{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:08:21Z","timestamp":1779210501535,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Labex Chemisyst","doi-asserted-by":"publisher","award":["ANR-10-LABX-05-01"],"award-info":[{"award-number":["ANR-10-LABX-05-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>The development of efficient and biocompatible sorbent nanomaterials for cesium removal is critical for environmental and biomedical decontamination. Here, hybrid composites based on ultra-small Prussian blue or Zn Prussian blue-type nanoparticles confined within porous chitosan beads are proposed for Cs+ extraction. Nanoparticle confinement ensures homogeneous dispersion and improved accessibility of ion-exchange sites, while preserving the porous polymeric network, as confirmed by physicochemical characterization. Cs+ adsorption was investigated under neutral and acidic conditions (pH 7.2 and 1.2), at concentrations of 0\u20139 mmol\/L and contact times of 0\u201350 h, showing efficient uptake and favorable kinetics, with confirmed stability in simulated gastric fluid. In vivo performance was assessed in a mouse model of cesium contamination (70 mg Cs+\/kg). Treatment with nanocomposites (225 mg\/kg) was compared to bulk Prussian blue (75 mg\/kg), revealing enhanced detoxification efficiency. Histological analysis of liver, spleen, and kidney tissues showed no detectable structural damage, consistent with unchanged systemic biomarkers. Overall, the proposed chitosan-confined Prussian blue-type nanocomposites combine high Cs+ removal efficiency, kinetic accessibility, and in vivo safety, highlighting their potential for decorporation applications.<\/jats:p>","DOI":"10.3390\/nano16090544","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:03:47Z","timestamp":1777536227000},"page":"544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prussian Blue Nanoparticles Confined in Chitosan for In Vivo Cesium Ion Removal"],"prefix":"10.3390","volume":"16","author":[{"given":"Irina E.","family":"Bordianu-Antochi","sequence":"first","affiliation":[{"name":"ICGM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France"},{"name":"IC, Hospices Civils de Lyon (HCL), 69495 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6083-5686","authenticated-orcid":false,"given":"Afitz","family":"Da Silva","sequence":"additional","affiliation":[{"name":"IBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France"},{"name":"CHU Sainte-Justine Research Centre, University of Montreal, Montreal, QC H3T 1C5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Massasso","sequence":"additional","affiliation":[{"name":"ICGM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France"},{"name":"Saint Gobain Research Provence, 84306 Cavaillon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Quignard","sequence":"additional","affiliation":[{"name":"ICGM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-8224","authenticated-orcid":false,"given":"Vanja","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"IBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France"},{"name":"Faculty of Sciences and Mathematics, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9641-212X","authenticated-orcid":false,"given":"Magali","family":"Gary-Bobo","sequence":"additional","affiliation":[{"name":"IBMM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3279-9158","authenticated-orcid":false,"given":"Joulia","family":"Larionova","sequence":"additional","affiliation":[{"name":"ICGM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-3225","authenticated-orcid":false,"given":"Yannick","family":"Guari","sequence":"additional","affiliation":[{"name":"ICGM, University of Montpellier, CNRS, ENSCM, 34293 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00004032-199403000-00002","article-title":"137Cs Internal Contamination Involving a Brazilian Accident, and the Efficacy of Prussian Blue Treatment","volume":"66","author":"Melo","year":"1994","journal-title":"Health Phys."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/rpd\/nch408","article-title":"Human Metabolism of Radiocaesium Revisited","volume":"112","author":"Falk","year":"2004","journal-title":"Radiat. 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