diverse metal oxidation states of TMOs result in a range of electronic properties, from metallicity to wide-bandgap insulating behavior. Notably, titanium oxide, manganese oxide, iron oxide, zinc oxide, and copper oxide have garnered interest due to their presence in tumor tissues and potential therapeutic implications. These nanoparticles (NPs) kickstart the tumor immunity cycle by inducing immunogenic cell death (ICD), prompting the release of ICD and tumor-associated antigens (TAAs) and working in conjunction with various therapies to trigger dendritic cell (DC) maturation, T cell response, and infiltration. Furthermore, they can alter the tumor microenvironment (TME) by reprogramming immunosuppressive tumor-associated macrophages into an inflammatory state, thereby impeding tumor growth. This review aims to bring attention to the research community regarding the diversity and significance of TMOs in the tumor immunity cycle, while also underscoring the potential and challenges associated with using TMOs in tumor immunotherapy.<\/jats:p>","DOI":"10.3390\/nano14131064","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T03:44:49Z","timestamp":1718941489000},"page":"1064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transition Metal Oxide Nanomaterials: New Weapons to Boost Anti-Tumor Immunity Cycle"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6915-090X","authenticated-orcid":false,"given":"Wanyi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Jinling Hospital, Nanjing University of Chinese Medicine, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-8441","authenticated-orcid":false,"given":"Xueru","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jinling Hospital, Nanjing University of Chinese Medicine, Nanjing 210000, China"},{"name":"Department of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2749-1415","authenticated-orcid":false,"given":"Wenqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4826-584X","authenticated-orcid":false,"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyuan","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jinling Hospital, Nanjing University of Chinese Medicine, Nanjing 210000, China"},{"name":"Department of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8961-3214","authenticated-orcid":false,"given":"Zengjie","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jinling Hospital, Nanjing University of Chinese Medicine, Nanjing 210000, China"},{"name":"Department of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","article-title":"Understanding the tumor immune microenvironment (TIME) for effective therapy","volume":"24","author":"Binnewies","year":"2018","journal-title":"Nat. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41423-020-0488-6","article-title":"The history and advances in cancer immunotherapy: Understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications","volume":"17","author":"Zhang","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.aar7112","article-title":"Personalized vaccines for cancer immunotherapy","volume":"359","author":"Sahin","year":"2018","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Yang, J., and Zhang, C. (2020). Regulation of cancer-immunity cycle and tumor microenvironment by nanobiomaterials to enhance tumor immunotherapy. WIREs Nanomed. Nanobiotechnol., 12.","DOI":"10.1002\/wnan.1612"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sundaram, A., Francis, B.M., Dhanabalan, S.C., and Ponraj, J.S. (2021). Transition metal carbide\u2014MXene. Handbook of Carbon-Based Nanomaterials, Elsevier.","DOI":"10.1016\/B978-0-12-821996-6.00017-8"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.2147\/IJN.S207666","article-title":"Manganese dioxide nanosheets: From preparation to biomedical applications","volume":"14","author":"Wu","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Grigore, M.E., Biscu, E.R., Holban, A.M., Gestal, M.C., and Grumezescu, A.M. (2016). Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles. Pharmarceuticals, 9.","DOI":"10.3390\/ph9040075"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16874","DOI":"10.1039\/D3NR02527F","article-title":"Enhancement of MXene optical properties towards medical applications via metal oxide incorporation","volume":"15","author":"Enoch","year":"2023","journal-title":"Nanoscale"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.scib.2019.09.021","article-title":"Two-dimensional nanomaterials: Fascinating materials in biomedical field","volume":"64","author":"Hu","year":"2019","journal-title":"Sci. Bull."