{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:18:21Z","timestamp":1784549901237,"version":"3.55.0"},"reference-count":58,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["23K09384"],"award-info":[{"award-number":["23K09384"]}]},{"name":"JSPS KAKENHI","award":["21K19617"],"award-info":[{"award-number":["21K19617"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Denture stomatitis is a common issue among denture users, primarily caused by pathogenic microorganisms such as Candida albicans that adhere to and multiply on the denture surface. While previous approaches have focused on incorporating antimicrobial agents into denture base resins, this study introduces a novel surface coating strategy for polymethyl-methacrylate (PMMA) using hinokitiol\u2014a natural antibacterial and antifungal compound derived from Hiba. This method enables the formation of a uniform silica\u2013resin layer containing hinokitiol, achieved through a simple immersion process. Using X-ray and neutron reflectivity techniques, we discovered that a uniform silica\u2013resin layer could form on PMMA with significant amounts of hinokitiol present. Time-dependent neutron reflectivity analysis revealed the presence of the following two types of hinokitiol molecules within the silica\u2013resin layer: one type desorbs rapidly with weak capture near the surface, and the other desorbs slowly with strong capture near the PMMA interface, facilitated by hydrogen bonding in the silica\u2013resin nanopores. These findings demonstrate a new mechanism for controlled release of antimicrobial agents from denture surfaces and highlight the potential of this coating technique as a practical and effective strategy for preventing denture-related infections.<\/jats:p>","DOI":"10.3390\/nano15211652","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:38:22Z","timestamp":1761759502000},"page":"1652","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physical Properties of New Silica-Based Denture Surface Coating"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-6604","authenticated-orcid":false,"given":"Kazuhiro","family":"Akutsu-Suyama","sequence":"first","affiliation":[{"name":"Neutron Science and Technology Center, Comprehensive Research Organization for Science and Society (CROSS), Tokai 319-1106, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3932-5913","authenticated-orcid":false,"given":"Reiko","family":"Tokuyama-Toda","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Stomatology, School of Dental Medicine, Tsurumi University, 2-1-3, Tsurumi, Tsurumi-ku, Yokohama 230-8501, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-7107","authenticated-orcid":false,"given":"Chiaki","family":"Tsutsumi-Arai","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Stomatology, School of Dental Medicine, Tsurumi University, 2-1-3, Tsurumi, Tsurumi-ku, Yokohama 230-8501, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5380-5599","authenticated-orcid":false,"given":"Chika","family":"Terada-Ito","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Stomatology, School of Dental Medicine, Tsurumi University, 2-1-3, Tsurumi, Tsurumi-ku, Yokohama 230-8501, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Iwamiya","sequence":"additional","affiliation":[{"name":"Choetsu Kaken Co., Ltd., Suehiro, Tsurumi, Yokohama 230-0045, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenji","family":"Hiroi","sequence":"additional","affiliation":[{"name":"Institute for Solid State Physics, University of Tokyo, Kashiwa 277-8581, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8683-5070","authenticated-orcid":false,"given":"Mitsuhiro","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Neutron Science and Technology Center, Comprehensive Research Organization for Science and Society (CROSS), Tokai 319-1106, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2159-1279","authenticated-orcid":false,"given":"Kazuhito","family":"Satomura","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Stomatology, School of Dental Medicine, Tsurumi University, 2-1-3, Tsurumi, Tsurumi-ku, Yokohama 230-8501, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.clindermatol.2016.02.022","article-title":"Oral candidiasis","volume":"34","author":"Millsop","year":"2016","journal-title":"Clin. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0300-5712(97)00026-2","article-title":"Denture plaque\u2013past and recent concerns","volume":"26","author":"Nikawa","year":"1998","journal-title":"J. Dent."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.4317\/medoral.16.e139","article-title":"Candida-associated denture stomatitis","volume":"16","author":"Salerno","year":"2011","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tripleo.2003.04.002","article-title":"Denture stomatitis: A role for Candida biofilms","volume":"98","author":"Ramage","year":"2004","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Rad. Endod."