{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:05:18Z","timestamp":1787951118439,"version":"build-2784847793"},"reference-count":44,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Energy of the Republic of Kazakhstan","award":["BR20081011"],"award-info":[{"award-number":["BR20081011"]}]},{"name":"Ministry of Energy of the Republic of Kazakhstan","award":["23K06738"],"award-info":[{"award-number":["23K06738"]}]},{"DOI":"10.13039\/501100001691","name":"Japanese Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["BR20081011"],"award-info":[{"award-number":["BR20081011"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japanese Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["23K06738"],"award-info":[{"award-number":["23K06738"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Cancer remains one of the most pressing global health challenges, driving the need for innovative treatment strategies. Boron neutron capture therapy (BNCT) offers a highly selective approach to destroying cancer cells while sparing healthy tissues. To improve boron delivery, Fe3O4@Au nanoparticles were developed and functionalized with a boron-containing carborane compound. Fe3O4 nanoparticles were synthesized and covered by gold, followed by (3-Aminopropyl)triethoxysilane (APTES) modification to introduce amino groups for carborane immobilization. Comprehensive characterization using SEM, DLS, FTIR, EDX, Brunauer\u2013Emmett\u2013Teller (BET), and XRD confirmed successful functionalization at each stage. TEM confirmed the final structure and elemental composition of the nanoparticles. BET analysis revealed a surface area of 94.69 m2\/g and a pore volume of 0.51 cm3\/g after carborane loading. Initial release studies in PBS demonstrated the removal of only loosely bound carborane within 48 h, with FTIR confirming stable retention of the compound on the nanoparticle surface. The modified nanoparticles achieved a stable zeta potential of \u221220 mV. The particles showed low toxicity within a range of concentrations (0\u2013300 \u03bcg Fe\/mL) and were efficiently accumulated by U251MG cells. These results demonstrate the potential of the obtained nanoparticles to carry boron and gold for their possible application as a theranostic agent.<\/jats:p>","DOI":"10.3390\/nano15161243","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:53:27Z","timestamp":1755100407000},"page":"1243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Carborane-Containing Iron Oxide@Gold Nanoparticles for Potential Application in Neutron Capture Therapy"],"prefix":"10.3390","volume":"15","author":[{"given":"Zhangali A.","family":"Bekbol","sequence":"first","affiliation":[{"name":"The Institute of Nuclear Physics, Ibragimov Str. 1, 050032 Almaty, Kazakhstan"},{"name":"Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, 010008 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kairat A.","family":"Izbasar","sequence":"additional","affiliation":[{"name":"The Institute of Nuclear Physics, Ibragimov Str. 1, 050032 Almaty, Kazakhstan"},{"name":"Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, 010008 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6833-9866","authenticated-orcid":false,"given":"Alexander","family":"Zaboronok","sequence":"additional","affiliation":[{"name":"The Institute of Nuclear Physics, Ibragimov Str. 1, 050032 Almaty, Kazakhstan"},{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-6366","authenticated-orcid":false,"given":"Lana I.","family":"Lissovskaya","sequence":"additional","affiliation":[{"name":"The Institute of Nuclear Physics, Ibragimov Str. 1, 050032 Almaty, Kazakhstan"},{"name":"Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, 010008 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9842-8082","authenticated-orcid":false,"given":"Haolan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriy","family":"Pihosh","sequence":"additional","affiliation":[{"name":"Office of University Professors, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-8656, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9224-9767","authenticated-orcid":false,"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-3034","authenticated-orcid":false,"given":"Rafael I.","family":"Shakirzyanov","sequence":"additional","affiliation":[{"name":"Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, 010008 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-2803","authenticated-orcid":false,"given":"Ilya V.","family":"Korolkov","sequence":"additional","affiliation":[{"name":"The Institute of Nuclear Physics, Ibragimov Str. 1, 050032 Almaty, Kazakhstan"},{"name":"Engineering Profile Laboratory, L.N. Gumilyov Eurasian National University, Satpaev Str. 5, 010008 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"ref_1","unstructured":"Ma, X., and Yu, H. (2007). Global Burden of Cancer. Yale J. Biol. Med., 79."},{"key":"ref_2","unstructured":"(2025, May 28). Global Cancer Observatory. 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