{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:15:13Z","timestamp":1790709313968,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and technology innovation team of Xinjiang Uygur Autonomous Region","award":["2023TSYCTD0005"],"award-info":[{"award-number":["2023TSYCTD0005"]}]},{"name":"Science and technology innovation team of Xinjiang Uygur Autonomous Region","award":["2024B0202010001"],"award-info":[{"award-number":["2024B0202010001"]}]},{"name":"Guangdong Key Areas Research and Development Project","award":["2023TSYCTD0005"],"award-info":[{"award-number":["2023TSYCTD0005"]}]},{"name":"Guangdong Key Areas Research and Development Project","award":["2024B0202010001"],"award-info":[{"award-number":["2024B0202010001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Neohesperidin (NH), a bioactive flavanone glycoside, exhibits multifaceted pharmacological properties including antioxidant and anti-inflammatory activities. However, its clinical application is severely constrained by inherent physicochemical limitations such as poor aqueous solubility and instability under physiological conditions. To address these challenges, this study developed a dual-carrier nano-liposomal system through the synergistic integration of phospholipid complexation and hydroxypropyl-\u03b2-cyclodextrin (HP-\u03b2-CD) inclusion technologies. Two formulations\u2014NH-PC (phospholipid complex) and NH-PC-CD (phospholipid\/HP-\u03b2-CD hybrid)\u2014were fabricated via ultrasonication-assisted ethanol precipitation. Comprehensive characterization using FTIR and PXRD confirmed the amorphous dispersion of NH within lipid bilayers, with complete elimination of crystalline diffraction peaks, indicative of molecular-level interactions between NH\u2019s hydroxyl groups and phospholipid polar moieties. The engineered nanosystems demonstrated remarkable solubility enhancement, achieving 321.77 \u03bcg\/mL (NH-PC) and 318.75 \u03bcg\/mL (NH-PC-CD), representing 2.01- and 1.99-fold increases over free NH. Encapsulation efficiencies exceeded 95% for both formulations, with sustained release profiles revealing 60.81% (NH-PC) and 80.78% (NH-PC-CD) cumulative release over 72 h, governed predominantly by non-Fickian diffusion kinetics. In vitro gastrointestinal simulations highlighted superior bioaccessibility for NH-PC-CD (66.35%) compared to NH-PC (58.52%) and free NH (20.85%), attributed to enhanced stability against enzymatic degradation. Storage stability assessments further validated the robustness of HP-\u03b2-CD-modified liposomes, with NH-PC-CD maintaining consistent particle size (&lt;3% variation) and encapsulation efficiency (&gt;92%) over 30 days. Antioxidant evaluations demonstrated concentration-dependent DPPH radical scavenging, wherein nanoencapsulation significantly amplified NH\u2019s activity compared to its free form. This study establishes a paradigm for dual-functional nanocarriers, offering a scalable strategy to optimize the delivery of hydrophobic nutraceuticals while addressing critical challenges in bioavailability and physiological stability.<\/jats:p>","DOI":"10.3390\/nano15110862","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T08:51:04Z","timestamp":1749027064000},"page":"862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Phospholipid\/HP-\u03b2-CD Hybrid Nanosystems Amplify Neohesperidin Bioavailability via Dual Enhancement of Solubility and Stability"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4084-1264","authenticated-orcid":false,"given":"Na","family":"Xia","sequence":"first","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau of Xinjiang, College of Life and Geographic Sciences, Kashi University, Kashi 844000, China"},{"name":"School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-1648","authenticated-orcid":false,"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau of Xinjiang, College of Life and Geographic Sciences, Kashi University, Kashi 844000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau of Xinjiang, College of Life and Geographic Sciences, Kashi University, Kashi 844000, China"},{"name":"School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-3056","authenticated-orcid":false,"given":"Dan","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau of Xinjiang, College of Life and Geographic Sciences, Kashi University, Kashi 844000, China"},{"name":"School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoshan","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.ijbiomac.2020.07.272","article-title":"Preparation of crystalline nanocellulose\/hydroxypropyl \u03b2 cyclodextrin\/carboxymethyl cellulose polyelectrolyte complexes and their controlled release of neohesperidin-copper (II) in vitro","volume":"163","author":"Xia","year":"2020","journal-title":"Int. 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