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.prosdent.2014.02.003","article-title":"Biofilm Development by Blastospores and Hyphae of Candida albicans on Abraded Denture Acrylic Resin Surfaces","volume":"112","author":"Jackson","year":"2014","journal-title":"J. Prosthet. Dent."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1532-849X.2011.00698.x","article-title":"Epidemiology and etiology of denture stomatitis","volume":"20","author":"Gendreau","year":"2011","journal-title":"J. Prosthodont."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Walczak, K., Schierz, G., Basche, S., Petto, C., Boening, K., and Wieckiewicz, M. (2020). Antifungal and Surface Properties of Chitosan-Salts Modified PMMA Denture Base Material. Molecules, 25.","DOI":"10.3390\/molecules25245899"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.archoralbio.2017.12.024","article-title":"Superhydrophilic Co-Polymer Coatings on Denture Surfaces Reduce Candida Albicans Adhesion\u2014An in Vitro Study","volume":"87","author":"Hirasawa","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/jopr.13118","article-title":"Effect of protective coating on surface properties and Candida albicans adhesion to denture base materials","volume":"29","author":"Alsrheed","year":"2020","journal-title":"J. Prosthodont."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jdent.2015.11.010","article-title":"Reduction of Candida biofilm adhesion by incorporation of prereacted glass ionomer filler in denture base resin","volume":"44","author":"Tsutsumi","year":"2016","journal-title":"J. Dent."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tsutsumi-Arai, C., Iwamiya, Y., Hoshino, R., Terada-Ito, C., Sejima, S., Akutsu-Suyama, K., Shibayama, M., Hiroi, Z., Tokuyama-Toda, R., and Iwamiya, R. (2022). Surface Functionalization of Non-Woven Fabrics Using a Novel Silica-Resin Coating Technology: Antiviral Treatment of Non-Woven Fabric Filters in Surgical Masks. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19063639"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Iwamiya, Y., and Kawai, M. (2020, January 11\u201316). Tungsten-coated cloth for radiation shielding made with the SilicaTech\u00ae coating technique. Proceedings of the 14th International Workshop on Spallation Materials Technology (JAPAN), Fukushima, Japan.","DOI":"10.7566\/JPSCP.28.051004"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1021\/acs.iecr.0c05173","article-title":"Modern Alchemy: Making \u201cPlastics\u201d from Paper","volume":"60","author":"Iwamiya","year":"2020","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/jac\/dkh053","article-title":"National surveillance of species in Japan and their susceptibility yo six antifungal agents including voriconazole and micafungin","volume":"53","author":"Takakura","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sakamoto, Y., Kawabe, K., Suzuki, T., Sano, K., Ide, K., Nishigaki, T., Enoki, Y., Taguchi, K., Koike, H., and Kato, H. (2021). Species distribution of candidemia and their susceptibility in a single Japanese university hospital: Prior micafungin use affects the appearance of Candida parapsilosis and elevation of micafungin MICs in non-parapsilosis Candida Species. J. Fungi, 7.","DOI":"10.3390\/jof7080596"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jiac.2018.10.007","article-title":"Antifungal susceptibility trend and analysis of resistance mechanism for Candida species isolated from bloodstream at a Japanese university hospital","volume":"25","author":"Sakagami","year":"2019","journal-title":"J. Infect. Chemother."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/adj.12826","article-title":"Efficacy of low-molecular weight chitosan against Candida albicans biofilm on polymethyl methacrylate resin","volume":"66","author":"Srimaneepong","year":"2021","journal-title":"Aust. Dent. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1021\/ja500036r","article-title":"Structure-Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active against Drug-Resistant Strains of Candida albicans","volume":"136","author":"Liu","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"ref_19","first-page":"228","article-title":"Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials\u2019 resistance","volume":"5","author":"Melo","year":"2020","journal-title":"Bioact. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1080\/08927014.2011.599101","article-title":"Silver colloidal nanoparticles: Antifungal effect against adhered cells and biofilms of Candida albicans and Candida glabrata","volume":"27","author":"Monteiro","year":"2011","journal-title":"Biofouling"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.nano.2016.10.011","article-title":"Inhibition of Candida albicans biofilm by pure selenium nanoparticles synthesized by pulsed laser ablation in liquids","volume":"13","author":"Guisbiers","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_22","first-page":"9477","article-title":"Chemical Composition and Effectiveness of Ocimum basilicum L. Extracts on the Adhesion of Candida albicans and C. dubliniensis on Acrylic Surfaces of RemovableOrthodontic Appliances","volume":"11","author":"Roozbehani","year":"2021","journal-title":"Biointerface Res. Appl. