{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:44:36Z","timestamp":1790621076397,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>The development of pressure ulcers, associated with increased temperature and moisture in specific areas of the body, and the risk of microbial infections in patients lying in a static position for prolonged periods of time represents a serious issue in medicine. In order to prevent the formation of pressure ulcers, this work aims to present advanced nanostructured coatings developed by three research groups. Nanometric silver, ash and functionalized torrefied biomass were the basis for the treatment of wound dressings to improve thermal conductivity and antimicrobial properties of the conventional cotton gauzes. Each treatment was performed according to its own optimized method. The treated fabrics were characterized in terms of antimicrobial properties, heat transfer, morphology and hydrophobic behavior. The results demonstrated the effectiveness of the deposition treatments also in synergistic actions. In particular, the antibacterial efficacy was improved in all the samples by the addition of silver treatment, and the thermal conductivity was enhanced by around 58% with nanometric ashes. A further step of the study involved the designing of two multilayer systems evaluated using circuit models for determining the total thermal conductivity. In this way, both systems were designed with the aim to guarantee simultaneous efficacy: high antibacterial and hydrophilic properties at the skin level and more hydrophobic and conductive behaviors toward the external environment.<\/jats:p>","DOI":"10.3390\/nano14151309","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T07:37:30Z","timestamp":1722843450000},"page":"1309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nanotechnological Antibacterial and Conductive Wound Dressings for Pressure Ulcer Prevention"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-6471","authenticated-orcid":false,"given":"Mauro","family":"Pollini","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Striani","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-6353","authenticated-orcid":false,"given":"Federica","family":"Paladini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4690-3710","authenticated-orcid":false,"given":"Aida","family":"Kiani","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-2271","authenticated-orcid":false,"given":"Maria Rosaria","family":"Acocella","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-1162","authenticated-orcid":false,"given":"Carola","family":"Esposito Corcione","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1086\/344059","article-title":"Infected pressure ulcers in elderly individuals","volume":"35","author":"Livesley","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lin, Y.H., Chen, Y.C., Cheng, K.S., Yu, P.J., Wang, J.L., and Ko, N.Y. (2021). Higher periwound temperature associated with wound healing of pressure ulcers detected by infrared thermography. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132883"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Amrani, G., Peko, L., Hoffer, O., Ovadia-Blechman, Z., and Gefen, A. (2020). The microclimate under dressings applied to intact weight-bearing skin: Infrared thermography studies. Clin. Biomech., 75.","DOI":"10.1016\/j.clinbiomech.2020.104994"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.clinbiomech.2018.09.010","article-title":"Microclimate: A critical review in the context of pressure ulcer prevention","volume":"59","author":"Kottner","year":"2018","journal-title":"Clin. Biomech."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/iwj.12048","article-title":"Microclimate and development of pressure ulcers and superficial skin changes","volume":"12","author":"Yusuf","year":"2015","journal-title":"Int. Wound J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.apnr.2004.03.005","article-title":"Elevated sacral skin temperature (Ts): A risk factor for pressure ulcer development in hospitalized neurologically impaired Thai patients","volume":"18","author":"Williams","year":"2005","journal-title":"Appl. Nurs. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1089\/wound.2016.0697","article-title":"Review of the Current Management of Pressure Ulcers","volume":"7","author":"Boyko","year":"2018","journal-title":"Adv. Wound Care"},{"key":"ref_8","first-page":"18","article-title":"The role of the thermal conductivity of dressings in prevention and treatment of wounds","volume":"12","author":"Gefen","year":"2021","journal-title":"Wounds Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/wrr.12883","article-title":"Comparing the effects of three different multilayer dressings for pressure ulcer prevention on sacral skin after prolonged loading: An exploratory crossover trial","volume":"29","author":"Lechner","year":"2021","journal-title":"Wound Repair Regen."},{"key":"ref_10","unstructured":"Cutting, K., and Gefen, A. (2019). PolyMem and Countering Inflammation Made Easy. Wounds Int., 1\u20136."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1746-1596-9-36","article-title":"Heat transfer model for deep tissue injury: A step towards an early thermographic diagnostic capability","volume":"9","author":"Bhargava","year":"2014","journal-title":"Diagn. Pathol."},{"key":"ref_12","first-page":"1114","article-title":"Role of Thermal Conductivity in Temperature Variation during Wound Healing Process after Plastic Surgery","volume":"18","author":"Jain","year":"2013","journal-title":"Int. J. Math. Comput. Model"},{"key":"ref_13","first-page":"261","article-title":"Thermal Conformability of Developed Fibrous Wound Dressings","volume":"2","author":"Uzun","year":"2017","journal-title":"J. Text. Eng. Fash. