{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:24:13Z","timestamp":1788297853178,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["22165012"],"award-info":[{"award-number":["22165012"]}]},{"name":"National Natural Science Foundation of China","award":["22166018"],"award-info":[{"award-number":["22166018"]}]},{"name":"National Natural Science Foundation of China","award":["22304049"],"award-info":[{"award-number":["22304049"]}]},{"name":"National Natural Science Foundation of China","award":["31960720"],"award-info":[{"award-number":["31960720"]}]},{"name":"National Natural 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University","award":["22166018"],"award-info":[{"award-number":["22166018"]}]},{"name":"Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University","award":["22304049"],"award-info":[{"award-number":["22304049"]}]},{"name":"Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University","award":["31960720"],"award-info":[{"award-number":["31960720"]}]},{"name":"Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University","award":["202409FE20"],"award-info":[{"award-number":["202409FE20"]}]},{"name":"Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University","award":["XJ2022007801"],"award-info":[{"award-number":["XJ2022007801"]}]},{"name":"Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University","award":["PALM 202403"],"award-info":[{"award-number":["PALM 202403"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Bacterial infections, particularly those caused by multidrug-resistant strains, remain a significant global public health challenge. The growing resistance to traditional antibiotics highlights the urgent need for novel antibacterial strategies. Herein, we successfully synthesized three types of nitrogen-doped carbon dots (tBuCz-CDs, HAH-CDs, and EC-CDs) via hydrothermal method using tert-butyl carbazate, hydroxyacetic acid hydrazide, and ethyl carbazate as precursors. tBuCz-CDs, HAH-CDs, and EC-CDs exhibited potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), with minimum inhibitory concentrations (MICs) of 100, 100, and 150 \u00b5g\/mL, respectively. Their antibacterial effect on MRSA was comparable to that of the widely used antibiotic vancomycin hydrochloride, as shown by the zone of inhibition assay. Furthermore, the carbon dots exhibited low cytotoxicity and hemolytic activity showing their excellent biocompatibility both in vitro and in vivo. They also significantly promoted wound healing compared to untreated controls. Notably, the serial passaging of MRSA exposed to these carbon dots did not result in the bacterial resistance. Mechanistic studies revealed that the carbon dots exerted antibacterial effects through multiple mechanisms, including the disruption of bacterial membranes, inhibition and eradication of biofilm formation, generation of reactive oxygen species, and DNA damage. This work highlights the potential of nitrogen-doped CDs as a promising material for combating drug-resistant bacterial infections and underscores their potential for further biomedical development.<\/jats:p>","DOI":"10.3390\/nano15120910","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T03:59:17Z","timestamp":1749700757000},"page":"910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hydrazine Derivative-Based Carbon Dots for Potent Antibacterial Activity Against Multidrug-Resistant Bacterial"],"prefix":"10.3390","volume":"15","author":[{"given":"Hou-Qun","family":"Yuan","sequence":"first","affiliation":[{"name":"Key Laboratory of Fermentation Engineering (Ministry of Education), National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, School of Life and Health Sciences, Hubei University of 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Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.csbj.2019.09.011","article-title":"capsule polysaccharide as a target for therapeutics and vaccines","volume":"17","author":"Kobayashi","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e10559","DOI":"10.7554\/eLife.10559","article-title":"How competition governs whether moderate or aggressive treatment minimizes antibiotic resistance","volume":"4","author":"Colijn","year":"2015","journal-title":"Elife"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5573345","DOI":"10.1155\/2021\/5573345","article-title":"Is Penicillin-Nonsusceptible Streptococcus pneumoniae a Significant Challenge to Healthcare System? A Systematic Review and