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.apmt.2016.09.012","article-title":"Two dimensional and layered transition metal oxides","volume":"5","author":"Ou","year":"2016","journal-title":"Appl. Mater. Today"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.7150\/thno.30238","article-title":"Iron Oxide Nanoflowers @ CuS Hybrids for Cancer Tri-Therapy: Interplay of Photothermal Therapy, Magnetic Hyperthermia and Photodynamic Therapy","volume":"9","author":"Curcio","year":"2019","journal-title":"Theranostics"},{"key":"ref_12","first-page":"1973","article-title":"The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment","volume":"6","author":"Yang","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s10311-020-01033-6","article-title":"Toxicity of metal and metal oxide nanoparticles: A review","volume":"18","author":"Sengul","year":"2020","journal-title":"Environ. Chem. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Shen, F., Fang, Y., Wu, Y., Zhou, M., Shen, J., and Fan, X. (2023). Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective. J. Nanobiotechnol., 21.","DOI":"10.1186\/s12951-023-01771-z"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41563-019-0566-2","article-title":"The entry of nanoparticles into solid tumours","volume":"19","author":"Sindhwani","year":"2020","journal-title":"Nat. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yang, G., Ji, J., and Liu, Z. (2021). Multifunctional MnO2 nanoparticles for tumor microenvironment modulation and cancer therapy. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 13.","DOI":"10.1002\/wnan.1720"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"17392","DOI":"10.1021\/acsami.1c03277","article-title":"Tumor Microenvironment-Responsive Theranostic Nanoplatform for Guided Molecular Dynamic\/Photodynamic Synergistic Therapy","volume":"13","author":"Zhang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"nwab139","DOI":"10.1093\/nsr\/nwab139","article-title":"Cascade-responsive nanobomb with domino effect for anti-tumor synergistic therapies","volume":"9","author":"Liu","year":"2022","journal-title":"Natl. Sci. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1515\/mr-2023-0002","article-title":"Modulation of macrophage polarization by iron-based nanoparticles","volume":"3","author":"Ding","year":"2023","journal-title":"Med. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1039\/D2TB00527A","article-title":"Mesoporous hollow Fe3O4 nanoparticles regulate the behavior of neuro-associated cells through induction of macrophage polarization in an alternating magnetic field","volume":"10","author":"Guo","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1039\/C9TB01250H","article-title":"Hyaluronic acid modified doxorubicin loaded Fe3O4 nanoparticles effectively inhibit breast cancer metastasis","volume":"7","author":"Gong","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1021\/acsnano.2c10352","article-title":"Biomineralized MnO2 Nanoplatforms Mediated Delivery of Immune Checkpoint Inhibitors with STING Pathway Activation to Potentiate Cancer Radio-Immunotherapy","volume":"17","author":"Deng","year":"2023","journal-title":"ACS Nano"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Xie, L., Wang, G., Sang, W., Li, J., Zhang, Z., Li, W., Yan, J., Zhao, Q., and Dai, Y. (2021). Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy. Biomaterials, 269.","DOI":"10.1016\/j.biomaterials.2020.120638"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1039\/C8NR08704K","article-title":"Application of radially grown ZnO nanowires on poly-l-lactide microfibers complexed with a tumor antigen for cancer immunotherapy","volume":"11","author":"Sharma","year":"2019","journal-title":"Nanoscale"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jconrel.2019.12.042","article-title":"Mesoporous carbon-manganese nanocomposite for multiple imaging guided oxygen-elevated synergetic therapy","volume":"319","author":"Li","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12645-022-00140-z","article-title":"Development of doped ZnO-based biomimicking and tumor-targeted nanotheranostics to improve pancreatic cancer treatment","volume":"13","author":"Barui","year":"2022","journal-title":"Cancer Nanotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"707618","DOI":"10.3389\/fonc.2021.707618","article-title":"Recent Advances of Manganese-Based Hybrid Nanomaterials for Cancer Precision Medicine","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e2106511","DOI":"10.1002\/smll.202106511","article-title":"Hollow Mesoporous Manganese Oxides: Application in Cancer Diagnosis and Therapy","volume":"18","author":"Xu","year":"2022","journal-title":"Small"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e1905823","DOI":"10.1002\/adma.201905823","article-title":"Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications","volume":"32","author":"Ding","year":"2020","journal-title":"Adv. Mater."