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"985832","DOI":"10.1155\/2011\/985832","article-title":"Action of Coriandrum sativum L. Essential Oil upon Oral Candida albicans Biofilm Formation","volume":"2011","author":"Furletti","year":"2011","journal-title":"Evid Based Complement Altern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/ijdr.IJDR_521_17","article-title":"Variableantifungalactivityof curcumin against planktonic and biofilm phase of different candida species","volume":"31","author":"Narayanan","year":"2020","journal-title":"Indian J. Dent. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/scd.12570","article-title":"Efficacy of essential oil of cinnamon for the treatment of oral candidiasis: A randomized trial","volume":"41","author":"Maciel","year":"2021","journal-title":"Spec. Care Dent."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"29618","DOI":"10.1021\/acsomega.0c04860","article-title":"Ionic Liquid-Assisted Extraction of Essential Oils from Thujopsis dolobrata (Hiba)","volume":"5","author":"Syahmina","year":"2020","journal-title":"ACS Omega"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/1348-0421.12688","article-title":"Antibacterial activity of hinokitiol against both antibiotic-resistant and-susceptible pathogenic bacteria that predominate in the oral cavity and upper airways","volume":"63","author":"Domon","year":"2019","journal-title":"Microbiol. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kim, D.J., Lee, M.W., Choi, J.S., Lee, S.G., Park, J.Y., and Kim, S.W. (2017). Inhibitory activity of hinokitiol against biofilm formation in fluconazole-resistant Candida species. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0171244"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1248\/bpb.31.735","article-title":"Antifungal mechanism of hinokitiol against Candida albicans","volume":"31","author":"Komaki","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ejphar.2017.12.014","article-title":"Hinokitiol inhibits compound action potentials in the frog sciatic nerve","volume":"819","author":"Magori","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1021\/jm00390a022","article-title":"Synthesis and antitumor activity of tropolone derivatives","volume":"30","author":"Yamato","year":"1987","journal-title":"J. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jid.2016.11.044","article-title":"SIRT1, a class III histone deacetylase, regulates LPS-induced inflammation in human keratinocytes and mediates the anti-inflammatory effects of hinokitiol","volume":"137","author":"Lee","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/02713683.2016.1151530","article-title":"Protective role of hinokitiol against H2O2-induced injury in human corneal epithelium","volume":"42","author":"Xu","year":"2017","journal-title":"Curr. Eye Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1139\/m73-216","article-title":"Antibacterial activity of \u03b2-thujaplicin","volume":"19","author":"Trust","year":"1973","journal-title":"Can. J. Microbiol."},{"key":"ref_35","first-page":"421","article-title":"Effects of heartwood inhabiting fungi on thujaplicin content and decay resistance of western redcedar (Thuja-Plicata Donn)","volume":"18","year":"1986","journal-title":"Wood Fiber Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.micres.2012.12.007","article-title":"In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines","volume":"168","author":"Shih","year":"2013","journal-title":"Microbiol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wang, T.-H., Hsia, S.-M., Wu, C.-H., Ko, S.-Y., Chen, M.Y., Shih, Y.-H., Shieh, T.-M., Chuang, L.-C., and Wu, C.-Y. (2016). Evaluation of the antibacterial potential of liquid and vapor phase phenolic essential oil compounds against oral microorganisms. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163147"},{"key":"ref_38","first-page":"17","article-title":"Studies of the antibacterial activity of plant extracts and their constituents against periodontopathic bacteria","volume":"31","author":"Osawa","year":"1990","journal-title":"Bull. Tokyo Dent. Coll."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"J43","DOI":"10.3314\/mmj.17.004","article-title":"Treatment and prevention of oral candidiasis in elderly patients","volume":"58","author":"Sakaguchi","year":"2017","journal-title":"Med. Mycol. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.oooo.2013.05.021","article-title":"Effect of mouth cleaning with hinokitiol-containing gel on oral malodor: A randomized, open-label pilot study","volume":"116","author":"Iha","year":"2013","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ohara, H., Odanaka, K., Shiine, M., and Hayasaka, M. (2023). Antimicrobial effect of oral care gel containing hinokitiol and 4-isopropyl-3-methylphenol against intraoral pathogenic microorganisms. PLoS ONE, 18.","DOI":"10.1101\/2023.03.07.531591"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00784-022-04670-z","article-title":"Antimicrobial surface processing of polymethyl methacrylate denture base resin using a novel silica-based coating technology","volume":"27","author":"Iwamiya","year":"2022","journal-title":"Clin. Oral Invest."