{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:33:54Z","timestamp":1792193634555,"version":"4.4.0"},"reference-count":88,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union (NextGenerationEU) through PNRR.C9-I8: Aerogel-based magnetic nanocomposites for water decontamination","award":["CF 231\/29.11.2022"],"award-info":[{"award-number":["CF 231\/29.11.2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>This study presents the preparation of hybrid iron oxide nanocomposites through a two-step process combining microfluidic-assisted synthesis and post-synthetic surface modification. Fe3O4 nanoparticles were synthesized and simultaneously functionalized with salicylic acid using a three-dimensional vortex-type microfluidic chip, enabling rapid and uniform particle formation. The resulting Fe3O4\/SA nanostructures were further modified with either silver or copper oxide to form iron oxide nanocomposites with enhanced antimicrobial functionality. These nanocomposites were subsequently integrated into silica aerogel matrices using a dip-coating approach to improve surface dispersion, structural stability, and biocompatibility. The structural and morphological properties of the samples were investigated using XRD, FT-IR, TEM with SAED analysis, and Raman microscopy. In vitro cytotoxicity and antimicrobial assays demonstrated that Fe3O4\/SA\u2013Ag and Fe3O4\/SA\u2013CuO exhibit potent antibacterial activity and cell type-dependent biocompatibility. In vivo biodistribution studies showed no accumulation in major organs and selective clearance via the spleen, validating the systemic safety of the platform. These findings highlight the potential of the synthesized nanocomposites as biocompatible, antimicrobial coatings for advanced biomedical surfaces.<\/jats:p>","DOI":"10.3390\/nano15090637","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T20:24:52Z","timestamp":1745353492000},"page":"637","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antimicrobial Coatings Based on Hybrid Iron Oxide Nanoparticles"],"prefix":"10.3390","volume":"15","author":[{"given":"Doina-Antonia","family":"Mercan","sequence":"first","affiliation":[{"name":"Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana-Ionela","family":"Tudorache (Trifa)","sequence":"additional","affiliation":[{"name":"Department of Science and 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Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-9432","authenticated-orcid":false,"given":"Ariana","family":"Hudi\u021b\u0103","sequence":"additional","affiliation":[{"name":"Research Institute of the University of Bucharest\u2014ICUB, University of Bucharest, 050657 Bucharest, Romania"},{"name":"Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei Street, 050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-3346","authenticated-orcid":false,"given":"Ionela Cristina","family":"Voinea","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei Street, 050095 Bucharest, 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