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jphotobiol.2016.12.011","article-title":"A review on biogenic synthesis of ZnO nanoparticles using plant extracts and microbes: A prospect towards green chemistry","volume":"166","author":"Ahmed","year":"2017","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1002\/adma.201502422","article-title":"Two-Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects","volume":"27","author":"Chimene","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9055","DOI":"10.1002\/anie.201603197","article-title":"General Self-Template Synthesis of Transition-Metal Oxide and Chalcogenide Mesoporous Nanotubes with Enhanced Electrochemical Performances","volume":"55","author":"Wang","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"26699","DOI":"10.1021\/jacs.3c08264","article-title":"High Flux and Stability of Cationic Intercalation in Transition-Metal Oxides: Unleashing the Potential of Mn t2g Orbital via Enhanced pi-Donation","volume":"145","author":"Yao","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ziental, D., Czarczynska-Goslinska, B., Mlynarczyk, D.T., Glowacka-Sobotta, A., Stanisz, B., Goslinski, T., and Sobotta, L. (2020). Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine. Nanomaterials, 10.","DOI":"10.20944\/preprints202002.0271.v1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1039\/C5BM00332F","article-title":"Biomedical applications of nano-titania in theranostics and photodynamic therapy","volume":"4","author":"Rehman","year":"2016","journal-title":"Biomater. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1039\/C9CS00648F","article-title":"Multifunctional sonosensitizers in sonodynamic cancer therapy","volume":"49","author":"Son","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/acsnano.1c07504","article-title":"A Cascade Nanozyme with Amplified Sonodynamic Therapeutic Effects through Comodulation of Hypoxia and Immunosuppression against Cancer","volume":"16","author":"Tao","year":"2022","journal-title":"ACS Nano"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1801175","DOI":"10.1002\/advs.201801175","article-title":"Exogenous Physical Irradiation on Titania Semiconductors: Materials Chemistry and Tumor-Specific Nanomedicine","volume":"5","author":"Zhang","year":"2018","journal-title":"Adv. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.7150\/thno.15088","article-title":"In vivo Biocompatibility, Biodistribution and Therapeutic Efficiency of Titania Coated Upconversion Nanoparticles for Photodynamic Therapy of Solid Oral Cancers","volume":"6","author":"Lucky","year":"2016","journal-title":"Theranostics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"10717","DOI":"10.1002\/anie.201704458","article-title":"Hybrid TiO2\u2013Ruthenium Nano-photosensitizer Synergistically Produces Reactive Oxygen Species in both Hypoxic and Normoxic Conditions","volume":"56","author":"Gilson","year":"2017","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jphotobiol.2017.10.016","article-title":"Enhancement of the photokilling effect of TiO2 in photodynamic therapy by conjugating with reduced graphene oxide and its mechanism exploration","volume":"177","author":"Shang","year":"2017","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zhou, J.-Y., Wang, W.-J., Zhang, C.-Y., Ling, Y.-Y., Hong, X.-J., Su, Q., Li, W.-G., Mao, Z.-W., Cheng, B., and Tan, C.-P. (2022). Ru(II)-modified TiO2 nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma. Biomaterials, 289.","DOI":"10.1016\/j.biomaterials.2022.121757"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Hesemans, E., Saffarzadeh, N., Maksoudian, C., Izci, M., Chu, T., Rios Luci, C., Wang, Y., Naatz, H., Thieme, S., and Richter, C. (2023). Cu-doped TiO2 nanoparticles improve local antitumor immune activation and optimize dendritic cell vaccine strategies. J. Nanobiotechnol., 21.","DOI":"10.1186\/s12951-023-01844-z"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e2205409","DOI":"10.1002\/adma.202205409","article-title":"Manganese-Based Tumor Immunotherapy","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/s41423-021-00669-w","article-title":"Manganese salts function as potent adjuvants","volume":"18","author":"Zhang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"25870","DOI":"10.1021\/acsami.7b07369","article-title":"Introducing Ratiometric Fluorescence to MnO2 Nanosheet-Based Biosensing: A Simple, Label-Free Ratiometric Fluorescent Sensor Programmed by Cascade Logic Circuit for Ultrasensitive GSH Detection","volume":"9","author":"Fan","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"21990","DOI":"10.1021\/acsami.6b05465","article-title":"Graphene Quantum Dot-MnO2 Nanosheet Based Optical Sensing Platform: A Sensitive Fluorescence \u201cTurn Off-On\u201d Nanosensor for Glutathione Detection and Intracellular Imaging","volume":"8","author":"Yan","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41467-017-01050-0","article-title":"Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses","volume":"8","author":"Yang","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"141369","DOI":"10.1016\/j.cej.2023.141369","article-title":"Intelligent manganese dioxide nanocomposites induce tumor immunogenic cell death and remould tumor