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0920-2307(05)80002-7","article-title":"X-Ray and Neutron Reflectivity for the Investigation of Polymers","volume":"5","author":"Russell","year":"1990","journal-title":"Mater. Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8519","DOI":"10.1021\/acs.langmuir.8b04315","article-title":"X-ray and Neutron Reflectometry of Thin Films at Liquid Interfaces","volume":"35","author":"Delcea","year":"2019","journal-title":"Langmuir"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.tetlet.2011.12.032","article-title":"Deuteration of molecules for neutron reflectometry on organic light-emitting diode thin films","volume":"53","author":"Darwish","year":"2012","journal-title":"Tetrahedron Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"17512","DOI":"10.1039\/C9CP02479D","article-title":"Controlled deuterium labelling of imidazolium ionic liquids to probe the fine structure of the electrical double layer using neutron reflectometry","volume":"21","author":"Cagnes","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_47","first-page":"011150","article-title":"Metal catalyzed H\u2013D Exchange methods using D2O as a deuterium source: A comparative study in different sealed devices","volume":"33","author":"Park","year":"2021","journal-title":"JPS Conf. Proc."},{"key":"ref_48","first-page":"161","article-title":"Current Status of a New Polarized Neutron Reflectometer at the Intense Pulsed Neutron Source of the Materials and Life Science Experimental Facility (MLF) of J-PARC","volume":"50","author":"Takeda","year":"2012","journal-title":"Chin. J. Phys."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Sakasai, K., Satoh, S., Seya, T., Nakamura, T., Toh, K., Yamagishi, H., Soyama, K., Yamazaki, D., Maruyama, R., and Oku, T. (2017). Materials and Life Science Experimental Facility at the Japan Proton Accelerator Research Complex III: Neutron Devices and Computational and Sample Environments. Quantum Beam Sci., 1.","DOI":"10.3390\/qubs1020010"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1107\/S0021889806005073","article-title":"Co-refinement of multiple-contrast neutron\/X-ray reflectivity data using MOTOFIT","volume":"39","author":"Nelson","year":"2006","journal-title":"J. Appl. Crystallogr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1107\/S1600576722007506","article-title":"Structure analysis of a buried interface between organic and porous inorganic layers using spin-contrast-variation neutron reflectivity","volume":"55","author":"Kumada","year":"2022","journal-title":"J. Appl. Crystallogr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1021\/j100846a039","article-title":"Adsorption on Hydroxylated Silica Surfaces","volume":"73","author":"Hair","year":"1969","journal-title":"J. Phys. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1021\/jp806815p","article-title":"Effects of surface chemistry on structure and thermodynamics of water layers at solid\u2212vapor interfaces","volume":"113","author":"Asay","year":"2008","journal-title":"J. Phys. Chem. C"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0022-3093(03)00361-2","article-title":"Computer modeling of water adsorption on silica and silicate glass fracture surfaces","volume":"325","author":"Leed","year":"2003","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"117326","DOI":"10.1016\/j.seppur.2020.117326","article-title":"Adsorption Equilibria and Kinetics of Silica Gel for N2O, O2, N2, and CO2","volume":"251","author":"Park","year":"2020","journal-title":"Sep. Purif. Technol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1109\/TBME.2014.2363173","article-title":"Modeling and validation of microwave ablations with internal vaporization","volume":"62","author":"Chiang","year":"2015","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"23338","DOI":"10.1021\/acs.iecr.9b04800","article-title":"Direct Air Capture of CO2 with Aqueous Amino Acids and Solid Bis-Iminoguanidines (BIGs)","volume":"58","author":"Custelcean","year":"2019","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/07366299.2023.2166351","article-title":"Deuterated malonamide synthesis for fundamental research on solvent extraction systems","volume":"41","author":"Micheau","year":"2023","journal-title":"Solvent Extr. Ion Exch."}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/15\/21\/1652\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:38:41Z","timestamp":1761889121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/15\/21\/1652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":58,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["nano15211652"],"URL":"https:\/\/doi.org\/10.3390\/nano15211652","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]}}}