{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:29:58Z","timestamp":1784078998533,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research","award":["21K08762"],"award-info":[{"award-number":["21K08762"]}]},{"name":"Grant-in-Aid for Transformative Research Areas","award":["20H05877"],"award-info":[{"award-number":["20H05877"]}]},{"DOI":"10.13039\/501100012412","name":"Kansai Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012412","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Oxaliplatin is an anticancer drug used to treat colorectal and gastric cancers. In many cases, chemotherapy is discontinued due to adverse events caused by anticancer drugs. To address this challenge, we developed a sustained-release drug delivery system using polycaprolactone sheets embedded with oxaliplatin (oxaliplatin sheets) and evaluated their therapeutic potential in murine models of colon and gastric cancers. Antitumor efficacy was compared with conventional intraperitoneal administration by monitoring tumor volume, body weight, and systemic oxaliplatin concentrations over 21 days, along with histopathological assessment of tumors and hepatic tissue. Oxaliplatin sheets demonstrated superior tumor suppression, significantly reduced Ki-67 positivity, and mitotic indices. Additionally, antitumor effects and blood oxaliplatin levels were consistent regardless of implantation site. Notably, oxaliplatin sheets significantly decreased weight loss compared with intraperitoneal administration. In our analysis of liver pathology, we found that hepatic sinusoidal obstruction and hepatocellular degeneration were significantly increased after intraperitoneal administration compared with untreated mice and mice treated with oxaliplatin sheets. Furthermore, treatment with oxaliplatin sheets improved survival. Thus, our oxaliplatin sheets exhibited effective tumor control and reduced side effects, indicating their potential as a promising treatment for advanced gastric and colorectal cancers.<\/jats:p>","DOI":"10.3390\/nano15191524","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T08:10:51Z","timestamp":1759738251000},"page":"1524","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Nanofiber Sheets Incorporating Oxaliplatin in Gastrointestinal Cancer Xenograft Models"],"prefix":"10.3390","volume":"15","author":[{"given":"Fusao","family":"Sumiyama","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Hai","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1191, Japan"},{"name":"Department of Gastrointestinal Hepatobiliary Surgery, Thainguyen National Hospital, Thainguyen 240000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7274-0177","authenticated-orcid":false,"given":"Kosuke","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-1830","authenticated-orcid":false,"given":"Terufumi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Kansai Medical University, Osaka 573-1191, Japan"},{"name":"Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4734-5084","authenticated-orcid":false,"given":"Hidekazu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-9973","authenticated-orcid":false,"given":"Hisashi","family":"Kosaka","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsugu","family":"Sekimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Khanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1191, Japan"},{"name":"Internal Gastroenterology Department, VNU University of Medicine and Pharmacy, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-9781","authenticated-orcid":false,"given":"Thanh Tung","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1191, Japan"},{"name":"Department of Surgery, Hanoi Medical University, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Ohigashi","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-6929","authenticated-orcid":false,"given":"Tomoya O.","family":"Akama","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Yoshii","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics in Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7326-7740","authenticated-orcid":false,"given":"Emiho","family":"Oe","sequence":"additional","affiliation":[{"name":"Research Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), Ibaraki 305-0047, 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