microenvironment","volume":"461","author":"He","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.actbio.2021.12.014","article-title":"Tumor microcalcification-mediated relay drug delivery for photodynamic immunotherapy of breast cancer","volume":"140","author":"Jian","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1021\/acsnano.8b00999","article-title":"Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation","volume":"12","author":"Zhu","year":"2018","journal-title":"ACS Nano"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","article-title":"The role of ROS in tumour development and progression","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"An, J., Hu, Y.G., Cheng, K., Li, C., Hou, X.L., Wang, G.L., Zhang, X.S., Liu, B., Zhao, Y.D., and Zhang, M.Z. (2020). ROS-augmented and tumor-microenvironment responsive biodegradable nanoplatform for enhancing chemo-sonodynamic therapy. Biomaterials, 234.","DOI":"10.1016\/j.biomaterials.2020.119761"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2306734","DOI":"10.1002\/adfm.202306734","article-title":"Schottky Heterojunction Realizes In Situ Vaccine-like Antitumor Efficacy and Microenvironment Remodeling upon Near-Infrared Laser Response in Cold Tumors","volume":"33","author":"Song","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1039\/D0BM01931C","article-title":"Metformin loaded porous particles with bio-microenvironment responsiveness for promoting tumor immunotherapy","volume":"9","author":"Wen","year":"2021","journal-title":"Biomater. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nnano.2016.72","article-title":"A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy","volume":"11","author":"Mi","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1021\/acsnano.0c09223","article-title":"Tumor-Specific Activatable Nanocarriers with Gas-Generation and Signal Amplification Capabilities for Tumor Theranostics","volume":"15","author":"Qi","year":"2021","journal-title":"ACS Nano"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.tcb.2020.03.002","article-title":"The Complex Interplay between Antioxidants and ROS in Cancer","volume":"30","author":"Harris","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.scib.2023.02.027","article-title":"Specific activation of cGAS-STING pathway by nanotherapeutics-mediated ferroptosis evoked endogenous signaling for boosting systemic tumor immunotherapy","volume":"68","author":"Liang","year":"2023","journal-title":"Sci. Bull."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7200","DOI":"10.7150\/thno.39831","article-title":"Cooperation of endogenous and exogenous reactive oxygen species induced by zinc peroxide nanoparticles to enhance oxidative stress-based cancer therapy","volume":"9","author":"Lin","year":"2019","journal-title":"Theranostics"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1021\/acsnano.5b07846","article-title":"ZnO-Based Nanoplatforms for Labeling and Treatment of Mouse Tumors without Detectable Toxic Side Effects","volume":"10","author":"Ye","year":"2016","journal-title":"ACS Nano"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Martinez-Carmona, M., Gun\u2019ko, Y., and Vallet-Regi, M. (2018). ZnO Nanostructures for Drug Delivery and Theranostic Applications. Nanomaterials, 8.","DOI":"10.3390\/nano8040268"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"11197","DOI":"10.7150\/thno.44920","article-title":"ZnO-based multifunctional nanocomposites to inhibit progression and metastasis of melanoma by eliciting antitumor immunity via immunogenic cell death","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1039\/C9SC00387H","article-title":"Upconversion-mediated ZnFe2O4 nanoplatform for NIR-enhanced chemodynamic and photodynamic therapy","volume":"10","author":"Dong","year":"2019","journal-title":"Chem. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.1202768","article-title":"X-ROS signaling: Rapid mechano-chemo transduction in heart","volume":"333","author":"Prosser","year":"2011","journal-title":"Science"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ha, N.Y., Shin, H.M., Sharma, P., Cho, H.A., Min, C.K., Kim, H.I., Yen, N.T., Kang, J.S., Kim, I.S., and Choi, M.S. (2016). Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen. J. Nanobiotechnol., 14.","DOI":"10.1186\/s12951-016-0229-2"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.molimm.2014.08.001","article-title":"Toxicological mode of action of ZnO nanoparticles: Impact on immune cells","volume":"63","author":"Roy","year":"2015","journal-title":"Mol. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/imm.12276","article-title":"Toll-like receptor 6 mediated inflammatory and functional responses of zinc oxide nanoparticles primed macrophages","volume":"142","author":"Roy","year":"2014","journal-title":"Immunology"},{"key":"ref_69","first-page":"239","article-title":"Role of Metallic Nanoparticles in Vaccinology: Implications for Infectious Disease Vaccine Development","volume":"8","author":"Kipnis","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1039\/C8MH01286E","article-title":"Hybrid \u2018clusterbombs\u2019 as multifunctional nanoplatforms potentiate brain tumor immunotherapy","volume":"6","author":"Shen","year":"2019","journal-title":"Mater. Horiz."