Meta-Analysis","volume":"2021","author":"Khademi","year":"2021","journal-title":"Scientifica"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chu, K.W., Lee, S.L., Chang, C.J., and Liu, L.Y. (2019). Recent Progress of Carbon Dot Precursors and Photocatalysis Applications. Polymers, 11.","DOI":"10.3390\/polym11040689"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Gonz\u00e1lez, R.B., Gonz\u00e1lez, L.T., Madou, M., Leyva-Porras, C., Martinez-Chapa, S.O., and Mendoza, A. (2022). Synthesis, Purification, and Characterization of Carbon Dots from Non-Activated and Activated Pyrolytic Carbon Black. Nanomaterials, 12.","DOI":"10.3390\/nano12030298"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e2409345","DOI":"10.1002\/advs.202409345","article-title":"Precise Regulation Strategy for Fluorescence Wavelength of Aggregation-Induced Emission Carbon Dots","volume":"11","author":"Ding","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.wasman.2024.09.016","article-title":"Identify the impact of pyrolysis temperature on preparation of carbon nanotubes by catalytic reforming polypropylene","volume":"190","author":"Cai","year":"2024","journal-title":"Waste Manag."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Song, K., Lin, J.W., Zhuang, Y.F., Han, Z.Z., and Chen, J.H. (2021). Construction of Photoelectrochemical DNA Biosensors Based on TiO2@Carbon Dots@Black Phosphorous Quantum Dots. Micromachines, 12.","DOI":"10.3390\/mi12121523"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chen, J.H., Luo, A.H., Xu, M.M., Zhang, Y., Wang, Z., Yu, S., Zhu, L., Wu, W., and Yang, D.Q. (2024). The application of phenylboronic acid pinacol ester functionalized ROS-responsive multifunctional nanoparticles in the treatment of Periodontitis. J. Nanobiotechnol., 22.","DOI":"10.1186\/s12951-024-02461-0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.21315\/tlsr2017.28.2.8","article-title":"Lactococcus Lactis Strain A5 Producing Nisin-like Bacteriocin Active against Gram Positive and Negative Bacteria","volume":"28","author":"Azhar","year":"2017","journal-title":"Trop. Life Sci. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"eabd7904","DOI":"10.1126\/sciadv.abd7904","article-title":"Inhaled immunoantimicrobials for the treatment of chronic obstructive pulmonary disease","volume":"10","author":"Zhu","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1038\/s41467-024-51933-2","article-title":"A Foundation Model Identifies Broad-Spectrum Antimicrobial Peptides against Drug-Resistant Bacterial Infection","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Dawa, Z.M., Zhai, T., Liu, C.C., and Fan, H.N. (2025). Efficacy and safety of pseudolaric acid B against and in a murine infection model. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1503472"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bal\u00e1zs, V.L., Filep, R., R\u00e9p\u00e1s, F., Kerekes, E., Szab\u00f3, P., Kocsis, B., B\u00f6sz\u00f6rm\u00e9nyi, A., Krisch, J., and Horv\u00e1th, G. (2022). Immortelle (Helichrysum italicum (Roth) G. Don) Essential Oil Showed Antibacterial and Biofilm Inhibitory Activity against Respiratory Tract Pathogens. Molecules, 27.","DOI":"10.3390\/molecules27175518"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Rao, S.Y., Lin, Y.P., Lin, R., Liu, J.G., Wang, H.S., Hu, W.X., Chen, B.L., and Chen, T.F. (2022). Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment. J. Nanobiotechnol., 20.","DOI":"10.1186\/s12951-022-01490-x"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1039\/D3RA08028E","article-title":"Fabrication of a PCN\/BiOBr 2D hybrid with improved photocatalytic performance of 2,4-dichorophenol degradation","volume":"14","author":"Chen","year":"2024","journal-title":"RSC Adv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.elecom.2019.01.025","article-title":"\u201cSelf-cleaning\u201d electrochemical regeneration of dye-loaded activated carbon","volume":"100","author":"Zhou","year":"2019","journal-title":"Electrochem. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Xu, W.J., Yang, M., Du, X.L., Peng, H., Yang, Y., Wang, J.T., and Zhang, Y.W. (2023). Multifunctional Nanoplatform Based on Sunitinib for Synergistic Phototherapy and Molecular Targeted Therapy of Hepatocellular Carcinoma. Micromachines, 14.","DOI":"10.3390\/mi14030613"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Xin, X., Wen, T., Gong, L.B., Deng, M.M., Hou, K.Z., Xu, L., Shi, S., Qu, X.J., Liu, Y.P., and Che, X.F. (2020). Inhibition of FEN1 Increases Arsenic Trioxide-Induced ROS Accumulation and Cell Death: Novel Therapeutic Potential for Triple Negative Breast Cancer. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00425"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/10717544.2020.1790693","article-title":"Precise engineering of Gemcitabine prodrug cocktails into single polymeric nanoparticles delivery for metastatic thyroid cancer cells","volume":"27","author":"Liu","year":"2020","journal-title":"Drug Deliv."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"An, Y.L., Liu, C., Li, Y., Chen, M.L., Zheng, Y.W., Tian, H., Shi, R., He, X.H., and Lin, X. (2022). Preparation of Multicolour Solid Fluorescent Carbon Dots for Light-Emitting Diodes Using Phenylethylamine as a Co-Carbonization Agent. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911071"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10079","DOI":"10.1021\/acsanm.4c00365","article-title":"Meso-Au\/BN Nanosensor for Trinitrotoluene Based on Fluorescence Resonance Energy Transfer and Surface-Enhanced Raman Spectroscopy Mechanisms","volume":"7","author":"Wang","year":"2024","journal-title":"Acs Appl. Nano Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e24949","DOI":"10.1016\/j.heliyon.2024.e24949","article-title":"Nanotechnology in toothpaste: Fundamentals, trends, and safety","volume":"10","author":"Abedi","year":"2024","journal-title":"Heliyon"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S1414","DOI":"10.4103\/jpbs.jpbs_735_23","article-title":"Estimation of MBC: MIC Ratio of Herbal Extracts against Common Endodontic Pathogens","volume":"16","author":"Makade","year":"2024","journal-title":"J Pharm. Bioallied Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12645-022-00144-9","article-title":"Carbon Nanoparticles Induce DNA Repair and PARP Inhibitor Resistance Associated with Nanozyme Activity in Cancer Cells","volume":"13","author":"Fan","year":"2022","journal-title":"Cancer Nanotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"41202","DOI":"10.1039\/D0RA07106D","article-title":"Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria","volume":"10","author":"Kung","year":"2020","journal-title":"RSC Adv."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chai, S., Zhou, L., Pei, S., Zhu, Z., and Chen, B. (2021). P-Doped Carbon Quantum Dots with Antibacterial Activity. Micromachines, 12.","DOI":"10.3390\/mi12091116"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1039\/D1FO03426J","article-title":"Green synthesis of fluorescent carbon dots with antibacterial activity and their application in Atlantic mackerel (Scomber scombrus) storage","volume":"13","author":"Lin","year":"2022","journal-title":"Food Funct."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1021\/acsabm.8b00421","article-title":"Degradable Carbon Dots from Cigarette Smoking with Broad-Spectrum Antimicrobial Activities against Drug-Resistant Bacteria","volume":"1","author":"Song","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.carbon.2020.11.092","article-title":"One-minute irradiation of white LED drives halogen\/nitrogen co-doped polymeric graphene quantum dots to photodynamic inactivation of bacteria in the infected wound","volume":"174","author":"Huang","year":"2020","journal-title":"Carbon"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1021\/acsbiomaterials.9b00583","article-title":"Nitrogen-Doped Carbon Quantum Dots for Preventing Biofilm Formation and Eradicating Drug-Resistant Bacteria Infection","volume":"5","author":"Wang","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1039\/D3TB02374E","article-title":"Biogenic carbon dots: A novel mechanistic approach to combat multidrug-resistant critical pathogens on the global priority list","volume":"12","author":"Parambil","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_34","unstructured":"Rajak, K.K., Pahilani, P., Patel, H., Kikani, B., Desai, R., and Kumar, H. (2023). Green synthesis of silver nanoparticles using Curcuma longa flower extract and antibacterial activity. arXiv."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/15\/12\/910\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:50:24Z","timestamp":1760032224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/15\/12\/910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,11]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["nano15120910"],"URL":"https:\/\/doi.org\/10.3390\/nano15120910","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,11]]}}}