{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:40:13Z","timestamp":1792024813741,"version":"4.4.0"},"reference-count":79,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"King Saud University","award":["RSPD2024R751"],"award-info":[{"award-number":["RSPD2024R751"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>The objective of this study is the development of innovative nanocurcumin-based formulations designed for the treatment and prevention of oxidative stress and diabetes. Nanocurcumin was obtained through a micronization process and subsequently encapsulated within biopolymers derived from corn starch and fenugreek mucilage, achieving encapsulation rates of 75% and 85%, respectively. Subsequently, the encapsulated nanocurcumin was utilized in the formulation of sugar-free syrups based on Stevia rebaudiana Bertoni. The stability of the resulting formulations was assessed by monitoring particle size distribution and zeta potential over a 25-day period. Dynamic light scattering (DLS) revealed a particle size of 119.9 nm for the fenugreek mucilage-based syrup (CURF) and 117 nm for the corn starch-based syrup (CURA), with polydispersity indices PDIs of 0.509 and 0.495, respectively. The dissolution rates of the encapsulated nanocurcumin were significantly enhanced, showing a 67% improvement in CURA and a 70% enhancement in CURF compared with crude curcumin (12.82%). Both formulations demonstrated excellent antioxidant activity, as evidenced by polyphenol quantification using the 2.2-diphenyl 1-pycrilhydrazyl (DPPH) assay. In the evaluation of antidiabetic activity conducted on Wistar rats, a substantial reduction in fasting blood sugar levels from 392 to 187 mg\/mL was observed. The antioxidant properties of CURF in reducing oxidative stress were clearly demonstrated by a macroscopic observation of the rats\u2019 livers, including their color and appearance.<\/jats:p>","DOI":"10.3390\/nano14131105","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T11:19:02Z","timestamp":1719487142000},"page":"1105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nanocurcumin-Based Sugar-Free Formulation: Development and Impact on Diabetes and Oxidative Stress Reduction"],"prefix":"10.3390","volume":"14","author":[{"given":"Safa","family":"Ferradj","sequence":"first","affiliation":[{"name":"Laboratory of Chemical Engineering, Chemical Engineering Department, Saad Dahlab University, Blida 09000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madiha Melha","family":"Yahoum","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Transport Phenomena (LBMPT), Nouveau P\u00f4le Urbain, Medea University, Medea 26000, Algeria"},{"name":"LME, Material and Environmental Laboratory, University of Medea, Medea 26001, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounia","family":"Rebiha","sequence":"additional","affiliation":[{"name":"Functional Analysis of Chemical Processes Laboratory, Chemical Engineering Department, Saad Dahlab University, Blida 09000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Nabi","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Engineering, Chemical Engineering Department, Saad Dahlab University, Blida 09000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"Toumi","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Transport Phenomena (LBMPT), Nouveau P\u00f4le Urbain, Medea University, Medea 26000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Lefnaoui","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Transport Phenomena (LBMPT), Nouveau P\u00f4le Urbain, Medea University, Medea 26000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7937-8951","authenticated-orcid":false,"given":"Amel","family":"Hadj-Ziane-Zafour","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Engineering, Chemical Engineering Department, Saad Dahlab University, Blida 09000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7091-9990","authenticated-orcid":false,"given":"Nabil","family":"Touzout","sequence":"additional","affiliation":[{"name":"Department of Nature and Life Sciences, Faculty of Sciences, Pole Urban Ouzera, University of Medea, Medea 26000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2209-6405","authenticated-orcid":false,"given":"Hichem","family":"Tahraoui","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Transport Phenomena (LBMPT), Nouveau P\u00f4le Urbain, Medea University, Medea 26000, Algeria"},{"name":"Laboratoire de G\u00e9nie des Proc\u00e9d\u00e9s Chimiques, Department of Process Engineering, University of Ferhat Abbas, Setif 19000, Algeria"},{"name":"National High School of Chemistry of Rennes, Scientific Research National Center (CNRS), ISCR\u2014UMR 6226, Rennes University, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-700X","authenticated-orcid":false,"given":"Adil","family":"Mihoub","sequence":"additional","affiliation":[{"name":"Biophysical Environment Station, Center for Scientific and Technical Research on Arid Regions, Touggourt 30000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4779-9414","authenticated-orcid":false,"given":"Mahmoud F.","family":"Seleiman","sequence":"additional","affiliation":[{"name":"Department of Plant Production, College of Food and Agriculture Sciences, King Saud University, P.O. 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