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14641","DOI":"10.1039\/C7NR03697C","article-title":"Mesoporous ZnO nanocapsules for the induction of enhanced antigen-specific immunological responses","volume":"9","author":"Afroz","year":"2017","journal-title":"Nanoscale"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.4049\/jimmunol.1502373","article-title":"Intravaginal Zinc Oxide Tetrapod Nanoparticles as Novel Immunoprotective Agents against Genital Herpes","volume":"196","author":"Antoine","year":"2016","journal-title":"J. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"43538","DOI":"10.1021\/acsami.7b16118","article-title":"Biodegradable Metal Ion-Doped Mesoporous Silica Nanospheres Stimulate Anticancer Th1 Immune Response in Vivo","volume":"9","author":"Wang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Kim, K.-S., Choi, B., Choi, H., Ko, M.J., Kim, D.-H., and Kim, D.-H. (2022). Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer. J. Nanobiotechnol., 20.","DOI":"10.1186\/s12951-022-01635-y"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Chin, Y.-C., Yang, L.-X., Hsu, F.-T., Hsu, C.-W., Chang, T.-W., Chen, H.-Y., Chen, L.Y.-C., Chia, Z.C., Hung, C.-H., and Su, W.-C. (2022). Iron oxide@chlorophyll clustered nanoparticles eliminate bladder cancer by photodynamic immunotherapy-initiated ferroptosis and immunostimulation. J. Nanobiotechnol., 20.","DOI":"10.1186\/s12951-022-01575-7"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: The role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.1039\/D0BM01168A","article-title":"Cascade reaction-mediated efficient ferroptosis synergizes with immunomodulation for high-performance cancer therapy","volume":"8","author":"Li","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1021\/acsnano.0c01681","article-title":"Boosting Potassium Storage Performance of the Cu2S Anode via Morphology Engineering and Electrolyte Chemistry","volume":"14","author":"Peng","year":"2020","journal-title":"ACS Nano"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1556-276X-8-102","article-title":"Liposome: Classification, preparation, and applications","volume":"8","author":"Akbarzadeh","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Han, J., Zhao, D., Li, D., Wang, X., Jin, Z., and Zhao, K. (2018). Polymer-Based Nanomaterials and Applications for Vaccines and Drugs. Polymers, 10.","DOI":"10.3390\/polym10010031"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1039\/D1NH00179E","article-title":"Iron oxide nanoparticles for immune cell labeling and cancer immunotherapy","volume":"6","author":"Chung","year":"2021","journal-title":"Nanoscale Horiz."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.1021\/acsnano.9b00892","article-title":"Engineering Magnetosomes for Ferroptosis\/Immunomodulation Synergism in Cancer","volume":"13","author":"Zhang","year":"2019","journal-title":"ACS Nano"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jcis.2022.08.186","article-title":"Macrophage-mediated delivery of magnetic nanoparticles for enhanced magnetic resonance imaging and magnetothermal therapy of solid tumors","volume":"629","author":"Xue","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"11614","DOI":"10.1039\/D1CS00427A","article-title":"Magnetic nanoparticles and clusters for magnetic hyperthermia: Optimizing their heat performance and developing combinatorial therapies to tackle cancer","volume":"50","author":"Gavilan","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7639","DOI":"10.1021\/acsnano.0c03881","article-title":"Nanoenabled Disruption of Multiple Barriers in Antigen Cross-Presentation of Dendritic Cells via Calcium Interference for Enhanced Chemo-Immunotherapy","volume":"14","author":"An","year":"2020","journal-title":"ACS Nano"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"8116","DOI":"10.1021\/jacs.1c02537","article-title":"Mild Magnetic Hyperthermia-Activated Innate Immunity for Liver Cancer Therapy","volume":"143","author":"Pan","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1021\/acsnano.9b01979","article-title":"Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis","volume":"13","author":"Liu","year":"2019","journal-title":"ACS Nano"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1039\/D0BM00172D","article-title":"Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy","volume":"8","author":"Qiao","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2023.03.035","article-title":"Nanoassembly with self-regulated magnetic thermal therapy and controlled immuno-modulating agent release for improved immune response","volume":"357","author":"Gao","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"18538","DOI":"10.1021\/acsnano.2c06776","article-title":"Multifunctional