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Glicksman, L.R. (1994). Heat transfer in foams. Low Density Cellular Plastics, Springer.","DOI":"10.1007\/978-94-011-1256-7_5"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/fam.2188","article-title":"Thermophysical properties of polyurethane foams and their melts","volume":"38","author":"Pau","year":"2014","journal-title":"Fire Mater."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Singh, G., Byrne, C., Thomason, H., and McBain, A.J. (2022). Investigating the microbial and metalloprotease sequestration properties of superabsorbent wound dressings. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-08361-3"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1179\/2045772314Y.0000000234","article-title":"Bacteriology of pressure ulcers in individuals with spinal cord injury: What we know and what we should know","volume":"38","author":"Dana","year":"2015","journal-title":"J. Spinal Cord Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Si, H., Xing, T., Ding, Y., Zhang, H., Yin, R., and Zhang, W. (2019). 3D bioprinting of the sustained drug release wound dressing with double-crosslinked hyaluronic-acid-based hydrogels. Polymers, 11.","DOI":"10.3390\/polym11101584"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.2217\/nnm-2018-0099","article-title":"Electrospun PLGA membrane incorporated with andrographolide-loaded mesoporous silica nanoparticles for sustained antibacterial wound dressing","volume":"13","author":"Jia","year":"2018","journal-title":"Nanomedicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"124888","DOI":"10.1016\/j.cej.2020.124888","article-title":"Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds","volume":"394","author":"He","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/acs.biomac.1c01334","article-title":"Improved Cooling Performance of Hydrogel Wound Dressings via Integrating Thermal Conductivity and Heat Storage Capacity for Burn Therapy","volume":"23","author":"Shi","year":"2022","journal-title":"Biomacromolecules"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"40326","DOI":"10.1002\/app.40326","article-title":"Antibacterial and Antifungal Dressings Obtained by Photochemical Deposition of Silver Nanoparticles","volume":"131","author":"Paladini","year":"2014","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Striani, R., Stasi, E., Giuri, A., Seiti, M., Ferraris, E., and Esposito Corcione, C. (2021). Development of an innovative and green method to obtain nanoparticles from carbon-based waste ashes. Nanomaterials, 11.","DOI":"10.3390\/nano11030577"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"141780","DOI":"10.1016\/j.electacta.2022.141780","article-title":"Waste carbon ashes\/PEDOT:PSS nano-inks for printing of supercapacitors","volume":"441","author":"Giuri","year":"2023","journal-title":"Electrochim. Acta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1039\/D3MA00804E","article-title":"Eco-friendly one-shot approach for producing a functionalized nano-torrefied biomass: A new application of ball milling technology","volume":"5","author":"Kiani","year":"2023","journal-title":"Mater. Adv."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Sportelli, M.C., Picca, R.A., Paladini, F., Mangone, A., Giannossa, L.C., Di Franco, C., Gallo, A.L., Valentini, A., Sannino, A., and Pollini, M. (2017). Spectroscopic characterization and nanosafety of Ag-modified antibacterial leather and leatherette. Nanomaterials, 7.","DOI":"10.3390\/nano7080203"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/jbm.b.33085","article-title":"In vivo testing of silver treated fibers for the evaluation of skin irritation effect and hypoallergenicity","volume":"102","author":"Paladini","year":"2014","journal-title":"J. Biomed. Mater. Res.-Part B Appl. Biomater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0040-6031(88)87254-X","article-title":"A method for the determination of thermal conductivity of sheet materials by DSC","volume":"126","author":"Flynn","year":"1988","journal-title":"Thermochim. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1515\/aut-2011-110205","article-title":"Study of heat transfer through multilayer clothing assemblies: A theoretical prediction","volume":"11","author":"Das","year":"2011","journal-title":"Autex Res. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s12221-019-9053-2","article-title":"Comfort and Infection Control of Chitosan-impregnated Cotton Gauze as Wound Dressing","volume":"20","author":"Souza","year":"2019","journal-title":"Fibers Polym."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1021\/acsami.3c16602","article-title":"High Thermal Conductivity and Radiative Cooling Designed Boron Nitride Nanosheets\/Silk Fibroin Films for Personal Thermal Management","volume":"16","author":"Xia","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2147\/CWCMR.S78422","article-title":"Pressure ulcer prevention and treatment: Use of prophylactic dressings","volume":"3","author":"Reid","year":"2016","journal-title":"Chronic Wound Care Manag. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jtv.2023.03.003","article-title":"Moist dressings in the treatment of pressure injuries: A network meta-analysis","volume":"32","author":"Geng","year":"2023","journal-title":"J Tissue Viability"}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/14\/15\/1309\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:29:32Z","timestamp":1760110172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/14\/15\/1309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,3]]},"references-count":33,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["nano14151309"],"URL":"https:\/\/doi.org\/10.3390\/nano14151309","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,3]]}}}