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However, their improper application has led to serious challenges, including environmental pollution, pesticide residues, and increasing insect resistance. Traditional chemical pesticides are no longer sufficient to meet the demands for sustainable modern agriculture. Recent advances in nanotechnology offer innovative strategies for improving pesticide delivery, bioavailability, and selectivity. This review systematically summarizes the current progress in nano-insecticides, including their definitions, classification, preparation techniques, synergistic mechanisms, insecticidal performance, and safety evaluation. In addition, emerging strategies, such as multi-stimuli responsive systems, co-delivery with multiple agents or genetic materials, and integration with biological control, are discussed. Finally, future perspectives are proposed to guide the design\/development of intelligent, efficient, and eco-friendly nano-insecticides for sustainable pest management in modern agriculture.<\/jats:p>","DOI":"10.3390\/nano15131050","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T02:53:07Z","timestamp":1751856787000},"page":"1050","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Nano-Enabled Insecticides for Efficient Pest Management: Definition, Classification, Synergistic Mechanism, and Safety Assessment"],"prefix":"10.3390","volume":"15","author":[{"given":"Ying","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-7151","authenticated-orcid":false,"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Horticulture, Beijing Vocational College of Agriculture, Beijing 102442, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9685-9810","authenticated-orcid":false,"given":"Shuo","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,6]]},"reference":[{"key":"ref_1","first-page":"1463","article-title":"Perennial grain crops: A new option for the future food and ecoagricultural environment","volume":"361\u2013363","author":"Zhang","year":"2012","journal-title":"Adv. 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