Magnetic Nanoclusters Can Induce Immunogenic Cell Death and Suppress Tumor Recurrence and Metastasis","volume":"16","author":"Zhang","year":"2022","journal-title":"ACS Nano"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.7150\/thno.29746","article-title":"Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I:C) promote melanoma regression","volume":"8","author":"Zhao","year":"2018","journal-title":"Theranostics"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS\u2212) vs. Alternatively Activated Macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/nnano.2016.168","article-title":"Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues","volume":"11","author":"Zanganeh","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1039\/C9NR06505A","article-title":"Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo","volume":"12","author":"Li","year":"2020","journal-title":"Nanoscale"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41586-018-0034-1","article-title":"Amino-acid- and peptide-directed synthesis of chiral plasmonic gold nanoparticles","volume":"556","author":"Lee","year":"2018","journal-title":"Nature"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Gezgin, S.Y., Kepceoglu, A., Gundogdu, Y., Zongo, S., Zawadzka, A., Kilic, H.S., and Sahraoui, B. (2020). Effect of Ar Gas Pressure on LSPR Property of Au Nanoparticles: Comparison of Experimental and Theoretical Studies. Nanomaterials, 10.","DOI":"10.3390\/nano10061071"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Zhuo, X., Liu, Z., Aishajiang, R., Wang, T., and Yu, D. (2023). Recent Progress of Copper-Based Nanomaterials in Tumor-Targeted Photothermal Therapy\/Photodynamic Therapy. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15092293"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Jiang, F., Ding, B., Liang, S., Zhao, Y., Cheng, Z., Xing, B., Ma, P., and Lin, J. (2021). Intelligent MoS2-CuO heterostructures with multiplexed imaging and remarkably enhanced antitumor efficacy via synergetic photothermal therapy\/ chemodynamic therapy\/ immunotherapy. Biomaterials, 268.","DOI":"10.1016\/j.biomaterials.2020.120545"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"10206","DOI":"10.1021\/acsnano.3c00326","article-title":"Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge","volume":"17","author":"Ning","year":"2023","journal-title":"ACS Nano"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e2302537","DOI":"10.1002\/adhm.202302537","article-title":"Engineered Microbial Nanohybrids for Tumor-Mediated NIR II Photothermal Enhanced Ferroptosis\/Cuproptosis and Immunotherapy","volume":"13","author":"Ruan","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.actbio.2020.11.036","article-title":"Cobalt oxide nanoparticle-synergized protein degradation and phototherapy for enhanced anticancer therapeutics","volume":"121","author":"Huang","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1021\/am405009f","article-title":"Co3O4 nanoparticles with multi-enzyme activities and their application in immunohistochemical assay","volume":"6","author":"Dong","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.1021\/am406033q","article-title":"Catalase mimic property of Co3O4 nanomaterials with different morphology and its application as a calcium sensor","volume":"6","author":"Mu","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e2000897","DOI":"10.1002\/smll.202000897","article-title":"A Glucose\/Oxygen-Exhausting Nanoreactor for Starvation- and Hypoxia-Activated Sustainable and Cascade Chemo-Chemodynamic Therapy","volume":"16","author":"Guo","year":"2020","journal-title":"Small"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"11683","DOI":"10.1021\/acsami.1c01006","article-title":"A Three-in-one ZIFs-Derived CuCo(O)\/GOx@PCNs Hybrid Cascade Nanozyme for Immunotherapy\/Enhanced Starvation\/Photothermal Therapy","volume":"13","author":"Wang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1700885","DOI":"10.1002\/aenm.201700885","article-title":"Recent Advances in Nanostructured Vanadium Oxides and Composites for Energy Conversion","volume":"7","author":"Liu","year":"2017","journal-title":"Adv. Energy Mater."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1002\/anie.202011711","article-title":"A Cerium Vanadate Nanozyme with Specific Superoxide Dismutase Activity Regulates Mitochondrial Function and ATP Synthesis in Neuronal Cells","volume":"60","author":"Singh","year":"2021","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"15159","DOI":"10.1002\/chem.202002335","article-title":"Natural Polyphenol-Vanadium Oxide Nanozymes for Synergistic Chemodynamic\/Photothermal Therapy","volume":"26","author":"Chen","year":"2020","journal-title":"Chemistry"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Hu, D., Xu, H., Zhang, W., Xu, X., Xiao, B., Shi, X., Zhou, Z., Slater, N.K.H., Shen, Y., and Tang, J. (2021). Vanadyl nanocomplexes enhance photothermia-induced cancer immunotherapy to inhibit tumor metastasis and recurrence. Biomaterials, 277.","DOI":"10.1016\/j.biomaterials.2021.121130"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e2101467","DOI":"10.1002\/adma.202101467","article-title":"A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy","volume":"33","author":"Liang","year":"2021","journal-title":"Adv. Mater."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Nie, Y., Zhang, W., Xiao, W., Zeng, W., Chen, T., Huang, W., Wu, X., Kang, Y., Dong, J., and Luo, W. (2022). Novel biodegradable two-dimensional vanadene augmented photoelectro-fenton process for cancer catalytic therapy. Biomaterials, 289.","DOI":"10.1016\/j.biomaterials.2022.121791"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"11537","DOI":"10.1021\/acsnano.3c01527","article-title":"A Vanadium-Based Nanoplatform Synergizing Ferroptotic-like Therapy with Glucose Metabolism Intervention for Enhanced Cancer Cell Death and Antitumor Immunity","volume":"17","author":"Zhang","year":"2023","journal-title":"ACS Nano"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Zhang, T., Zheng, Q., Fu, Y., Xie, C., Fan, G., Wang, Y., Wu, Y., Cai, X., Han, G., and Li, X. (2021). alpha-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-01105-x"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jcis.2023.04.108","article-title":"Near-infrared-II-activatable sulfur-deficient plasmonic Bi2S3\u2212x-Au heterostructures for photoacoustic imaging-guided ultrasound enhanced high performance phototherapy","volume":"644","author":"Meng","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1039\/D4RA00497C","article-title":"Integration of O2-economised tumour-targeted photosensitive magnetic nanomaterials in the diagnosis and therapy of gastric cancer","volume":"14","author":"Situ","year":"2024","journal-title":"RSC Adv."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2003036","DOI":"10.1002\/advs.202003036","article-title":"Theranostic Nanomedicine for Synergistic Chemodynamic Therapy and Chemotherapy of Orthotopic Glioma","volume":"7","author":"Tan","year":"2020","journal-title":"Adv. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"025069","DOI":"10.1088\/2053-1583\/aa652f","article-title":"Functional manganese dioxide nanosheet for targeted photodynamic therapy and bioimaging in vitro and in vivo","volume":"4","author":"Kim","year":"2017","journal-title":"2D Mater."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"962161","DOI":"10.3389\/fchem.2022.962161","article-title":"Triggering cell death in cancers using self-illuminating nanocomposites","volume":"10","author":"Rajh","year":"2022","journal-title":"Front. Chem."},{"key":"ref_119","first-page":"195","article-title":"Immunotoxicity of zinc oxide nanoparticles with different size and electrostatic charge","volume":"9","author":"Kim","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.biomaterials.2015.02.068","article-title":"Polyethylenimine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podosome dynamics","volume":"52","author":"Rojas","year":"2015","journal-title":"Biomaterials"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/jbm.a.34024","article-title":"The chronic spleen injury of mice following long-term exposure to titanium dioxide nanoparticles","volume":"100","author":"Sang","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1039\/D1NR00664A","article-title":"Transition metal oxide and chalcogenide-based nanomaterials for antibacterial activities: An overview","volume":"13","author":"Tang","year":"2021","journal-title":"Nanoscale"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1080\/1061186X.2020.1815209","article-title":"Manganese dioxide (MnO2) based nanomaterials for cancer therapies and theranostics","volume":"29","author":"Zhu","year":"2021","journal-title":"J. Drug Target."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1039\/C9BM01039D","article-title":"Manganese neurotoxicity: Nano-oxide compensates for ion-damage in mammals","volume":"7","author":"Adhikari","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/hipo.22252","article-title":"Impact of manganese on primary hippocampal neurons from rodents","volume":"24","author":"Daoust","year":"2014","journal-title":"Hippocampus"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1038\/s41598-018-19628-z","article-title":"Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings","volume":"8","author":"Feng","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/14\/13\/1064\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:07Z","timestamp":1760108527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/14\/13\/1064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":126,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["nano14131064"],"URL":"https:\/\/doi.org\/10.3390\/nano14131064","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]}}}